Shc phosphotyrosine-binding domain dominantly interacts with epidermal growth factor receptors and mediates ras activation in intact cells

Molecular Endocrinology

Volumn 12, Issue 4, 1998, Pages 536-543

  Sakaguchi, K ^a   Okabayashi, Y ^a   Kido, Y ^a   Kimura, S ^a   Matsumura, Y ^a   Inushima, K ^a   Kasuga, M ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; ARGININE; EPIDERMAL GROWTH FACTOR RECEPTOR; LYSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL INTERACTION; CHO CELL; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 0032230322     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/mend.12.4.0094     Document Type: Article

References (34)

1. Signal transduction by receptors with tyrosine kinase activity
2. Epidermal growth factor
3. Protein modules and signalling networks
4. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
5. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins
6. A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors
7. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
8. Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells
9. Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras
10. Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation
11. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
12. The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif
13. PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine
14. Affinity, specificity, and kinetics of the interaction of the SHC phosphotyrosine binding domain with asparagine-X-X-phosphotyrosine motifs of growth factor receptors
15. Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites
16. Tyrosines 1148 and 1173 of activated human epidermal growth factor receptors are binding sites of Shc in intact cells
17. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
18. The phosphotyrosine interaction domain of Shc binds an LXNPXY motif on the epidermal growth factor receptor
19. Identification of residues within the SHC phosphotyrosine binding/phosphotyrosine interaction domain crucial for phosphopeptide interaction
20. Solution structure of the Shc SH2 domain complexed with a tyrosine-phosphorylated peptide from the T-cell receptor
21. Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo
22. Structure and ligand recognition of the phosphotyrosine binding domain of Shc
23. Binding affinities of tyrosine-phosphorylated peptides to the COOH-terminal SH2 and NH2-terminal phosphotyrosine binding domains of Shc
24. Binding of Shc to the NPXY motif is mediated by its N-terminal domain
25. Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain
26. Shc binding to nerve growth factor receptor is mediated by the phosphotyrosine interaction domain
27. Specificity of the PTB domain of Shc for β turn-forming pentapeptide motifs amino-terminal to phosphotyrosine
28. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities
29. Binding of Vav to Grb2 through dimerization of Src homology 3 domains
30. Interactions of Cb1 with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells
31. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase
32. A complex of Grb2-dynamin binds to tyrosine-phosphorylated insulin receptor substrate-1 after insulin treatment
33. SH3 domain-mediated interaction of dystroglycan and Grb2
34. Interaction of Shc with adaptor protein adaptins