Effect of Ganoderma lucidum spores intervention on glucose and lipid metabolism gene expression profiles in type 2 diabetic rats

Lipids in Health and Disease

Volumn 14, Issue 1, 2015, Pages

  Wang, Fang ^a   Zhou, Zhongkai ^a   Ren, Xiaochong ^a   Wang, Yuyang ^a   Yang, Rui ^a   Luo, Jinhua ^b   Strappe, Padraig ^c  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Chongqing Research Institute   (China)

^c CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Blood glucose; Ganoderma lucidum; Gene expression; Lipid composition; Type 2 diabetes

Indexed keywords

ACYL COENZYME A DESATURASE 1; ANTIDIABETIC AGENT; CHOLESTEROL; DIACYLGLYCEROL ACYLTRANSFERASE 1; FAS ANTIGEN; GANODERMA LUCIDUM SPORE POWDER; GLUCOSE; GLUTATHIONE PEROXIDASE; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INSULIN INDUCED GENE 1; INSULIN INDUCED GENE 2; PROTEIN ACC; PROTEIN ACLY; PROTEIN ACOX1; PROTEIN G6P1; PROTEIN GPAM; PROTEIN PEPCK; REACTIVE OXYGEN METABOLITE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCOGEN SYNTHESIS; INSULIN BLOOD LEVEL; LIPID METABOLISM; LIPOGENESIS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ANALYSIS; ANIMAL; BLOOD; CHINESE MEDICINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; FUNGUS SPORE; GANODERMA LUCIDUM; GENE EXPRESSION; GENETICS; METABOLISM; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALIA; GANODERMA LUCIDUM; RATTUS;

ANIMALS; BLOOD GLUCOSE; CHOLESTEROL; CHOLESTEROL, HDL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION; GLUCOSE; INSULIN; LIPID METABOLISM; MALE; MEDICINE, CHINESE TRADITIONAL; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REISHI; SPORES, FUNGAL; TRIGLYCERIDES;

EID: 84930212299     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/s12944-015-0045-y     Document Type: Article

References (41)

1. Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National estimates and General Information on Diabetes and Prediabetes in the United States, 2011. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2011. http://www.cdc.gov/diabetes/pubs/pdf/ndfs-2011.pdf. Accessed March 1, 2014.
2. Saydah SH, Fradkin J, Cowie CC. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA. 2004;291:335-42.
3. Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr. 2004;2:263-9.
4. Russell R, Paterson M. Ganoderma-A therapeutic fungal biofactory. Phytochemistry. 2006;67:1985-2001.
5. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009;10:717-42.
6. Zhang W, Tang YJ. A novel three-stage light irradiation strategy in the submerged fermentation of medicinal mushroom Ganoderma lucidum for the efficient production of ganoderic acid and Ganoderma polysaccharides. Biotechnol Prog. 2008;24:1249-61.
7. Liu J, Kurashiki K, Shimizu K, Kondo R. 5 alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. Biol Pharm Bull. 2006;29:392-5.
8. Liu J, Shiono J, Shimizu K, Kukita A, Kukita AT, Kondo R. Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorg Med Chem Lett. 2009;19:2154-7.
9. Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, et al. Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. Chem Biodivers. 2007;4:224-31.
10. Liu X, Yuan JP, Chung CK, Chen XJ. Antitumor activity of the sporoderm-broken germinating spores of Ganoderma lucidum. Cancer Lett. 2002;182:155-61.
11. Min BS, Gao JJ, Nakamura N, Hattori M. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem Pharm Bull. 2000;48:1026-33.
12. Xie YZ, Li SZ, Yee A, La Pierre DP, Deng ZQ, Lee DY. Ganoderma lucidum inhibits tumour cell proliferation and induces tumour cell death. Enzyme Microb Technol. 2006;40:177-85.
13. Huie CW, Di X. Chromatographic and electrophoretic methods for Lingzhi pharmacologically active components. J Chromatogr B. 2004;812:241-57.
14. Gao P, Hirano T, Chen Z, Yasuhara T, Nakata Y, Sugimoto A. Isolation and identification of C-19 fatty acids with anti-tumor activity from the spores of Ganoderma lucidum (reishi mushroom). Fitoterapia. 2012;83:490-9.
15. Zheng J, Yang B, Yu Y, Chen Q, Huang T, Li D. Ganoderma lucidum polysaccharides exert anti-hyperglycemic effect on streptozotocin-induced diabetic rats through affecting β-cells. Comb Chem High Throughput Screen. 2012;15:542-50.
16. Chevalier L, Bos C, Gryson C, Luengo C, Walrand S, Tomé D, et al. High-protein diets differentially modulate protein content and protein synthesis in visceral and peripheral tissues in rats. Nutrition. 2009;25:932-9.
17. Seto SW, Lam TY, Tam HL, Au AL, Chan SW, Wu JH, et al. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice. Phytomedicine. 2009;16:426-36.
18. Teng BS, Wang CD, Zhang D, Wu JS, Pan D, Pan LF, et al. Hypoglycemic effect and mechanism of a proteoglycan from Ganoderma lucidum on streptozotocin-induced type 2 diabetic rats. Eur Rev Med Pharmacol Sci. 2012;16(2):166-75.
19. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, et al. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015;2:CD007259.
20. Winther K, Mehlsen J, Rein E, Hansen A, Goino T. A combination of Japanese ginseng, Ganoderma lucidum and trametes versicolor, referred to as the GOINO PROCEDURE, can lower blood glucose and LDL-cholesterol in patients with NIDDM. Atherosclerosis Suppl. 2003;4:339.
21. Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005;15:316-28.
22. Victor VM. Mitochondrial Oxidative Stress in Diabetes. In: Preedy VR, editor. Diabetes: Oxidative Stress and Dietary Antioxidants. Chapter 5. London: Academic; 2014. p. 41-9.
23. Hafizur RM, Babiker R, Yagi S, Chishti S, Kabir N, Choudhary MI. The antidiabetic effect of Geigeria alata is mediated by enhanced insulin secretion, modulation of β-cell function and improvement of antioxidant activity in treptozotocin-induced diabetic rats. J Endocrinol. 2012;214:329-35.
24. Hikino H, Konno C, Mirin Y, Hayashi T. Isolation and hypoglycemic activity of Ganoderans A and B, glycans of Ganoderma lucidum fruit bodies. Planta Med. 1985;51:339-40.
25. Hikino H, Ishiyama M, Suzuki Y, Konno C. Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies. Planta Med. 1989;55:423-8.
26. Jung KH, Ha E, Kim MJ, Uhm YK, Kim HK, Hong SJ, et al. Ganoderma lucidum extract stimulates glucose uptake in L6 rat skeletal muscle cells. Acta Biochim Pol. 2006;53:597-601.
27. Ni T, Hu Y, Sun L, Chen X, Zhong J, Ma H, et al. Oral route of mini-proinsulin-expressing Ganoderma lucidum decreases blood glucose level in streptozocin-induced diabetic rats. Int J Mol Med. 2007;20:45-51.
28. Krapivner S, Chernogubova E, Ericsson M, Ahlbeck-Glader C, Hamsten A, van't Hooft FM. Human evidence for the involvement of insulin-induced gene 1 in the regulation of plasma glucose concentration. Diabetologia. 2007;50:94-102.
29. Goldstein JL, DeBose-Boyd RA, Brown MS. Protein sensors for membrane sterols. Cell. 2006;124:35-46.
30. Xie YH, Mo ZH, Chen K, Yang YB, Xing XW, Liao EY. Effect of different glucose concentrations on the expressions of insig-1 and insig-2 mRNA during the differentiation of 3T3-L1 cells. J Central South Uni [Article in Chinese]. 2008;33:238-44.
31. Chen K, Jin P, He HH, Xie YH, Xie XY, Mo ZH. Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c. J Biomed Sci. 2011;18:57.
32. Espenshade PJ, Hughes AL. Regulation of sterol synthesis in eukaryotes. Annu Rev Genet. 2007;41:401-27.
33. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, et al. A common genetic variant is associated with adult and childhood obesity. Science. 2006;312:279-83.
34. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002;109:1125-31.
35. Jain SK, Rains JL, Croad JL. Effect of chromium niacinate and chromium picolinate supplementation on lipid peroxidation, TNF-alpha, IL-6, CRP, glycated hemoglobin, triglycerides and cholesterol levels in blood of streptozotocin-treated diabetic rats. Free Radic Biol Med. 2007;43:1124-31.
36. Yang DW, Jia RH, Yang DP, Ding GH, Huang CX. Dietary hypercholesterolemia aggravates contrast media-induced nephropathy. Chin Med J (Engl). 2004;117:542-6.
37. Lemhadri A, Hajji L, Michel JB, Eddouks M. Cholesterol and triglycerides lowering activities of caraway fruits in normal and streptozotocin diabetic rats. J Ethnopharmacol. 2006;106:321-6.
38. Sharma SB, Nasir A, Prabhu KM, Murthy PS, DevG. Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol. 2003;85:201-6.
39. Hiltunen JK, Qin Y. Beta-oxidation-strategies for the metabolism of a wide variety of acyl-CoA esters. Biochim Biophys Acta. 2000;1484:117-28.
40. Kenneth J, Thomas D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-44CT method. Methods. 2001;25:402-8.
41. Michael W. A new mathematical model for relative quantification in real-time RT-PCR. Nucl Acid Res. 2001;29:2002-7.