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Volumn 21, Issue 6, 2015, Pages 385-393

EGFR and NF-κB: Partners in cancer

Author keywords

EGFR; Erlotinib; Gefitinib; NF B; Resistance; Tumor initiating cells

Indexed keywords

BORTEZOMIB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GEFITINIB; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ERLOTINIB; KIAA1199 PROTEIN, HUMAN; PROTEIN; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

EID: 84930542408     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.04.001     Document Type: Review
Times cited : (183)

References (82)
  • 1
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R., et al. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004, 305:1163-1167.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1
  • 3
    • 0031197193 scopus 로고    scopus 로고
    • SH2 and PTB domain interactions in tyrosine kinase signal transduction
    • Shoelson S.E. SH2 and PTB domain interactions in tyrosine kinase signal transduction. Curr. Opin. Chem. Biol. 1997, 1:227-234.
    • (1997) Curr. Opin. Chem. Biol. , vol.1 , pp. 227-234
    • Shoelson, S.E.1
  • 4
    • 55849103180 scopus 로고    scopus 로고
    • Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network
    • Morandell S., et al. Quantitative proteomics and phosphoproteomics reveal novel insights into complexity and dynamics of the EGFR signaling network. Proteomics 2008, 8:4383-4401.
    • (2008) Proteomics , vol.8 , pp. 4383-4401
    • Morandell, S.1
  • 5
    • 0026729382 scopus 로고
    • The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
    • Lowenstein E.J., et al. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell 1992, 70:431-442.
    • (1992) Cell , vol.70 , pp. 431-442
    • Lowenstein, E.J.1
  • 6
    • 0028034549 scopus 로고
    • Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells
    • Okutani T., et al. Grb2/Ash binds directly to tyrosines 1068 and 1086 and indirectly to tyrosine 1148 of activated human epidermal growth factor receptors in intact cells. J. Biol. Chem. 1994, 269:31310-31314.
    • (1994) J. Biol. Chem. , vol.269 , pp. 31310-31314
    • Okutani, T.1
  • 7
    • 0032230322 scopus 로고    scopus 로고
    • Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells
    • Sakaguchi K., et al. Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates Ras activation in intact cells. Mol. Endocrinol. 1998, 12:536-543.
    • (1998) Mol. Endocrinol. , vol.12 , pp. 536-543
    • Sakaguchi, K.1
  • 8
    • 0034600849 scopus 로고    scopus 로고
    • The ErbB signaling network: receptor heterodimerization in development and cancer
    • Olayioye M.A., et al. The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 2000, 19:3159-3167.
    • (2000) EMBO J. , vol.19 , pp. 3159-3167
    • Olayioye, M.A.1
  • 9
    • 79954539965 scopus 로고    scopus 로고
    • Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations
    • Wykosky J., et al. Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations. Chin. J. Cancer 2011, 30:5-12.
    • (2011) Chin. J. Cancer , vol.30 , pp. 5-12
    • Wykosky, J.1
  • 10
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
    • Baselga J., Swain S.M. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat. Rev. Cancer 2009, 9:463-475.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 11
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial
    • Kris M.G., et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003, 290:2149-2158.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1
  • 12
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350:2129-2139.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2129-2139
    • Lynch, T.J.1
  • 13
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez J.G., et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304:1497-1500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1
  • 14
    • 0025790916 scopus 로고
    • Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo
    • Ekstrand A.J., et al. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas in vivo. Cancer Res. 1991, 51:2164-2172.
    • (1991) Cancer Res. , vol.51 , pp. 2164-2172
    • Ekstrand, A.J.1
  • 15
    • 0026548240 scopus 로고
    • Structural alterations of the epidermal growth factor receptor gene in human gliomas
    • Wong A.J., et al. Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:2965-2969.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 2965-2969
    • Wong, A.J.1
  • 16
    • 33847323129 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations in lung cancer
    • Sharma S.V., et al. Epidermal growth factor receptor mutations in lung cancer. Nat. Rev. Cancer 2007, 7:169-181.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 169-181
    • Sharma, S.V.1
  • 17
    • 84862823259 scopus 로고    scopus 로고
    • Molecular pathology of lung cancer: key to personalized medicine
    • Cheng L., et al. Molecular pathology of lung cancer: key to personalized medicine. Mod. Pathol. 2012, 25:347-369.
