Bone Marrow-Derived Mesenchymal Stem Cells Inhibit Acute Rejection of Rat Liver Allografts in Association With Regulatory T-Cell Expansion

Transplantation Proceedings

Volumn 41, Issue 10, 2009, Pages 4352-4356

  Wang, Y ^a   Zhang, A ^a   Ye, Z ^a   Xie, H ^a   Zheng, S ^a  

^a BEIJING HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN NORWAY RAT; CELL EXPANSION; COMPARATIVE STUDY; CONTROLLED STUDY; EXPERIMENTAL MODEL; GRAFT RECIPIENT; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL; HISTOLOGY; IMMUNOREGULATION; INBRED STRAIN; LEWIS RAT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MESENCHYMAL STEM CELL; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; SURVIVAL RATE;

ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; GRAFT REJECTION; GRAFT SURVIVAL; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LIVER TRANSPLANTATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MODELS, ANIMAL; RATS; RATS, INBRED BN; RATS, INBRED LEW; RATS, WISTAR; T-LYMPHOCYTES, REGULATORY; TRANSPLANTATION, HOMOLOGOUS;

EID: 71549118838     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.08.072     Document Type: Article

References (17)

1. Pittenger M.F., Mackay A.M., Beck S.C., et al. Multilineage potential of adult mesenchymal stem cells. Science 284 (1999) 143
2. Maccario R., Podestà M., Moretta A., et al. Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype. Haematologica 90 (2005) 516
3. Prevosto C., Zancolli M., Canevali P., et al. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica 92 (2007) 881
4. + regulatory T cells. Stem Cells 26 (2008) 212
5. Le Blanc K., Tammik L., Sundberg B., et al. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 57 (2003) 11
6. Kamada N., and Calne R.Y. Orthotopic liver transplantation in the rat: technique using cuff for portal vein anastomosis and biliary drainage. Transplantation 28 (1979) 47
7. Banff schema for grading liver allograft rejection: an international consensus document. Hepatology 25 (1997) 658
8. Murase N., Starzl T.E., Tanabe M., et al. Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to Brown Norway rats. Transplantation 60 (1995) 158
9. Bartholomew A., Sturgeon C., Siatskas M., et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30 (2002) 42
10. Zhang W., Qin C., and Zhou Z.M. Mesenchymal stem cells modulate immune responses combined with cyclosporine in a rat renal transplantation model. Transplant Proc 39 (2007) 3404
11. Zhou H.P., Yi D.H., Yu S.Q., et al. Administration of donor-derived mesenchymal stem cells can prolong the survival of rat cardiac allograft. Transplant Proc 38 (2006) 3046
12. Inoue S., Popp F.C., Koehl G.E., et al. Immunomodulatory effects of mesenchymal stem cells in a rat organ transplant model. Transplantation 81 (2006) 1589
13. Krampera M., Cosmi L., Angeli R., et al. Role of IFN-γ in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 24 (2006) 386
14. Parekkadan B., Tilles A.W., and Yarmush M.L. Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independent of regulatory T cells. Stem Cells 26 (2008) 1913
15. Mills K.H. Regulatory T cells: friend or foe in immunity to infection?. Nat Rev Immunol 4 (2004) 841
16. 2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells. J Immunol 175 (2005) 1483
17. English K., Ryan J.M., Tobin L., et al. Cell contact, prostaglandin E(2) and transforming growth factor-beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(high) forkhead box P3+ regulatory T cells. Clin Exp Immunol 156 (2009) 149