Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs

Structure

Volumn 23, Issue 6, 2015, Pages 1106-1115

  Bourne, Yves ^a,b   Sulzenbacher, Gerlind ^a,b   Radić, Zoran ^c   Aráoz, Rómulo ^b,d   Reynaud, Morgane ^d   Benoit, Evelyne ^b,d   Zakarian, Armen ^e   Servent, Denis ^d   Molgó, Jordi ^b,d   Taylor, Palmer ^c   Marchot, Pascale ^a,b  

^a AIX MARSEILLE UNIVERSITY   (France)

^b CNRS   (France)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SERVICE DE CHIMIE BIOORGANIQUE ET DE MARQUAGE   (France)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA BUNGAROTOXIN; BUNGAROTOXIN RECEPTOR; CYCLOHEXENE DERIVATIVE; EPIBATIDINE; IMINE; NEUROTOXIN; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA1 2 BETA GAMMA DELTA; PINNATOXIN A; PINNATOXIN G; UNCLASSIFIED DRUG; ACHBP PROTEIN, LYMNAEA; ALKALOID; ALPHA1BETA1GAMMADELTA RECEPTOR, HUMAN; CARRIER PROTEIN; MACROCYCLIC COMPOUND; MARINE TOXIN; NICOTINIC RECEPTOR ALPHA3BETA2; NICOTINIC RECEPTOR ALPHA4BETA2; PROTEIN BINDING; SPIRO COMPOUND;

ARTICLE; BINDING AFFINITY; COMPARATIVE STUDY; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROPHOBICITY; LIGAND BINDING; MAMMAL CELL; MARINE BIOLOGY; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; TOXIN STRUCTURE; VOLTAGE CLAMP TECHNIQUE; ANTAGONISTS AND INHIBITORS; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; METABOLISM; MOLECULAR MODEL; PATCH CLAMP TECHNIQUE; PROTEIN CONFORMATION;

ALGAE;

ALKALOIDS; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; CARRIER PROTEINS; CELL MEMBRANE; IMINES; KINETICS; MACROCYCLIC COMPOUNDS; MARINE TOXINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, NICOTINIC; SPIRO COMPOUNDS;

EID: 84930277833     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2015.04.009     Document Type: Article

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