Mechanical stretch-induced endoplasmic reticulum stress, apoptosis and inflammation contribute to thoracic aortic aneurysm and dissection

Journal of Pathology

Volumn 236, Issue 3, 2015, Pages 373-383

  Jia, Li Xin ^a   Zhang, Wen Mei ^a   Zhang, Hong Jia ^a   Li, Tao Tao ^a   Wang, Yue Li ^a   Qin, Yan Wen ^a   Gu, Hong ^a   Du, Jie ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; CHOP; ER stress; SMCs; thoracic aortic aneurysm dissection

Indexed keywords

3 AMINOPROPIONITRILE; ACTIVATING TRANSCRIPTION FACTOR 4; RNA; ATF4 PROTEIN, HUMAN; ATF4 PROTEIN, MOUSE; DDIT3 PROTEIN, HUMAN; DDIT3 PROTEIN, MOUSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153;

ANEURYSM RUPTURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA DISSECTION; APOPTOSIS; ARTICLE; CELL LOSS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; MALE; MECHANICAL STRESS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; STRETCHING; THORACIC AORTA ANEURYSM; TUNEL ASSAY; WILD TYPE; ANIMAL; AORTA; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ACTIVATING TRANSCRIPTION FACTOR 4; AMINOPROPIONITRILE; ANIMALS; AORTA; AORTIC ANEURYSM, THORACIC; APOPTOSIS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOPLASMIC RETICULUM STRESS; HUMANS; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCYTES, SMOOTH MUSCLE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP;

EID: 84930484757     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4534     Document Type: Article

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