Insight into the function of DIO2, a susceptibility gene in human osteoarthritis, as an inducer of cartilage damage in a rat model: Is there a role for chondrocyte hypertrophy?

Osteoarthritis and Cartilage

Volumn 21, Issue 5, 2013, Pages 643-645

  Goldring, M B ^a,b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; CARTILAGE INJURY; CELL DIFFERENTIATION; CHONDROCYTE HYPERTROPHY; DEIODINASE IODOTHYRONINE TYPE 2 GENE; DEIODINASE IODOTHYRONINE TYPE GENE; DEIODINASE TYPE 2 PROTEIN GENE; DNA POLYMORPHISM; EDITORIAL; GENE; GENE EXPRESSION; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GROWTH DIFFERENTIATION FACTOR 5 GENE; HUMAN; HYPERTROPHY; MICROARRAY ANALYSIS; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMAD FAMILY MEMBER 3 GENE;

ANIMALS; CARTILAGE, ARTICULAR; CHONDROCYTES; HUMANS; IODIDE PEROXIDASE; OSTEOARTHRITIS, KNEE;

EID: 84875895095     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.02.659     Document Type: Editorial

References (27)

1. Valdes A.M., Spector T.D. The clinical relevance of genetic susceptibility to osteoarthritis. Best Pract Res Clin Rheumatol 2010, 24:3-14.
2. Chapman K., Takahashi A., Meulenbelt I., Watson C., Rodriguez-Lopez J., Egli R., et al. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet 2008, 17:1497-1504.
3. Evangelou E., Chapman K., Meulenbelt I., Karassa F.B., Loughlin J., Carr A., et al. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum 2009, 60:1710-1721.
4. Valdes A.M., Spector T.D., Tamm A., Kisand K., Doherty S.A., Dennison E.M., et al. Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis. Arthritis Rheum 2010, 62:2347-2352.
5. Meulenbelt I., Min J.L., Bos S., Riyazi N., Houwing-Duistermaat J.J., van der Wijk H.J., et al. Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis. Hum Mol Genet 2008, 17:1867-1875.
6. Meulenbelt I., Bos S.D., Chapman K., van der Breggen R., Houwing-Duistermaat J.J., Kremer D., et al. Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility. Ann Rheum Dis 2011, 70:164-167.
7. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012, 380:815-823.
8. Day-Williams A.G., Southam L., Panoutsopoulou K., Rayner N.W., Esko T., Estrada K., et al. A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet 2011, 89:446-450.
9. Panoutsopoulou K., Southam L., Elliott K.S., Wrayner N., Zhai G., Beazley C., et al. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis 2011, 70:864-867.
10. Kerkhof H.J., Lories R.J., Meulenbelt I., Jonsdottir I., Valdes A.M., Arp P., et al. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum 2010, 62:499-510.
11. Castano Betancourt M.C., Cailotto F., Kerkhof H.J., Cornelis F.M., Doherty S.A., Hart D.J., et al. Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. Proc Natl Acad Sci USA 2012, 109:8218-8223.
12. Bos S.D., Slagboom P.E., Meulenbelt I. New insights into osteoarthritis: early developmental features of an ageing-related disease. Curr Opin Rheumatol 2008, 20:553-559.
13. Nagase H., Nagasawa Y., Tachida Y., Sakakibara S., Okutsu J., Suematsu N., et al. Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats. Osteoarthritis Cartilage 2013, 21:514-523.
14. Wang L., Shao Y.Y., Ballock R.T. Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling. J Bone Miner Res 2010, 25:1138-1146.
15. Adams S.L., Cohen A.J., Lassova L. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. J Cell Physiol 2007, 213:635-641.
16. van der Kraan P.M., van den Berg W.B. Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?. Osteoarthritis Cartilage 2012, 20:223-232.
17. Bos S.D., Bovee J.V., Duijnisveld B.J., Raine E.V., van Dalen W.J., Ramos Y.F., et al. Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Ann Rheum Dis 2012, 71:1254-1258.
18. Karlsson C., Dehne T., Lindahl A., Brittberg M., Pruss A., Sittinger M., et al. Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 2010, 18:581-592.
19. Waarsing J.H., Kloppenburg M., Slagboom P.E., Kroon H.M., Houwing-Duistermaat J.J., Weinans H., et al. Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis. Arthritis Rheum 2011, 63:1349-1354.
20. Dentice M., Bandyopadhyay A., Gereben B., Callebaut I., Christoffolete M.A., Kim B.W., et al. The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate. Nat Cell Biol 2005, 7:698-705.
21. Alini M., Kofsky Y., Wu W., Pidoux I., Poole A.R. In serum-free culture thyroid hormones can induce full expression of chondrocyte hypertrophy leading to matrix calcification. J Bone Miner Res 1996, 11:105-113.
22. Ballock R.T., Reddi A.H. Thyroxine is the serum factor that regulates morphogenesis of columnar cartilage from isolated chondrocytes in chemically defined medium. J Cell Biol 1994, 126:1311-1318.
23. Wang L., Shao Y.Y., Ballock R.T. Thyroid hormone interacts with the Wnt/beta-catenin signaling pathway in the terminal differentiation of growth plate chondrocytes. J Bone Miner Res 2007, 22:1988-1995.
24. Zeold A., Doleschall M., Haffner M.C., Capelo L.P., Menyhert J., Liposits Z., et al. Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene. Endocrinology 2006, 147:4419-4429.
25. Cheng A.W., Bolognesi M., Kraus V.B. DIO2 modifies inflammatory responses in chondrocytes. Osteoarthritis Cartilage 2012, 20:440-445.
26. Aigner T., Fundel K., Saas J., Gebhard P.M., Haag J., Weiss T., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 2006, 54:3533-3544.
27. Ijiri K., Zerbini L.F., Peng H., Otu H.H., Tsuchimochi K., Otero M., et al. Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum 2008, 58:2075-2087.