Metabonomic evaluation of melamine-induced acute renal toxicity in rats

Journal of Proteome Research

Volumn 9, Issue 1, 2010, Pages 125-133

  Xie, Guoxiang ^a,b   Zheng, Xiaojiao ^c   Qi, Xin ^c   Cao, Yu ^c   Chi, Yi ^c   Su, Mingming ^c   Ni, Yan ^c   Qiu, Yunping ^c   Liu, Yumin ^c   Li, Houkai ^c   Zhao, Aihua ^c   Jia, Wei ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b Shanghai Jiao Tong University   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Cyanuric acid; Melamine; Metabonomics; Multivariate statistical analysis; Nephrotoxicity; Ultraperformance liquid chromatography time of flight mass spectrometry; Urine

Indexed keywords

CYANURIC ACID; MELAMINE; POLYAMINE; TRYPTOPHAN; TYROSINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHINA; CONTROLLED STUDY; DOSE RESPONSE; HISTOPATHOLOGY; INTESTINE FLORA; KIDNEY FAILURE; METABOLOMICS; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD CONTAMINATION; KIDNEY; KIDNEY FAILURE, ACUTE; MALE; METABOLOMICS; MULTIVARIATE ANALYSIS; ORGAN SIZE; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRIAZINES;

RATTUS; RATTUS NORVEGICUS;

EID: 73649128909     PISSN: 15353893     EISSN: None     Source Type: Journal    
DOI: 10.1021/pr900333h     Document Type: Article

References (42)

