Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2154-2157

  Liu, Jie ^a   Shiono, Jun ^a   Shimizu, Kuniyoshi ^a   Kukita, Akiko ^b   Kukita, Toshio ^a   Kondo, Ryuichiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Androgen receptor; Anti androgen activities; Ganoderic acid DM; Ganoderma lucidum; Osteoclast; Prostate cancer

Indexed keywords

ALCOHOL; ANDROGEN RECEPTOR; ANTIANDROGEN; GANODERIC ACID DM; GANODERMA LUCIDUM EXTRACT; OSTEOPROTEGERIN; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BONE METASTASIS; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; NONHUMAN; PROSTATE CANCER;

ANDROGEN ANTAGONISTS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; GROWTH INHIBITORS; HUMANS; MALE; MICE; OSTEOCLASTS; RATS; REISHI; TRITERPENES;

GANODERMA LUCIDUM;

EID: 63149183342     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.119     Document Type: Article

References (30)

1. Jemal A., Tiwari R.C., Murray T., Ghafoor A., Samuels A., Ward E., Feuer E.J., and Thun M.J. J. Clin. 54 (2004) 8
2. Niu Y.J., Ma T.X., Zhang J., Xu Y., Han R.F., and Sun G. Asin. J. Androl. 51 (2003) 19
3. DePrimo S.E., Diehn M., Nelson J.B., Reiter R.E., Matese J., Fero M., Tibshirani R., Brown P.O., and Brooks J.D. Genome Biol. 3 (2002) Research00321
4. Gelmann E.P. J. Clin. Oncol. 20 (2002) 3001
5. Denmeade S.R., Lin X.S., and Isaacs J.T. Prostate 28 (1996) 251
6. Hofbauer L.C., and Schoppet M. JAMA 292 (2004) 490
7. Roodman G.D. N. Engl. J. Med. 64 (2004) 9209
8. Capodice J.L., and Katz A.E. World J. Urol. 24 (2006) 378
9. Denis L., Morton M.S., and Griffiths K. Eur. Urol. 35 (1999) 377
10. McCann M.J., Gill G.I., McGlynn H., and Rowland I.R. Nutr. Cancer 52 (2005) 1
11. Liu, J.; Tamura, S.; Kurashiki, K.; Shimizu, K.; Noda, K.; Konishi, F.; Kumamoto, S.; Kondo, R. Chem. biodivers., in press.
12. Shimizu, K.; Miyamoto, I.; Liu, J.; Konishi, F.; Kumamoto, S.; Kondo, R. J. Wood. Sci., in press.
13. Fujita R., Liu J., Shimizu K., Konishi F., Noda K., Kumamoto S., Ueda C., Tajili H., Kaneko S., Suimi Y., and Kondo R. J. Ethnopharmacol. 102 (2005) 107
14. Shiao M.S. Chem. Rec. 3 (2003) 172
15. Liu J., Kurashiki K., Shimizu K., and Kondo R. Biol. Pharm. Bull. 29 (2006) 392
16. Zeelin F.J. Adv. Drug Res. 22 (1992) 149
17. Metcalf B.W., Levy M.A., and Holt D.A. Trends Pharmacol. Sci. 10 (1989) 491
18. McDonald I.A., Nyce P.L., Muench D.M., Gates C.A., Blohm T.R., Laughlin M.E., and Werntraub P.M. Bioorg. Med. Chem. Lett. 4 (1994) 847
19. Horoszewicz J.S., Leong S.S., Kawinski E., Karr J.P., Rosenthal H., Chu T.M., Mirand E.A., and Murphy G.P. Cancer Res. 43 (1983) 1809
20. Negri-Cesi P., and Motta M. Biochem. Mol. Biol. 51 (1994) 89
21. Kaighn M.E., Narayan S., Ohnuki Y., Lechner J.F., and Jones L.W. Invest. Urol. 17 (1979) 16
22. Liu J., Shimizu K., Konishi F., Kumamoto S., and Kondo. R. Bioorg. Med. Chem. 15 (2007) 4966
23. Eilon G., and Mundy G.R. Nature 276 (1978) 726
24. Kong Y.Y., Boyle W.J., and Penninger J.M. Immunol. Today 21 (2000) 495
25. Lee S.K., and Lorenzo J.A. Endocrinology 140 (1999) 3552
26. Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M.T., and Martin T.J. Endocrinol. Rev. 20 (1999) 345
27. Wang F., Cai H., Yang J.S., Zhang Y.M., Hou C.Y., Liu J.Q., and Zhao M.J. Yaoxue Xuebao 32 (1997) 447
28. 14C] DHT.
29. 22 Androgen receptor ligand-binding domain (25 nM, 20 μl) was incubated with each concentration of ganoderic acid DM or DHT for 4 h. The polarization was then measured on a beacon 2000 fluorescence polarization instrument using 485 nm excitation and 535 nm emission interference filters in polarization mode.
30. Watanabe T., Kukita T., Kukita A., Wada N., Toh K., Nagata K., Nomiyama H., and Iijima T.J. Endocrinology 180 (2004) 193