메뉴 건너뛰기




Volumn 69, Issue 5, 2015, Pages 364-372

Role of T helper lymphokines in the immune-inflammatory pathophysiology of schizophrenia: Systematic review and meta-Analysis

Author keywords

Immune activation; Interleukin; Schizophrenia; T helper cells; Th1:Th2 ratio

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOKINE; CYTOKINE;

EID: 84929889656     PISSN: 08039488     EISSN: 15024725     Source Type: Journal    
DOI: 10.3109/08039488.2014.986761     Document Type: Article
Times cited : (26)

References (75)
  • 1
    • 84859701278 scopus 로고    scopus 로고
    • Lessons learned at the intersection of immunology and neuroscience
    • Steinman L. Lessons learned at the intersection of immunology and neuroscience. J Clin Invest. 2012 ; 122 : 1146-1148
    • (2012) J Clin Invest , vol.122 , pp. 1146-1148
    • Steinman, L.1
  • 2
    • 0031301027 scopus 로고    scopus 로고
    • Physiological and pathological roles of interleukin-6 in the central nervous system
    • Gruol DL, Nelson TE. Physiological and pathological roles of interleukin-6 in the central nervous system. Mol Neurobiol. 1997 ; 15 : 307-339
    • (1997) Mol Neurobiol , vol.15 , pp. 307-339
    • Gruol, D.L.1    Nelson, T.E.2
  • 4
    • 84865268482 scopus 로고    scopus 로고
    • PGC Schizophrenia (GWAS) Consortium. Expression QTL analysis of top loci from GWAS meta-Analysis highlights additional schizophrenia candidate genes
    • De Jong S, Van Eijk KR, Zeegers DW, Strengman E, Janson E, Veldink JH, et al ; PGC Schizophrenia (GWAS) Consortium. Expression QTL analysis of top loci from GWAS meta-Analysis highlights additional schizophrenia candidate genes. Eur J Hum Genet. 2012 ; 20 : 1004-1008
    • (2012) Eur J Hum Genet , vol.20 , pp. 1004-1008
    • De Jong, S.1    Van Eijk, K.R.2    Zeegers, D.W.3    Strengman, E.4    Janson, E.5    Veldink, J.H.6
  • 5
    • 0032722572 scopus 로고    scopus 로고
    • Development, disease and Degeneration in schizophrenia: A unitary pathophysiological moDel
    • KeshaVan MS. Development, disease and Degeneration in schizophrenia: A unitary pathophysiological moDel. J Psychiatry Res. 1999 ; 33 : 513-521
    • (1999) J Psychiatry Res , vol.33 , pp. 513-521
    • Keshavan, M.S.1
  • 6
    • 0035183947 scopus 로고    scopus 로고
    • Neural Development cell-cell signaling and the two-hit hypothesis of schizophrenia
    • Maynard TM, Sikich L, Lieberman JA, LaMantia AS. Neural Development, cell-cell signaling, and the two-hit hypothesis of schizophrenia. Schizophr Bull. 2001 ; 27 : 457-476
    • (2001) Schizophr Bull , vol.27 , pp. 457-476
    • Maynard, T.M.1    Sikich, L.2    Lieberman, J.A.3    Lamantia, A.S.4
  • 7
    • 84873522724 scopus 로고    scopus 로고
    • Developmental neuroinfl ammation and schizophrenia
    • Meyer U. Developmental neuroinfl ammation and schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2013 ; 42 : 20-34
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.42 , pp. 20-34
    • Meyer, U.1
  • 8
    • 40849097773 scopus 로고    scopus 로고
    • Cryoglobulins as indicators of upregulated immune response in schizophrenia
    • Boyajyan A, Khoyetsyan A, Tsakanova G, Sim RB. Cryoglobulins as indicators of upregulated immune response in schizophrenia. Clin Biochem. 2008 ; 41 : 355-360
    • (2008) Clin Biochem , vol.41 , pp. 355-360
    • Boyajyan, A.1    Khoyetsyan, A.2    Tsakanova, G.3    Sim, R.B.4
  • 10
    • 84873524352 scopus 로고    scopus 로고
    • Schizophrenia: Linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neuroDevelopment and neuroprogression
    • AnDerson G, Maes M. Schizophrenia: Linking prenatal infection to cytokines, the tryptophan catabolite (TRYCAT) pathway, NMDA receptor hypofunction, neuroDevelopment and neuroprogression. Prog Neuropsychopharmacol Biol Psychiatry. 2013 ; 42 : 5-19
