The dual role of TNF-α and its receptors in seizures

Experimental Neurology

Volumn 247, Issue , 2013, Pages 267-271

  Balosso, Silvia ^a   Ravizza, Teresa ^a   Aronica, Eleonora ^b,c,d   Vezzani, Annamaria ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

BLOOD BRAIN BARRIER; BRAIN SLICE; CELL LOSS; CYTOKINE PRODUCTION; EPILEPTOGENESIS; EXCITOTOXICITY; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; NERVE CELL EXCITABILITY; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; NOTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; SEIZURE; SEIZURE SUSCEPTIBILITY;

ANIMALS; HIPPOCAMPUS; HUMANS; LIMBIC SYSTEM; MALE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SEIZURES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84878822187     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2013.05.010     Document Type: Note

References (62)

1. Akassoglou K., Probert L., Kontogeorgos G., Kollias G. Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice. J. Immunol. 1997, 158:438-445.
2. Auvin S., Shin D., Mazarati A., Nakagawa J., Miyamoto J., Sankar R. Inflammation exacerbates seizure-induced injury in the immature brain. Epilepsia 2007, 48(Suppl. 5):27-34.
3. Balosso S., Ravizza T., Perego C., Peschon J., Campbell I.L., De Simoni M.G., Vezzani A. Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors. Ann. Neurol. 2005, 57:804-812.
4. Balosso S., Ravizza T., Pierucci M., Calcagno E., Invernizzi R.W., Di Giovanni G., Esposito E., Vezzani A. Molecular and functional interactions between TNF-alpha receptors and the glutamatergic system in the mouse hippocampus: implications for seizure susceptibility. Neuroscience 2009, 161:293-300.
5. Barone F.C., Arvin B., White R.F., Miller A., Webb C.L., Willette R.N., Lysko P.G., Feuerstein G.Z. Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 1997, 28:1233-1244.
6. Beattie E.C., Stellwagen D., Morishita W., Bresnahan J.C., Ha B.K., Von Zastrow M., Beattie M.S., Malenka R.C. Control of synaptic strength by glial TNFalpha. Science 2002, 295:2282-2285.
7. Bezzi P., Domercq M., Brambilla L., Galli R., Schols D., De Clercq E., Vescovi A., Bagetta G., Kollias G., Meldolesi J., Volterra A. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat. Neurosci. 2001, 4:702-710.
8. Botchkina G.I., Meistrell M.E., Botchkina I.L., Tracey K.J. Expression of TNF and TNF receptors (p55 and p75) in the rat brain after focal cerebral ischemia. Mol. Med. 1997, 3:765-781.
9. de Bock F., Dornand J., Rondouin G. Release of TNF alpha in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. Neuroreport 1996, 7:1125-1129.
10. De Simoni M.G., Perego C., Ravizza T., Moneta D., Conti M., Marchesi F., De Luigi A., Garattini S., Vezzani A. Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur. J. Neurosci. 2000, 12:2623-2633.
11. Dhote F., Peinnequin A., Carpentier P., Baille V., Delacour C., Foquin A., Lallement G., Dorandeu F. Prolonged inflammatory gene response following soman-induced seizures in mice. Toxicology 2007, 238:166-176.
12. Dubé C., Vezzani A., Behrens M., Bartfai T., Baram T.Z. Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann. Neurol. 2005, 57:152-155.
13. Friedman A., Dingledine R. Molecular cascades that mediate the influence of inflammation on epilepsy. Epilepsia 2011, 52(Suppl. 3):33-39.
14. Friedman A., Kaufer D., Heinemann U. Blood-brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy. Epilepsy Res. 2009, 85:142-149.
15. Frigerio F., Frasca A., Weissberg I., Parrella S., Friedman A., Vezzani A., Noé F.M. Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology. Epilepsia 2012, 53:1887-1897.
16. Grell M., Wajant H., Zimmermann G., Scheurich P. The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:570-575.
17. Henshall D.C., Araki T., Schindler C.K., Shinoda S., Lan J.Q., Simon R.P. Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures. J. Neurochem. 2003, 86:1260-1270.
