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Volumn 10, Issue 3, 2015, Pages 305-315

Immunogenicity of allogeneic mesenchymal stromal cells: What has been seen in vitro and in vivo?

Author keywords

antigen presenting cells; direct indirect alloimmunity; immunogenicity; immunomodulation; major histocompatibility complex; mesenchymal stromal cells

Indexed keywords

ALLOANTIGEN;

EID: 84930003573     PISSN: 17460751     EISSN: 1746076X     Source Type: Journal    
DOI: 10.2217/rme.15.14     Document Type: Review
Times cited : (58)

References (82)
  • 1
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 284(5411), 143-147 (1999).
    • (1999) Science , vol.284 , Issue.5411 , pp. 143-147
    • Pittenger, M.F.1    MacKay, A.M.2    Beck, S.C.3
  • 2
    • 84872159367 scopus 로고    scopus 로고
    • Cellular and molecular interactions of mesenchymal stem cells in innate immunity
    • Spaggiari GM, Moretta L. Cellular and molecular interactions of mesenchymal stem cells in innate immunity. Immunol. Cell Biol. 91(1), 27-31 (2013).
    • (2013) Immunol. Cell Biol. , vol.91 , Issue.1 , pp. 27-31
    • Spaggiari, G.M.1    Moretta, L.2
  • 3
    • 84857032992 scopus 로고    scopus 로고
    • Mesenchymal stromal cell therapy: A revolution in Regenerative Medicine?
    • Bernardo ME, Pagliara D, Locatelli F. Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine? Bone Marrow Transplant. 47(2), 164-171 (2012).
    • (2012) Bone Marrow Transplant. , vol.47 , Issue.2 , pp. 164-171
    • Bernardo, M.E.1    Pagliara, D.2    Locatelli, F.3
  • 4
    • 84892449142 scopus 로고    scopus 로고
    • Phase i trial: The use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia
    • Bura A, Planat-Benard V, Bourin P et al. Phase I trial: the use of autologous cultured adipose-derived stroma/stem cells to treat patients with non-revascularizable critical limb ischemia. Cytotherapy 16(2), 245-257 (2014).
    • (2014) Cytotherapy , vol.16 , Issue.2 , pp. 245-257
    • Bura, A.1    Planat-Benard, V.2    Bourin, P.3
  • 5
    • 47949131746 scopus 로고    scopus 로고
    • Placental-derived and expanded mesenchymal stromal cells (PLX-I) to enhance the engraftment of hematopoietic stem cells derived from umbilical cord blood
    • Prather WR, Toren A, Meiron M. Placental-derived and expanded mesenchymal stromal cells (PLX-I) to enhance the engraftment of hematopoietic stem cells derived from umbilical cord blood. Expert Opin. Biol. Ther. 8(8), 1241-1250 (2008).
    • (2008) Expert Opin. Biol. Ther. , vol.8 , Issue.8 , pp. 1241-1250
    • Prather, W.R.1    Toren, A.2    Meiron, M.3
  • 6
    • 84886718723 scopus 로고    scopus 로고
    • Cardioprotection by placenta-derived stromal cells in a murine myocardial infarction model
    • Roy R, Brodarac A, Kukucka M et al. Cardioprotection by placenta-derived stromal cells in a murine myocardial infarction model. J. Surg. Res. 185(1), 70-83 (2013).
    • (2013) J. Surg. Res. , vol.185 , Issue.1 , pp. 70-83
    • Roy, R.1    Brodarac, A.2    Kukucka, M.3
  • 7
    • 84862702680 scopus 로고    scopus 로고
    • Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications
    • Yi T, Song SU. Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications. Arch. Pharm. Res. 35(2), 213-221 (2012).
    • (2012) Arch. Pharm. Res. , vol.35 , Issue.2 , pp. 213-221
    • Yi, T.1    Song, S.U.2
  • 8
    • 67549126317 scopus 로고    scopus 로고
    • The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia
    • Prather WR, Toren A, Meiron M, Ofir R, Tschope C, Horwitz EM. The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia. Cytotherapy 11(4), 427-434 (2009).
    • (2009) Cytotherapy , vol.11 , Issue.4 , pp. 427-434
    • Prather, W.R.1    Toren, A.2    Meiron, M.3    Ofir, R.4    Tschope, C.5    Horwitz, E.M.6
  • 9
    • 70350444497 scopus 로고    scopus 로고
    • Safety and biodistribution profile of placental-derived mesenchymal stromal cells (PLX-PAD) following intramuscular delivery
    • Ramot Y, Meiron M, Toren A, Steiner M, Nyska A. Safety and biodistribution profile of placental-derived mesenchymal stromal cells (PLX-PAD) following intramuscular delivery. Toxicol. Pathol. 37(5), 606-616 (2009).
