Effect of amlodipine, lisinopril and allopurinol on acetaminophen-induced hepatotoxicity in rats

Saudi Pharmaceutical Journal

Volumn 24, Issue 6, 2016, Pages 635-644

  Mohammed, Nesreen E M ^a   Messiha, Basim A S ^b   Abo Saif, Ali A ^a  

^a Nahda University Beni Suef   (Egypt)

^b Beni Suef University   (Egypt)

Author keywords

Acetaminophen; Allopurinol; Amlodipine; Hepatotoxicity; Lisinopril; Rat

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALLOPURINOL; AMLODIPINE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CALCIUM CHANNEL; CATALASE; DIPEPTIDYL CARBOXYPEPTIDASE; GLUTATHIONE; LISINOPRIL; MALONALDEHYDE; MYELOPEROXIDASE; NITRATE; NITRITE; PARACETAMOL; THIOBARBITURIC ACID REACTIVE SUBSTANCE; XANTHINE OXIDASE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG EFFECT; HISTOPATHOLOGY; LIVER CELL; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; RAT;

EID: 84930014798     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsps.2015.04.004     Document Type: Article

References (73)

1. 4. J. Pharmacol. Toxicol. 2 (2007), 610–620.
2. Abla, L.E., Gomes, H.C., Percario, S., Ferreira, L.M., Acetylcysteine in random skin flap in rats. Acta Cir. Bras. 20 (2005), 121–123.
3. Agha, A.M., Mansour, M., Effects of captopril on interleukin-6, leukotriene b and oxidative stress markers in serum and inflammatory exudate of arthritic rats: evidence of anti-inflammatory activity. Toxicol. Appl. Pharmacol. 168 (2000), 123–130.
4. Akbulut, S., Elbe, H., Eris, C., Dogan, Z., Toprak, G., Yalcin, E., Turkoz, Y., Effects of antioxidant agents against CsA-induced hepatotoxicity. J. Surg. Res. 193 (2015), 658–666.
5. Al Maruf, A., Wan, L., O'Brien, P.J., Evaluation of azathioprine-induced cytotoxicity in an in vitro rat hepatocyte system. Biomed. Res. Int., 2014, 2014, 379748.
6. Albarwani, S., Al-Siyabi, S., Al-Husseini, I., Al-Ismail, A., Al-Lawati, I., Al-Bahrani, I., Tanira, M.O., Lisinopril alters contribution of nitric oxide and K(Ca) channels to vasodilatation in small mesenteric arteries of spontaneously hypertensive rats. Physiol. Res. 64:1 (2015), 39–49.
7. Aldaba-Muruato, L.R., Moreno, M.G., Shibayama, M., Tsutsumi, V., Muriel, P., Allopurinol reverses liver damage induced by chronic carbon tetrachloride treatment by decreasing oxidative stress, TGF-β production and NF-κB nuclear translocation. Pharmacology 92 (2013), 138–149.
8. Alipour, M., Buonocore, C., Omri, A., Szabo, M., Pucaj, K., Suntres, Z.E., Therapeutic effect of liposomal-N-acetylcysteine against acetaminophen-induced hepatotoxicity. J. Drug Target. 21 (2013), 466–473.
9. Amacher, D.E., Schomaker, S.J., Aubrecht, J., Development of blood biomarkers for drug-induced liver injury: an evaluation of their potential for risk assessment and diagnostics. Mol. Diagn. Ther. 17 (2013), 343–354.
10. Ansari, M.A., Hussain, S.K., Mudagal, M.P., Goli, D., Neuroprotective effect of allopurinol and nimesulide against cerebral ischemic reperfusion injury in diabetic rats. Eur. Rev. Med. Pharmacol. Sci. 17 (2013), 170–178.
11. Banchroft, G.D., Steven, A., Theory and practice of histological technique. fourth ed., 1983, Churchil Livingstone Publications, London.