    • (2012) Mod. Pathol. , vol.25 , pp. 347-369
    • Cheng, L.1
  • 18
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S., et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2005, 352:786-792.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 786-792
    • Kobayashi, S.1
  • 19
    • 84877100240 scopus 로고    scopus 로고
    • Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
    • Yu H.A., et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin. Cancer Res. 2013, 19:2240-2247.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2240-2247
    • Yu, H.A.1
  • 20
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • Imai K., Takaoka A. Comparing antibody and small-molecule therapies for cancer. Nat. Rev. Cancer 2006, 6:714-727.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 21
    • 72949092456 scopus 로고    scopus 로고
    • Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
    • Zhou W., et al. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature 2009, 462:1070-1074.
    • (2009) Nature , vol.462 , pp. 1070-1074
    • Zhou, W.1
  • 22
    • 80052868947 scopus 로고    scopus 로고
    • Dual kinase inhibition of EGFR and HER2 overcomes resistance to cetuximab in a novel in vivo model of acquired cetuximab resistance
    • Quesnelle K.M., Grandis J.R. Dual kinase inhibition of EGFR and HER2 overcomes resistance to cetuximab in a novel in vivo model of acquired cetuximab resistance. Clin. Cancer Res. 2011, 17:5935-5944.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5935-5944
    • Quesnelle, K.M.1    Grandis, J.R.2
  • 23
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman J.A., et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316:1039-1043.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1
  • 24
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • Sergina N.V., et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007, 445:437-441.
    • (2007) Nature , vol.445 , pp. 437-441
    • Sergina, N.V.1
  • 25
    • 46249087766 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members
    • Wheeler D.L., et al. Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members. Oncogene 2008, 27:3944-3956.
    • (2008) Oncogene , vol.27 , pp. 3944-3956
    • Wheeler, D.L.1
  • 26
    • 2142843806 scopus 로고    scopus 로고
    • Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
    • Pinkas-Kramarski R., et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J. 1996, 15:2452-2467.
    • (1996) EMBO J. , vol.15 , pp. 2452-2467
    • Pinkas-Kramarski, R.1
  • 27
    • 77649095719 scopus 로고    scopus 로고
    • HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy
    • Campbell M.R., et al. HER3 comes of age: new insights into its functions and role in signaling, tumor biology, and cancer therapy. Clin. Cancer Res. 2010, 16:1373-1383.
    • (2010) Clin. Cancer Res. , vol.16 , pp. 1373-1383
    • Campbell, M.R.1
  • 28
    • 84900535617 scopus 로고    scopus 로고
    • Targeting of erbB3 receptor to overcome resistance in cancer treatment
    • Ma J., et al. Targeting of erbB3 receptor to overcome resistance in cancer treatment. Mol. Cancer 2014, 13:105.
    • (2014) Mol. Cancer , vol.13 , pp. 105
    • Ma, J.1
  • 29
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-kappaB in inflammation
    • Ghosh S., Hayden M.S. New regulators of NF-kappaB in inflammation. Nat. Rev. Immunol. 2008, 8:837-848.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 30
    • 0034682527 scopus 로고    scopus 로고
    • Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells
    • Biswas D.K., et al. Epidermal growth factor-induced nuclear factor kappa B activation: A major pathway of cell-cycle progression in estrogen-receptor negative breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:8542-8547.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 8542-8547
    • Biswas, D.K.1
  • 31
    • 0032559962 scopus 로고    scopus 로고
    • Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium
    • Sun L., Carpenter G. Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium. Oncogene 1998, 16:2095-2102.
    • (1998) Oncogene , vol.16 , pp. 2095-2102
    • Sun, L.1    Carpenter, G.2
  • 32
    • 3042716638 scopus 로고    scopus 로고
    • NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis
    • Biswas D.K., et al. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:10137-10142.
