메뉴 건너뛰기




Volumn 56, Issue 6, 2015, Pages 895-905

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

Author keywords

Cytokine; Inflammation; Kainate; Pilocarpine; Seizure; Status epilepticus

Indexed keywords

ARGINASE 1; CD11B ANTIGEN; CD16 ANTIGEN; CD86 ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; KAINIC ACID; M1 PROTEIN; MESSENGER RNA; PILOCARPINE; PROTEIN; PROTEIN M2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ARG1 PROTEIN, MOUSE; ARGINASE; BETA N ACETYLHEXOSAMINIDASE; CHI3L3 PROTEIN, MOUSE; CONVULSANT AGENT; CYTOKINE; LECTIN;

EID: 84930478595     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12960     Document Type: Article
Times cited : (147)

References (45)
  • 2
    • 84872706357 scopus 로고    scopus 로고
    • Review: Activation patterns of microglia and their identification in the human brain
    • Boche D, Perry V, Nicoll J,. Review: activation patterns of microglia and their identification in the human brain. Neuropathol Appl Neurobiol 2013; 39: 3-18.
    • (2013) Neuropathol Appl Neurobiol , vol.39 , pp. 3-18
    • Boche, D.1    Perry, V.2    Nicoll, J.3
  • 3
    • 70449526190 scopus 로고    scopus 로고
    • Heterogeneity of microglial activation in the innate immune response in the brain
    • Colton CA,. Heterogeneity of microglial activation in the innate immune response in the brain. J Neuroimmune Pharmacol 2009; 4: 399-418.
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 399-418
    • Colton, C.A.1
  • 4
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: Mechanism and functions
    • Gordon S, Martinez FO,. Alternative activation of macrophages: mechanism and functions. Immunity 2010; 32: 593-604.
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 5
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP,. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8: 958-969.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 6
    • 84868209611 scopus 로고    scopus 로고
    • Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia
    • Hu X, Li P, Guo Y, et al., Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia. Stroke 2012; 43: 3063-3070.
    • (2012) Stroke , vol.43 , pp. 3063-3070
    • Hu, X.1    Li, P.2    Guo, Y.3
  • 7
    • 70350558453 scopus 로고    scopus 로고
    • Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    • Kigerl KA, Gensel JC, Ankeny DP, et al., Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009; 29: 13435-13444.
    • (2009) J Neurosci , vol.29 , pp. 13435-13444
    • Kigerl, K.A.1    Gensel, J.C.2    Ankeny, D.P.3
  • 8
    • 0029850114 scopus 로고    scopus 로고
    • Microglial activation by epileptic activities through the propagation pathway of kainic acid-induced hippocampal seizures in the rat
    • Taniwaki Y, Kato M, Araki T, et al., Microglial activation by epileptic activities through the propagation pathway of kainic acid-induced hippocampal seizures in the rat. Neurosci Lett 1996; 217: 29-32.
    • (1996) Neurosci Lett , vol.217 , pp. 29-32
    • Taniwaki, Y.1    Kato, M.2    Araki, T.3
  • 9
    • 55249116379 scopus 로고    scopus 로고
    • Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling
    • Avignone E, Ulmann L, Levavasseur F, et al., Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. J Neurosci 2008; 28: 9133-9144.
    • (2008) J Neurosci , vol.28 , pp. 9133-9144
    • Avignone, E.1    Ulmann, L.2    Levavasseur, F.3
  • 10
    • 38449102377 scopus 로고    scopus 로고
    • Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats
    • Shapiro LA, Wang L, Ribak CE,. Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats. Epilepsia 2008; 49: 33-41.
    • (2008) Epilepsia , vol.49 , pp. 33-41
    • Shapiro, L.A.1    Wang, L.2    Ribak, C.E.3
  • 11
    • 0038434119 scopus 로고    scopus 로고
    • Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model
    • Borges K, Gearing M, McDermott DL, et al., Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Exp Neurol 2003; 182: 21-34.
    • (2003) Exp Neurol , vol.182 , pp. 21-34
    • Borges, K.1    Gearing, M.2    McDermott, D.L.3
  • 12
    • 84880468112 scopus 로고    scopus 로고
    • Early activation of ventral hippocampus and subiculum during spontaneous seizures in a rat model of temporal lobe epilepsy
