The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung

European Journal of Pharmacology

Volumn 746, Issue , 2015, Pages 174-179

  Kataoka, Hiroshi ^a   Yang, Ke ^a   Rock, Kenneth L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Acetaminophen; Febuxostat; Inflammation; Liver damage; Lung damage; Uric acid

Indexed keywords

ALLOPURINOL; FEBUXOSTAT; MYELOPEROXIDASE; PARACETAMOL; URIC ACID; XANTHINE OXIDASE; ZYMOSAN; ANTIGOUT AGENT; ENZYME INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL DEATH; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; FLOW CYTOMETRY; HEPATITIS; INFLAMMATORY CELL; LIVER INJURY; LUNG INJURY; MALE; MOUSE; NONHUMAN; PNEUMONIA; TISSUE LEVEL; URIC ACID BLOOD LEVEL; ZYMOSAN-INDUCED PERITONITIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; C57BL MOUSE; CHEMICAL AND DRUG INDUCED LIVER INJURY; COMPARATIVE STUDY; DRUG EFFECTS; GASTROESOPHAGEAL REFLUX; IMMUNOLOGY; LIVER; LUNG; METABOLISM; NECROSIS; NEUTROPHIL CHEMOTAXIS; PATHOPHYSIOLOGY; PERITONEUM; PERITONITIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DEATH; CHEMICAL AND DRUG INDUCED LIVER INJURY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEBUXOSTAT; GASTROESOPHAGEAL REFLUX; GOUT SUPPRESSANTS; LIVER; LUNG; LUNG INJURY; MALE; MICE, INBRED C57BL; NECROSIS; NEUTROPHIL INFILTRATION; PERITONEUM; PERITONITIS; THIAZOLES; URIC ACID; XANTHINE OXIDASE;

EID: 84949116775     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.11.013     Document Type: Article

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