    • (2004) Proc. Natl. Acad. Sci. U.S.A. , vol.101 , pp. 10137-10142
    • Biswas, D.K.1
  • 33
    • 25444494484 scopus 로고    scopus 로고
    • EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells
    • Le Page C., et al. EGFR and Her-2 regulate the constitutive activation of NF-kappaB in PC-3 prostate cancer cells. Prostate 2005, 65:130-140.
    • (2005) Prostate , vol.65 , pp. 130-140
    • Le Page, C.1
  • 34
    • 84870885534 scopus 로고    scopus 로고
    • EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis
    • Yang W., et al. EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis. Mol. Cell 2012, 48:771-784.
    • (2012) Mol. Cell , vol.48 , pp. 771-784
    • Yang, W.1
  • 35
    • 79952761245 scopus 로고    scopus 로고
    • CARMA3 is crucial for EGFR-Induced activation of NF-kappaB and tumor progression
    • Jiang T., et al. CARMA3 is crucial for EGFR-Induced activation of NF-kappaB and tumor progression. Cancer Res. 2011, 71:2183-2192.
    • (2011) Cancer Res. , vol.71 , pp. 2183-2192
    • Jiang, T.1
  • 36
    • 33846118297 scopus 로고    scopus 로고
    • CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells
    • McAllister-Lucas L.M., et al. CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:139-144.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 139-144
    • McAllister-Lucas, L.M.1
  • 37
    • 39749123870 scopus 로고    scopus 로고
    • Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells
    • Mahanivong C., et al. Protein kinase C alpha-CARMA3 signaling axis links Ras to NF-kappa B for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. Oncogene 2008, 27:1273-1280.
    • (2008) Oncogene , vol.27 , pp. 1273-1280
    • Mahanivong, C.1
  • 38
    • 46249085882 scopus 로고    scopus 로고
    • Multifunctional roles for MALT1 in T-cell activation
    • Thome M. Multifunctional roles for MALT1 in T-cell activation. Nat. Rev. Immunol. 2008, 8:495-500.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 495-500
    • Thome, M.1
  • 39
    • 84905962129 scopus 로고    scopus 로고
    • EGF receptor uses SOS1 to drive constitutive activation of NFkappaB in cancer cells
    • De S., et al. EGF receptor uses SOS1 to drive constitutive activation of NFkappaB in cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:11721-11726.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 11721-11726
    • De, S.1
  • 40
    • 34447568476 scopus 로고    scopus 로고
    • Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos
    • Zhao C., et al. Phospholipase D2-generated phosphatidic acid couples EGFR stimulation to Ras activation by Sos. Nat. Cell Biol. 2007, 9:706-712.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 706-712
    • Zhao, C.1
  • 41
    • 84923320522 scopus 로고    scopus 로고
    • NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling
    • Shostak K., et al. NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling. Nat. Commun. 2014, 5:5232.
    • (2014) Nat. Commun. , vol.5 , pp. 5232
    • Shostak, K.1
  • 42
    • 84866075905 scopus 로고    scopus 로고
    • Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer
    • Kuscu C., et al. Transcriptional and epigenetic regulation of KIAA1199 gene expression in human breast cancer. PLoS ONE 2012, 7:e44661.
    • (2012) PLoS ONE , vol.7 , pp. e44661
    • Kuscu, C.1
  • 43
    • 84896729984 scopus 로고    scopus 로고
    • Aberrant IKKalpha and IKKbeta cooperatively activate NF-kappaB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer
    • Nottingham L.K., et al. Aberrant IKKalpha and IKKbeta cooperatively activate NF-kappaB and induce EGFR/AP1 signaling to promote survival and migration of head and neck cancer. Oncogene 2014, 33:1135-1147.
    • (2014) Oncogene , vol.33 , pp. 1135-1147
    • Nottingham, L.K.1
  • 44
    • 38049120928 scopus 로고    scopus 로고
    • RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR
    • Ramnarain D.B., et al. RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR. Cell Death Differ. 2008, 15:344-353.
