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Volumn 10, Issue 4, 2015, Pages 296-306

Harnessing the potential of mesenchymal stem cells for IVD regeneration

Author keywords

Biomaterials; Differentiation; Intervertebral disc; Lower back pain; Mesenchymal stem cells; Microenvironment; Tissue engineering

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL POPULATION; CELLS BY BODY ANATOMY; GENE EXPRESSION; HUMAN; INTERVERTEBRAL DISK DEGENERATION; LOW BACK PAIN; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROENVIRONMENT; PRIORITY JOURNAL; STEM CELL; STEM CELL NICHE; TISSUE ENGINEERING; TISSUE SCAFFOLD; WEIGHT REDUCTION; ANIMAL; BIOLOGICAL THERAPY; CYTOLOGY; INTERVERTEBRAL DISC DEGENERATION; MESENCHYMAL STROMA CELL; PHYSIOLOGY; PROCEDURES; REGENERATION;

EID: 84930515622     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574888X10666141202112638     Document Type: Article
Times cited : (20)

References (139)
  • 1
    • 0242410368 scopus 로고    scopus 로고
    • Lost productive time and cost due to common pain conditions in the US workforce
    • Stewart WF, Ricci JA, Chee E, Morganstein D, Lipton R. Lost productive time and cost due to common pain conditions in the US workforce. JAMA 2003; 290(18): 2443-54.
    • (2003) JAMA , vol.290 , Issue.18 , pp. 2443-2454
    • Stewart, W.F.1    Ricci, J.A.2    Chee, E.3    Morganstein, D.4    Lipton, R.5
  • 2
    • 0034464943 scopus 로고    scopus 로고
    • The prevalence of low back pain: A systematic review of the literature from 1966 to 1998
    • Walker BF. The prevalence of low back pain: a systematic review of the literature from 1966 to 1998. J Spinal Disord 2000; 13(3): 205-17.
    • (2000) J Spinal Disord , vol.13 , Issue.3 , pp. 205-217
    • Walker, B.F.1
  • 3
    • 84861837610 scopus 로고    scopus 로고
    • A systematic review of the global prevalence of low back pain
    • Hoy D, Bain C, Williams G, et al.A systematic review of the global prevalence of low back pain. Arthritis Rheum 2012; 64(6): 2028-37.
    • (2012) Arthritis Rheum , vol.64 , Issue.6 , pp. 2028-2037
    • Hoy, D.1    Bain, C.2    Williams, G.3
  • 4
    • 72949090125 scopus 로고    scopus 로고
    • The epidemiology, economic burden, and pharmacological treatment of chronic low back pain in France, Germany, Italy, Spain and the UK: A literature-based review
    • Junpier M, Le TK, Mladsi D. The epidemiology, economic burden, and pharmacological treatment of chronic low back pain in France, Germany, Italy, Spain and the UK: a literature-based review. Expert Opin Pharmacother 2009; 10(16): 2581-92.
    • (2009) Expert Opin Pharmacother , vol.10 , Issue.16 , pp. 2581-2592
    • Junpier, M.1    Le, T.K.2    Mladsi, D.3
  • 6
    • 0033992410 scopus 로고    scopus 로고
    • The economic burden of back pain in the UK
    • Maniadakis N, Gray A. The economic burden of back pain in the UK. Pain 2000; 84(1): 95-103.
    • (2000) Pain , vol.84 , Issue.1 , pp. 95-103
    • Maniadakis, N.1    Gray, A.2
  • 7
    • 84930524592 scopus 로고    scopus 로고
    • The costs of accidents at work, HS(G)96 2nd Edition, HMSO
    • The costs of accidents at work, HS(G)96 2nd Edition, HMSO 1997.
    • (1997)
  • 9
    • 79953865229 scopus 로고    scopus 로고
    • A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status
    • Samartzis D, Karppinen J, Mok F, Fong DY, Luk KD, Cheung KM. A population-based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status. J Bone Joint Surg Am 2011; 93(7): 662-70.
    • (2011) J Bone Joint Surg Am , vol.93 , Issue.7 , pp. 662-670
    • Samartzis, D.1    Karppinen, J.2    Mok, F.3    Fong, D.Y.4    Luk, K.D.5    Cheung, K.M.6
  • 11
    • 0020461748 scopus 로고
    • Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus
    • Trout JJ, Buckwalter JA, Moore KC. Ultrastructure of the human intervertebral disc: II. Cells of the nucleus pulposus. Anat Rec 1982; 204(4): 307-14
    • (1982) Anat Rec , vol.204 , Issue.4 , pp. 307-314
    • Trout, J.J.1    Buckwalter, J.A.2    Moore, K.C.3
  • 12
    • 0021894505 scopus 로고
    • Swelling pressure of the inervertebral disc: Influence of proteoglycan and collagen contents
    • Urban JP, McMullin JF. Swelling pressure of the inervertebral disc: influence of proteoglycan and collagen contents. Biorheology 1985; 22(2): 145-57.
    • (1985) Biorheology , vol.22 , Issue.2 , pp. 145-157
    • Urban, J.P.1    McMullin, J.F.2
  • 14
    • 84881547350 scopus 로고    scopus 로고
    • Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging
    • Moon SM, Yoder, JH, Wright AC, Smith LJ, Vresilovic, EJ, Elliott DM. Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging. Eur Spine J 2013; 22 (8): 1820-8.
    • (2013) Eur Spine J , vol.22 , Issue.8 , pp. 1820-1828
    • Moon, S.M.1    Yoder, J.H.2    Wright, A.C.3    Smith, L.J.4    Vresilovic, E.J.5    Elliott, D.M.6
  • 16
    • 0023916080 scopus 로고
    • Nutrition of the intervertebral disc: Acute effects of cigarette smoking. An experimental animal study
    • Holm S, Nachemson A. Nutrition of the intervertebral disc: acute effects of cigarette smoking. An experimental animal study. Ups J Med Sci 1988; 93: 91-99.