12. 2+-permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology. Biochim. Biophys. Acta 1783 (2008), 651–672.
13. Bateman, D.N., Dear, J.W., Thanacoody, H.K., Thomas, S.H., Eddleston, M., Sandilands, E.A., Coyle, J., Cooper, J.G., Rodriguez, A., Butcher, I., Lewis, S.C., Vliegenthart, A.D., Veiraiah, A., Webb, D.J., Gray, A., Reduction of adverse effects from intravenous acetylcysteine treatment for paracetamol poisoning: a randomised controlled trial. Lancet 383 (2014), 697–704.
14. Begum, S., Akhter, N., Cardioprotective effect of amlodipine in oxidative stress induced by experimental myocardial infarction in rats. Bangladesh J. Pharmacol. 2 (2007), 55–60.
15. Berkels, R., Breitenbach, T., Bartels, H., Taubert, D., Rosenkranz, A., Klaus, W., Roesen, R., Different antioxidative potencies of dihydropyridine calcium channel modulators in various models. Vascul. Pharmacol. 42 (2005), 145–152.
16. 1 receptor antagonist on D-galactosamine-induced acute liver injury. Clin. Exp. Pharmacol. Physiol. 34 (2007), 985–991.
17. Chandrasekaran, V.R., Hsu, D.Z., Liu, M.Y., The protective effect of sesamol against mitochondrial oxidative stress and hepatic injury in acetaminophen-overdosed rats. Shock 32 (2009), 89–93.
18. Claiborne, A., Catalase activity. Greenwald, R.A., (eds.) Handbook of Methods for Oxygen Radical Research, 1985, CRC Press, Boca Raton, 283–284.
19. Coen, M., Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity. Drug Metab. Rev. 23 (2014), 1–16.
20. Corcoran, G.B., Wong, B.K., Neese, B.L., Early sustained rise in total liver calcium during acetaminophen hepatotoxicity in mice. Res. Commun. Chem. Pathol. Pharmacol. 58 (1987), 291–305.
21. Demirel, U., Yalniz, M., Aygün, C., Orhan, C., Tuzcu, M., Sahin, K., Ozercan, I.H., Bahçecioğlu, I.H., Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats. Inflammation 35 (2012), 1549–1557.
22. Eesha, B.R., Mohanbabu Amberkar, V., Meena Kumari, K., Sarath, B., Vijay, M., Lalit, M., Rajput, R., Hepatoprotective activity of Terminalia paniculata against paracetamol induced hepatocellular damage in Wistar albino rats. Asian Pac. J. Trop. Med. 4 (2011), 466–469.
23. Gardner, C.R., Laskin, J.D., Dambach, D.M., Sacco, M., Durham, S.K., Bruno, M.K., Cohen, S.D., Gordon, M.K., Gerecke, D.R., Zhou, P., Laskin, D.L., Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol. Appl. Pharmacol. 184 (2002), 27–36.
24. Gokcimen, A., Kocak, A., Kilbas, S., Bayram, D., Kilbas, A., Cim, A., Kockar, C., Kutluhan, S., Effect of lisinopril on rat liver tissues in L-NAME induced hypertension model. Mol. Cell. Biochem. 296 (2007), 159–164.
25. Gupta, G., Krishna, G., Chellappan, D.K., Gubbiyappa, K.S., Candasamy, M., Dua, K., Protective effect of pioglitazone, a PPARγ agonist against acetaminophen-induced hepatotoxicity in rats. Mol. Cell. Biochem. 393 (2014), 223–228.
26. Harada, N., Okajima, K., Kushimoto, S., Isobe, H., Tanaka, K., Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin. Blood 93 (1999), 157–164.
27. Hirsch, G.A., Bottomley, P.A., Gerstenblith, G., Weiss, R.G., Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J. Am. Coll. Cardiol. 59 (2012), 802–808.