    • (2008) Cell Death Differ. , vol.15 , pp. 344-353
    • Ramnarain, D.B.1
  • 45
    • 0037427122 scopus 로고    scopus 로고
    • NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells
    • Bentires-Alj M., et al. NF-kappaB transcription factor induces drug resistance through MDR1 expression in cancer cells. Oncogene 2003, 22:90-97.
    • (2003) Oncogene , vol.22 , pp. 90-97
    • Bentires-Alj, M.1
  • 46
    • 79956344228 scopus 로고    scopus 로고
    • FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB
    • Guo C., Stark G.R. FER tyrosine kinase (FER) overexpression mediates resistance to quinacrine through EGF-dependent activation of NF-kappaB. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:7968-7973.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 7968-7973
    • Guo, C.1    Stark, G.R.2
  • 47
    • 0032483517 scopus 로고    scopus 로고
    • Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER
    • Kim L., Wong T.W. Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER. J. Biol. Chem. 1998, 273:23542-23548.
    • (1998) J. Biol. Chem. , vol.273 , pp. 23542-23548
    • Kim, L.1    Wong, T.W.2
  • 48
    • 0029003669 scopus 로고
    • The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors
    • Kim L., Wong T.W. The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors. Mol. Cell. Biol. 1995, 15:4553-4561.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4553-4561
    • Kim, L.1    Wong, T.W.2
  • 49
    • 79953046542 scopus 로고    scopus 로고
    • FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR
    • Bivona T.G., et al. FAS and NF-kappaB signalling modulate dependence of lung cancers on mutant EGFR. Nature 2011, 471:523-526.
    • (2011) Nature , vol.471 , pp. 523-526
    • Bivona, T.G.1
  • 50
    • 84907210240 scopus 로고    scopus 로고
    • Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-kappaB, and cell-cycle progression in non-small cell lung cancer
    • Dermawan J.K., et al. Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-kappaB, and cell-cycle progression in non-small cell lung cancer. Mol. Cancer Ther. 2014, 13:2203-2214.
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 2203-2214
    • Dermawan, J.K.1
  • 51
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M., et al. Tumour stem cells and drug resistance. Nat. Rev. Cancer 2005, 5:275-284.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1
  • 52
    • 77956178360 scopus 로고    scopus 로고
    • EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
    • Singh A., Settleman J. EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer. Oncogene 2010, 29:4741-4751.
    • (2010) Oncogene , vol.29 , pp. 4741-4751
    • Singh, A.1    Settleman, J.2
  • 53
    • 84899860489 scopus 로고    scopus 로고
    • An integrin beta(3)-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
    • Seguin L., et al. An integrin beta(3)-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition. Nat. Cell Biol. 2014, 16:457-468.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 457-468
    • Seguin, L.1
  • 54
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin D.A., Sabatini D.M. The pharmacology of mTOR inhibition. Sci. Signal. 2009, 2:pe24.
    • (2009) Sci. Signal. , vol.2 , pp. pe24
    • Guertin, D.A.1    Sabatini, D.M.2
  • 55
    • 84860816141 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance
    • Tanaka K., et al. Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance. Cancer Discov. 2011, 1:524-538.
    • (2011) Cancer Discov. , vol.1 , pp. 524-538
    • Tanaka, K.1
  • 56
    • 84883276560 scopus 로고    scopus 로고
    • Opposing effect of EGFRWT on EGFRvIII-mediated NF-kappaB activation with RIP1 as a cell death switch
    • Puliyappadamba V.T., et al. Opposing effect of EGFRWT on EGFRvIII-mediated NF-kappaB activation with RIP1 as a cell death switch. Cell Rep. 2013, 4:764-775.
    • (2013) Cell Rep. , vol.4 , pp. 764-775
    • Puliyappadamba, V.T.1
  • 57
    • 84906094991 scopus 로고    scopus 로고
    • Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFalpha in glioblastoma
    • ra75
    • Kusne Y., et al. Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFalpha in glioblastoma. Sci. Signal. 2014, 7:ra75.