    • (2009) Toxicol. Pathol. , vol.37 , Issue.5 , pp. 606-616
    • Ramot, Y.1    Meiron, M.2    Toren, A.3    Steiner, M.4    Nyska, A.5
  • 10
    • 0041431109 scopus 로고    scopus 로고
    • Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: Feasibility, cell migration, and body distribution
    • Barbash IM, Chouraqui P, Baron J et al. Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution. Circulation 108(7), 863-868 (2003).
    • (2003) Circulation , vol.108 , Issue.7 , pp. 863-868
    • Barbash, I.M.1    Chouraqui, P.2    Baron, J.3
  • 11
    • 80054809361 scopus 로고    scopus 로고
    • Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells
    • Chiesa S, Morbelli S, Morando S et al. Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells. Proc. Natl Acad. Sci. USA 108(42), 17384-17389 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , Issue.42 , pp. 17384-17389
    • Chiesa, S.1    Morbelli, S.2    Morando, S.3
  • 12
    • 84862835586 scopus 로고    scopus 로고
    • Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-Term engraftment and no ectopic tissue formation
    • Von Bahr L, Batsis I, Moll G et al. Analysis of tissues following mesenchymal stromal cell therapy in humans indicates limited long-Term engraftment and no ectopic tissue formation. Stem Cells 30(7), 1575-1578 (2012).
    • (2012) Stem Cells , vol.30 , Issue.7 , pp. 1575-1578
    • Von Bahr, L.1    Batsis, I.2    Moll, G.3
  • 13
    • 0037325716 scopus 로고    scopus 로고
    • Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma
    • Fouillard L, Bensidhoum M, Bories D et al. Engraftment of allogeneic mesenchymal stem cells in the bone marrow of a patient with severe idiopathic aplastic anemia improves stroma. Leukemia 17(2), 474-476 (2003).
    • (2003) Leukemia , vol.17 , Issue.2 , pp. 474-476
    • Fouillard, L.1    Bensidhoum, M.2    Bories, D.3
  • 14
    • 84862214282 scopus 로고    scopus 로고
    • The influence of cardiovascular risk factors on bone marrow mesenchymal stromal cell fitness
    • Neef K, Choi YH, Weichel A et al. The influence of cardiovascular risk factors on bone marrow mesenchymal stromal cell fitness. Cytotherapy 14(6), 670-678 (2012).
    • (2012) Cytotherapy , vol.14 , Issue.6 , pp. 670-678
    • Neef, K.1    Choi, Y.H.2    Weichel, A.3
  • 15
    • 47049124714 scopus 로고    scopus 로고
    • Cardiac cell therapy: A realistic concept for elderly patients? Exp
    • Stamm C, Nasseri B, Drews T, Hetzer R. Cardiac cell therapy: a realistic concept for elderly patients? Exp. Gerontol. 43(7), 679-690 (2008).
    • (2008) Gerontol. , vol.43 , Issue.7 , pp. 679-690
    • Stamm, C.1    Nasseri, B.2    Drews, T.3    Hetzer, R.4
  • 16
    • 84879160785 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience
    • Wang D, Zhang H, Liang J et al. Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant. 22(12), 2267-2277 (2013).
    • (2013) Cell Transplant. , vol.22 , Issue.12 , pp. 2267-2277
    • Wang, D.1    Zhang, H.2    Liang, J.3
  • 17
    • 34447639255 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells
    • Le Blanc K, Samuelsson H, Gustafsson B et al. Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic stem cells. Leukemia 21(8), 1733-1738 (2007).
    • (2007) Leukemia , vol.21 , Issue.8 , pp. 1733-1738
    • Le Blanc, K.1    Samuelsson, H.2    Gustafsson, B.3
  • 18
    • 84872164299 scopus 로고    scopus 로고
    • Detrimental effects of rat mesenchymal stromal cell pre-Treatment in a model of acute kidney rejection
    • Seifert M, Stolk M, Polenz D, Volk HD. Detrimental effects of rat mesenchymal stromal cell pre-Treatment in a model of acute kidney rejection. Front. Immunol. 3, 202 (2012).
    • (2012) Front. Immunol. , vol.3 , pp. 202
    • Seifert, M.1    Stolk, M.2    Polenz, D.3    Volk, H.D.4
  • 19
    • 33746514768 scopus 로고    scopus 로고
    • Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting
    • Nauta AJ, Westerhuis G, Kruisselbrink AB, Lurvink EG, Willemze R, Fibbe WE. Donor-derived mesenchymal stem cells are immunogenic in an allogeneic host and stimulate donor graft rejection in a nonmyeloablative setting. Blood 108(6), 2114-2120 (2006).