    • (1988) Ups J Med Sci , vol.93 , pp. 91-99
    • Holm, S.1    Nachemson, A.2
  • 19
    • 0029892728 scopus 로고    scopus 로고
    • Mechanical stress reduction during seated jolt/vibration exposure
    • Wilder DG, Pope MH, Magnusson M. Mechanical stress reduction during seated jolt/vibration exposure. Semin Perinatol 1996; 20: 54-60.
    • (1996) Semin Perinatol , vol.20 , pp. 54-60
    • Wilder, D.G.1    Pope, M.H.2    Magnusson, M.3
  • 22
    • 10444232467 scopus 로고    scopus 로고
    • Effect of nutrient deprivation on the viability of intervertebral disc cells
    • Bibby SR, Urban JP. Effect of nutrient deprivation on the viability of intervertebral disc cells. Eur Spine J 2004; 13: 695-701.
    • (2004) Eur Spine J , vol.13 , pp. 695-701
    • Bibby, S.R.1    Urban, J.P.2
  • 25
    • 0031438388 scopus 로고    scopus 로고
    • Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration
    • Boos N, Nerlich AG, Wiest I, von der Mark K, Aebi M. Immunolocalization of type X collagen in human lumbar intervertebral discs during ageing and degeneration. Histochem Cell Biol 1997; 108: 471-80.
    • (1997) Histochem Cell Biol , vol.108 , pp. 471-480
    • Boos, N.1    Nerlich, A.G.2    Wiest, I.3    Von Der Mark, K.4    Aebi, M.5
  • 27
    • 34548620230 scopus 로고    scopus 로고
    • The cell biology of intervertebral disc aging and degeneration
    • Zhao CQ, Wang LM, Jiang LS, Dai LY The cell biology of intervertebral disc aging and degeneration. Ageing Res Rev 2007; 6: 247-61.
    • (2007) Ageing Res Rev , vol.6 , pp. 247-261
    • Zhao, C.Q.1    Wang, L.M.2    Jiang, L.S.3    Dai, L.Y.4
  • 28
    • 0034753182 scopus 로고    scopus 로고
    • Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation
    • Johnson WE, Eisenstein SM, Roberts S . Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation. Connect Tissue Res 2001; 42: 197-207.
    • (2001) Connect Tissue Res , vol.42 , pp. 197-207
    • Johnson, W.E.1    Eisenstein, S.M.2    Roberts, S.3
  • 32
    • 77954525615 scopus 로고    scopus 로고
    • Theoretical and experimental evaluation of human annulus fibrosus degeneration
    • O’Connell GD, Guerin HL, Elliott DM. Theoretical and experimental evaluation of human annulus fibrosus degeneration. J. Biomech. Eng 2007; 131: 111007.
    • (2007) J. Biomech. Eng , vol.131
    • O’connell, G.D.1    Guerin, H.L.2    Elliott, D.M.3
  • 33
    • 0036035627 scopus 로고    scopus 로고
    • A biological approach to treating disc degeneration: Not for today, but maybe for tomorrow
    • Alini M, Roughley PJ, Antoniou J, Stoll T, Aebi M. A biological approach to treating disc degeneration: not for today, but maybe for tomorrow. Eur Spine J 2002; 11(Suppl 2): S215-S220.
    • (2002) Eur Spine J , vol.11
    • Alini, M.1    Roughley, P.J.2    Antoniou, J.3    Stoll, T.4    Aebi, M.5
  • 35
    • 70450286272 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration
    • Bachmeier BE, Nerlich A, Mittermaier N, et al.Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration. Eur. Spine J 2009; 18: 1573-86.
    • (2009) Eur. Spine J , vol.18 , pp. 1573-1586
    • Bachmeier, B.E.1    Nerlich, A.2    Mittermaier, N.3
  • 36
    • 4544272466 scopus 로고    scopus 로고
    • Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc
    • Le Maitre CL, Freemont AJ, Hoyland JA. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 2004; 204: 47-54.
    • (2004) J Pathol , vol.204 , pp. 47-54
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 37
    • 59649113254 scopus 로고    scopus 로고
    • Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration
    • Pockert AJ, Richardson SM, Le Maitre CL, et al.Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis Rheum 2009; 60: 482-91.
    • (2009) Arthritis Rheum , vol.60 , pp. 482-491
    • Pockert, A.J.1    Richardson, S.M.2    Le Maitre, C.L.3
  • 38
    • 73349098227 scopus 로고    scopus 로고
    • Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc
    • Richardson SM, Doyle P, Minogue BM, Gnanalingham K, Hoyland JA. Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther 2009; 11: R126.
    • (2009) Arthritis Res Ther , vol.11
    • Richardson, S.M.1    Doyle, P.2    Minogue, B.M.3    Gnanalingham, K.4    Hoyland, J.A.5
  • 40
    • 34447262134 scopus 로고    scopus 로고
    • The aging spine: The role of inflammatory mediators in intervertebral disc degeneration
    • Podichetty VK. The aging spine: the role of inflammatory mediators in intervertebral disc degeneration. Cell Mol Biol (Noisy-legrand). 2007; 53(5): 4-18.
    • (2007) Cell Mol Biol (Noisy-Legrand) , vol.53 , Issue.5 , pp. 4-18
    • Podichetty, V.K.1
  • 41
    • 29744447597 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA. The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther 2005 7: R732-45.
    • (2005) Arthritis Res Ther , vol.7
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 42
    • 33644951210 scopus 로고    scopus 로고
    • A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA. A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 2006; 87: 17-28.
    • (2006) Int J Exp Pathol , vol.87 , pp. 17-28
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 43
    • 34548790240 scopus 로고    scopus 로고
    • Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile
    • Le Maitre CL, Hoyland JA, Freemont AJ. Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther 2007; 9: R77
    • (2007) Arthritis Res Ther , vol.9
    • Le Maitre, C.L.1    Hoyland, J.A.2
  • 44
    • 34848893110 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: An in situ zymographic and gene therapy study
    • Le Maitre CL, Hoyland JA, Freemont AJ. Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther 2007; 9: R83.
