The flavonoids effect against vinblastine, cyclophosphamide and paracetamol toxicity by inhibition of lipid-peroxydation and increasing liver glutathione concentration;Effet protecteur des flavonoïdes contre la toxicité de la vinblastine, du cyclophosphamide et du paracétamol par inhibition de la peroxydation lipidique et augmentation du glutathion hépatique

Pathologie Biologie

Volumn 52, Issue 6, 2004, Pages 314-322

  Lahouel, M ^a   Boulkour, S ^a   Segueni, N ^b   Fillastre, J P ^c  

^a UNIVERSITY OF JIJEL   (Algeria)

^b Universite Mentouri Constantine   (Algeria)

^c Dept de Médecine Interne Ctr Hosp Univ Rouen Boisguillaume   (France)

Author keywords

Chemoprevention; Flavono des; Flavonoids; Glutathion; Lipidp roxydation; Lipidperoxydation; Pr vention; Rats

Indexed keywords

ALKALINE PHOSPHATASE; AMINOTRANSFERASE; CYCLOPHOSPHAMIDE; DIOSMIN; FLAVONOID; GLUTATHIONE; LIPID PEROXIDE; MALONALDEHYDE; PARACETAMOL; QUERCETIN; VINBLASTINE; FLAVONOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD ANALYSIS; BLOOD LEVEL; BLOOD TOXICITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; LEUKOPENIA; LIPID PEROXIDATION; LIVER LEVEL; LIVER TOXICITY; NONHUMAN; RAT; THROMBOCYTOPENIA; ANIMAL; KINETICS; LIVER; LIVER CELL; METABOLISM; TIME; WISTAR RAT;

ACETAMINOPHEN; ANIMALS; CYCLOPHOSPHAMIDE; DIOSMIN; FEMALE; FLAVONOLS; GLUTATHIONE; HEPATOCYTES; KINETICS; LIPID PEROXIDATION; LIVER; MALONDIALDEHYDE; MODELS, ANIMAL; QUERCETIN; RATS; RATS, WISTAR; TIME FACTORS; VINBLASTINE;

EID: 16544389996     PISSN: 03698114     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.patbio.2004.01.001     Document Type: Article

References (27)