    • (2006) Blood , vol.108 , Issue.6 , pp. 2114-2120
    • Nauta, A.J.1    Westerhuis, G.2    Kruisselbrink, A.B.3    Lurvink, E.G.4    Willemze, R.5    Fibbe, W.E.6
  • 20
    • 79959938424 scopus 로고    scopus 로고
    • Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells
    • Deuse T, Stubbendorff M, Tang-Quan K et al. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant. 20(5), 655-667 (2011).
    • (2011) Cell Transplant. , vol.20 , Issue.5 , pp. 655-667
    • Deuse, T.1    Stubbendorff, M.2    Tang-Quan, K.3
  • 21
    • 47249146422 scopus 로고    scopus 로고
    • Immunological properties of umbilical cord blood-derived mesenchymal stromal cells
    • Oh W, Kim DS, Yang YS, Lee JK. Immunological properties of umbilical cord blood-derived mesenchymal stromal cells. Cell Immunol. 251(2), 116-123 (2008).
    • (2008) Cell Immunol. , vol.251 , Issue.2 , pp. 116-123
    • Oh, W.1    Kim, D.S.2    Yang, Y.S.3    Lee, J.K.4
  • 22
    • 84896727247 scopus 로고    scopus 로고
    • IDOindependent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells
    • Chinnadurai R, Copland IB, Patel SR, Galipeau J. IDOindependent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells. J. Immunol. 192(4), 1491-1501 (2014).
    • (2014) J. Immunol. , vol.192 , Issue.4 , pp. 1491-1501
    • Chinnadurai, R.1    Copland, I.B.2    Patel, S.R.3    Galipeau, J.4
  • 23
    • 70350512378 scopus 로고    scopus 로고
    • Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties
    • Francois M, Romieu-Mourez R, Stock-Martineau S, Boivin MN, Bramson JL, Galipeau J. Mesenchymal stromal cells cross-present soluble exogenous antigens as part of their antigen-presenting cell properties. Blood 114(13), 2632-2638 (2009).
    • (2009) Blood , vol.114 , Issue.13 , pp. 2632-2638
    • Francois, M.1    Romieu-Mourez, R.2    Stock-Martineau, S.3    Boivin, M.N.4    Bramson, J.L.5    Galipeau, J.6
  • 24
    • 0037221583 scopus 로고    scopus 로고
    • Characterization and functionality of cell surface molecules on human mesenchymal stem cells
    • Majumdar MK, Keane-Moore M, Buyaner D et al. Characterization and functionality of cell surface molecules on human mesenchymal stem cells. J. Biomed. Sci. 10(2), 228-241 (2003).
    • (2003) J. Biomed. Sci. , vol.10 , Issue.2 , pp. 228-241
    • Majumdar, M.K.1    Keane-Moore, M.2    Buyaner, D.3
  • 25
    • 33745076513 scopus 로고    scopus 로고
    • Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma
    • Chan JL, Tang KC, Patel AP et al. Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma. Blood 107(12), 4817-4824 (2006).
    • (2006) Blood , vol.107 , Issue.12 , pp. 4817-4824
    • Chan, J.L.1    Tang, K.C.2    Patel, A.P.3
  • 26
    • 84899935769 scopus 로고    scopus 로고
    • Interferon-gamma modification of mesenchymal stem cells: Implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation
    • Sivanathan KN, Gronthos S, Rojas-Canales D, Thierry B, Coates PT. Interferon-gamma modification of mesenchymal stem cells: implications of autologous and allogeneic mesenchymal stem cell therapy in allotransplantation. Stem Cell Rev. 10(3), 351-375 (2014).
    • (2014) Stem Cell Rev. , vol.10 , Issue.3 , pp. 351-375
    • Sivanathan, K.N.1    Gronthos, S.2    Rojas-Canales, D.3    Thierry, B.4    Coates, P.T.5
  • 27
    • 77949308137 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially
    • Prasanna SJ, Gopalakrishnan D, Shankar SR, Vasandan AB. Pro-inflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS ONE 5(2), e9016 (2010).
    • (2010) PLoS ONE , vol.5 , Issue.2 , pp. e9016
    • Prasanna, S.J.1    Gopalakrishnan, D.2    Shankar, S.R.3    Vasandan, A.B.4
  • 28
    • 84922505648 scopus 로고    scopus 로고
    • Influence of inflammation on the immunological profile of adultderived human liver mesenchymal stromal cells and stellate cells
    • Raicevic G, Najar M, Najimi M et al. Influence of inflammation on the immunological profile of adultderived human liver mesenchymal stromal cells and stellate cells. Cytotherapy 17(2), 174-185 (2015).
    • (2015) Cytotherapy , vol.17 , Issue.2 , pp. 174-185
    • Raicevic, G.1    Najar, M.2    Najimi, M.3
  • 29
    • 68849088180 scopus 로고    scopus 로고
    • Diagnostic value of T-cell monitoring assays in kidney transplantation
    • Nickel P, Bestard O, Volk HD, Reinke P. Diagnostic value of T-cell monitoring assays in kidney transplantation. Curr. Opin. Organ Transplant. 14(4), 426-431 (2009).