    • (2007) Arthritis Res Ther , vol.9
    • Le Maitre, C.L.1    Hoyland, J.A.2    Freemont, A.J.3
  • 45
    • 44849136816 scopus 로고    scopus 로고
    • Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc
    • Hoyland, JA, Le Maitre, CL, Freemont, AJ. Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology (Oxford) 2008; 47 (6): 809-14.
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.6 , pp. 809-814
    • Hoyland, J.A.1    Le Maitre, C.L.2    Freemont, A.J.3
  • 46
  • 47
    • 34247250302 scopus 로고    scopus 로고
    • Analysis of tissue distribution of TNF-alpha, TNFalphareceptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc
    • Bachmeier BE, Nerlich AG, Weiler C, Paesold G, Jochum M, Boos N. Analysis of tissue distribution of TNF-alpha, TNFalphareceptors, and the activating TNF-alpha-converting enzyme suggests activation of the TNF-alpha system in the aging intervertebral disc. Ann N Y Acad Sci 2007; 1096: 44-54
    • (2007) Ann N Y Acad Sci , vol.1096 , pp. 44-54
    • Bachmeier, B.E.1    Nerlich, A.G.2    Weiler, C.3    Paesold, G.4    Jochum, M.5    Boos, N.6
  • 50
    • 34249788140 scopus 로고    scopus 로고
    • Accelerated cellular senescence in degenerate intervertebral discs: A possible role in the pathogenesis of intervertebral disc degeneration
    • Le Maitre CL, Freemont AJ, Hoyland JA. Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther 2007; 9: R45.
    • (2007) Arthritis Res Ther , vol.9
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 52
    • 34848897219 scopus 로고    scopus 로고
    • Nonpharmacologic therapies for acute and chronic low back pain: A review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline
    • Chou R, Huffman LH. Nonpharmacologic therapies for acute and chronic low back pain: a review of the evidence for an American Pain Society/American College of Physicians clinical practice guideline. Ann Intern Med 2007; 147: 492-504.
    • (2007) Ann Intern Med , vol.147 , pp. 492-504
    • Chou, R.1    Huffman, L.H.2
  • 53
    • 34248402067 scopus 로고    scopus 로고
    • Unloaded movement facilitation exercise compared to no exercise or alternative therapy on outcomes for people with nonspecific chronic low back pain: A systematic review
    • Slade SC, Keating JL. Unloaded movement facilitation exercise compared to no exercise or alternative therapy on outcomes for people with nonspecific chronic low back pain: a systematic review. J Manipulative Physiol Ther 2007; 30: 301-11.
    • (2007) J Manipulative Physiol Ther , vol.30 , pp. 301-311
    • Slade, S.C.1    Keating, J.L.2
  • 54
    • 52449120123 scopus 로고    scopus 로고
    • Biological treatment for degenerative disc disease: Implications for the field of physical medicine and rehabilitation
    • Zhang Y, An SH, Tannoury C Thonar EJ, Freedman MK, Anderson DG. Biological treatment for degenerative disc disease: implications for the field of physical medicine and rehabilitation. Am J Phys Med Rehabil 2008; 87: 694-702.
    • (2008) Am J Phys Med Rehabil , vol.87 , pp. 694-702
    • Zhang, Y.1    An, S.H.2    Tannoury C Thonar, E.J.3    Freedman, M.K.4    Erson, D.G.5
  • 56
    • 0042069643 scopus 로고    scopus 로고
    • The fate of the adjacent motion segments after lumbar fusion
    • Gillet P. The fate of the adjacent motion segments after lumbar fusion. J Spinal Disord Tech 2003; 16: 338-45.
    • (2003) J Spinal Disord Tech , vol.16 , pp. 338-345
    • Gillet, P.1
  • 57
    • 84858775231 scopus 로고    scopus 로고
    • Disc height and motion patterns in the lumbar spine in patients operated with total disc replacement or fusion for discogenic back pain. Results from a randomized controlled trial
    • Berg S, Tropp HT, Leivseth G. Disc height and motion patterns in the lumbar spine in patients operated with total disc replacement or fusion for discogenic back pain. Results from a randomized controlled trial. Spine J 2011; 11: 991-8.
    • (2011) Spine J , vol.11 , pp. 991-998
    • Berg, S.1    Tropp, H.T.2    Leivseth, G.3
  • 58
    • 0031586347 scopus 로고    scopus 로고
    • Human intervertebral disc cells from the annulus: Three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1
    • Gruber HE, Fisher EC JR, Desai B, Stasky AA, Hoelscher G, Hanley EN JR. Human intervertebral disc cells from the annulus: three-dimensional culture in agarose or alginate and responsiveness to TGF-beta1. Exp Cell Res 1997; 235: 13-21.
    • (1997) Exp Cell Res , vol.235 , pp. 13-21
    • Gruber, H.E.1    Fisher, E.2    Desai, B.3    Stasky, A.A.4    Hoelscher, G.5    Hanley, E.6
  • 59
    • 0042388216 scopus 로고    scopus 로고
    • Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads
    • Masuda K, Takegami K, An H, et al. Recombinant osteogenic protein-1 upregulates extracellular matrix metabolism by rabbit annulus fibrosus and nucleus pulposus cells cultured in alginate beads. J Orthop Res 2003; 21: 922-30.
    • (2003) J Orthop Res , vol.21 , pp. 922-930
    • Masuda, K.1    Takegami, K.2    An, H.3
  • 62
    • 0030250337 scopus 로고    scopus 로고
    • Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs
    • Osada R, Oshima, H, Ishihara H, Yudoh K, Sakai K, Matsui H, Tsuji H. Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs. J Orthop Res 1996; 14: 690-9.
    • (1996) J Orthop Res , vol.14 , pp. 690-699
    • Osada, R.1    Oshima, H.2    Ishihara, H.3    Yudoh, K.4    Sakai, K.5    Matsui, H.6    Tsuji, H.7
  • 66
    • 57049121084 scopus 로고    scopus 로고
    • Cell transplantation in lumbar spine disc degeneration disease
    • Hohaus C, Ganey TM, Minkus Y, Meisel HJ. Cell transplantation in lumbar spine disc degeneration disease. Eur Spine J 2008; 17 (Suppl 4): 492-503.