28. Hsieh, C.C., Hsieh, S.C., Chiu, J.H., Wu, Y.L., Protective effects of N-acetylcysteine and a prostaglandin E1 analog, alprostadil, against hepatic ischemia: reperfusion injury in rats. J. Tradit. Complement. Med. 4 (2014), 64–71.
29. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak. J. Biol. Sci. 16 (2013), 1353–1357.
30. Kataoka, H., Yang, K., Rock, K.L., The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung. Eur. J. Pharmacol. 746 (2015), 174–179.
31. Kheradpezhouh, E., Ma, L., Morphett, A., Barritt, G.J., Rychkov, G.Y., TRPM2 channels mediate acetaminophen-induced liver damage. Proc. Natl. Acad. Sci. USA 111 (2014), 3176–3181.
32. Kiran, P.M., Raju, A.V., Rao, B.G., Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats. Asian Pac. J. Trop. Biomed. 2 (2012), 352–356.
33. Krenkel, O., Mossanen, J.C., Tacke, F., Immune mechanisms in acetaminophen-induced acute liver failure. Hepatobiliary Surg. Nutr. 3 (2014), 331–343.
34. Kumar, V., Kalita, J., Misra, U.K., Bora, H.K., A study of dose response and organ susceptibility of copper toxicity in a rat model. J. Trace Elem. Med Biol. 29 (2015), 269–274.
35. Lahouel, M., Boulkour, S., Segueni, N., Fillastre, J.P., The flavonoids effect against vinblastine, cyclophosphamide and paracetamol toxicity by inhibition of lipid-peroxydation and increasing liver glutathione concentration. Pathol. Biol. 52 (2004), 314–322.
36. Li, H.B., Qin, D.N., Ma, L., Miao, Y.W., Zhang, D.M., Lu, Y., Song, X.A., Zhu, G.Q., Kang, Y.M., Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension. Toxicol. Appl. Pharmacol. 279 (2014), 141–149.
37. Li, Y., Shen, G., Yu, C., Li, G., Shen, J., Gong, J., Xu, Y., Angiotensin II induces mitochondrial oxidative stress and mtDNA damage in osteoblasts by inhibiting SIRT1–FoxO3a–MnSOD pathway. Biochem. Biophys. Res. Commun. 455 (2014), 113–118.
38. Liu, H.M., Yan, L.H., Luo, Z., Sun, X.M., Cui, R.B., Li, X.H., Yan, M., Role of store-operated Ca2+ channels in ethanol-induced intracellular Ca2+ increase in HepG2 cells. Zhonghua Gan. Zang. Bing. Za Zhi., 21, 2013 949-254.
39. Makay, O., Yenisey, C., Icoz, G., Genc Simsek, N., Ozgen, G., Akyildiz, M., Yetkin, E., The role of allopurinol on oxidative stress in experimental hyperthyroidism. J. Endocrinol. Invest. 32 (2009), 641–646.
40. Margaritis, E.V., Yanni, A.E., Agrogiannis, G., Liarakos, N., Pantopoulou, A., Vlachos, I., Papachristodoulou, A., Korkolopoulou, P., Patsouris, E., Kostakis, M., Perrea, D.N., Kostakis, A., Effects of oral administration of (L)-arginine, (L)-NAME and allopurinol on intestinal ischemia/reperfusion injury in rats. Life Sci. 88 (2011), 1070–1076.
41. Marotto, M.E., Thurman, R.G., Lemasters, J.J., Early midzonal cell death during low-flow hypoxia in the isolated, perfused rat liver: protection by allopurinol. Hepatology 8 (1988), 585–590.
42. Mason, R.P., Jacob, R.F., Corbalan, J.J., Kaliszan, R., Malinski, T., Amlodipine increased endothelial nitric oxide and decreased nitroxidative stress disproportionately to blood pressure changes. Am. J. Hypertens. 27 (2014), 482–488.
43. McCord, J.M., Oxygen-derived free radicals in postischemic tissue injury. New Engl. J. Med. 312 (1985), 159–163.