    • (2009) Curr. Opin. Organ Transplant. , vol.14 , Issue.4 , pp. 426-431
    • Nickel, P.1    Bestard, O.2    Volk, H.D.3    Reinke, P.4
  • 30
    • 84878605056 scopus 로고    scopus 로고
    • Effects of cellular sensitization and donor age on acute rejection and graft function after deceased-donor kidney transplantation
    • Hricik DE, Poggio ED, Woodside KJ et al. Effects of cellular sensitization and donor age on acute rejection and graft function after deceased-donor kidney transplantation. Transplantation 95(10), 1254-1258 (2013).
    • (2013) Transplantation , vol.95 , Issue.10 , pp. 1254-1258
    • Hricik, D.E.1    Poggio, E.D.2    Woodside, K.J.3
  • 31
    • 33645455798 scopus 로고    scopus 로고
    • Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogeneic cell bank
    • Andree H, Nickel P, Nasiadko C et al. Identification of dialysis patients with panel-reactive memory T cells before kidney transplantation using an allogeneic cell bank. J. Am. Soc. Nephrol. 17(2), 573-580 (2006).
    • (2006) J. Am. Soc. Nephrol. , vol.17 , Issue.2 , pp. 573-580
    • Andree, H.1    Nickel, P.2    Nasiadko, C.3
  • 32
    • 68449086888 scopus 로고    scopus 로고
    • HSCT recipients have specific tolerance to MSC but not to the MSC donor
    • Sundin M, Barrett AJ, Ringden O et al. HSCT recipients have specific tolerance to MSC but not to the MSC donor. J. Immunother. 32(7), 755-764 (2009).
    • (2009) J. Immunother. , vol.32 , Issue.7 , pp. 755-764
    • Sundin, M.1    Barrett, A.J.2    Ringden, O.3
  • 33
    • 84898466874 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Immune evasive, not immune privileged
    • Ankrum JA, Ong JF, Karp JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat. Biotechnol. 32(3), 252-260 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , Issue.3 , pp. 252-260
    • Ankrum, J.A.1    Ong, J.F.2    Karp, J.M.3
  • 34
    • 84899493349 scopus 로고    scopus 로고
    • Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo
    • Lee M, Jeong SY, Ha J et al. Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo. Biochem. Biophys. Res. Commun. 446(4), 983-989 (2014).
    • (2014) Biochem. Biophys. Res. Commun. , vol.446 , Issue.4 , pp. 983-989
    • Lee, M.1    Jeong, S.Y.2    Ha, J.3
  • 35
    • 13444262764 scopus 로고    scopus 로고
    • Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming
    • Martin-Fontecha A, Thomsen LL, Brett S et al. Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming. Nat. Immunol. 5(12), 1260-1265 (2004).
    • (2004) Nat. Immunol. , vol.5 , Issue.12 , pp. 1260-1265
    • Martin-Fontecha, A.1    Thomsen, L.L.2    Brett, S.3
  • 36
    • 33748865886 scopus 로고    scopus 로고
    • NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion
    • Morandi B, Bougras G, Muller WA, Ferlazzo G, Munz C. NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion. Eur. J. Immunol. 36(9), 2394-2400 (2006).
    • (2006) Eur. J. Immunol. , vol.36 , Issue.9 , pp. 2394-2400
    • Morandi, B.1    Bougras, G.2    Muller, W.A.3    Ferlazzo, G.4    Munz, C.5
  • 37
    • 18544371666 scopus 로고    scopus 로고
    • Human mesenchymal stem cells inhibit differentiation and function of monocytederived dendritic cells
    • Jiang XX, Zhang Y, Liu B et al. Human mesenchymal stem cells inhibit differentiation and function of monocytederived dendritic cells. Blood 105(10), 4120-4126 (2005).
    • (2005) Blood , vol.105 , Issue.10 , pp. 4120-4126
    • Jiang, X.X.1    Zhang, Y.2    Liu, B.3
  • 38
    • 33746898242 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells
    • Nauta AJ, Kruisselbrink AB, Lurvink E, Willemze R, Fibbe WE. Mesenchymal stem cells inhibit generation and function of both CD34+-derived and monocyte-derived dendritic cells. J. Immunol. 177(4), 2080-2087 (2006).
    • (2006) J. Immunol. , vol.177 , Issue.4 , pp. 2080-2087
    • Nauta, A.J.1    Kruisselbrink, A.B.2    Lurvink, E.3    Willemze, R.4    Fibbe, W.E.5
  • 39
    • 40749110247 scopus 로고    scopus 로고
    • Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the notch pathway
    • Li YP, Paczesny S, Lauret E et al. Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the notch pathway. J. Immunol. 180(3), 1598-1608 (2008).
