In vivo evaluation of an oral drug delivery system for peptides based on S-protected thiolated chitosan

Journal of Controlled Release

Volumn 160, Issue 3, 2012, Pages 477-485

  Dünnhaupt, Sarah ^a   Barthelmes, Jan ^a   Iqbal, Javed ^a   Perera, Glen ^a   Thurner, Clemens C ^b   Friedl, Heike ^b   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b Thiomatrix Forschungs und Beratungs GmbH   (Austria)

Author keywords

Antide; Disulfide bond formation; Oral peptide delivery; Permeation enhancement; S protected chitosan; Thiolated chitosan

Indexed keywords

ANTIDE; DISULFIDE BOND FORMATION; ORAL PEPTIDE DELIVERY; PERMEATION ENHANCEMENT; THIOLATED CHITOSAN;

BIOCHEMISTRY; CHITOSAN; COVALENT BONDS; DRUG PRODUCTS; LIGANDS; PEPTIDES; RATS;

MULTILAYERS;

6 MERCAPTONICOTINAMIDE; CHITOSAN; ITURELIX; NICOTINAMIDE; S PROTECTED THIOLATED CHITOSAN; THIOGLYCOLIC ACID; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; COVALENT BOND; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG RELEASE; DRUG TRANSPORT; ELECTRIC RESISTANCE; INTESTINE MUCOSA; INTESTINE MUCOSA PERMEABILITY; MALE; MATRIX TABLET; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; TABLET DISINTEGRATION; TABLET SWELLING; TRANSEPITHELIAL ELECTRICAL RESISTANCE;

ADMINISTRATION, ORAL; ANIMALS; CHITOSAN; DRUG DELIVERY SYSTEMS; ILEUM; JEJUNUM; MALE; NIACINAMIDE; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; THIOGLYCOLATES;

EID: 84861990596     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.04.020     Document Type: Article

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