18. Holmin S., Schalling M., Hojeberg B., Nordqvist A.C., Skeftruna A.K., Mathiesen T. Delayed cytokine expression in rat brain following experimental contusion. J. Neurosurg. 1997, 86:493-504.
19. Kaplitt M.G., During M.J. Gene therapy in the central nervous system. From Bench to Bedside 2006, Elsevier Inc., San Diego, CA 92101-4495.
20. Kita T., Liu L., Tanaka N., Kinoshita Y. The expression of tumor necrosis factor-alpha in the rat brain after fluid percussive injury. Int. J. Legal Med. 1997, 110:305-311.
21. Knoblach S.M., Fan L., Faden A.I. Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment. J. Neuroimmunol. 1999, 95:115-125.
22. Kuteykin-Teplyakov K., Brandt C., Hoffmann K., Loscher W. Complex time-dependent alterations in the brain expression of different drug efflux transporter genes after status epilepticus. Epilepsia 2009, 50:887-897.
23. Lehtimaki K.A., Peltola J., Koskikallio E., Keranen T., Honkaniemi J. Expression of cytokines and cytokine receptors in the rat brain after kainic acid-induced seizures. Brain Res. Mol. Brain Res. 2003, 110:253-260.
24. Lenzlinger P.M., Morganti-Kossmann M.C., Laurer H.L., McIntosh T.K. The duality of the inflammatory response to traumatic brain injury. Mol. Neurobiol. 2001, 24:169-181.
25. Leonoudakis D., Braithwaite S.P., Beattie M.S., Beattie E.C. TNFalpha-induced AMPA-receptor trafficking in CNS neurons; relevance to excitotoxicity?. Neuron Glia Biol. 2004, 1:263-273.
26. Lu M.O., Zhang X.M., Mix E., Quezada H.C., Jin T., Zhu J., Adem A. TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice. J. Neurosci. Res. 2008, 86:1608-1614.
27. MacEwan D.J. TNF receptor subtype signalling: differences and cellular consequences. Cell. Signal. 2002, 14:477-492.
28. Mayhan W.G. Cellular mechanisms by which tumor necrosis factor-alpha produces disruption of the blood-brain barrier. Brain Res. 2002, 927:144-152.
29. Meldolesi J., Sciorati C., Clementi E. The p75 receptor: first insights into the transduction mechanisms leading to either cell death or survival. Trends Pharmacol. Sci. 2000, 21:242-243.
30. 2+-permeable alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA)/kainate (Ca-A/K) channels in a subset of hippocampal pyramidal neurons. Exp. Neurol. 2005, 193:384-393.
31. Ohtori S., Takahashi K., Moriya H., Myers R.R. TNF-alpha and TNF-alpha receptor type 1 upregulation in glia and neurons after peripheral nerve injury: studies in murine DRG and spinal cord. Spine 2004, 29:1082-1088. (Phila Pa 1976).
32. Pickering M., O'Connor J.J. Pro-inflammatory cytokines and their effects in the dentate gyrus. Prog. Brain Res. 2007, 163:339-354.
33. Ravizza T., Lucas S.M., Balosso S., Bernardino L., Ku G., Noé F., Malva J., Randle J.C., Allan S., Vezzani A. Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Epilepsia 2006, 47:1160-1168.
34. Ravizza T., Gagliardi B., Noé F., Boer K., Aronica E., Vezzani A. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol. Dis. 2008, 29:142-160.
35. Ravizza T., Balosso S., Aronica E., Vezzani A. Brain inflammation and epilepsy. Epilepsy. Mechanisms, models, and translational perspectives 2010, 45-59. CRC Press, Boca Raton, FL. J.M. Rho, R. Sankar, C.E. Strafstrom (Eds.).
36. Ravizza T., Balosso S., Vezzani A. Inflammation and prevention of epileptogenesis. Neurosci. Lett. 2011, 497:223-230.
37. Riazi K., Galic M.A., Pittman Q.J. Contributions of peripheral inflammation to seizure susceptibility: cytokines and brain excitability. Epilepsy Res. 2010, 89:34-42.
38. Rigau V., Morin M., Rousset M.C., de Bock F., Lebrun A., Coubes P., Picot M.C., Baldy-Moulinier M., Bockaert J., Crespel A., Lerner-Natoli M. Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain 2007, 130:1942-1956.
39. Rothwell N.J., Luheshi G.N. Brain TNF: damage limitation or damaged reputation?. Nat. Med. 1996, 2:746-747.