1. Brown, C. A.; Jeong, K. S.; Poppenga, R. H.; Puschner, B.; Miller, D. M.; Ellis, A. E.; Kang, K. I.; Sum, S.; Cistola, A. M.; Brown, S. A. Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007. J. Vet. Diagn. Invest. 2007, 19 (5), 525-531.
2. US Food and Drug Administration (USFDA) Available: http://www. FoodandDrugAdministration.gov/oc/opacom/hottopics/petfood.html. Accessed May 18, 2007.
3. Reimschuessel, R.; Gieseker, C. M.; Miller, R. A.; Ward, J.; Boehmer, J.; Rummel, N.; Heller, D. N.; Nochetto, C.; de Alwis, G. K. H.; Bataller, N.; Andersen, W. C.; Turnipseed, S. B.; Karbiwnyk, C. M.; Satzger, R. D.; Crowe, J. B.; Wilber, N. R.; Reinhard, M. K.; Roberts, J. F.; Witkowski, M. R. Evaluation of the renal effects of experimental feeding of melamine and cyanuric acid to fish and pigs. Am. J. Vet. Res. 2008, 69 (9), 1217-1228.
4. U.S. Food and Drug Administration, Pet Food Recall (Melamine)/ Tainted Animal Feed. http://www.fda.gov/AnimalVeterinary/SafetyHealth/ RecallsWithdrawals/ucm129575.htm, accessed: December 3, 2007.
5. Janson, D. J. FDA will test more food ingredients. Chem. Eng. News 2007, 85, 22.
6. Pressure For Food Safety Reform. Chem. Eng. News 2007 85 (20), 31.
7. Hauck, R. D.; Stephenson, H. F. Nitrification of triazine nitrogen. J. Agric. Food Chem. 1964, 12 (2), 147-151.
8. McDonald, S. Nearly 53,000 Chinese children sick from milk. Associated Press, Sept. 22 2008.
9. Macartney, J. China baby milk scandal spreads as sick toll rises to 13,000. The Times, Sept 22, 2008.
10. Lenz, E. M.; Williams, R. E.; Sidaway, J.; Smith, B. W.; Plumb, R. S.; Johnson, K. A.; Rainville, P.; Shockcor, J.; Stumpf, C. L.; Granger, J. H.; Wilson, I. D. The application of microbore UPLC/oa-TOFMS and H-1 NMR spectroscopy to the metabonomic analysis of rat urine following the intravenous administration of pravastatin. J. Pharm. Biomed. Anal. 2007, 44 (4), 845-852.
11. Zhe, Z.; Ho, L., Melamine found in more milk, http://www.chinadaily.com. cn/china/2008-09/17/content-7032353.htm, Sept 17, 2008.
12. ColbyR. W. MeslerR. J., Jr. Ruminant feed compositions. U.S. Patent 2819968, 1958.
13. Jutzi, K.; Cook, A. M.; Hutter, R. The degradative pathway of the s-triazine melamine. The steps to ring cleavage. Biochem. J. 1982, 208 (3), 679-684.
14. Shelton, D. R.; Karns, J. S.; McCarty, G. W.; Durham, D. R. Metabolism of melamine by Klebsiella terragena. Appl. Environ. Microbiol. 1997, 63 (7), 2832-2835.
15. Puschner, B.; Poppenga, R. H.; Lowenstine, L. J.; Filigenzi, M. S.; Pesavento, P. A. Assessment of melamine and cyanuric acid toxicity in cats. J. Vet. Diagn. Invest. 2007, 19 (6), 616-624.
16. Roy, L. M. D.; Safa, M.; Mike, Q.; Cambron, R. T.; Timothy, R. B.; Aletha, M. P.; Brian, T. R.; Adrienne, S. B.-K.; Thomas, V.; Andrew, F.; Renate, R.; Gary, O.; Yuching, S.; George, P. D. Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol. Sci. 2008, 106 (1), 251-251.
17. Cianciolo, R. E.; Bischoff, K.; Ebel, J. G.; Van Winkle, T. J.; Goldstein, R. E.; Serfilippi, L. M. Clinicopathologic, histologic, and toxicologic findings in 70 cats inadvertently exposed to pet food contaminated with melamine and cyanuric acid. J. Am. Vet. Med. Assoc. 2008, 233 (5), 729-737.
18. Mackenize, H. I.; van Rensburg, I. Ammeide and ammeline as nonprotein nitrogen supplements for sheep. J. S. Afr. Vet. Med. Assoc. 1968, 39, 41-45.
19. Lindon, J. C.; Holmes, E.; Nicholson, J. K. Metabonomics in pharmaceutical R & D. FEBS J. 2007, 274 (5), 1140-1151.
20. Nicholson, J. K.; Connelly, J.; Lindon, J. C.; Holmes, E. Metabonomics: a platform for studying drug toxicity and gene function. Nat. Rev. Drug Discovery 2002, 1 (2), 153-161.
21. Lindon, J. C.; Holmes, E.; Nicholson, J. K. Metabonomics: Systems biology in pharmaceutical research and development. Curr. Opin. Mol. Ther. 2004, 6 (3), 265-272.
22. Chen, M. J.; Zhao, L. P.; Jia, W. Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model. J. Proteome Res. 2005, 4 (6), 2391-2396.