    • (2008) J. Immunol. , vol.180 , Issue.3 , pp. 1598-1608
    • Li, Y.P.1    Paczesny, S.2    Lauret, E.3
  • 40
    • 69249227552 scopus 로고    scopus 로고
    • MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: Central role of MSC-derived prostaglandin E2
    • Spaggiari GM, Abdelrazik H, Becchetti F, Moretta L. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood 113(26), 6576-6583 (2009).
    • (2009) Blood , vol.113 , Issue.26 , pp. 6576-6583
    • Spaggiari, G.M.1    Abdelrazik, H.2    Becchetti, F.3    Moretta, L.4
  • 41
    • 33846408655 scopus 로고    scopus 로고
    • Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
    • Varol C, Landsman L, Fogg DK et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204(1), 171-180 (2007).
    • (2007) J. Exp. Med. , vol.204 , Issue.1 , pp. 171-180
    • Varol, C.1    Landsman, L.2    Fogg, D.K.3
  • 42
    • 65249089638 scopus 로고    scopus 로고
    • In vivo analysis of dendritic cell development and homeostasis
    • Liu K, Victora GD, Schwickert TA et al. In vivo analysis of dendritic cell development and homeostasis. Science 324(5925), 392-397 (2009).
    • (2009) Science , vol.324 , Issue.5925 , pp. 392-397
    • Liu, K.1    Victora, G.D.2    Schwickert, T.A.3
  • 43
    • 37349075167 scopus 로고    scopus 로고
    • Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation
    • English K, Barry FP, Mahon BP. Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation. Immunol. Lett. 115(1), 50-58 (2008).
    • (2008) Immunol. Lett. , vol.115 , Issue.1 , pp. 50-58
    • English, K.1    Barry, F.P.2    Mahon, B.P.3
  • 44
    • 84906545300 scopus 로고    scopus 로고
    • Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1
    • Deng Y, Yi S, Wang G et al. Umbilical cord-derived mesenchymal stem cells instruct dendritic cells to acquire tolerogenic phenotypes through the IL-6-mediated upregulation of SOCS1. Stem Cells Dev. 23(17), 2080-2092 (2014).
    • (2014) Stem Cells Dev. , vol.23 , Issue.17 , pp. 2080-2092
    • Deng, Y.1    Yi, S.2    Wang, G.3
  • 45
    • 84861669648 scopus 로고    scopus 로고
    • Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells
    • Bassi EJ, De Almeida DC, Moraes-Vieira PM, Camara NO. Exploring the role of soluble factors associated with immune regulatory properties of mesenchymal stem cells. Stem Cell Rev. 8(2), 329-342 (2012).
    • (2012) Stem Cell Rev. , vol.8 , Issue.2 , pp. 329-342
    • Bassi, E.J.1    De Almeida, D.C.2    Moraes-Vieira, P.M.3    Camara, N.O.4
  • 46
    • 84878469967 scopus 로고    scopus 로고
    • Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6
    • Melief SM, Geutskens SB, Fibbe WE, Roelofs H. Multipotent stromal cells skew monocytes towards an anti-inflammatory interleukin-10-producing phenotype by production of interleukin-6. Haematologica 98(6), 888-895 (2013).
    • (2013) Haematologica , vol.98 , Issue.6 , pp. 888-895
    • Melief, S.M.1    Geutskens, S.B.2    Fibbe, W.E.3    Roelofs, H.4
  • 47
    • 77958087116 scopus 로고    scopus 로고
    • Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells
    • Yanez R, Oviedo A, Aldea M, Bueren JA, Lamana M. Prostaglandin E2 plays a key role in the immunosuppressive properties of adipose and bone marrow tissue-derived mesenchymal stromal cells. Exp. Cell Res. 316(19), 3109-3123 (2010).
    • (2010) Exp. Cell Res. , vol.316 , Issue.19 , pp. 3109-3123
    • Yanez, R.1    Oviedo, A.2    Aldea, M.3    Bueren, J.A.4    Lamana, M.5
  • 48
    • 59449096601 scopus 로고    scopus 로고
    • Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population
    • Zhang B, Liu R, Shi D et al. Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population. Blood 113(1), 46-57 (2009).
    • (2009) Blood , vol.113 , Issue.1 , pp. 46-57
    • Zhang, B.1    Liu, R.2    Shi, D.3
  • 49
    • 32644438233 scopus 로고    scopus 로고
    • Mesenchymal stem cell-natural killer cell interactions: Evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NKcell proliferation
    • Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NKcell proliferation. Blood 107(4), 1484-1490 (2006).
