Ganoderma lucidum polysaccharides exert anti-hyperglycemic effect on streptozotocin-induced diabetic rats through affecting β-cells

Combinatorial Chemistry and High Throughput Screening

Volumn 15, Issue 7, 2012, Pages 542-550

  Zheng, Jusheng ^a   Yang, Bin ^a   Yu, Yinghua ^a,b   Chen, Qi ^a   Huang, Tao ^a   Li, Duo ^a,c  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c APCNS Centre of Nutrition and Food Safety   (China)

Author keywords

Anti hyperglycemic effect; Apoptosis; Bax; Bcl 2; Casp 3; Catalase; Diabetes; Ganoderma lucidum; Glutathione peroxidase; Inos; Metformin; Mrna expression; Pancreatic cells; PDX 1; Polysaccharides; Streptozotocin; Superoxide dismutase

Indexed keywords

ACYLGLYCEROL; CASPASE 3; CATALASE; CHOLESTEROL; GANODERMA LUCIDUM EXTRACT; GANODERMA LUCIDUM POLYSACCHARIDE; GLUCOSE; GLUTATHIONE PEROXIDASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; METFORMIN; NITRIC OXIDE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR PDX 1; TRIACYLGLYCERIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CELL PROTECTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG EFFICACY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN WEIGHT; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES; UPREGULATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIGH-THROUGHPUT SCREENING ASSAYS; HYPOGLYCEMIC AGENTS; INSULIN-SECRETING CELLS; MALE; POLYSACCHARIDES; RATS; RATS, SPRAGUE-DAWLEY; REISHI; STREPTOZOCIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84865394400     PISSN: 13862073     EISSN: 18755402     Source Type: Journal    
DOI: 10.2174/138620712801619168     Document Type: Article

References (40)

