Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 7, 2013, Pages 1090-1097

  Smeland, Olav B ^a   Hadera, Mussie G ^a   Mcdonald, Tanya S ^b   Sonnewald, Ursula ^a   Borges, Karin ^b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

13C isotope; glutamate; mitochondria; neurometabolism; NMR spectroscopy; temporal lobe epilepsy

Indexed keywords

4 AMINOBUTYRIC ACID; CITRIC ACID; CREATINE; CREATINE PHOSPHATE; EXCITATORY AMINO ACID TRANSPORTER; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLYCINE; INOSITOL; MALIC ACID; PILOCARPINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SUCCINATE DEHYDROGENASE; TAURINE; THREONINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN METABOLISM; BRAIN REGION; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY METABOLISM; EPILEPTIC STATE; GLUCOSE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; MASS FRAGMENTOGRAPHY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TEMPORAL LOBE EPILEPSY;

AMINO ACIDS; ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; EPILEPSY, TEMPORAL LOBE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOSE; GLUTAMIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICE, INBRED STRAINS; MITOCHONDRIA; NEUROTRANSMITTER AGENTS; PILOCARPINE;

EID: 84880331357     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2013.54     Document Type: Article

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