Evaluation of functional characteristics of preactivated thiolated chitosan as potential therapeutic agent for dry mouth syndrome

Acta Biomaterialia

Volumn 21, Issue , 2015, Pages 123-131

  Laffleur, Flavia ^a   Fischer, Alexander ^a   Schmutzler, Matthias ^a   Hintzen, Fabian ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Chitosan thioglycolic acid; Dry mouth syndrome; Mercaptonicotinamide; Preactivated thiomers; Thiomers

Indexed keywords

CYLINDERS (SHAPES); TENSILE STRENGTH;

CHITOSAN-THIOGLYCOLIC ACID; COHESIVE PROPERTY; DRY MOUTH; DRY MOUTH SYNDROME; MERCAPTONICOTINAMIDE; PREACTIVATED THIOMER; THIOGLYCOLIC ACID; THIOLATED CHITOSAN; THIOMERS;

CHITOSAN;

ADHESIVE AGENT; CHITOSAN; DRUG CARRIER; MERCAPTONICOTINAMIDE; NICOTINIC ACID DERIVATIVE; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG; THIOL DERIVATIVE;

ARTICLE; CACO 2 CELL LINE; COLORECTAL CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DISULFIDE BOND; DRUG DELIVERY SYSTEM; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MUCOADHESION; NUCLEOPHILICITY; OXIDATIVE COUPLING; PRIORITY JOURNAL; SHEAR STRENGTH; TENSILE STRENGTH; TREATMENT OUTCOME; WATER TRANSPORT; XEROSTOMIA; CHEMISTRY; MATERIALS TESTING; TUMOR CELL LINE;

CELL LINE, TUMOR; CHITOSAN; HUMANS; MATERIALS TESTING; SULFHYDRYL COMPOUNDS; XEROSTOMIA;

EID: 84929943387     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.04.016     Document Type: Article

References (33)