    • (2014) Sci. Signal. , vol.7
    • Kusne, Y.1
  • 58
    • 33947202249 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in development, prevention, and therapy of cancer
    • Van Waes C. Nuclear factor-kappaB in development, prevention, and therapy of cancer. Clin. Cancer Res. 2007, 13:1076-1082.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1076-1082
    • Van Waes, C.1
  • 59
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • Vermorken J.B., et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J. Clin. Oncol. 2007, 25:2171-2177.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 2171-2177
    • Vermorken, J.B.1
  • 60
    • 77956941983 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
    • Wheeler S.E., et al. Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation. Oncogene 2010, 29:5135-5145.
    • (2010) Oncogene , vol.29 , pp. 5135-5145
    • Wheeler, S.E.1
  • 61
    • 84861123278 scopus 로고    scopus 로고
    • Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer
    • Wheeler S.E., et al. Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer. Clin. Cancer Res. 2012, 18:2850-2860.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 2850-2860
    • Wheeler, S.E.1
  • 62
    • 65349130024 scopus 로고    scopus 로고
    • Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer
    • Pernas F.G., et al. Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer. Clin. Cancer Res. 2009, 15:2361-2372.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2361-2372
    • Pernas, F.G.1
  • 63
    • 2642551603 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor Velcade (bortezomib)
    • Adams J., Kauffman M. Development of the proteasome inhibitor Velcade (bortezomib). Cancer Invest. 2004, 22:304-311.
    • (2004) Cancer Invest. , vol.22 , pp. 304-311
    • Adams, J.1    Kauffman, M.2
  • 64
    • 48249140693 scopus 로고    scopus 로고
    • Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer
    • Allen C., et al. Bortezomib-induced apoptosis with limited clinical response is accompanied by inhibition of canonical but not alternative nuclear factor-{kappa}B subunits in head and neck cancer. Clin. Cancer Res. 2008, 14:4175-4185.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 4175-4185
    • Allen, C.1
  • 65
    • 84929471891 scopus 로고    scopus 로고
    • CCR 20th Anniversary Commentary: preclinical study of proteasome inhibitor bortezomib in head and neck cancer
    • Allen C.T., et al. CCR 20th Anniversary Commentary: preclinical study of proteasome inhibitor bortezomib in head and neck cancer. Clin. Cancer Res. 2015, 21:942-943.
    • (2015) Clin. Cancer Res. , vol.21 , pp. 942-943
    • Allen, C.T.1
  • 66
    • 80052428483 scopus 로고    scopus 로고
    • Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer
    • Argiris A., et al. Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer. Clin. Cancer Res. 2011, 17:5755-5764.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 5755-5764
    • Argiris, A.1
  • 67
    • 52649173202 scopus 로고    scopus 로고
    • Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells
    • Sloss C.M., et al. Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells. Clin. Cancer Res. 2008, 14:5116-5123.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5116-5123
    • Sloss, C.M.1
  • 68
    • 84927176668 scopus 로고    scopus 로고
    • SCF ubiquitin ligase-targeted therapies
    • Skaar J.R., et al. SCF ubiquitin ligase-targeted therapies. Nat. Rev. Drug Discov. 2014, 13:889-903.
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 889-903
    • Skaar, J.R.1
  • 69
    • 1642433084 scopus 로고    scopus 로고
    • Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
    • Kobori M., et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ. 2004, 11:123-130.
    • (2004) Cell Death Differ. , vol.11 , pp. 123-130
    • Kobori, M.1
  • 70
    • 77955870224 scopus 로고    scopus 로고
    • 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition
    • Hertlein E., et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood 2010, 116:45-53.
    • (2010) Blood , vol.116 , pp. 45-53
    • Hertlein, E.1
  • 71
    • 33846245846 scopus 로고    scopus 로고
    • Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management
    • Hu J.C., et al. Cutaneous side effects of epidermal growth factor receptor inhibitors: clinical presentation, pathogenesis, and management. J. Am. Acad. Dermatol. 2007, 56:317-326.