    • (2008) Eur Spine J , vol.17 , pp. 492-503
    • Hohaus, C.1    Ganey, T.M.2    Minkus, Y.3    Meisel, H.J.4
  • 67
    • 33846821899 scopus 로고    scopus 로고
    • Clinical experience in cell-based therapeutics: Disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc
    • Meisel HJ, Siodla V, Ganey T, Minkus Y, Hutton WC, Alasevic OJ. Clinical experience in cell-based therapeutics: disc chondrocyte transplantation A treatment for degenerated or damaged intervertebral disc. Biomol Eng 2007; 24(1): 5-21.
    • (2007) Biomol Eng , vol.24 , Issue.1 , pp. 5-21
    • Meisel, H.J.1    Siodla, V.2    Ganey, T.3    Minkus, Y.4    Hutton, W.C.5    Alasevic, O.J.6
  • 70
    • 84874099730 scopus 로고    scopus 로고
    • The presence of local mesenchymal progenitor cells in human degenerated intervertebral discs and possibilities to influence these in vitro: A descriptive study in humans
    • Brisby H, Papadimitriou N, Brantsing C, Bergh P, Lindahl A, Barreto Henriksson H. The presence of local mesenchymal progenitor cells in human degenerated intervertebral discs and possibilities to influence these in vitro: a descriptive study in humans. Stem Cells Dev 2013; 22(5): 804-14.
    • (2013) Stem Cells Dev , vol.22 , Issue.5 , pp. 804-814
    • Brisby, H.1    Papadimitriou, N.2    Brantsing, C.3    Bergh, P.4    Lindahl, A.5    Barreto Henriksson, H.6
  • 71
    • 84871794357 scopus 로고    scopus 로고
    • Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
    • Sakai D, Nakamura Y, Nakai T, et al.Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc. Nat Commun 2012; 3: 1264
    • (2012) Nat Commun , vol.3 , pp. 1264
    • Sakai, D.1    Nakamura, Y.2    Nakai, T.3
  • 72
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC, et al.Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-7.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 74
    • 33745002760 scopus 로고    scopus 로고
    • Intervertebral disc cell-mediated mesenchymal stem cell differentiation
    • Richardson SM, Walker RV, Parker S, et al.Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 2006; 24: 707-16.
    • (2006) Stem Cells , vol.24 , pp. 707-716
    • Richardson, S.M.1    Walker, R.V.2    Parker, S.3
  • 75
    • 78650060236 scopus 로고    scopus 로고
    • Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation
    • Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA. Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation. Arthritis Rheum 2010; 62(12): 3695-705.
    • (2010) Arthritis Rheum , vol.62 , Issue.12 , pp. 3695-3705
    • Minogue, B.M.1    Richardson, S.M.2    Zeef, L.A.3    Freemont, A.J.4    Hoyland, J.A.5
  • 76
    • 84899141905 scopus 로고    scopus 로고
    • Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs
    • Clarke LE, McConnell, JC, Sherratt, MJ, Derby, B, Richardson, SM, Hoyland, J.A. Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs. Arth Res Ther 2014; 16: R67
    • (2014) Arth Res Ther , vol.16
    • Clarke, L.E.1    McConnell, J.C.2    Sherratt, M.J.3    Derby, B.4    Richardson, S.M.5    Hoyland, J.A.6
  • 77
    • 61449135224 scopus 로고    scopus 로고
    • An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue
    • Le Maitre CL, Baird P, Freemont AJ, Hoyland JA. An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue. Arthritis Res Ther 2009; 11: R20.
    • (2009) Arthritis Res Ther , vol.11
    • Le Maitre, C.L.1    Baird, P.2    Freemont, A.J.3    Hoyland, J.A.4
  • 79
    • 79952365932 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: A comparison of 2 cell types as potential candidates for disc regeneration
    • Feng G, Zhao X, Liu H, et al.Transplantation of mesenchymal stem cells and nucleus pulposus cells in a degenerative disc model in rabbits: a comparison of 2 cell types as potential candidates for disc regeneration. J Neurosurg Spine 2011; 14: 322-9.
    • (2011) J Neurosurg Spine , vol.14 , pp. 322-329
    • Feng, G.1    Zhao, X.2    Liu, H.3
  • 80
    • 43649093152 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells in a canine disc degeneration model
    • Hiyama A, Mochida J, Iwashina T, et al.Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res 2008; 26: 589-600.
    • (2008) J Orthop Res , vol.26 , pp. 589-600
    • Hiyama, A.1    Mochida, J.2    Iwashina, T.3
  • 81
    • 67349178136 scopus 로고    scopus 로고
    • Human mesenchymal stem cells implantation into the degenerated coccygeal disc of the rat
    • Jeong JH, Jin ES, Min JK, et al.Human mesenchymal stem cells implantation into the degenerated coccygeal disc of the rat. Cytotechnology 2009; 59: 55-64.
    • (2009) Cytotechnology , vol.59 , pp. 55-64
    • Jeong, J.H.1    Jin, E.S.2    Min, J.K.3
  • 82
    • 80053324854 scopus 로고    scopus 로고
    • Intervertebral disc repair by autologous mesenchymalbone marrow cells: A pilot study
    • Orozco L, Soler R, Morera C, Alberca M, Sanchez A, GarciaSancho J. Intervertebral disc repair by autologous mesenchymalbone marrow cells: a pilot study. Transplantation 2011; 92(7): 822-8.
    • (2011) Transplantation , vol.92 , Issue.7 , pp. 822-828
    • Orozco, L.1    Soler, R.2    Morera, C.3    Alberca, M.4    Sanchez, A.5    Garciasancho, J.6
  • 83
    • 0036216444 scopus 로고    scopus 로고
    • Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs
    • Sive JI, Baird P, Jeziorsk M, Watkins A, Hoyland JA, Freemont AJ. Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol Pathol 2002; 55(2): 91-7.