    • (2006) Blood , vol.107 , Issue.4 , pp. 1484-1490
    • Spaggiari, G.M.1    Capobianco, A.2    Becchetti, S.3    Mingari, M.C.4    Moretta, L.5
  • 52
    • 38949183675 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: Role of indoleamine 2, 3-dioxygenase and prostaglandin E2
    • Spaggiari GM, Capobianco A, Abdelrazik H, Becchetti F, Mingari MC, Moretta L. Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2, 3-dioxygenase and prostaglandin E2. Blood 111(3), 1327-1333 (2008).
    • (2008) Blood , vol.111 , Issue.3 , pp. 1327-1333
    • Spaggiari, G.M.1    Capobianco, A.2    Abdelrazik, H.3    Becchetti, F.4    Mingari, M.C.5    Moretta, L.6
  • 53
    • 84897018474 scopus 로고    scopus 로고
    • Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells
    • Chatterjee D, Tufa DM, Baehre H, Hass R, Schmidt RE, Jacobs R. Natural killer cells acquire CD73 expression upon exposure to mesenchymal stem cells. Blood 123(4), 594-595 (2014).
    • (2014) Blood , vol.123 , Issue.4 , pp. 594-595
    • Chatterjee, D.1    Tufa, D.M.2    Baehre, H.3    Hass, R.4    Schmidt, R.E.5    Jacobs, R.6
  • 54
    • 38349053355 scopus 로고    scopus 로고
    • Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells
    • Selmani Z, Naji A, Zidi I et al. Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells. Stem Cells 26(1), 212-222 (2008).
    • (2008) Stem Cells , vol.26 , Issue.1 , pp. 212-222
    • Selmani, Z.1    Naji, A.2    Zidi, I.3
  • 55
    • 0028265155 scopus 로고
    • Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones
    • Manetti R, Gerosa F, Giudizi MG et al. Interleukin 12 induces stable priming for interferon gamma (IFN-gamma) production during differentiation of human T helper (Th) cells and transient IFN-gamma production in established Th2 cell clones. J. Exp. Med. 179(4), 1273-1283 (1994).
    • (1994) J. Exp. Med. , vol.179 , Issue.4 , pp. 1273-1283
    • Manetti, R.1    Gerosa, F.2    Giudizi, M.G.3
  • 56
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99(10), 3838-3843 (2002).
    • (2002) Blood , vol.99 , Issue.10 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 57
    • 78650673843 scopus 로고    scopus 로고
    • Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation
    • Cutler AJ, Limbani V, Girdlestone J, Navarrete CV. Umbilical cord-derived mesenchymal stromal cells modulate monocyte function to suppress T cell proliferation. J. Immunol. 185(11), 6617-6623 (2010).
    • (2010) J. Immunol. , vol.185 , Issue.11 , pp. 6617-6623
    • Cutler, A.J.1    Limbani, V.2    Girdlestone, J.3    Navarrete, C.V.4
  • 58
    • 84856960632 scopus 로고    scopus 로고
    • Human MSC suppression correlates with cytokine induction of indoleamine 2, 3-dioxygenase and bystander M2 macrophage differentiation
    • Francois M, Romieu-Mourez R, Li M, Galipeau J. Human MSC suppression correlates with cytokine induction of indoleamine 2, 3-dioxygenase and bystander M2 macrophage differentiation. Mol. Ther. 20(1), 187-195 (2012).
    • (2012) Mol. Ther. , vol.20 , Issue.1 , pp. 187-195
    • Francois, M.1    Romieu-Mourez, R.2    Li, M.3    Galipeau, J.4
  • 59
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105(4), 1815-1822 (2005).
    • (2005) Blood , vol.105 , Issue.4 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 60
    • 78751694808 scopus 로고    scopus 로고
    • Transplantation of CTLA4Ig gene-Transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis
    • Choi EW, Shin IS, Lee HW et al. Transplantation of CTLA4Ig gene-Transduced adipose tissue-derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis. J. Gene Med. 13(1), 3-16 (2011).
    • (2011) J. Gene Med. , vol.13 , Issue.1 , pp. 3-16
    • Choi, E.W.1    Shin, I.S.2    Lee, H.W.3
  • 61
    • 33750933744 scopus 로고    scopus 로고
    • Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: Relevance to tissue engineering human heart valves
    • Batten P, Sarathchandra P, Antoniw JW et al. Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves. Tissue Eng. 12(8), 2263-2273 (2006).
    • (2006) Tissue Eng. , vol.12 , Issue.8 , pp. 2263-2273
    • Batten, P.1    Sarathchandra, P.2    Antoniw, J.W.3
  • 62
    • 65649113921 scopus 로고    scopus 로고
    • Human bone marrowderived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis
    • Bai L, Lennon DP, Eaton V et al. Human bone marrowderived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 57(11), 1192-1203 (2009).
