N-methyl-d-aspartate receptor mRNA levels change during reproductive senescence in the hippocampus of female rats

Experimental Neurology

Volumn 170, Issue 1, 2001, Pages 171-179

  Adams, Michelle M ^a   Morrison, John H ^a   Gore, Andrea C ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Estrogen; Estrous cycle; Gene expression; NMDA

Indexed keywords

ESTROGEN; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; DENDRITIC SPINE; ESTRUS CYCLE; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTION; RIBONUCLEASE PROTECTION ASSAY; SENESCENCE; SYNAPSE;

EID: 0034948350     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2001.7687     Document Type: Article

References (58)

1. Different modes of hippocampal plasticity in response to estrogen in young and aged female rats
2. Hippocampal dependent learning ability correlates with N-methyl-D-aspartate (NMDA) receptor levels in CA3 neurons of young and aged rats
3. r-mediated excitatory postsynaptic potential in hippocampal region CA1
4. Spatial learning and memory at defined points of the estrous cycle: Effects on performance of a hippocampal-dependent task
5. Estradiol replacement to female rats facilitates dorsal hippocampal but not ventral hippocampal kindled seizure acquisition
6. In vitro autoradiography of hippocampal excitatory amino acid binding in aged Fischer 344 rats: Relationship to performance on Morris water maze
7. Estrogen facilitates induction of long term potentiation in the hippocampus of awake rats
8. Regional and selective effects of oestradiol and progesterone on NMDA and AMPA receptors in the rat brain
9. 17 β-estradiol enhances NMDA receptor-mediated EPSPs and long-term potentiation
10. Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys
11. Differential regulation of NMDAR1 mRNA and protein by estradiol in the rat hippocampus
12. Cyclical changes in endogenous levels of oestrogen modulate the induction of LTD and LTP in the hippocampal CA1 region
13. Regulation of gonadotropin-releasing hormone gene expression by the excitatory amino acids kainic acid and N-methyl-D,L-aspartate in the male rat
14. Gonadotropin-releasing hormone and NMDA receptor gene expression and colocalization change during puberty in female rats
15. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood
16. Cloned glutamate receptors
17. Multiplex solution hybridization-ribonuclease protection assay for quantification of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals
18. Inhibin subunit gene expression and distribution in the ovaries of immature, young adult, middle-aged, and old female rats
19. Glutamate receptor binding in the human hippocampus and adjacent cortex during development and aging
20. Ionotropic glutamate receptor subtypes in the aged memory-impaired and unimpaired long-evans rat
21. Distribution of estrogen receptor-β-like immunoreactivity in rat forebrain
22. Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging female rats displaying different reporductive states
23. Declines in mRNA expression of different subunits may account for differential effects of aging on agonist and antagonist binding to the NMDA receptor
24. Age-related changes in excitatory amino acid receptors in two mouse strains
25. Granule cells in aging rats are sexually dimorphic in their response to estradiol
26. Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
27. Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones
28. In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged long-evans rats: Relationship to spatial learning
29. Intra-hippocampal estradiol infusion enhances memory in ovariectomized rats
30. Putative estrogen receptor β and α mRNA expression in male and female rhesus macaques
31. 2, a functional variant of estrogen receptor β expressed in normal rat tissues
32. 2+ transients in spines of CA1 pyramidal neurons from hippocampal slices
33. Expression of estrogen receptor α and β transcripts in female monkey hippocampus and hypothalamus
34. A reduced proportion of luteinizing hormone (LH)-releasing hormone neurons express fos protein during the preovulatory or steroid-induced LH surge in middle-aged rats
35. Aging differentially alters form of long-term potentiation in rat hippocampal area CA1
36. Estrogen effects on cognition in menopausal women
37. N-Methyl-D-aspartate receptor binding in brains of rats at different ages
38. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system
39. Evidence for novel estrogen binding sites in the rat hippocampus
40. Evidence for the colocalization of estrogen receptor-β mRNA and estrogen receptor-α immunoreactivity in neurons of the rat forebrain
41. Stability of spatial working memory across the estrous cycle of Long-Evans rats
42. Effects of age on hormone levels and in vitro steroidogenesis by rat ovary and adrenal
43. NMDA receptors: From genes to channels
44. Age-related decreases of the N-methyl-D-apartate receptor complex in the rat cerebral cortex and hippocampus
45. Genetic enhancement of learning and memory in mice
46. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
47. LTP varies across the estrous cycle: Enhanced synaptic plasticity in proestrous rats
48. Spatial and nonspatial learning across the rat estrous cycle
49. Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus
50. Distribution and hormone regulation of estrogen receptor immunoreactive cells in the hippocampus of male and female rats
51. Loss of NMDA, but not GABA-A, binding in the brains of aged rats and monkeys
52. Estrogen and NMDA receptor antagonism: Effects upon reference and working memory
53. Estradiol mediates fluctuations in hippocampal synapse density during the estrous cycle in the adult rat
54. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat
55. Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism
56. Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat
57. Naturally occurring fluctuations in dendritic spine density on adult hippocampal pyramidal neurons