    • Toyoda I, Bower MR, Leyva F, et al., Early activation of ventral hippocampus and subiculum during spontaneous seizures in a rat model of temporal lobe epilepsy. J Neurosci 2013; 33: 11100-11115.
    • (2013) J Neurosci , vol.33 , pp. 11100-11115
    • Toyoda, I.1    Bower, M.R.2    Leyva, F.3
  • 13
    • 0029031842 scopus 로고
    • Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy
    • Beach T, Woodhurst W, MacDonald D, et al., Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci Lett 1995; 191: 27-30.
    • (1995) Neurosci Lett , vol.191 , pp. 27-30
    • Beach, T.1    Woodhurst, W.2    Macdonald, D.3
  • 14
    • 0037131063 scopus 로고    scopus 로고
    • Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis
    • Crespel A, Coubes P, Rousset M-C, et al., Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis. Brain Res 2002; 952: 159-169.
    • (2002) Brain Res , vol.952 , pp. 159-169
    • Crespel, A.1    Coubes, P.2    Rousset, M.-C.3
  • 15
    • 33644947009 scopus 로고    scopus 로고
    • Evidence of activated microglia in focal cortical dysplasia
    • Boer K, Spliet W, Van Rijen P, et al., Evidence of activated microglia in focal cortical dysplasia. J Neuroimmunol 2006; 173: 188-195.
    • (2006) J Neuroimmunol , vol.173 , pp. 188-195
    • Boer, K.1    Spliet, W.2    Van Rijen, P.3
  • 16
    • 80052642998 scopus 로고    scopus 로고
    • Refractory epilepsy associated with microglial activation
    • Najjar S, Pearlman D, Miller DC, et al., Refractory epilepsy associated with microglial activation. Neurologist 2011; 17: 249-254.
    • (2011) Neurologist , vol.17 , pp. 249-254
    • Najjar, S.1    Pearlman, D.2    Miller, D.C.3
  • 17
    • 0033563321 scopus 로고    scopus 로고
    • Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: Functional evidence for enhancement of electrographic seizures
    • Vezzani A, Conti M, De Luigi A, et al., Interleukin-1β immunoreactivity and microglia are enhanced in the rat hippocampus by focal kainate application: functional evidence for enhancement of electrographic seizures. J Neurosci 1999; 19: 5054-5065.
    • (1999) J Neurosci , vol.19 , pp. 5054-5065
    • Vezzani, A.1    Conti, M.2    De Luigi, A.3
  • 18
    • 55949107105 scopus 로고    scopus 로고
    • Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation
    • Riazi K, Galic MA, Kuzmiski JB, et al., Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation. Proc Natl Acad Sci U S A 2008; 105: 17151-17156.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17151-17156
    • Riazi, K.1    Galic, M.A.2    Kuzmiski, J.B.3
  • 19
    • 0037829339 scopus 로고    scopus 로고
    • Profound increase in sensitivity to glutamatergic-but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6
    • Samland H, Huitron-Resendiz S, Masliah E, et al., Profound increase in sensitivity to glutamatergic-but not cholinergic agonist-induced seizures in transgenic mice with astrocyte production of IL-6. J Neurosci Res 2003; 73: 176-187.
    • (2003) J Neurosci Res , vol.73 , pp. 176-187
    • Samland, H.1    Huitron-Resendiz, S.2    Masliah, E.3
  • 20
    • 0036337913 scopus 로고    scopus 로고
    • Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis
    • Vezzani A, Moneta D, Richichi C, et al., Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis. Epilepsia 2002; 43: 30-35.
    • (2002) Epilepsia , vol.43 , pp. 30-35
    • Vezzani, A.1    Moneta, D.2    Richichi, C.3
  • 21
    • 12944273495 scopus 로고    scopus 로고
    • Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice
    • Vezzani A, Moneta D, Conti M, et al., Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc Natl Acad Sci U S A 2000; 97: 11534-11539.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 11534-11539
    • Vezzani, A.1    Moneta, D.2    Conti, M.3
  • 22
    • 79955053045 scopus 로고    scopus 로고
    • Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice
    • Maroso M, Balosso S, Ravizza T, et al., Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice. Neurotherapeutics 2011; 8: 304-315.
    • (2011) Neurotherapeutics , vol.8 , pp. 304-315
    • Maroso, M.1    Balosso, S.2    Ravizza, T.3
  • 23
    • 79953135552 scopus 로고    scopus 로고
    • Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics
    • Marchi N, Granata T, Freri E, et al., Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics. PLoS ONE 2011; 6: e18200.
    • (2011) PLoS ONE , vol.6 , pp. e18200
    • Marchi, N.1    Granata, T.2    Freri, E.3
  • 24
    • 0021921141 scopus 로고
    • Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
    • Ben-Ari Y,. Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy. Neuroscience 1985; 14: 375-403.
    • (1985) Neuroscience , vol.14 , pp. 375-403
    • Ben-Ari, Y.1
  • 25
    • 84866665261 scopus 로고    scopus 로고
    • Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization
    • Mazzuferi M, Kumar G, Rospo C, et al., Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization. Exp Neurol 2012; 238: 156-167.
    • (2012) Exp Neurol , vol.238 , pp. 156-167
    • Mazzuferi, M.1    Kumar, G.2    Rospo, C.3
  • 26
    • 0032940256 scopus 로고    scopus 로고
    • Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: Electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy
    • Bouilleret V, Ridoux V, Depaulis A, et al., Recurrent seizures and hippocampal sclerosis following intrahippocampal kainate injection in adult mice: electroencephalography, histopathology and synaptic reorganization similar to mesial temporal lobe epilepsy. Neuroscience 1999; 89: 717-729.
    • (1999) Neuroscience , vol.89 , pp. 717-729
    • Bouilleret, V.1    Ridoux, V.2    Depaulis, A.3
  • 27
    • 84891676185 scopus 로고    scopus 로고
    • Issues related to development of new antiseizure treatments
    • Wilcox KS, Dixon-Salazar T, Sills GJ, et al., Issues related to development of new antiseizure treatments. Epilepsia 2013; 54: 24-34.
    • (2013) Epilepsia , vol.54 , pp. 24-34
    • Wilcox, K.S.1    Dixon-Salazar, T.2    Sills, G.J.3
  • 28
    • 35148890786 scopus 로고    scopus 로고
    • In vivo and in vitro effects of pilocarpine: Relevance to ictogenesis
    • Marchi N, Oby E, Batra A, et al., In vivo and in vitro effects of pilocarpine: relevance to ictogenesis. Epilepsia 2007; 48: 1934-1946.
    • (2007) Epilepsia , vol.48 , pp. 1934-1946
    • Marchi, N.1    Oby, E.2    Batra, A.3
  • 29
    • 84880331357 scopus 로고    scopus 로고
    • Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice
    • Smeland OB, Hadera MG, McDonald TS, et al., Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice. J Cereb Blood Flow Metab 2013; 33: 1090-1097.
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 1090-1097
    • Smeland, O.B.1    Hadera, M.G.2    McDonald, T.S.3
  • 30
    • 65549130913 scopus 로고    scopus 로고
    • Temporal and spatial dynamics of cerebral immune cell accumulation in stroke
    • Gelderblom M, Leypoldt F, Steinbach K, et al., Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke 2009; 40: 1849-1857.
    • (2009) Stroke , vol.40 , pp. 1849-1857
    • Gelderblom, M.1    Leypoldt, F.2    Steinbach, K.3
  • 31
    • 84931272198 scopus 로고    scopus 로고
    • PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
    • Low PC, Manzanero S, Mohannak N, et al., PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. Nat Commun 2014; 5: 3450. doi: 10.1038/ncomms4450.
    • (2014) Nat Commun , vol.5 , pp. 3450
    • Low, P.C.1    Manzanero, S.2    Mohannak, N.3
  • 32
    • 80052532398 scopus 로고    scopus 로고
    • Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures
    • Marchi N, Johnson AJ, Puvenna V, et al., Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures. Epilepsia 2011; 52: 1627-1634.
    • (2011) Epilepsia , vol.52 , pp. 1627-1634
    • Marchi, N.1    Johnson, A.J.2    Puvenna, V.3
  • 33
    • 84859508331 scopus 로고    scopus 로고
    • Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats
    • Costa-Ferro ZS, Souza BS, Leal MM, et al., Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats. Neurobiol Dis 2012; 46: 302-313.
    • (2012) Neurobiol Dis , vol.46 , pp. 302-313
    • Costa-Ferro, Z.S.1    Souza, B.S.2    Leal, M.M.3
  • 34
    • 0001139213 scopus 로고
    • Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus
    • Lieberman AP, Pitha PM, Shin HS, et al., Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proc Natl Acad Sci U S A 1989; 86: 6348-6352.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 6348-6352
