Retinal Toxicity Induced by a Novel β-secretase Inhibitor in the Sprague-Dawley Rat

Toxicologic Pathology

Volumn 43, Issue 4, 2015, Pages 581-592

  Fielden, Mark R ^a   Werner, Jonathan ^a   Jamison, Jeff A ^b   Coppi, Aldo ^a   Hickman, Dean ^a   Dunn, Robert T ^a   Trueblood, Esther ^a   Zhou, Lei ^a   Afshari, Cynthia A ^a   Lightfoot Dunn, Ruth ^a  

^a AMGEN INC   (United States)

^b Ophthy DS   (United States)

Author keywords

electroretinogram; fundus autofluorescence; optical coherence tomography; retina; retinal pigment epithelium; secretase

Indexed keywords

AMG 8718; BETA SECRETASE INHIBITOR; UNCLASSIFIED DRUG; (S)-7-(2-FLUOROPYRIDIN-3-YL)-3-((3-METHYLOXETAN-3-YL)ETHYNYL)-5'H-SPIRO(CHROMENO(2,3-B)PYRIDINE-5,4'-OXAZOL)-2'-AMINE; ASPARTIC PROTEINASE; BACE PROTEIN, RAT; BENZOPYRAN DERIVATIVE; ENZYME INHIBITOR; PYRIDINE DERIVATIVE; SECRETASE; SPIRO COMPOUND;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOFLUORESCENCE IMAGING; CELL LOSS; CELL NUCLEUS; CONTROLLED STUDY; ELECTRORETINOGRAM; ELECTRORETINOGRAPHY; FLUORESCENCE MICROSCOPY; KNOCKOUT RAT; MALE; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA DISEASE; RETINAL THINNING; RETINAL TOXICITY; SLIT LAMP; SPRAGUE DAWLEY RAT; TOXICITY; TOXICITY TESTING; TOXICOKINETICS; VISUAL SYSTEM PARAMETERS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYMOLOGY; PATHOLOGY; RETINA;

RATTUS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; BENZOPYRANS; ELECTRORETINOGRAPHY; ENZYME INHIBITORS; MALE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL DISEASES; SPIRO COMPOUNDS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84930339289     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623314553804     Document Type: Article

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