In vitro evaluation of chitosan-EDTA conjugate polyplexes as a nanoparticulate gene delivery system

AAPS Journal

Volumn 8, Issue 4, 2006, Pages

  Loretz, Brigitta ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Caco 2; Cross linking; Cytotoxicity; Gene transfer; Nanoparticles; Stability

Indexed keywords

BETA GALACTOSIDASE; CHITOSAN EDETATE CONJUGATE; LACTATE DEHYDROGENASE; NANOCARRIER; PLASMID DNA; UNCLASSIFIED DRUG; CHITOSAN; CHITOSAN EDTA; CHITOSAN-EDTA; DRUG DERIVATIVE; EDETIC ACID; NANOPARTICLE;

ARTICLE; CELL STRAIN CACO 2; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON MICROSCOPY; ELECTROPHORESIS; ENZYME ASSAY; ENZYME DEGRADATION; FLUORESCENCE ANALYSIS; GENE TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR STABILITY; MOLECULAR WEIGHT; NANOTECHNOLOGY; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PLASMID VECTOR; REPORTER GENE; TOXICITY TESTING; VISCOSITY; ZETA POTENTIAL; COMPARATIVE STUDY; DRUG SCREENING; METHODOLOGY;

CACO-2 CELLS; CHITOSAN; DRUG EVALUATION, PRECLINICAL; EDETIC ACID; GENE TRANSFER TECHNIQUES; HUMANS; NANOPARTICLES; PARTICLE SIZE;

EID: 33846099911     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/aapsj080485     Document Type: Article

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