    • (2007) J. Am. Acad. Dermatol. , vol.56 , pp. 317-326
    • Hu, J.C.1
  • 72
    • 33749018219 scopus 로고    scopus 로고
    • Mechanisms of cutaneous toxicities to EGFR inhibitors
    • Lacouture M.E. Mechanisms of cutaneous toxicities to EGFR inhibitors. Nat. Rev. Cancer 2006, 6:803-812.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 803-812
    • Lacouture, M.E.1
  • 73
    • 84883884440 scopus 로고    scopus 로고
    • Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy
    • 199ra110
    • Mascia F., et al. Genetic ablation of epidermal EGFR reveals the dynamic origin of adverse effects of anti-EGFR therapy. Sci. Transl. Med. 2013, 5:199ra110.
    • (2013) Sci. Transl. Med. , vol.5
    • Mascia, F.1
  • 74
    • 84883890133 scopus 로고    scopus 로고
    • Epidermal EGFR controls cutaneous host defense and prevents inflammation
    • 199ra111
    • Lichtenberger B.M., et al. Epidermal EGFR controls cutaneous host defense and prevents inflammation. Sci. Transl. Med. 2013, 5:199ra111.
    • (2013) Sci. Transl. Med. , vol.5
    • Lichtenberger, B.M.1
  • 75
    • 53249129484 scopus 로고    scopus 로고
    • Advances in targeting IKK and IKK-related kinases for cancer therapy
    • Lee D.F., Hung M.C. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clin. Cancer Res. 2008, 14:5656-5662.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 5656-5662
    • Lee, D.F.1    Hung, M.C.2
  • 76
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappa B system: a treasure trove for drug development
    • Karin M., et al. The IKK NF-kappa B system: a treasure trove for drug development. Nat. Rev. Drug Discov. 2004, 3:17-26.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 17-26
    • Karin, M.1
  • 77
    • 84912077303 scopus 로고    scopus 로고
    • Receptor proximal kinases in NF-kappaB signaling as potential therapeutic targets in cancer and inflammation
    • Verstrepen L., Beyaert R. Receptor proximal kinases in NF-kappaB signaling as potential therapeutic targets in cancer and inflammation. Biochem. Pharmacol. 2014, 92:519-529.
    • (2014) Biochem. Pharmacol. , vol.92 , pp. 519-529
    • Verstrepen, L.1    Beyaert, R.2
  • 78
    • 84922393807 scopus 로고    scopus 로고
    • Ubiquitination in disease pathogenesis and treatment
    • Popovic D., et al. Ubiquitination in disease pathogenesis and treatment. Nat. Med. 2014, 20:1242-1253.
    • (2014) Nat. Med. , vol.20 , pp. 1242-1253
    • Popovic, D.1
  • 79
    • 63749086305 scopus 로고    scopus 로고
    • ErbB receptors and signaling pathways in cancer
    • Hynes N.E., MacDonald G. ErbB receptors and signaling pathways in cancer. Curr. Opin. Cell Biol. 2009, 21:177-184.
    • (2009) Curr. Opin. Cell Biol. , vol.21 , pp. 177-184
    • Hynes, N.E.1    MacDonald, G.2
  • 80
    • 84890041471 scopus 로고    scopus 로고
    • The ErbB/HER family of protein-tyrosine kinases and cancer
    • Roskoski R. The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol. Res. 2014, 79:34-74.
    • (2014) Pharmacol. Res. , vol.79 , pp. 34-74
    • Roskoski, R.1
  • 81
    • 84856641109 scopus 로고    scopus 로고
    • NF-kappaB, the first quarter-century: remarkable progress and outstanding questions
    • Hayden M.S., Ghosh S. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 2012, 26:203-234.
    • (2012) Genes Dev. , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 82
    • 84875236362 scopus 로고    scopus 로고
    • Regulation of NF-kappaB by ubiquitination
    • Chen J., Chen Z.J. Regulation of NF-kappaB by ubiquitination. Curr. Opin. Immunol. 2013, 25:4-12.
    • (2013) Curr. Opin. Immunol. , vol.25 , pp. 4-12
    • Chen, J.1    Chen, Z.J.2


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