    • Lieberman, A.P.1    Pitha, P.M.2    Shin, H.S.3
  • 35
    • 38149129457 scopus 로고    scopus 로고
    • A transcriptome database for astrocytes, neurons, and oligodendrocytes: A new resource for understanding brain development and function
    • Cahoy JD, Emery B, Kaushal A, et al., A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. J Neurosci 2008; 28: 264-278.
    • (2008) J Neurosci , vol.28 , pp. 264-278
    • Cahoy, J.D.1    Emery, B.2    Kaushal, A.3
  • 36
    • 84875659084 scopus 로고    scopus 로고
    • Effect of stroke on arginase expression and localization in the rat brain
    • Quirie A, Demougeot C, Bertrand N, et al., Effect of stroke on arginase expression and localization in the rat brain. Eur J Neurosci 2013; 37: 1193-1202.
    • (2013) Eur J Neurosci , vol.37 , pp. 1193-1202
    • Quirie, A.1    Demougeot, C.2    Bertrand, N.3
  • 37
    • 58149510132 scopus 로고    scopus 로고
    • Antagonism of peripheral inflammation reduces the severity of status epilepticus
    • Marchi N, Fan Q, Ghosh C, et al., Antagonism of peripheral inflammation reduces the severity of status epilepticus. Neurobiol Dis 2009; 33: 171-181.
    • (2009) Neurobiol Dis , vol.33 , pp. 171-181
    • Marchi, N.1    Fan, Q.2    Ghosh, C.3
  • 38
    • 79957807767 scopus 로고    scopus 로고
    • Inflammation and prevention of epileptogenesis
    • Ravizza T, Balosso S, Vezzani A,. Inflammation and prevention of epileptogenesis. Neurosci Lett 2011; 497: 223-230.
    • (2011) Neurosci Lett , vol.497 , pp. 223-230
    • Ravizza, T.1    Balosso, S.2    Vezzani, A.3
  • 39
    • 67649804600 scopus 로고    scopus 로고
    • Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model
    • Somera-Molina KC, Nair S, Van Eldik LJ, et al., Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model. Brain Res 2009; 1282: 162-172.
    • (2009) Brain Res , vol.1282 , pp. 162-172
    • Somera-Molina, K.C.1    Nair, S.2    Van Eldik, L.J.3
  • 40
    • 80054741188 scopus 로고    scopus 로고
    • Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus
    • Serrano G, Lelutiu N, Rojas A, et al., Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. J Neurosci 2011; 31: 14850-14860.
    • (2011) J Neurosci , vol.31 , pp. 14850-14860
    • Serrano, G.1    Lelutiu, N.2    Rojas, A.3
  • 41
    • 70350787254 scopus 로고    scopus 로고
    • Epileptogenesis in the immature brain: Emerging mechanisms
    • Rakhade SN, Jensen FE,. Epileptogenesis in the immature brain: emerging mechanisms. Nat Rev Neurol 2009; 5: 380-391.
    • (2009) Nat Rev Neurol , vol.5 , pp. 380-391
    • Rakhade, S.N.1    Jensen, F.E.2
  • 42
    • 82955249182 scopus 로고    scopus 로고
    • Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy
    • Pernot F, Heinrich C, Barbier L, et al., Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy. Epilepsia 2011; 52: 2315-2325.
    • (2011) Epilepsia , vol.52 , pp. 2315-2325
    • Pernot, F.1    Heinrich, C.2    Barbier, L.3
  • 43
    • 84873452455 scopus 로고    scopus 로고
    • Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states
    • Kumar A, Stoica BA, Sabirzhanov B, et al., Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states. Neurobiol Aging 2013; 34: 1397-1411.
    • (2013) Neurobiol Aging , vol.34 , pp. 1397-1411
    • Kumar, A.1    Stoica, B.A.2    Sabirzhanov, B.3
  • 44
    • 84878822187 scopus 로고    scopus 로고
    • The dual role of TNF-α and its receptors in seizures
    • Balosso S, Ravizza T, Aronica E, et al., The dual role of TNF-α and its receptors in seizures. Exp Neurol 2013; 247: 267-271.
    • (2013) Exp Neurol , vol.247 , pp. 267-271
    • Balosso, S.1    Ravizza, T.2    Aronica, E.3
  • 45
    • 0033768486 scopus 로고    scopus 로고
    • The peripheral benzodiazepine binding site in the brain in multiple sclerosis: Quantitative in vivo imaging of microglia as a measure of disease activity
    • Banati RB, Newcombe J, Gunn RN, et al., The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000; 123: 2321-2337.
    • (2000) Brain , vol.123 , pp. 2321-2337
    • Banati, R.B.1    Newcombe, J.2    Gunn, R.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.