    • (2009) Glia , vol.57 , Issue.11 , pp. 1192-1203
    • Bai, L.1    Lennon, D.P.2    Eaton, V.3
  • 63
    • 84879124355 scopus 로고    scopus 로고
    • Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation
    • Tatara R, Ozaki K, Kikuchi Y et al. Mesenchymal stromal cells inhibit Th17 but not regulatory T-cell differentiation. Cytotherapy 13(6), 686-694 (2011).
    • (2011) Cytotherapy , vol.13 , Issue.6 , pp. 686-694
    • Tatara, R.1    Ozaki, K.2    Kikuchi, Y.3
  • 64
    • 80053153051 scopus 로고    scopus 로고
    • Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor
    • Duffy MM, Pindjakova J, Hanley SA et al. Mesenchymal stem cell inhibition of T-helper 17 cell-differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor. Eur. J. Immunol. 41(10), 2840-2851 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , Issue.10 , pp. 2840-2851
    • Duffy, M.M.1    Pindjakova, J.2    Hanley, S.A.3
  • 65
    • 84930380040 scopus 로고    scopus 로고
    • Amniotic membrane mesenchymal cells-derived factors skew T cell polarization toward Treg and downregulate Th1 and Th17 cells subsets
    • doi:10.1007/s12015-014-9558-4. Epub ahead of print
    • Pianta S, Bonassi Signoroni P, Muradore I et al. Amniotic membrane mesenchymal cells-derived factors skew T cell polarization toward Treg and downregulate Th1 and Th17 cells subsets. Stem Cell Rev. doi:10.1007/s12015-014-9558-4. (2014) (Epub ahead of print)
    • (2014) Stem Cell Rev.
    • Pianta, S.1    Bonassi Signoroni, P.2    Muradore, I.3
  • 66
    • 84872139846 scopus 로고    scopus 로고
    • Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far?
    • Griffin MD, Ryan AE, Alagesan S, Lohan P, Treacy O, Ritter T. Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far? Immunol. Cell Biol. 91(1), 40-51 (2013).
    • (2013) Immunol. Cell Biol. , vol.91 , Issue.1 , pp. 40-51
    • Griffin, M.D.1    Ryan, A.E.2    Alagesan, S.3    Lohan, P.4    Treacy, O.5    Ritter, T.6
  • 67
    • 2942595706 scopus 로고    scopus 로고
    • Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation
    • Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase-mediated tryptophan degradation. Blood 103(12), 4619-4621 (2004).
    • (2004) Blood , vol.103 , Issue.12 , pp. 4619-4621
    • Meisel, R.1    Zibert, A.2    Laryea, M.3    Gobel, U.4    Daubener, W.5    Dilloo, D.6
  • 68
    • 77955093536 scopus 로고    scopus 로고
    • Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: Combined comparison of adipose tissue Wharton's Jelly and bone marrow sources
    • Najar M, Raicevic G, Boufker HI et al. Mesenchymal stromal cells use PGE2 to modulate activation and proliferation of lymphocyte subsets: combined comparison of adipose tissue, Wharton's Jelly and bone marrow sources. Cell Immunol. 264(2), 171-179 (2010).
    • (2010) Cell Immunol. , vol.264 , Issue.2 , pp. 171-179
    • Najar, M.1    Raicevic, G.2    Boufker, H.I.3
  • 69
    • 33746889097 scopus 로고    scopus 로고
    • Role for interferongamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells
    • Krampera M, Cosmi L, Angeli R et al. Role for interferongamma in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 24(2), 386-398 (2006).
    • (2006) Stem Cells , vol.24 , Issue.2 , pp. 386-398
    • Krampera, M.1    Cosmi, L.2    Angeli, R.3
  • 70
    • 84876801639 scopus 로고    scopus 로고
    • Mechanism of umbilical cord mesenchymal stem cells in the up-regulation of regulatory T cells by transforming growth factor beta1 in systemic lupus erythematosus
    • Lu L, Wang DD, Li X, Zeng XF, Sun LY. [Mechanism of umbilical cord mesenchymal stem cells in the up-regulation of regulatory T cells by transforming growth factor beta1 in systemic lupus erythematosus]. Zhonghua Yi Xue Za Zhi 93(13), 980-983 (2013).
    • (2013) Zhonghua Yi Xue Za Zhi , vol.93 , Issue.13 , pp. 980-983
    • Lu, L.1    Wang, D.D.2    Li, X.3    Zeng, X.F.4    Sun, L.Y.5
  • 71
    • 71549118838 scopus 로고    scopus 로고
    • Bone marrowderived mesenchymal stem cells inhibit acute rejection of rat liver allografts in association with regulatory T-cell expansion
    • Wang Y, Zhang A, Ye Z, Xie H, Zheng S. Bone marrowderived mesenchymal stem cells inhibit acute rejection of rat liver allografts in association with regulatory T-cell expansion. Transplant. Proc. 41(10), 4352-4356 (2009).
