ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells

Autophagy

Volumn 11, Issue 2, 2015, Pages 239-252

  Chen, Jing Hong ^a,b   Zhang, Peng ^c   Chen, Wen Dan ^a   Li, Dan Dan ^a   Wu, Xiao Qi ^d   Deng, Rong ^a   Jiao, Lin ^a   Li, Xuan ^a   Ji, Jiao ^a   Feng, Gong Kan ^a   Zeng, Yi Xin ^a   Jiang, Jian Wei ^c   Zhu, Xiao Feng ^a  

^a SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

ATM; Autophagy; DNA damage; PTEN; Topotecan

Indexed keywords

ATM PROTEIN; CISPLATIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN SERINE THREONINE KINASE; TOPOTECAN; ANTINEOPLASTIC AGENT; ATM PROTEIN, HUMAN; DNA TOPOISOMERASE INHIBITOR; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; AUTOPHAGY; CANCER CELL; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; ACTIVE TRANSPORT; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; AUTOPHAGY; CISPLATIN; DNA DAMAGE; HUMANS; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TOPOISOMERASE I INHIBITORS; TOPOTECAN; TUMOR SUPPRESSOR PROTEINS;

EID: 84930516235     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1009767     Document Type: Article

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