1. G.S. Asane, S.A. Nirmal, K.B. Rasal, A.A. Naik, M.S. Mahadik, and Y.M. Rao Polymers for mucoadhesive drug delivery system: a current status Drug Dev Ind Pharm 34 11 2008 1246 1266
2. D. Sakloetsakun, J. Iqbal, G. Millotti, A. Vetter, and A. Bernkop-Schnurch Thiolated chitosans: influence of various sulfhydryl ligands on permeation-enhancing and P-gp inhibitory properties Drug Dev Ind Pharm 37 6 2011 648 655
3. G. Gannot, H.E. Lancaster, and P.C. Fox Clinical course of primary Sjogren's syndrome: salivary, oral, and serologic aspects J Rheumatol 27 8 2000 1905 1909
4. V. Hearnden, V. Sankar, and K. Hull New developments and opportunities in oral mucosal drug delivery for local and systemic disease Adv Drug Delivery Rev 64 1 2012 16 28
5. C. Scully Drug effects on salivary glands: dry mouth Oral Dis 9 4 2003 165 176
6. R.I. Fox Sjogren's syndrome Lancet 366 9482 2005 321 331
7. M. Garcia-Carrasco, M. Ramos-Casals, and J. Rosas Primary sjogren syndrome: clinical and immunologic disease patterns in a cohort of 400 patients Medicine (Baltimore) 81 4 2002 270 280
8. Y. Sudhakar, K. Kuotsu, and A.K. Bandyopadhyay Buccal bioadhesive drug delivery-a promising option for orally less efficient drugs J Control Release 114 1 2006 15 40
9. V.F. Patel, F. Liu, and M.B. Brown Advances in oral transmucosal drug delivery J Control Release 153 2 2011 106 116
10. F. Laffleur, and A. Bernkop-Schnurch Thiomers: promising platform for macromolecular drug delivery Future Med Chem 4 17 2012 2205 2216
11. F. Laffleur, F. Hintzen, D. Rahmat, G. Shahnaz, G. Millotti, and A. Bernkop-Schnurch Enzymatic degradation of thiolated chitosan Drug Dev Ind Pharm 2012
12. S. Dunnhaupt, J. Barthelmes, C.C. Thurner, C. Waldner, D. Sakloetsakun, and A. Bernkop-Schnurch S-protected thiolated chitosan: synthesis and in vitro characterization Carbohydr Polym 90 2 2012 765 772
13. G. Shahnaz, J. Iqbal, and D. Rahmat Development and in vivo characterization of a novel peptide drug delivery system providing extended plasma half life J Control Release 157 3 2012 375 382
14. D. Rahmat, D. Sakloetsakun, G. Shahnaz, F. Sarti, F. Laffleur, and A.B. Schnurch HEC-cysteamine conjugates: influence of degree of thiolation on efflux pump inhibitory and permeation enhancing properties Int J Pharm 422 1-2 2012 40 46
15. S. Dunnhaupt, J. Barthelmes, and D. Rahmat S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: evaluation of permeation enhancing and efflux pump inhibitory properties Mol Pharm 9 5 2012 1331 1341
16. H.S. Forrest, and J. Walker Chemotherapeutic agents of the sulphone type; 2: 5-disubstituted derivatives of pyridine J Chem Soc 70 1948 1939 1945
17. J. Iqbal, G. Shahnaz, S. Dunnhaupt, C. Muller, F. Hintzen, and A. Bernkop-Schnurch Preactivated thiomers as mucoadhesive polymers for drug delivery Biomaterials 33 5 2012 1528 1535
18. B. Loretz, and A. Bernkop-Schnurch In vitro evaluation of chitosan-EDTA conjugate polyplexes as a nanoparticulate gene delivery system AAPS J 8 4 2006 E756 E764
19. D. Rahmat, C. Muller, and G. Shahnaz HEC-cysteamine particles: influence of particle size, zeta potential, morphology and sulfhydryl groups on permeation enhancing properties Drug Dev Ind Pharm 2012
20. C.E. Kast, and A. Bernkop-Schnurch Thiolated polymers-thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates Biomaterials 22 17 2001 2345 2352
21. F. Sarti, C. Muller, J. Iqbal, G. Perera, F. Laffleur, and A. Bernkop-Schnurch Development and in vivo evaluation of an oral vitamin B12 delivery system Eur J Pharm Biopharm 84 1 2013 132 137
22. M.R. Saboktakin, R.M. Tabatabaie, A. Maharramov, and M.A. Ramazanov Development and in vitro evaluation of thiolated chitosan-poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system Int J Biol Macromol 48 3 2011 403 407
23. F. Laffleur, G. Shahnaz, Z. Islambulchilar, and A. Bernkop-Schnurch Design and in vitro evaluation of a novel polymeric excipient for buccal applications Future Med Chem 5 5 2013 511 522
24. A. Bernkop-Schnurch, and S. Steininger Synthesis and characterisation of mucoadhesive thiolated polymers Int J Pharm 194 2 2000 239 247
25. P.K. Metia, and A.K. Bandyopadhyay In vitro evaluation of novel mucoadhesive buccal tablet of oxytocin prepared with diospyros peregrina fruit mucilages Yakugaku Zasshi 128 4 2008 603 609
26. G. Shahnaz, A. Vetter, and J. Barthelmes Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization Int J Pharm 428 1-2 2012 164 170
27. S. Dunnhaupt, J. Barthelmes, and J. Iqbal In vivo evaluation of an oral drug delivery system for peptides based on S-protected thiolated chitosan J Control Release 160 3 2012 477 485
28. A. Bernkop-Schnurch, A.H. Krauland, V.M. Leitner, and T. Palmberger Thiomers: potential excipients for non-invasive peptide delivery systems Eur J Pharm Biopharm 58 2 2004 253 263
29. S.A. Mortazavi, and J.D. Smart An investigation into the role of water-movement and mucus gel dehydration in mucoadhesion J Control Release 25 3 1993 197 203
30. D. Duchene, and G. Ponchel Principle and investigation of the bioadhesion mechanism of solid dosage forms Biomaterials 13 10 1992 709 714
31. B.M. Boddupalli, Z.N. Mohammed, R.A. Nath, and D. Banji Mucoadhesive drug delivery system: an overview J Adv Pharm Technol Res 1 4 2010 381 387
32. N. Salamat-Miller, M. Chittchang, and T.P. Johnston The use of mucoadhesive polymers in buccal drug delivery Adv Drug Deliver Rev 57 11 2005 1666 1691
33. D.M. Shinkar, A.S. Dhake, and C.M. Setty Drug delivery from the oral cavity: a focus on mucoadhesive buccal drug delivery systems PDA J Pharm Sci Technol 66 5 2012 466 500