    • (2009) Transplant. Proc. , vol.41 , Issue.10 , pp. 4352-4356
    • Wang, Y.1    Zhang, A.2    Ye, Z.3    Xie, H.4    Zheng, S.5
  • 72
    • 79952042164 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells
    • Kavanagh H, Mahon BP. Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 66(4), 523-531 (2011).
    • (2011) Allergy , vol.66 , Issue.4 , pp. 523-531
    • Kavanagh, H.1    Mahon, B.P.2
  • 73
    • 61849123247 scopus 로고    scopus 로고
    • Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells
    • English K, Ryan JM, Tobin L, Murphy MJ, Barry FP, Mahon BP. Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells. Clin. Exp. Immunol. 156(1), 149-160 (2009).
    • (2009) Clin. Exp. Immunol. , vol.156 , Issue.1 , pp. 149-160
    • English, K.1    Ryan, J.M.2    Tobin, L.3    Murphy, M.J.4    Barry, F.P.5    Mahon, B.P.6
  • 74
    • 33846229305 scopus 로고    scopus 로고
    • Immunologic consequences of multiple, high-dose administration of allogeneic mesenchymal stem cells to baboons
    • Beggs KJ, Lyubimov A, Borneman JN et al. Immunologic consequences of multiple, high-dose administration of allogeneic mesenchymal stem cells to baboons. Cell Transplant. 15(8-9), 711-721 (2006).
    • (2006) Cell Transplant. , vol.15 , Issue.8-9 , pp. 711-721
    • Beggs, K.J.1    Lyubimov, A.2    Borneman, J.N.3
  • 75
    • 68049127805 scopus 로고    scopus 로고
    • Monitoring and treating posttransplant human leukocyte antigen antibodies
    • Everly MJ, Terasaki PI. Monitoring and treating posttransplant human leukocyte antigen antibodies. Hum. Immunol. 70(8), 655-659 (2009).
    • (2009) Hum. Immunol. , vol.70 , Issue.8 , pp. 655-659
    • Everly, M.J.1    Terasaki, P.I.2
  • 76
    • 84655170198 scopus 로고    scopus 로고
    • Mechanisms of rejection: Current perspectives
    • Wood KJ, Goto R. Mechanisms of rejection: current perspectives. Transplantation 93(1), 1-10 (2012).
    • (2012) Transplantation , vol.93 , Issue.1 , pp. 1-10
    • Wood, K.J.1    Goto, R.2
  • 77
    • 50849088328 scopus 로고    scopus 로고
    • The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes
    • Tabera S, Perez-Simon JA, Diez-Campelo M et al. The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes. Haematologica 93(9), 1301-1309 (2008).
    • (2008) Haematologica , vol.93 , Issue.9 , pp. 1301-1309
    • Tabera, S.1    Perez-Simon, J.A.2    Diez-Campelo, M.3
  • 79
    • 33947593728 scopus 로고    scopus 로고
    • Mesenchymal stem cells stimulate antibody secretion in human B cells
    • Rasmusson I, Le Blanc K, Sundberg B, Ringden O. Mesenchymal stem cells stimulate antibody secretion in human B cells. Scand. J. Immunol. 65(4), 336-343 (2007).
    • (2007) Scand. J. Immunol. , vol.65 , Issue.4 , pp. 336-343
    • Rasmusson, I.1    Le Blanc, K.2    Sundberg, B.3    Ringden, O.4
  • 80
    • 40949119840 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients
    • Traggiai E, Volpi S, Schena F et al. Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients. Stem Cells 26(2), 562-569 (2008).
    • (2008) Stem Cells , vol.26 , Issue.2 , pp. 562-569
    • Traggiai, E.1    Volpi, S.2    Schena, F.3
  • 81
    • 84919782445 scopus 로고    scopus 로고
    • Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells Is mediated by T cells
    • Rosado MM, Bernardo ME, Scarsella M et al. Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells Is mediated by T cells. Stem Cells Dev. 24(1), 93-103 (2014).
    • (2014) Stem Cells Dev. , vol.24 , Issue.1 , pp. 93-103
    • Rosado, M.M.1    Bernardo, M.E.2    Scarsella, M.3
  • 82
    • 84923217704 scopus 로고    scopus 로고
    • Human adipose tissue-derived mesenchymal stem cells abrogate plasmablast formation and induce regulatory B cells independently of T helper cells
    • doi:10.1002/stem.188 Epub ahead of print
    • Franquesa M, Mensah FK, Huizinga R et al. Human adipose tissue-derived mesenchymal stem cells abrogate plasmablast formation and induce regulatory B cells independently of T helper cells. Stem Cells doi:10.1002/stem.188 (2014) (Epub ahead of print).
    • (2014) Stem Cells
    • Franquesa, M.1    Mensah, F.K.2    Huizinga, R.3


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