40. Sairanen T., Carpen O., Karjalainen-Lindsberg M.L., Paetau A., Turpeinen U., Kaste M., Lindsberg P.J. Evolution of cerebral tumor necrosis factor-alpha production during human ischemic stroke. Stroke 2001, 32:1750-1758.
41. Santello M., Volterra A. TNFalpha in synaptic function: switching gears. Trends Neurosci. 2012, 35:638-647.
42. Sayyah M., Javad-Pour M., Ghazi-Khansari M. The bacterial endotoxin lipopolysaccharide enhances seizure susceptibility in mice: involvement of proinflammatory factors: nitric oxide and prostaglandins. Neuroscience 2003, 122:1073-1080.
43. Schafers M., Sorkin L. Effect of cytokines on neuronal excitability. Neurosci. Lett. 2008, 437:188-193.
44. Shinoda S., Skradski S.L., Araki T., Schindler C.K., Meller R., Lan J.Q., Taki W., Simon R.P., Henshall D.C. Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death. Eur. J. Neurosci. 2003, 17:2065-2076.
45. Somera-Molina K.C., Nair S., Van Eldik L.J., Watterson D.M., Wainwright M.S. Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model. Brain Res. 2009, 1282:162-172.
46. Sriram K., O'Callaghan J.P. Divergent roles for tumor necrosis factor-alpha in the brain. J. Neuroimmune Pharmacol. 2007, 2:140-153.
47. Stellwagen D., Malenka R.C. Synaptic scaling mediated by glial TNF-alpha. Nature 2006, 440:1054-1059.
48. Stellwagen D., Beattie E.C., Seo J.Y., Malenka R.C. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J. Neurosci. 2005, 25:3219-3228.
49. Tancredi V., D'Arcangelo G., Grassi F., Tarroni P., Palmieri G., Santoni A., Eusebi F. Tumor necrosis factor alters synaptic transmission in rat hippocampal slices. Neurosci. Lett. 1992, 146:176-178.
50. Turrin N.P., Rivest S. Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. Neurobiol. Dis. 2004, 16:321-334.
51. van Vliet E.A., da Costa Araujo S., Redeker S., van Schaik R., Aronica E., Gorter J.A. Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 2007, 130:521-534.
52. Venters H.D., Dantzer R., Kelley K.W. A new concept in neurodegeneration: TNFalpha is a silencer of survival signals. Trends Neurosci. 2000, 23:175-180.
53. Vezzani A., Moneta D., Conti M., Richichi C., Ravizza T., De Luigi A., De Simoni M.G., Sperk G., Andell-Jonsson S., Lundkvist J., Iverfeldt K., Bartfai T. Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:11534-11539.
54. Vezzani A., Balosso S., Ravizza T. The role of cytokines in the pathophysiology of epilepsy. Brain Behav. Immun. 2008, 22:797-803.
55. Vezzani A., French J., Bartfai T., Baram T.Z. The role of inflammation in epilepsy. Nat. Rev. Neurol. 2010, 7:31-40.
56. Viviani B., Gardoni F., Marinovich M. Cytokines and neuronal ion channels in health and disease. Int. Rev. Neurobiol. 2007, 82:247-263.
57. Wheeler D., Knapp E., Bandaru V.V., Wang Y., Knorr D., Poirier C., Mattson M.P., Geiger J.D., Haughey N.J. Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. J. Neurochem. 2009, 109:1237-1249.
58. Yamamoto A., Schindler C.K., Murphy B.M., Bellver-Estelles C., So N.K., Taki W., Meller R., Simon R.P., Henshall D.C. Evidence of tumor necrosis factor receptor 1 signaling in human temporal lobe epilepsy. Exp. Neurol. 2006, 202:410-420.
59. Yang G.Y., Gong C., Qin Z., Liu X.H., Lorris Betz A. Tumor necrosis factor alpha expression produces increased blood-brain barrier permeability following temporary focal cerebral ischemia in mice. Brain Res. Mol. Brain Res. 1999, 69:135-143.
60. Yang L., Lindholm K., Konishi Y., Li R., Shen Y. Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways. J. Neurosci. 2002, 22:3025-3032.
61. Yu Z., Cheng G., Wen X., Wu G.D., Lee W.T., Pleasure D. Tumor necrosis factor alpha increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit GluR1 via an acid sphingomyelinase- and NF-kappaB-dependent mechanism. Neurobiol. Dis. 2002, 11:199-213.
62. Zou J.Y., Crews F.T. TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition. Brain Res. 2005, 1034:11-24.