Hypoxia reduces the inhibitory effect of IL-1β on chondrogenic differentiation of FCS-free expanded MSC

Osteoarthritis and Cartilage

Volumn 17, Issue 10, 2009, Pages 1368-1376

  Felka, T ^a   Schafer R ^a   Schewe, B ^b   Benz, K ^c   Aicher, W K ^a,d  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b BG Center for Traumatology   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Chondrogenic differentiation; FCS free expansion; Hypoxia; Inflammation; Mesenchymal stem cells

Indexed keywords

INTERLEUKIN 1BETA; MEMBRANE ANTIGEN; MESSENGER RNA; SCLEROPROTEIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW; CELL DIFFERENTIATION; CELL ISOLATION; CHONDROGENESIS; CONTROLLED STUDY; FETAL CALF SERUM; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HYPOXIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MESENCHYMAL STEM CELL; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 70349233954     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2009.04.023     Document Type: Article

References (48)

1. Ganey T.M., and Meisel H.J. A potential role for cell-based therapeutics in the treatment of intervertebral disc herniation. Eur Spine J 11 (2002) 206-214
2. Urban J.P., and Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther 5 (2003) 120-130
3. Maroudas A., Stockwell R.A., Nachemson A., and Urban J. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat 120 (1975) 113-130
4. Buckwalter J.A. Aging and degeneration of the human intervertebral disc. Spine 20 (1995) 1307-1314
5. Kraemer J. Natural course and prognosis of intervertebral disc diseases. International Society for the Study of the Lumbar Spine Seattle, Washington, June 1994. Spine 20 (1995) 635-639
6. Colombini A., Lombardi G., Corsi M.M., and Banfi G. Pathophysiology of the human intervertebral disc. Int J Biochem Cell Biol 40 (2008) 837-842
7. Sakai D., Mochida J., Iwashina T., Watanabe T., Nakai T., Ando K., et al. Differentiation of mesenchymal stem cells transplanted to a rabbit degenerative disc model: potential and limitations for stem cell therapy in disc regeneration. Spine 30 (2005) 2379-2387
8. Nishimura K., and Mochida J. Percutaneous reinsertion of the nucleus pulposus. An experimental study. Spine 23 (1998) 1531-1539
9. Okuma M., Mochida J., Nishimura K., Sakabe K., and Seiki K. Reinsertion of stimulated nucleus pulposus cells retards intervertebral disc degeneration: an in vitro and in vivo experimental study. J Orthop Res 18 (2000) 988-997
10. Kluba T., Niemeyer T., Gaissmaier C., and Grunder T. Human anulus fibrosis and nucleus pulposus cells of the intervertebral disc: effect of degeneration and culture system on cell phenotype. Spine 30 (2005) 2743-2748
11. Raghunath J., Salacinski H.J., Sales K.M., Butler P.E., and Seifalian A.M. Advancing cartilage tissue engineering: the application of stem cell technology. Curr Opin Biotechnol 16 (2005) 503-509
12. Steck E., Bertram H., Abel R., Chen B., Winter A., and Richter W. Induction of intervertebral disc-like cells from adult mesenchymal stem cells. Stem Cells 23 (2005) 403-411
13. Richardson S.M., Walker R.V., Parker S., Rhodes N., Hunt J.A., Freemont A.J., et al. Intervertebral disc cell-mediated mesenchymal stem cell differentiation. Stem Cells 24 (2006) 707-716
14. Bartels E.M., Fairbank J.C., Winlove C.P., and Urban J.P. Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine 23 (1998) 1-8
15. Bibby S.R., and Urban J.P. Effect of nutrient deprivation on the viability of intervertebral disc cells. Eur Spine J 13 (2004) 695-701
16. Ishihara H., and Urban J.P. Effects of low oxygen concentrations and metabolic inhibitors on proteoglycan and protein synthesis rates in the intervertebral disc. J Orthop Res 17 (1999) 829-835
17. Urban J.P., Smith S., and Fairbank J.C. Nutrition of the intervertebral disc. Spine 29 (2004) 2700-2709
18. Le Maitre C.L., Freemont A.J., and Hoyland J.A. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol 204 (2004) 47-54
19. Majumdar M.K., Wang E., and Morris E.A. BMP-2 and BMP-9 promotes chondrogenic differentiation of human multipotential mesenchymal cells and overcomes the inhibitory effect of IL-1. J Cell Physiol 189 (2001) 275-284
20. Mohamed-Ali H. Influence of interleukin-1 beta, tumour necrosis factor alpha and prostaglandin E2 on chondrogenesis and cartilage matrix breakdown in vitro. Rheumatol Int 14 (1995) 191-199
21. Egli R.J., Bastian J.D., Ganz R., Hofstetter W., and Leunig M. Hypoxic expansion promotes the chondrogenic potential of articular chondrocytes. J Orthop Res 13 (2008) 1159-1171
22. Kanichai M., Ferguson D., Prendergast P.J., and Campbell V.A. Hypoxia promotes chondrogenesis in rat mesenchymal stem cells: a role for AKT and hypoxia-inducible factor (HIF)-1alpha. J Cell Physiol (2008)