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.42 , pp. 5-19
    • Anderson, G.1    Maes, M.2
  • 11
    • 0029086519 scopus 로고
    • Unraveling the neuroimmune mechanisms for the HIV-1-Associated cognitive/motor complex
    • Nottet HS, GenDelman HE. Unraveling the neuroimmune mechanisms for the HIV-1-Associated cognitive/motor complex. Immunol Today. 1995 ; 16 : 441-448
    • (1995) Immunol Today , vol.16 , pp. 441-448
    • Nottet, H.S.1    Gendelman, H.E.2
  • 12
    • 22744455058 scopus 로고    scopus 로고
    • HIV-1 infection and AIDS: Consequences for the central nervous system
    • Kaul M, Zheng J, Okamoto S, GenDelman HE, Lipton SA. HIV-1 infection and AIDS: Consequences for the central nervous system. Cell Death Differ. 2005 ; 12 Suppl 1 : 878-892
    • (2005) Cell Death Differ , vol.12 , Issue.1 , pp. 878-892
    • Kaul, M.1    Zheng, J.2    Okamoto, S.3    Gendelman, H.E.4    Lipton, S.A.5
  • 14
    • 84856351556 scopus 로고    scopus 로고
    • Experimental schizophrenia moDels in roDents established with infl ammatory agents and cytokines
    • Nawa H, Yamada K. Experimental schizophrenia moDels in roDents established with infl ammatory agents and cytokines. Methods Mol Biol. 2012 ; 829 : 445-451
    • (2012) Methods Mol Biol , vol.829 , pp. 445-451
    • Nawa, H.1    Yamada, K.2
  • 15
    • 0028073036 scopus 로고
    • Increased prevalence of antibrain antibodies in the sera from schizophrenic patients
    • Henneberg AE, Horter S, Ruffert S. Increased prevalence of antibrain antibodies in the sera from schizophrenic patients. Schizophr Res. 1994 ; 14 : 15-22
    • (1994) Schizophr Res , vol.14 , pp. 15-22
    • Henneberg, A.E.1    Horter, S.2    Ruffert, S.3
  • 17
    • 84862208120 scopus 로고    scopus 로고
    • Maternal immune activation by poly(I:C) induces expression of cytokines IL-1and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain
    • ArroDe-Bruses G, Bruses JL. Maternal immune activation by poly(I:C) induces expression of cytokines IL-1and IL-13, chemokine MCP-1 and colony stimulating factor VEGF in fetal mouse brain. J Neuroinfl ammation. 2012 ; 9 : 83
    • (2012) J Neuroinfl Ammation , vol.9 , pp. 83
    • Arrode-Bruses, G.1    Bruses, J.L.2
  • 18
    • 32844463928 scopus 로고    scopus 로고
    • The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia
    • Ashdown H, Dumont Y, Ng M, Poole S, Boksa P, Luheshi GN. The role of cytokines in mediating effects of prenatal infection on the fetus: Implications for schizophrenia. Mol Psychiatry. 2006 ; 11 : 47-55
    • (2006) Mol Psychiatry , vol.11 , pp. 47-55
    • Ashdown, H.1    Dumont, Y.2    Ng, M.3    Poole, S.4    Boksa, P.5    Luheshi, G.N.6
  • 19
    • 77649167678 scopus 로고    scopus 로고
    • Prenatal infection and schizophrenia: A review of epiDemiologic and translational studies
    • Brown AS, Derkits EJ. Prenatal infection and schizophrenia: A review of epiDemiologic and translational studies. Am J Psychiatry. 2010 ; 167 : 261-280
    • (2010) Am J Psychiatry , vol.167 , pp. 261-280
    • Brown, A.S.1    Derkits, E.J.2
  • 20
    • 84865973655 scopus 로고    scopus 로고
    • Prenatal maternal infection, neuroDevelopment and adult schizophrenia: A systematic review of population based studies
    • Khandaker GM, Zimbron J, Lewis G, Jones PB. Prenatal maternal infection, neuroDevelopment and adult schizophrenia: A systematic review of population based studies. Psychol Med. 2012 ; 16 : 1-19
    • (2012) Psychol Med , vol.16 , pp. 1-19
    • Khandaker, G.M.1    Zimbron, J.2    Lewis, G.3    Jones, P.B.4
  • 21