23. Chen, M. J.; Su, M. M.; Zhao, L. P.; Jiang, J.; Liu, P.; Cheng, J. Y.; Lai, Y. J.; Liu, Y. M.; Jia, W. Metabonomic study of aristolochic acid-induced nephrotoxicity in rats. J. Proteome Res. 2006, 5 (4), 995-1002.
24. U.S.Food and Drug Administration, Interim Melamine and Analogues Safety/risk Assessment. http://www.foodsafety.gov/~dms/melamra.html. 2007.
25. Xie, G.; Ye, M.; Wang, Y.; Ni, Y.; Su, M.; Huang, H.; Qiu, M.; Zhao, A.; Zheng, X.; Chen, T.; Jia, W. Characterization of Pu-erh tea using chemical and metabolic profiling approaches. J. Agric. Food Chem. 2009, 57, 3046-3054.
26. Ni, Y.; Su, M. M.; Qiu, Y. P.; Chen, M. J.; Liu, Y. M.; Zhao, A. H.; Jia, W. Metabolic profiling using combined GC-MS and LC-MS provides a systems understanding of aristolochic acid-induced nephrotoxicity in rat. FEBS Lett. 2007, 581 (4), 707-711.
27. Crockford, D. J.; Holmes, E.; Lindon, J. C.; Plumb, R. S.; Zirah, S.; Bruce, S. J.; Rainville, P.; Stumpf, C. L.; Nicholson, J. K. Statistical heterospectroscopy, an approach to the integrated analysis of NMR and UPLC-MS data sets: Application in metabonomic toxicology studies. Anal. Chem. 2006, 78 (2), 363-371.
28. Barry, G. H. A Textbook of Science for the Health Professions, 2nd ed.; Nelson Thornes: Cheltenham, U.K., 1992; p 304.
29. Gagliardi, A. C. M.; Miname, M. H.; Santos, R. D. Uric acid: A marker of increased cardiovascular risk. Atherosclerosis 2009, 202 (1), 11-17.
30. Papaioannou, A.; Karamanis, G.; Rigas, I.; Spanos, T.; Roupa, Z. Determination and modelling of clinical laboratory data of healthy individuals and patients with end-stage renal failure. Cent. Eur. J. Med. 2009, 4 (1), 37-48.
31. Mast, R.; Jeffcoat, A.; Sadler, B.; Kraska, R.; Friedman, M. Metabolism, disposition and excretion of [14C]melamine in male Fischer 344 rats. Food Chem. Toxicol. 1983, 21 (6), 807-10.
32. Brandacher, G.; Cakar, F.; Winkler, C.; Schneeberger, S.; Obrist, P.; Bosmuller, C.; Werner-Felmayer, G.; Werner, E. R.; Bonatti, H.; Margreiter, R.; Fuchs, D. Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation. Kidney Int. 2007, 71 (1), 60-67.
33. Ferdinande, L.; Demetter, P.; Perez-Novo, C.; Waeytens, A.; Taildeman, J.; Rottiers, I.; Rottiers, P.; De Vos, M.; Cuvelier, C. A. Inflamed intestinal mucosa features a specific epithelial expression pattern of indoleamine 2,3-dioxygenase. Int. J. Immunopathol. Pharmacol. 2008, 21 (2), 289-295.
34. Gerner, E. W.; Meyskens, F. L. Polyamines and cancer: Old molecules, new understanding. Nat. Rev. Cancer 2004, 4 (10), 781-792.
35. Marescau, B.; Nagels, G.; Possemiers, I.; DeBroe, M. E.; Becaus, I.; Billiouw, J. M.; Lornoy, W.; DeDeyn, P. P. Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency. Metab., Clin. Exp. 1997, 46 (9), 1024-1031.
36. Shitomoto, M.; Otsuji, S. [Changes of guanidino compounds in chronic renal failure (author's transl)]. Nippon Jinzo Gakkaishi 1979, 21 (1), 33-49.
37. Smith, J. L.; Wishnok, J. S.; Deen, W. M. Metabolism and excretion of methylamines in rats. Toxicol. Appl. Pharmacol. 1994, 125 (2), 296-308.
38. Wang, Y. L.; Holmes, E.; Nicholson, J. K.; Cloarec, O.; Chollet, J.; Tanner, M.; Singer, B. H.; Utzinger, J. Metabonomic investigations in mice infected with Schistosoma mansoni: An approach for biomarker identification. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (34), 12676-12681.
39. Gartland, K. P. R.; Bonner, F. W.; Nicholson, J. K. Investigations into the Biochemical Effects of Region-Specific Nephrotoxins. Mol. Pharmacol. 1989, 35 (2), 242-250.
40. Seiler, N.; Raul, F. Polyamines and the intestinal tract. Crit. Rev. Clin. Lab. Sci. 2007, 44 (4), 365-411.
41. Luk, G. D.; Marton, L. J.; Baylin, S. B. Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats. Science 1980, 210 (4466), 195-198.
42. Yarrington, J. T.; Sprinkle, D. J.; Loudy, D. E.; Diekema, K. A.; McCann, P. P.; Gibson, J. P. Intestinal changes caused by Dl-alpha- difluoromethylornithine (Dfmo), an inhibitor of ornithine decarboxylase. Exp. Mol. Pathol. 1983, 39 (3), 300-316.