44. Miranda, K.M., Espey, M.G., Wink, D.A., A rapid, simple spectro-photometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5 (2001), 62–71.
45. Mohanty, I.R., Arya, D.S., Dinda, A., Gupta, S.K., Comparative cardioprotective effects and mechanisms of vitamin E and lisinopril against ischemic reperfusion induced cardiac toxicity. Environ. Toxicol. Pharmacol. 35 (2013), 207–217.
46. Morsy, M.A., Protective effect of lisinopril on hepatic ischemia/reperfusion injury in rats. Indian. J. Pharmacol. 43 (2011), 652–655.
47. Muir, S.W., Harrow, C., Dawson, J., Lees, K.R., Weir, C.J., Sattar, N., Walters, M.R., Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial. Stroke 39 (2008), 3303–3307.
48. Ohishi, T., Saito, H., Tsusaka, K., Toda, K., Inagaki, H., Hamada, Y., Kumagai, N., Atsukawa, K., Ishii, H., Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic carbon tetrachloride-induced hepatic fibrosis in rats. Hepatol. Res. 21 (2001), 147–158.
49. Öktem, F., Kirbas, A., Armagan, A., Kuybulu, A.E., Yilmaz, H.R., Ozguner, F., Uz, E., Lisinopril attenuates renal oxidative injury in L-NAME-induced hypertensive rats. Mol. Cell. Biochem. 352 (2011), 247–253.
50. Olaleye, M.T., Amobonye, A.E., Komolafe, K., Akinmoladun, A.C., Protective effects of Parinari curatellifolia flavonoids against acetaminophen-induced hepatic necrosis in rats. Saudi J. Biol. Sci. 21 (2014), 486–492.
51. Omidi, A., Riahinia, N., Montazer Torbati, M.B., Behdani, M.A., Hepatoprotective effect of Crocus sativus (saffron) petals extract against acetaminophen toxicity in male Wistar rats. Avicenna J. Phytomed. 4 (2014), 330–336.
52. Prieto-Moure, B., Carabén-Redaño, A., Aliena-Valero, A., Cejalvo, D., Toledo, A.H., Flores-Bellver, M., Martínez-Gil, N., Toledo-Pereyra, L.H., Lloris Carsí, J.M., Allopurinol in renal ischemia. J. Invest. Surg. 27 (2014), 304–316.
53. Rachmat, F.D., Rachmat, J., Sastroasmoro, S., Wanandi, S.I., Effect of allopurinol on oxidative stress and hypoxic adaptation response during surgical correction of tetralogy of fallot. Acta Med. Indones. 45 (2013), 94–100.
54. Rajaraman, G., Wang, G., Smith, H.J., Gong, Y., Burczynski, F.J., Effect of diltiazem isomers and thiamine on piglet liver microsomal peroxidation using dichlorofluorescein. J. Pharm. Pharm. Sci. 10 (2007), 380–387.
55. Rodrigues, A.F., Roecker, R., Junges, G.M., de Lima, D.D., da Cruz, J.G., Wyse, A.T., Dal Magro, D.D., Hypoxanthine induces oxidative stress in kidney of rats: protective effect of vitamins E plus C and allopurinol. Cell Biochem. Funct. 32 (2014), 387–394.
56. Salman, S., Kumbasar, S., Yilmaz, M., Kumtepe, Y., Borekci, B., Bakan, E., Suleyman, H., Investigation of the effects of the chronic administration of some antihypertensive drugs on enzymatic and non-enzymatic oxidant/antioxidant parameters in rat ovarian tissue. Gynecol. Endocrinol. 27 (2011), 895–899.
57. Sedlak, J., Lindsay, R.H., Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25 (1968), 192–205.
58. Sen, H., Deniz, S., Yedekci, A.E., Inangil, G., Muftuoglu, T., Haholu, A., Ozkan, S., Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia/reperfusion injury. Ren. Fail. 36 (2014), 1570–1574.