    • (2002) Mol Pathol , vol.55 , Issue.2 , pp. 91-97
    • Sive, J.I.1    Baird, P.2    Jeziorsk, M.3    Watkins, A.4    Hoyland, J.A.5    Freemont, A.J.6
  • 84
    • 12344260899 scopus 로고    scopus 로고
    • Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: A requisite for tissue engineering of intervertebral disc
    • discussion-4
    • Mwale F, Roughley P, Antoniou J. Distinction between the extracellular matrix of the nucleus pulposus and hyaline cartilage: a requisite for tissue engineering of intervertebral disc. Eur Cell Mater. 2004; 8: 58-63. discussion-4.
    • (2004) Eur Cell Mater , vol.8 , pp. 58-63
    • Mwale, F.1    Roughley, P.2    Antoniou, J.3
  • 86
    • 37249032718 scopus 로고    scopus 로고
    • A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat
    • Lee CR, Sakai D, Nakai T, et al.A phenotypic comparison of intervertebral disc and articular cartilage cells in the rat. Eur Spine J 2007; 16(12): 2174-85.
    • (2007) Eur Spine J , vol.16 , Issue.12 , pp. 2174-2185
    • Lee, C.R.1    Sakai, D.2    Nakai, T.3
  • 87
    • 77949474632 scopus 로고    scopus 로고
    • Transcriptional profiling of bovine intervertebral disc cells: Implications for identification of normal and degenerate human intervertebral disc cell phenotypes
    • Minogue BM, Richardson SM, Zeef LA, Freemont AJ, Hoyland JA. Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Res Ther 2010; 12(1): R22.
    • (2010) Arthritis Res Ther , vol.12 , Issue.1
    • Minogue, B.M.1    Richardson, S.M.2    Zeef, L.A.3    Freemont, A.J.4    Hoyland, J.A.5
  • 88
    • 82455163775 scopus 로고    scopus 로고
    • Identification of cell surfacespecific markers to target human nucleus pulposus cells: Expression of carbonic anhydrase XII varies with age and degeneration
    • Power KA, Grad S, Rutges JP, et al.Identification of cell surfacespecific markers to target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with age and degeneration. Arthritis Rheum 2011; 63(12): 3876-86.
    • (2011) Arthritis Rheum , vol.63 , Issue.12 , pp. 3876-3886
    • Power, K.A.1    Grad, S.2    Rutges, J.P.3
  • 89
    • 80052575577 scopus 로고    scopus 로고
    • Differential response of human bone marrow stromal cells to either TGF-β (1) or rhGDF-5
    • Gantenbein-Ritter B, Benneker LM, Alini M, Grad S. Differential response of human bone marrow stromal cells to either TGF-β (1) or rhGDF-5. Eur Spine J 2011; 20: 962-971.
    • (2011) Eur Spine J , vol.20 , pp. 962-971
    • Gantenbein-Ritter, B.1    Benneker, L.M.2    Alini, M.3    Grad, S.4
  • 90
    • 80053157000 scopus 로고    scopus 로고
    • Role of hypoxia and growth differentiation factor-5 on differentiation of human mesenchymal stem cells toward intervertebral nucleus pulposus like cells
    • Stoyanov JV, Gantenbein-Ritter B, Bertolo A, Aebli N, Baur M, Alini M, Grad S. Role of hypoxia and growth differentiation factor-5 on differentiation of human mesenchymal stem cells toward intervertebral nucleus pulposus like cells. Eur Cell Mater 2011; 21: 533-47.
    • (2011) Eur Cell Mater , vol.21 , pp. 533-547
    • Stoyanov, J.V.1    Gantenbein-Ritter, B.2    Bertolo, A.3    Aebli, N.4    Baur, M.5    Alini, M.6    Grad, S.7
  • 91
    • 84888984503 scopus 로고    scopus 로고
    • Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells
    • Peroglio M, Eglin D, Benneker LM, Alini M, Grad S. Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells. Spine J 2013; 13: 1627-39.
    • (2013) Spine J , vol.13 , pp. 1627-1639
    • Peroglio, M.1    Eglin, D.2    Benneker, L.M.3    Alini, M.4    Grad, S.5
  • 92
    • 84861687086 scopus 로고    scopus 로고
    • Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs
    • Buckley CT, Kelly DJ. Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs. J Mech Behav Biomed Mater 2012; 11: 102-11.
    • (2012) J Mech Behav Biomed Mater , vol.11 , pp. 102-111
    • Buckley, C.T.1    Kelly, D.J.2
  • 93
    • 84875271422 scopus 로고    scopus 로고
    • Stimulation of chondrogenic differentiation of mesenchymal stem cells
    • Yu DA, Han J, Kim BS. Stimulation of chondrogenic differentiation of mesenchymal stem cells. Int J Stem Cells 2012; 5: 16-22.
    • (2012) Int J Stem Cells , vol.5 , pp. 16-22
    • Yu, D.A.1    Han, J.2    Kim, B.S.3
  • 94
    • 33645337383 scopus 로고    scopus 로고
    • Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling
    • Longobardi L, O'Rear L, Aakula S, et al.Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling. J Bone Miner Res. 2006; 21(4): 626-36.
    • (2006) J Bone Miner Res , vol.21 , Issue.4 , pp. 626-636
    • Longobardi, L.1    O'rear, L.2    Aakula, S.3
  • 95
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2002; 2: 389-406.
    • (2002) Dev Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 96
    • 0037330644 scopus 로고    scopus 로고
    • Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes
    • Settle SH Jr, Rountree RB, Sinha A, Thacker A, Higgins K, Kingsley DM. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol 2003; 254: 116-30.
    • (2003) Dev Biol , vol.254 , pp. 116-130
    • Settle, S.H.1    Rountree, R.B.2    Sinha, A.3    Thacker, A.4    Higgins, K.5    Kingsley, D.M.6
  • 97
    • 61849115313 scopus 로고    scopus 로고
    • Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculoskeletal phenotypes
    • Asai-Coakwell M, French CR, Ye M, et al.Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculoskeletal phenotypes. Hum Mol Genet 2009; 18: 1110-21.
