Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

Oncotarget

Volumn 6, Issue 14, 2015, Pages 12505-12519

  Suijker, Johnny ^a   Oosting, Jan ^a   Koornneef, Annemarie ^a   Struys, Eduard A ^b   Salomons, Gajja S ^b   Schaap, Frank G ^a   Waaijer, Cathelijn J F ^a   Wijers Koster, Pauline M ^a   Briaire de Bruijn, Inge H ^a   Haazen, Lizette ^c   Riester, Scott M ^d   Dudakovic, Amel ^d   Danen, Erik ^c   Cleton Jansen, Anne Marie ^a   van Wijnen, Andre J ^d   Bovée, Judith V M G ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY   (Netherlands)

^d MAYO CLINIC   (United States)

Author keywords

AGI 5198; Chondrosarcoma; D 2 hydroxyglutarate; Isocitrate dehydrogenase; Sarcoma

Indexed keywords

2 HYDROXYGLUTARIC ACID; AGI 5198; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG; ALPHA-HYDROXYGLUTARATE; GLUTARIC ACID DERIVATIVE; IDH1 PROTEIN, HUMAN; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CHONDROSARCOMA; CONTROLLED STUDY; CPG ISLAND; ENCHONDROMA; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; HISTONE METHYLATION; METASTASIS; TUMOR GROWTH; BONE TUMOR; DNA MUTATIONAL ANALYSIS; GENETICS; HUMAN; LIQUID CHROMATOGRAPHY; METABOLISM; MUTATION; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE; WESTERN BLOTTING;

BLOTTING, WESTERN; BONE NEOPLASMS; CELL LINE, TUMOR; CHONDROSARCOMA; CHROMATOGRAPHY, LIQUID; DNA MUTATIONAL ANALYSIS; GLUTARATES; HUMANS; ISOCITRATE DEHYDROGENASE; MUTATION; REAL-TIME POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY;

EID: 84930023859     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3723     Document Type: Article

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