Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 12, 2015, Pages 2594-2598

  Dockendorff, Chris ^a,b   Faloon, Patrick W ^a   Germain, Andrew ^a   Yu, Miao ^c   Youngsaye, Willmen ^a   Nag, Partha P ^a   Bennion, Melissa ^a   Penman, Marsha ^c   Nieland, Thomas J F ^c   Dandapani, Sivaraman ^a   Perez, José R ^a   Munoz, Benito ^a   Palmer, Michelle A ^a   Schreiber, Stuart L ^a,d   Krieger, Monty ^c  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b Marquette University   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Cholesterol transport; HCV; HDL receptor; ML279; SR BI inhibitor

Indexed keywords

AGENTS AFFECTING LIPID METABOLISM; HETEROCYCLIC COMPOUND; PEPTIDOMIMETIC AGENT; SCAVENGER RECEPTOR BI; ALANINE; BISAMIDINE; CD36 ANTIGEN; FURAN DERIVATIVE; HIGH DENSITY LIPOPROTEIN; ML279 COMPOUND; PROTEIN BINDING; TETRAZOLE DERIVATIVE;

ALKYLATION; ANIMAL CELL; ARTICLE; CHO CELL LINE; CYCLOADDITION; DRUG SOLUBILITY; ENANTIOMER; ENDOCYTOSIS; FEMALE; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; HYDROLYSIS; IC50; LIPID TRANSPORT; NONHUMAN; PEPTIDE SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CRICETULUS; GENETICS; HAMSTER; METABOLISM; PRECLINICAL STUDY; SYNTHESIS;

HEPATITIS C VIRUS;

ALANINE; ANIMALS; ANTIGENS, CD36; CHO CELLS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; FURANS; HETEROCYCLIC COMPOUNDS; LIPOPROTEINS, HDL; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES;

EID: 84929994575     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.03.074     Document Type: Article

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