    • (2009) Hum Mol Genet , vol.18 , pp. 1110-1121
    • Asai-Coakwell, M.1    French, C.R.2    Ye, M.3
  • 98
    • 75649092677 scopus 로고    scopus 로고
    • Expression of cartilagederived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells
    • Le Maitre CL, Freemont AJ, Hoyland JA. Expression of cartilagederived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells. Arthritis Res Ther 2009; 11: R137.
    • (2009) Arthritis Res Ther , vol.11
    • Le Maitre, C.L.1    Freemont, A.J.2    Hoyland, J.A.3
  • 99
    • 78149322604 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells toward chondrocytes
    • Oldershaw RA, Baxter MA, Lowe ET, et al.Directed differentiation of human embryonic stem cells toward chondrocytes. Nat Biotechnol 2010; 28: 1187-94.
    • (2010) Nat Biotechnol , vol.28 , pp. 1187-1194
    • Oldershaw, R.A.1    Baxter, M.A.2    Lowe, E.T.3
  • 100
    • 84906935083 scopus 로고    scopus 로고
    • A comparative study of the effects of growth differentiation factor 5 on muscle-derived stem cells and bone marrow stromal cells in an in vitro tendon healing model
    • Ozasa Y, Gingery A, Thoreson AR, An KN, Zhao C, Amadio PC. A comparative study of the effects of growth differentiation factor 5 on muscle-derived stem cells and bone marrow stromal cells in an in vitro tendon healing model. J Hand Surg Am 2014; 39: 1706-13.
    • (2014) J Hand Surg Am , vol.39 , pp. 1706-1713
    • Ozasa, Y.1    Gingery, A.2    Thoreson, A.R.3    An, K.N.4    Zhao, C.5    Amadio, P.C.6
  • 101
    • 49149100486 scopus 로고    scopus 로고
    • Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome
    • Tassabehji M, Fang ZM, Hilton EN, et al.Mutations in GDF6 are associated with vertebral segmentation defects in Klippel-Feil syndrome. Hum Mutat 2008; 29: 1017-27
    • (2008) Hum Mutat , vol.29 , pp. 1017-1027
    • Tassabehji, M.1    Fang, Z.M.2    Hilton, E.N.3
  • 103
    • 51049102386 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stem cells from the sand rat: Transforming growth factor beta and 3D co-culture with huam disc cells stimulate proteoglycan and collagen type I rich extracellulr matrix
    • Tapp H, Deepe R, Ingram JA, Kuremsky M, Hanley EN Jr, Gruber HE. Adipose-derived mesenchymal stem cells from the sand rat: transforming growth factor beta and 3D co-culture with huam disc cells stimulate proteoglycan and collagen type I rich extracellulr matrix. Arthritis Res Ther 2008; 10: R89.
    • (2008) Arthritis Res Ther , vol.10
    • Tapp, H.1    Deepe, R.2    Ingram, J.A.3    Kuremsky, M.4    Hanley, E.N.5    Gruber, H.E.6
  • 104
    • 84879570605 scopus 로고    scopus 로고
    • Analysis of molecular expression in adipose tissue-derived mesenchymal stem cells: Prospects for use in the treatment of intervertebral disc degeneration
    • Jin ES, Min J, Jeon SR, Choi KH, Jeong JH. Analysis of molecular expression in adipose tissue-derived mesenchymal stem cells: prospects for use in the treatment of intervertebral disc degeneration. J Korean Neurosurg Soc 2013; 53: 207-12.
    • (2013) J Korean Neurosurg Soc , vol.53 , pp. 207-212
    • Jin, E.S.1    Min, J.2    Jeon, S.R.3    Choi, K.H.4    Jeong, J.H.5
  • 105
    • 78149416500 scopus 로고    scopus 로고
    • Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells
    • Jeong JH, Lee JH, Jin ES, Min JK, Jeon SR, Choi KH. Regeneration of intervertebral discs in a rat disc degeneration model by implanted adipose-tissue-derived stromal cells. Acta Neurochir (Wien) 2010; 152: 1771-77.
    • (2010) Acta Neurochir (Wien) , vol.152 , pp. 1771-1777
    • Jeong, J.H.1    Lee, J.H.2    Jin, E.S.3    Min, J.K.4    Jeon, S.R.5    Choi, K.H.6
  • 106
    • 84988838280 scopus 로고    scopus 로고
    • Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: A preliminary study on biglycan-deficient murine model of chronic disc degeneration
    • Marfia G, Campanella R, Navone S, et al.Potential use of human adipose mesenchymal stromal cells for intervertebral disc regeneration: a preliminary study on biglycan-deficient murine model of chronic disc degeneration. Arthritis Res Ther 2014; 16: 457.
    • (2014) Arthritis Res Ther , vol.16
    • Marfia, G.1    Campanella, R.2    Navone, S.3
  • 107
    • 4444330267 scopus 로고    scopus 로고
    • Biomaterials: Where we have been and where we are going
    • Ratner BD, Bryant SJ. Biomaterials: where we have been and where we are going. Annu Rev Biomed Eng 2004; 6: 41-75.
    • (2004) Annu Rev Biomed Eng , vol.6 , pp. 41-75
    • Ratner, B.D.1    Bryant, S.J.2
  • 110
    • 84898057507 scopus 로고    scopus 로고
    • Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: Effect of TGF-b3 supplementation and oxygen culture conditions
    • Guillaume O, Daly A, Lennon K, Gansau J, Buckley SF, Buckley CT. Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: effect of TGF-b3 supplementation and oxygen culture conditions. Acta Biomater 2014; 10: 1985-95.