1. Wild, S.; Roglic, G.; Green, A.; Sicree, R.; King, H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care, 2004, 27, 1047-1053. (Pubitemid 38579764)
2. O'Brien, J.A.; Patrick, A.R.; Caro, J.J. Cost of managing complications resulting from type 2 diabetes mellitus in Canada. BMC Health Serv. Res., 2003, 3, 7.
3. Nissen, S.E.; Wolski, K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N. Engl. J. Med., 2007, 356, 2457-2471. (Pubitemid 46919772)
4. Hu, X.; Sato, J.; Oshida, Y.; Xu, M.; Bajotto, G.; Sato, Y. Effect of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on insulin resistance in streptozotocin-induced diabetic rats. Diabetes Res. Clin. Pr., 2003, 59, 103-111. (Pubitemid 36135828)
5. Li, W.L.; Zheng, H.C.; Bukuru, J.; De Kimpe, N. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. J. Ethnopharmacol., 2004, 92, 1-21. (Pubitemid 38510258)
6. Grover, J.K.; Yadav, S.; Vats, V. Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol., 2002, 81, 81-100. (Pubitemid 34518472)
7. Cao, Q.Z.; Lin, Z.B. Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta Pharmacol. Sin., 2004, 25, 833-838.
8. You, Y.H.; Lin, Z.B. Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species. Acta Pharmacol. Sin., 2002, 23, 787-791.
9. Zhang, H.N.; Lin, Z.B. Hypoglycemic effect of Ganoderma lucidum polysaccharides. Acta Pharmacol. Sin., 2004, 25, 191-195.
10. Hikino, H.; Ishiyama, M.; Suzuki, Y.; Konno, C. Mechanisms of hypoglycemic activity of ganoderan B: a glycan of Ganoderma lucidum fruit bodies. Planta Med., 1989, 55, 423-428. (Pubitemid 19249810)
11. Hikino, H.; Konno, C.; Mirin, Y.; Hayashi, T. Isolation and hypoglycemic activity of ganoderans A and B, glycans of Ganoderma lucidum fruit bodies. Planta Med., 1985, 4, 339-340.
12. Nukatsuka, M.; Yoshimura, Y.; Nishida, M.; Kawada, J. Importance of the concentration of ATP in rat pancreatic beta cells in the mechanism of streptozotocin-induced cytotoxicity. J. Endocrinol., 1990, 127, 161-165. (Pubitemid 20306001)
13. Elsner, M.; Guldbakke, B.; Tiedge, M.; Munday, R.; Lenzen, S. Relative importance of transport and alkylation for pancreatic betacell toxicity of streptozotocin. Diabetologia, 2000, 43, 1528-1533. (Pubitemid 32734859)
14. Kwon, N.S.; Lee, S.H.; Choi, C.S.; Kho, T.; Lee, H.S. Nitric oxide generation from streptozotocin. FASEB J., 1994, 8, 529-533. (Pubitemid 24161126)
15. Gandy, S.E.; Buse, M.G.; Crouch, R.K. Protective role of superoxide dismutase against diabetogenic drugs. J. Clin. Invest., 1982, 70, 650-658. (Pubitemid 12054591)
16. Niedowicz, D.M.; Daleke, D.L. The role of oxidative stress in diabetic complications. Cell Biochem. Biophys., 2005, 43, 289-330. (Pubitemid 41095268)
17. Liu, W.; Wang, H.; Pang, X.; Yao, W.; Gao, X. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. Int. J. Bio. Macromol., 2010, 46, 451-457.
18. Tieking, M.; Kaditzky, S.; Valcheva, R.; Korakli, M.; Vogel, R.F.; Ganzle, M.G. Extracellular homopolysaccharides and oligosaccharides from intestinal lactobacilli. J. Appl. Microbiol., 2005, 99, 692-702. (Pubitemid 41215847)
19. Shimada., K.; Fujikawa., K.; Yahara., K.; Nakamurat, T. Antioxidative properties of xanthone on the auto oxidation of soybean in cylcodextrin emulsion. J. Agr. Food Chem., 1992, 40, 945-948.
20. Oyaizu, M. Studies on products of browning reactions: antioxidative activities of products of browning reaction prepared from glucosamine. Jpn. J. Nutr., 1986, 44, 307-315.
21. Lenzen, S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia, 2008, 51, 216-226.
22. Cheng, J.T.; Huang, C.C.; Liu, I.M.; Tzeng, T.F.; Chang, C.J. Novel mechanism for plasma glucose-lowering action of metformin in streptozotocin-induced diabetic rats. Diabetes, 2006, 55, 819-825.
23. Sheena, N.; Ajith, T.A.; Janardhanan, K.K. Prevention of nephrotoxicity induced by the anticancer drug cisplatin, using Ganoderma lucidum, a medicinal mushroom occurring in South India. Curr. Sci. India, 2003, 85, 478-482. (Pubitemid 39160498)
24. Green, L.C.; Wagner, D.A.; Glogowski, J.; Skipper, P.L.; Wishnok, J.S.; Tannenbaum, S.R. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem., 1982, 126, 131-138. (Pubitemid 13203451)
25. Bradford, M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding. Anal. Biochem., 1976, 72, 248-254.
26. Uthus, E.O.; Brown-Borg, H.M. Methionine flux to trans sulfuration is enhanced in the long living Ames dwarf mouse. Mech. Ageing Dev., 2006, 127, 444-450.
27. Turk, J.; Corbett, J.A.; Ramanadham, S.; Bohrer, A.; McDaniel, M.L. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. Biochem. Bioph. Res. Co., 1993, 197, 1458-1464. (Pubitemid 24042786)
28. Yang, Q.; Wang, S.; Xie, Y.; Sun, J.; Wang, J. HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression. Int. J. Bio. Macromol., 2010, 46, 167-172.
29. Agarwal, S.; Sohal, R.S. Relationship between aging and susceptibility to protein oxidative damage. Biochem. Bioph. Res. Co., 1993, 194, 1203-1206. (Pubitemid 23255008)
30. Anderson, D. Antioxidant defences against reactive oxygen species causing genetic and other damage. Mutat Res., 1996, 350, 103-108. (Pubitemid 26072403)
31. Lenzen, S. Oxidative stress: the vulnerable beta-cell. Biochem. Soc. Trans., 2008, 36, 343-347.
32. Shi, Y.C.; Pan, T.M. Antioxidant and pancreas-protective effect of red mold fermented products on streptozotocin-induced diabetic rats. J. Sci. Food Agric., 2010, 90, 2519-2525.
33. Jia, J.; Zhang, X.; Hu, Y.S.; Wu, Y.; Wang, Q.Z.; Li, N.N.; Guo, Q.C.; Dong, X.C. Evaluation of in vivo antioxidant activities of Ganoderma lucidum polysaccharides in STZ-diabetic rats. Food Chemistry, 2009, 115, 32-36.
34. Seto, S.W.; Lam, T.Y.; Tam, H.L.; Au, A.L.; Chan, S.W.; Wu, J.H.; Yu, P.H.; Leung, G.P.; Ngai, S.M.; Yeung, J.H.; Leung, P.S.; Lee, S.M.; Kwan, Y.W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice. Phytomedicine, 2009, 16, 426-436.
35. Majewski, N.; Nogueira, V.; Bhaskar, P.; Coy, P.E.; Skeen, J.E.; Gottlob, K.; Chandel, N.S.; Thompson, C.B.; Robey, R.B.; Hay, N. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol. Cell, 2004, 16, 819-830. (Pubitemid 39586539)
36. Qi, S.; Wang, S.; Zhao, X.; Sui, H.; Luan, H. Mechanisms of protective effect of Ganoderma lucidum spores on pancreas in type 2 diabetic rats. Chin Trad Pat Med, 2009, 31, 476-478.
37. Oliver-Krasinski, J.M.; Kasner, M.T.; Yang, J.; Crutchlow, M.F.; Rustgi, A.K.; Kaestner, K.H.; Stoffers, D.A. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J. Clin. Invest., 2009, 119, 1888-1898.
38. Wachtel-Galor, S.; Tomlinson, B.; Benzie, I.F. Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br. J. Nutr., 2004, 91, 263-269. (Pubitemid 38263543)
39. Gao, Y.; Lan, J.; Dai, X.; Ye, J.; Zhou, S. A phase I/II study of Ling Zhi mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) extract in patients with type II diabetes mellitus. Int. J. Med. Mushrooms, 2004, 66, 33-39.
40. Hundal, R.S.; Inzucchi, S.E. Metformin: new understandings, new uses. Drugs, 2003, 63, 1879-1894 (Pubitemid 37108399)