    • 35148872226 scopus 로고    scopus 로고
    • Maternal immune activation alters fetal brain Development through interleukin-6
    • Smith SEP, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain Development through interleukin-6. J Neurosci. 2007 ; 27 : 10695-10702
    • (2007) J Neurosci , vol.27 , pp. 10695-10702
    • Sep, S.1    Li, J.2    Garbett, K.3    Mirnics, K.4    Patterson, P.H.5
  • 22
    • 13844276635 scopus 로고    scopus 로고
    • Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring
    • Zuckerman L, Weiner I. Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring. J Psychiatr Res. 2005 ; 39 : 311-323
    • (2005) J Psychiatr Res , vol.39 , pp. 311-323
    • Zuckerman, L.1    Weiner, I.2
  • 24
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain Development and synaptic plasticity
    • Boulanger LM. Immune proteins in brain Development and synaptic plasticity. Neuron. 2009 ; 64 : 93-109
    • (2009) Neuron , vol.64 , pp. 93-109
    • Boulanger, L.M.1
  • 27
    • 80052037435 scopus 로고    scopus 로고
    • Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia
    • Arakelyan A, Zakharyan R, Khoyetsyan A, Poghosyan D, Aroutiounian R, Mrazek F, et al. Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia. BMC Clin Pathol. 2011 ; 11 : 10
    • (2011) BMC Clin Pathol , vol.11 , pp. 10
    • Arakelyan, A.1    Zakharyan, R.2    Khoyetsyan, A.3    Poghosyan, D.4    Aroutiounian, R.5    Mrazek, F.6
  • 30
    • 14544299356 scopus 로고    scopus 로고
    • Classical pathway complement activity in schizophrenia
    • Hakobyan S, Boyajyan A, Sim RB. Classical pathway complement activity in schizophrenia. Neurosci Lett. 2005 ; 374 : 35-37
    • (2005) Neurosci Lett , vol.374 , pp. 35-37
    • Hakobyan, S.1    Boyajyan, A.2    Sim, R.B.3
  • 31
    • 84889088936 scopus 로고    scopus 로고
    • Type III hypersensitivity reaction with immune complex Deposition in 2 critically ill dogs administered human serum albumin
    • Powell C, Thompson L, Murtaugh RJ. Type III hypersensitivity reaction with immune complex Deposition in 2 critically ill dogs administered human serum albumin. J Vet Emerg Crit Care (San Antonio). 2013 ; 23 : 598-604
    • (2013) J Vet Emerg Crit Care (San Antonio , vol.23 , pp. 598-604
    • Powell, C.1    Thompson, L.2    Murtaugh, R.J.3
  • 32
    • 0035133525 scopus 로고    scopus 로고
    • EviDence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia
    • Herken H, Uz E, Ozyurt H, Sogut S, Virit O, Akyol O. EviDence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia. Mol Psychiatry. 2001 ; 6 : 66-73
    • (2001) Mol Psychiatry , vol.6 , pp. 66-73
    • Herken, H.1    Uz, E.2    Ozyurt, H.3    Sogut, S.4    Virit, O.5    Akyol, O.6
  • 33
    • 0036313848 scopus 로고    scopus 로고
    • The possible pathophysiological role of plasma nitric oxiDe and adrenomedullin in schizophrenia
    • Zoroglu SS, Herken H, Yurekli M, Uz E, Tutkun H, SavapHA, et al. The possible pathophysiological role of plasma nitric oxiDe and adrenomedullin in schizophrenia. J Psychiatr Res. 2002 ; 36 : 309-315
    • (2002) J Psychiatr Res , vol.36 , pp. 309-315
    • Zoroglu, S.S.1    Herken, H.2    Yurekli, M.3    Uz, E.4    Tutkun, H.5    Savap, H.A.6
  • 34
    • 0141678875 scopus 로고    scopus 로고
    • Plasma nitrate levels in Defi cit versus non-Defi cit forms of schizophrenia
    • Suzuki E, Nakaki T, Nakamura M, Miyaoka H. Plasma nitrate levels in Defi cit versus non-Defi cit forms of schizophrenia. J. Psychiatry Neurosci. 2003 ; 28 : 288-292
    • (2003) J. Psychiatry Neurosci , vol.28 , pp. 288-292
    • Suzuki, E.1    Nakaki, T.2    Nakamura, M.3    Miyaoka, H.4
  • 35
    • 4043106393 scopus 로고    scopus 로고