    • (2014) Acta Biomater , vol.10 , pp. 1985-1995
    • Guillaume, O.1    Daly, A.2    Lennon, K.3    Gansau, J.4    Buckley, S.F.5    Buckley, C.T.6
  • 112
    • 79960558164 scopus 로고    scopus 로고
    • Biomimetic method for combining the nucleus pulposus and annulus fibrosus for intervertebral disc tissue engineering
    • Lazebnik M, Singh M, Glatt P, Friis LA, Berkland CJ, Detamore MS. Biomimetic method for combining the nucleus pulposus and annulus fibrosus for intervertebral disc tissue engineering. J Tissue Eng Regen Med 2011; 5: e179-87.
    • (2011) J Tissue Eng Regen Med , vol.5
    • Lazebnik, M.1    Singh, M.2    Glatt, P.3    Friis, L.A.4    Berkland, C.J.5    Detamore, M.S.6
  • 113
    • 35348971546 scopus 로고    scopus 로고
    • Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels
    • Richardson SM, Hughes N, Hunt JA, Freemont AJ, Hoyland JA. Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials 2008; 29: 85-93.
    • (2008) Biomaterials , vol.29 , pp. 85-93
    • Richardson, S.M.1    Hughes, N.2    Hunt, J.A.3    Freemont, A.J.4    Hoyland, J.A.5
  • 114
    • 84891390709 scopus 로고    scopus 로고
    • In situ-forming robust chitosan-poly(Ethylene glycol) hydrogels prepared by copper-free azide-alkyne click reaction for tissue engineering
    • Truong VX, Ablett MP, Gilbert HTJ, et al.In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide-alkyne click reaction for tissue engineering. Biomaterials Science 2014; 2: 167-175.
    • (2014) Biomaterials Science , vol.2 , pp. 167-175
    • Truong, V.X.1    Ablett, M.P.2    Gilbert, H.3
  • 115
    • 2942536282 scopus 로고    scopus 로고
    • Intervertebral disc cell therapy for regeneration: Mesenchymal stem cell implantation in rat intervertebral discs
    • Crevensten G, Walsh AJ, Anathakrishnan D, Page P, Wahba GM, Lotz JC, Berven S. Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs. Ann Biomed Eng 2004; 32: 430-4.
    • (2004) Ann Biomed Eng , vol.32 , pp. 430-434
    • Crevensten, G.1    Walsh, A.J.2    Anathakrishnan, D.3    Page, P.4    Wahba, G.M.5    Lotz, J.C.6    Berven, S.7
  • 117
    • 84874968953 scopus 로고    scopus 로고
    • Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells
    • Bertolo A, Mehr M, Aebli N, Baur M, Ferguson SJ. Influence of different commercial scaffolds on the in vitro differentiation of human mesenchymal stem cells to nucleus pulposus-like cells. Eur Spine J 2012; 21: S826-S838.
    • (2012) Eur Spine J , vol.21
    • Bertolo, A.1    Mehr, M.2    Aebli, N.3    Baur, M.4    Ferguson, S.J.5
  • 118
    • 84921412855 scopus 로고    scopus 로고
    • Differential response of encapsulated nucleus pulposus and bone marrow stem cells in isolation and coculture in isolation and coculture in alginate and chitosan hydrogels
    • Naqvi SM, Buckley CT. Differential response of encapsulated nucleus pulposus and bone marrow stem cells in isolation and coculture in isolation and coculture in alginate and chitosan hydrogels. Tissue Eng 2014; DOI: 10.1089/ten.tea.2013.0719
    • (2014) Tissue Eng
    • Naqvi, S.M.1    Buckley, C.T.2
  • 119
    • 84916234905 scopus 로고    scopus 로고
    • Microgel microenvironment primes adipose-derived stem cells towards an NP cells-like phenotype
    • Fontana G, Thomas D, Collin E, Pandit A. Microgel microenvironment primes adipose-derived stem cells towards an NP cells-like phenotype. Adv Healthcare Mater 2014; DOI: 10.1089/ten.tea.2013.0719
    • (2014) Adv Healthcare Mater
    • Fontana, G.1    Thomas, D.2    Collin, E.3    Pandit, A.4
  • 120
    • 84899830821 scopus 로고    scopus 로고
    • Delivering mesenchymal stem cells in collagen microsphere carriers to a rabbit degenerative disc: Reduced risk of osteophyte formation
    • Li YY, Diao HJ, Chik TK, Chow CT, An XM, Leung V, Cheung KMC, Chan BP. Delivering mesenchymal stem cells in collagen microsphere carriers to a rabbit degenerative disc: reduced risk of osteophyte formation. Tissue Eng Part A 2014; 20: 1379-91.
    • (2014) Tissue Eng Part A , vol.20 , pp. 1379-1391
    • Li, Y.Y.1    Diao, H.J.2    Chik, T.K.3    Chow, C.T.4    An, X.M.5    Leung, V.6    Cheung, K.7    Chan, B.P.8
  • 121
    • 82355181393 scopus 로고    scopus 로고
    • Transfroming growth factor-beta 3 stimulates cartilage matrix elaboration by human marrow-derived stromal cells encapsulated in photocrosslinked carboxymethylcellulose hydrogels: Potential for nucleus pulposus replacement
    • Gupta MS, Cooper ES, Nicoll SB. Transfroming growth factor-beta 3 stimulates cartilage matrix elaboration by human marrow-derived stromal cells encapsulated in photocrosslinked carboxymethylcellulose hydrogels: potential for nucleus pulposus replacement. Tissue Eng Part A 2011; 17: 2903-10.
    • (2011) Tissue Eng Part A , vol.17 , pp. 2903-2910
    • Gupta, M.S.1    Cooper, E.S.2    Nicoll, S.B.3
  • 122
    • 84904189245 scopus 로고    scopus 로고
    • In vitro
    • Smith LJ, Gorth DJ, Showalter BL, et al. In vitro characterization of stem-cell-seeded triple-interpenetrating-netweok hydrogel for functional regeneration of the nucleus pulposus. Tissue Eng Part A 2014; 20: 1841-9.
    • (2014) Tissue Eng Part A , vol.20 , pp. 1841-1849
    • Smith, L.J.1    Gorth, D.J.2    Showalter, B.L.3
  • 123
    • 84903746142 scopus 로고    scopus 로고
    • The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs
    • Pereira CL, Goncalves RM, Peroglio M, et al.The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs. Biomaterials 2014; 35: 8144-53.
