Evaluation of the usefulness of biomarkers for cardiac and skeletal myotoxicity in rats

Toxicology

Volumn 266, Issue 1-3, 2009, Pages 48-54

  Tonomura, Yutaka ^a   Mori, Yoko ^a   Torii, Mikinori ^a   Uehara, Takeki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Cardiotoxicity; Combinatorial safety biomarkers; Rats; Skeletal myotoxicity

Indexed keywords

ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CARBOFURAN; CREATINE KINASE; FATTY ACID BINDING PROTEIN; FATTY ACID BINDING PROTEIN 3; ISOPRENALINE; LACTATE DEHYDROGENASE; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN 1; TROPONIN I; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; HEART LEFT VENTRICLE; HEART VENTRICLE SEPTUM; HISTOPATHOLOGY; MALE; MYOPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; RAT; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SKELETAL MUSCLE; SKELETAL MYOTOXICITY; SLOW MUSCLE FIBER; TISSUE DISTRIBUTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CARBOFURAN; CHOLINESTERASE INHIBITORS; CREATINE KINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACID-BINDING PROTEINS; HEART; INJECTIONS, INTRAPERITONEAL; ISOPROTERENOL; KINETICS; L-LACTATE DEHYDROGENASE; MALE; MUSCLE, SKELETAL; MYOCARDIUM; MYOSIN LIGHT CHAINS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; ROC CURVE; TOXICITY TESTS; TROPONIN I; TROPONIN T;

RATTUS;

EID: 70449628755     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.10.014     Document Type: Article

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