59. Shaker, O., Sourour, D.A., How to protect doxorubicin-induced cardiomyopathy in male albino rats?. J. Cardiovasc. Pharmacol. 55 (2010), 262–268.
60. Stephens, C., Andrade, R.J., Lucena, M.I., Mechanisms of drug-induced liver injury. Curr. Opin. Allergy Clin. Immunol. 14 (2014), 286–292.
61. Thakur, K.S., Prakash, A., Bisht, R., Bansal, P.K., 2014. Beneficial effect of candesartan and lisinopril against haloperidol-induced tardive dyskinesia in rat. J. Renin Angiotensin Aldosterone Syst. (in press).
62. Tobwala, S., Khayyat, A., Fan, W., Ercal, N., Comparative evaluation of N-acetylcysteine and N-acetylcysteineamide in acetaminophen-induced hepatotoxicity in human hepatoma HepaRG cells. Exp. Biol. Med. 240 (2015), 261–272.
63. Uchiyama, M., Mihara, M., Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal. Biochem. 86 (1978), 271–278.
64. Velayutham, P.K., Adhikary, S.D., Babu, S.K., Vedantam, R., Korula, G., Ramachandran, A., Oxidative stress-associated hypertension in surgically induced brain injury patients: effects of β-blocker and angiotensin-converting enzyme inhibitor. J. Surg. Res. 179 (2013), 125–131.
65. Vitolina, R., Krauze, A., Duburs, G., Velena, A., Aspects of the amlodipine pleiotropy in biochemistry, pharmacology and clinics. Int. J. Pharm. Sci. Res. 3 (2012), 1215–1232.
66. Williams, C.D., McGill, M.R., Lebofsky, M., Bajt, M.L., Jaeschke, H., Protection against acetaminophen-induced liver injury by allopurinol is dependent on aldehyde oxidase-mediated liver preconditioning. Toxicol. Appl. Pharmacol. 274 (2014), 417–424.
67. Yasu, T., Kobayashi, M., Mutoh, A., Yamakawa, K., Momomura, S., Ueda, S., Dihydropyridine calcium channel blockers inhibit non-esterified-fatty-acid-induced endothelial and rheological dysfunction. Clin. Sci. 125 (2013), 247–255.
68. Yilmaz, N., Vural, H., Yilmaz, M., Sutcu, R., Sirmali, R., Hicyilmaz, H., Delibas, N., Calorie restriction modulates hippocampal NMDA receptors in diet-induced obese rats. J. Recept. Signal. Transduct. Res. 31 (2011), 214–219.
69. Yirmibeşoğlu, O.A., Büyükgebiz, O., Ars, D., Unay, O., Cevik, D., Lisinopril inhibits endothelin-1 in the early period of hepatic reperfusion injury in a partial hepatectomy model. Transplant. Proc. 43 (2011), 2524–2530.
70. Young, D.S., Effects of Drugs on Clinical Laboratory Tests. fourth ed., 1995, AACC Press, Washington.
71. Yousef, M.I., Omar, S.A., El-Guendi, M.I., Abdelmegid, L.A., Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem. Toxicol. 48 (2010), 3246–3261.
72. Zhang, X., Tian, F., Kawai, H., Kurata, T., Deguchi, S., Deguchi, K., Shang, J., Liu, N., Liu, W., Ikeda, Y., Matsuura, T., Kamiya, T., Abe, K., Anti-inflammatory effect of amlodipine plus atorvastatin treatment on carotid atherosclerosis in zucker metabolic syndrome rats. Transl. Stroke Res. 3 (2012), 435–441.
73. Zyoud, S.H., Awang, R., Sulaiman, S.A., Al-Jabi, S.W., Effects of delay in infusion of N-acetylcysteine on appearance of adverse drug reactions after acetaminophen overdose: a retrospective study. Pharmacoepidemiol. Drug Saf. 19 (2010), 1064–1070.