Screening, verification, and optimization of biomarkers for early prediction of cardiotoxicity based on metabolomics

Journal of Proteome Research

Volumn 14, Issue 6, 2015, Pages 2437-2445

  Li, Yubo ^a   Ju, Liang ^a   Hou, Zhiguo ^a   Deng, Haoyue ^a   Zhang, Zhenzhu ^a   Wang, Lei ^a   Yang, Zhen ^a   Yin, Jia ^a   Zhang, Yanjun ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

biomarkers for early prediction of cardiotoxicity; metabolomics; support vector machine; UPLC Q TOF MS

Indexed keywords

19 HYDROXYDEOXYCORTICOSTERONE; BIOLOGICAL MARKER; CARNITINE; CHOLIC ACID; CORTICOSTERONE DERIVATIVE; DOXORUBICIN; FLUOROURACIL; ISOPRENALINE; LYSOPHOSPHATIDYLCHOLINE; PALMITOYLCARNITINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL ANALYSIS; CARDIOTOXICITY; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; EARLY DIAGNOSIS; HISTOPATHOLOGY; MALE; METABOLIC DISORDER; METABOLOMICS; NEPHROTOXICITY; NONHUMAN; PLASMA; PREDICTIVE VALUE; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; RAT; SENSITIVITY AND SPECIFICITY; SUPPORT VECTOR MACHINE; TIME OF FLIGHT MASS SPECTROMETRY; TOXIC HEPATITIS; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANIMAL; DRUG EFFECTS; HEART; METABOLISM; WISTAR RAT;

RATTUS;

ANIMALS; BIOMARKERS; CARDIOTOXICITY; DOXORUBICIN; FLUOROURACIL; HEART; ISOPROTERENOL; MALE; METABOLOMICS; MODELS, ANIMAL; RATS; RATS, WISTAR;

EID: 84930607856     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr501116c     Document Type: Article

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