23. Khan W.S., Adesida A.B., and Hardingham T.E. Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients. Arthritis Res Ther 9 (2007) R55
24. Malladi P., Xu Y., Chiou M., Giaccia A.J., and Longaker M.T. Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells. Tissue Eng 13 (2007) 1159-1171
25. Medicinal and other products and human and animal transmissible spongiform encephalopathies: memorandum from a WHO meeting. Bull World Health Organ 75 (1997) 505-513
26. MacDermott R.P., and Bragdon M.J. Fetal calf serum augmentation during cell separation procedures accounts for the majority of human autologous mixed leukocyte reactivity. Behring Inst Mitt (1983) 122-128
27. Kievits F., Boerenkamp W.J., and Ivanyi P. H-2-dependent binding of xenogeneic beta 2-microglobulin from culture media. J Immunol 140 (1988) 4253-4255
28. Skottman H., Dilber M.S., and Hovatta O. The derivation of clinical-grade human embryonic stem cell lines. FEBS Lett 580 (2006) 2875-2878
29. Muller I., Kordowich S., Holzwarth C., Spano C., Isensee G., Staiber A., et al. Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy 8 (2006) 437-444
30. Yamamoto N., Isobe M., Negishi A., Yoshimasu H., Shimokawa H., Ohya K., et al. Effects of autologous serum on osteoblastic differentiation in human bone marrow cells. J Med Dent Sci 50 (2003) 63-69
31. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F., Krause D., et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8 (2006) 315-317
32. Böck P. Romeis Mikroskopische Technik, 1989.
33. Tscheudschilsuren G., Bosserhoff A.K., Schlegel J., Vollmer D., Anton A., Alt V., et al. Regulation of mesenchymal stem cell and chondrocyte differentiation by MIA. Exp Cell Res 312 (2006) 63-72
34. Lucarelli E., Beccheroni A., Donati D., Sangiorgi L., Cenacchi A., Del Vento A.M., et al. Platelet-derived growth factors enhance proliferation of human stromal stem cells. Biomaterials 24 (2003) 3095-3100
35. Banfi A., Muraglia A., Dozin B., Mastrogiacomo M., Cancedda R., and Quarto R. Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: implications for their use in cell therapy. Exp Hematol 28 (2000) 707-715
36. van den Berg W.B., and Bresnihan B. Pathogenesis of joint damage in rheumatoid arthritis: evidence of a dominant role for interleukin-I. Baillieres Best Pract Res Clin Rheumatol 13 (1999) 577-597
37. Dinarello C.A. Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation. Curr Opin Pharmacol 4 (2004) 378-385
38. Alten R., Gram H., Joosten L.A., van den Berg W.B., Sieper J., Wassenberg S., et al. The human anti-IL-1 beta monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis. Arthritis Res Ther 10 (2008) R67
39. Risbud M.V., Albert T.J., Guttapalli A., Vresilovic E.J., Hillibrand A.S., Vaccaro, et al. Differentiation of mesenchymal stem cells towards a nucleus pulposus-like phenotype in vitro: implications for cell-based transplantation therapy. Spine 29 (2004) 2627-2632
40. Koay E.J., and Athanasiou K.A. Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionality. Osteoarthritis Cartilage 16 (2008) 1450-1456
41. Gelse K., Muhle C., Knaup K., Swoboda B., Wiesener M., Hennig F., et al. Chondrogenic differentiation of growth factor-stimulated precursor cells in cartilage repair tissue is associated with increased HIF-1alpha activity. Osteoarthritis Cartilage 16 (2008) 1457-1465
42. Mueller M.B., and Tuan R.S. Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells. Arthritis Rheum 58 (2008) 1377-1388
43. Pelttari K., Steck E., and Richter W. The use of mesenchymal stem cells for chondrogenesis. Injury 39 (2008) 58-65
44. Zimmermann P., Boeuf S., Dickhut A., Boehmer S., Olek S., and Richter W. Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter. Arthritis Rheum 58 (2008) 2743-2753
45. Mwale F., Girard-Lauriault P.L., Wang H.T., Lerouge S., Antoniou J., and Wertheimer M.R. Suppression of genes related to hypertrophy and osteogenesis in committed human mesenchymal stem cells cultured on novel nitrogen-rich plasma polymer coatings. Tissue Eng 12 (2006) 2639-2647
46. Kavalkovich K.W., Boynton R.E., Murphy J.M., and Barry F. Chondrogenic differentiation of human mesenchymal stem cells within an alginate layer culture system. In Vitro Cell Dev Biol Anim 38 (2002) 457-466
47. Steinert A., Weber M., Dimmler A., Julius C., Schutze N., Noth U., et al. Chondrogenic differentiation of mesenchymal progenitor cells encapsulated in ultrahigh-viscosity alginate. J Orthop Res 21 (2003) 1090-1097
48. Cho J.H., Kim S.H., Park K.D., Jung M.C., Yang W.I., Han S.W., et al. Chondrogenic differentiation of human mesenchymal stem cells using a thermosensitive poly(N-isopropylacrylamide) and water-soluble chitosan copolymer. Biomaterials 25 (2004) 5743-5751