    • (2014) Biomaterials , vol.35 , pp. 8144-8153
    • Pereira, C.L.1    Goncalves, R.M.2    Peroglio, M.3
  • 125
    • 0033385413 scopus 로고    scopus 로고
    • Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc
    • Ishihara H, Urban JP. Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc. J Orthop Res 1999; 17: 829-35.
    • (1999) J Orthop Res , vol.17 , pp. 829-835
    • Ishihara, H.1    Urban, J.P.2
  • 126
    • 34547763262 scopus 로고    scopus 로고
    • Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc
    • Soukane DM, Shirazi-Adl A, Urban JP. Computation of coupled diffusion of oxygen, glucose and lactic acid in an intervertebral disc. J Biomech 2007; 40: 2645-54.
    • (2007) J Biomech , vol.40 , pp. 2645-2654
    • Soukane, D.M.1    Shirazi-Adl, A.2    Urban, J.P.3
  • 128
    • 0042236784 scopus 로고    scopus 로고
    • The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus
    • Razaq S, Wilkins RJ, Urban JP. The effect of extracellular pH on matrix turnover by cells of the bovine nucleus pulposus. Eur Spine J 2003; 12: 341-9.
    • (2003) Eur Spine J , vol.12 , pp. 341-349
    • Razaq, S.1    Wilkins, R.J.2    Urban, J.P.3
  • 130
    • 0033558074 scopus 로고    scopus 로고
    • Cyclic mechanical stretch increases the growth rate and collagen synthesis of nucleus cells in vitro
    • Matsumoto, T., M. Kawakami, K. Kuribayashi, T. Takenaka, and T. Tamaki. Cyclic mechanical stretch increases the growth rate and collagen synthesis of nucleus cells in vitro. Spine 1999; 24: 315-9.
    • (1999) Spine , vol.24 , pp. 315-319
    • Matsumoto, T.1    Kawakami, M.2    Kuribayashi, K.3    Takenaka, T.4    Tamaki, T.5
  • 131
    • 4844225379 scopus 로고    scopus 로고
    • Anabolic and Catabolic mRNA Levels of the Intervertebral Disc Vary with the Magnitude and Frequency of In vivo dynamic Compression
    • MacLean JJ, Lee CR, Alini M, Iatridis JC. Anabolic and Catabolic mRNA Levels of the Intervertebral Disc Vary with the Magnitude and Frequency of In vivo dynamic Compression. J Orth Res 2004; 22: 1193-200.
    • (2004) J Orth Res , vol.22 , pp. 1193-1200
    • Maclean, J.J.1    Lee, C.R.2    Alini, M.3    Iatridis, J.C.4
  • 132
    • 0742269711 scopus 로고    scopus 로고
    • Biological Response of the Intervertebral Disc to Dynamic Loading
    • Walsh AJ, Lotz JC. Biological Response of the Intervertebral Disc to Dynamic Loading. J Biomech 2004; 37: 329-37.
    • (2004) J Biomech , vol.37 , pp. 329-337
    • Walsh, A.J.1    Lotz, J.C.2
  • 135
    • 84862828293 scopus 로고    scopus 로고
    • Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc
    • Liang C, Li H, Tao Y, et al.Responses of human adipose-derived mesenchymal stem cells to chemical microenvironment of the intervertebral disc. J Transl Med 2012; 10: 49. doi:10.1186/1479-5876-10-49
    • (2012) J Transl Med , vol.10
    • Liang, C.1    Li, H.2    Tao, Y.3
  • 136
    • 58949101273 scopus 로고    scopus 로고
    • MSC response to pH levels found in degenerating intervertebral discs
    • Wuertz K, Godburn K, Iatridis JC. MSC response to pH levels found in degenerating intervertebral discs. Biochem Biophys Res Commun 2009; 379: 824-9.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 824-829
    • Wuertz, K.1    Godburn, K.2    Iatridis, J.C.3
  • 137
    • 70349233954 scopus 로고    scopus 로고
    • Hypoxia reduces the inhibitory effect of IL-1beta on chondrogenic differentiation of FCS-free expanded MSC
    • Felka T, Schafer R, Schewe B, Benz K, Aicher WK. Hypoxia reduces the inhibitory effect of IL-1beta on chondrogenic differentiation of FCS-free expanded MSC. Osteoarthritis Cartilage 2009; 10: 1368-76.
    • (2009) Osteoarthritis Cartilage , vol.10 , pp. 1368-1376
    • Felka, T.1    Schafer, R.2    Schewe, B.3    Benz, K.4    Aicher, W.K.5
  • 138
    • 77950554759 scopus 로고    scopus 로고
    • Enhanced chondrogenic differentiation of human bone marrowderived mesenchymal stem cells in low oxygen environment micropellet cultures
    • Markway BD, Tan GK, Hudson JE, Cooper-White JJ, Doran MR. Enhanced chondrogenic differentiation of human bone marrowderived mesenchymal stem cells in low oxygen environment micropellet cultures. Cell Transplant 2010; 19: 29-42.
    • (2010) Cell Transplant , vol.19 , pp. 29-42
    • Markway, B.D.1    Tan, G.K.2    Hudson, J.E.3    Cooper-White, J.J.4    Doran, M.R.5
  • 139
    • 84896729962 scopus 로고    scopus 로고
    • Influence of hypoxia in the intervertebral disc on the biological behaviors of rat adipose-and nucleus pulposus-derived mesenchymal stem cells
    • Li H, Tao Y, Liang C, Han B, Li F, Chen G, Chen Q. Influence of hypoxia in the intervertebral disc on the biological behaviors of rat adipose-and nucleus pulposus-derived mesenchymal stem cells. Cells Tissues Organs 2013; 198: 266-77.
    • (2013) Cells Tissues Organs , vol.198 , pp. 266-277
    • Li, H.1    Tao, Y.2    Liang, C.3    Han, B.4    Li, F.5    Chen, G.6    Chen, Q.7


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