1. Lahouel M., Viotte G., Sumereau, Morin J.P., Fillastre J.P. Haematotoxicity of doxorubicin and CCNU and of their association in rats. Drugs Exptl Clin Res. 13:(10):1987;593-599
2. Raguenez-Viotte G., Lahouel M., Ducastelle T.H., Morin J.P., Fillastre J.P. CCNU-adriamycin association induces earlier and more server nephropathy in rats. Arch Toxicol. 61:(4):1988;282-291
3. Kawabata T.T., Chapman M.Y., Kim D.H., Stevens W.D., Holsapple M.P. Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroxycyclophosphamide. Biochem Pharmacol. 40:(5):1990;927
4. Le Pecq J.B. Mécanisme d'action des substances antitumorales. 1978;Hermann, Paris
5. Lahouel M., Ouadi O., Khiari N. Effets hépatique et hématologique du paracétamol. Saidal info. 7:1998;60-66
6. Harborne J.B., Williams C.A. Advances in flavonoid research since 1992. Phytochem. 55:(6):2000;481-504
7. Kamei H., Koide T., Kojimam T., Hasegawa M., Terabe K., Umeda T., et al. Flavonoid-mediated tumor growth suppression demonstrated by in vivo study. Cancer Biother Radiopharm. (3):1996;193-196
8. Sadzuka Y., Sugiyama T., Shimoi K., Kinae N., Hirota S. Protective effect of flavonoids on doxorubicin-induced cardiotoxicity. Toxicol Lett. 92:(1):1997;1-7
9. Siess M.H., Le Bon A.M., Canivenc-lavier M.C., Suschetet M. Mechanisms involved in the chemoprevention of flavonoids. Biofactors. 12:(1-4):2000;193-199
10. Bridger S., Henderson K., Glucksman E., Ellis A.J., Henry J.A., Williams R. Death from low dose paracetamol poisoning. BMJ. 316:(7146):1998 Jun 6;1724-1725
11. Draganov P., Durrence H., Cox C., Reuben A. Alcohol-acetaminophen syndrome. Even moderate social drinkers are a risk. Postgrad Med. 107:(1):2000 Jan;189-195
12. O'Grady J.G. Paracetamol-induced acute liver failure: prevention and management. J Hepatol. 26:(suppl1):1997;41-46
13. Park Y.K., Ikegaki M., Matias de Alencar S. Classificaçâo das propolis Brazileiro a partir de suas caracteristicas fisico-quimicas e propriedades biologicas. Mensagem Doce. 2000;58
14. Park Y.K., Matias de Alencar S., Zima de Agenar C., Scamparini R.P., Ganzalez M., Maria A.A. Comparaço Das caracteristicas fisico-quimicas das propolis produgidas na rigiâo sub-tropical da America Do Sud:Evidencia fitoquimica de sua origem botânia. Mensagem Doce. 2001;61
15. Vanhaelen M., Vanhaelen-Fasté R. High performance_liquid, gas-liquid and thin-layer chromatography of naturally occuring flavonoids, phenolic and related compounds. Journal of chromatography. 187:1980;255-260
16. Settaf M., Zahidy A., Elimadi R., Sapena I., Abd A., Tillement J.-P., et al. S-15176 reduces the hepatic injury in rats subjected to experimental ischemia and reperfusion. Eur J Pharmacol. 406:2000;281-292
17. Torel J. Antioxidant activity of flavonoids and reactivity with peroxy radical. Phytochem. 25:1986;383-385
18. Lopez-Lazaro M., Martin-Cordero C., Ayuso M.J. Two new flavonol glycosides as DNA topoisomerase I poisons. Z Naturforsch. 55:(11-12):2000;898- 902
19. Chang P., Riggs C.E. Jr, Scheerer M.T., Wiernik P.H., Bachur N.R. Combination chemotherapy with adriamycin and streptozotocin.II. Clinicopharmacologic correlation of augmented adriamycin toxicity caused by streptozotocin. Clin pharm ther. 20:1976;611-616
20. Fillastre J.P., Morin J.P., Godin M., Josse S. Complications rénales de la chimiothérapie anticancéreuse. Path Biol. 34:(9):1986;1013-1028
21. Guengerich E.P. Mammalian cytochromes P450. 1986;Florida: CRC press
22. Krähenbühl S. Acarbose and Acetaminophen - A dangerous combination? Hepatology. 29:(1):Jan. 1999;285-287
23. Mofredj A., Cadranel J.F., Darchy B., Barbare J.C., Cazier A., Pras V., B.M. Toxicité hépatique du paracétamol à dose thérapeutique chez le sujet éthylique chronique (à propos de deux cas d'hépatite mortelle chez des patients cirrhotiques). Ann Med Int. 150:1999;507-511
24. Merghem R. Origine et biogenèse des molécules d'origine naturelle, importances pour l'industrie pharmaceutique. Proceeding du 1er séminaire national sur les substances bioactives d'origine végétale, 2001 Mai 7 et 8 ; Jijel(Algérie). p.105-111.
25. Morin D., Barthelemy S., Zini R., Labidalle S., Tillement J.P. Curcumin induces the mitochondrial permeability transition pore mediated by membrane protein thiol oxidation. Febs Letters. 495:2001;131-136
26. Bromont P., Lantz B., Préface de Fillastre J.P. Évaluation de la sécurité d'emploi des médicaments. 1989;Doin, Paris
27. Koreichi L. Etude du rôle antioxydant des flavonoïdes extraits des plantes au cours des réactions immunologiques. 2003;1-186 [Thèse] : Université Mentouri, Constantine