    • Nitric oxiDe as a physiopathological factor in neuropsychiatric disorDers
    • Akyol O, Zoroolu SS, Armutcu F, Sahin S, Gurel A. Nitric oxiDe as a physiopathological factor in neuropsychiatric disorDers. In Vivo. 2004 ; 18 : 377-390
    • (2004) Vivo , vol.18 , pp. 377-390
    • Akyol, O.1    Zoroolu, S.S.2    Armutcu, F.3    Sahin, S.4    Gurel, A.5
  • 36
    • 16344368087 scopus 로고    scopus 로고
    • Increased nitric oxiDe radicals in postmortem brain from patients with schizophrenia
    • Yao JK, Leonard S, Reddy RD. Increased nitric oxiDe radicals in postmortem brain from patients with schizophrenia. Schizophr Bull. 2004 ; 30 : 923-934
    • (2004) Schizophr Bull , vol.30 , pp. 923-934
    • Yao, J.K.1    Leonard, S.2    Reddy, R.D.3
  • 37
    • 39049193486 scopus 로고    scopus 로고
    • Imbalanced free radicals and antioxidant Defense systems in schizophrenia: A comparative study
    • Li HC, Chen QZ, Ma Y, Zhou JF. Imbalanced free radicals and antioxidant Defense systems in schizophrenia: A comparative study. J Zhejiang Univ Sci B. 2006 ; 7 : 981-986
    • (2006) J Zhejiang Univ Sci B , vol.7 , pp. 981-986
    • Li, H.C.1    Chen, Q.Z.2    Ma, Y.3    Zhou, J.F.4
  • 38
    • 34249656988 scopus 로고    scopus 로고
    • Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia
    • Zhang XY, Tan YL, Zhou DF, Cao LY, Wu GY, Haile CN, et al. Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia. J Clin Psychiatry. 2007 ; 68 : 754-760
    • (2007) J Clin Psychiatry , vol.68 , pp. 754-760
    • Zhang, X.Y.1    Tan, Y.L.2    Zhou, D.F.3    Cao, L.Y.4    Wu, G.Y.5    Haile, C.N.6
  • 39
    • 33646377916 scopus 로고    scopus 로고
    • Oxidative stress involvement in schizophrenia pathophysiology: A review
    • Fendri C, Mechri A, Khiari G, Othman A, Kerkeni A, Gaha L. Oxidative stress involvement in schizophrenia pathophysiology: A review. Encephale. 2006 ; 32 : 244-252
    • (2006) Encephale , vol.32 , pp. 244-252
    • Fendri, C.1    Mechri, A.2    Khiari, G.3    Othman, A.4    Kerkeni, A.5    Gaha, L.6
  • 40
    • 0037961694 scopus 로고    scopus 로고
    • Viruses and schizophrenia, connection or coinciDence?
    • Karlsson H. Viruses and schizophrenia, connection or coinciDence? Neuroreport. 2003 ; 14 : 535-542
    • (2003) Neuroreport , vol.14 , pp. 535-542
    • Karlsson, H.1
  • 41
    • 84873568650 scopus 로고    scopus 로고
    • NeuroDevelopment and infl ammatory patterns in schizophrenia in relation to pathophysiology. Prog Neuropsychopharmacol
    • Altamura AC, Pozzoli S, Fiorentini A, Dell osso B. NeuroDevelopment and infl ammatory patterns in schizophrenia in relation to pathophysiology. Prog Neuropsychopharmacol Biol Psychiatry. 2013 ; 42 : 63-70
    • (2013) Biol Psychiatry , vol.42 , pp. 63-70
    • Altamura, A.C.1    Pozzoli, S.2    Fiorentini, A.3    Dellosso, B.4
  • 42
    • 84867507735 scopus 로고    scopus 로고
    • Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia
    • Prasad KM, Watson AM, Dickerson FB, Yolken RH, Nimgaonkar VL. Exposure to herpes simplex virus type 1 and cognitive impairments in individuals with schizophrenia. Schizophr Bull. 2012 ; 38 : 1137-1148
    • (2012) Schizophr Bull , vol.38 , pp. 1137-1148
    • Prasad, K.M.1    Watson, A.M.2    Dickerson, F.B.3    Yolken, R.H.4    Nimgaonkar, V.L.5
  • 43
    • 73949137920 scopus 로고    scopus 로고
    • Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: Cytomegalovirus, infl uenza, herpes simplex, rubella, and Toxoplasma gondii
    • Carter CJ. Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: Cytomegalovirus, infl uenza, herpes simplex, rubella, and Toxoplasma gondii. Schizophr Bull. 2009 ; 35 : 1163-1182
    • (2009) Schizophr Bull , vol.35 , pp. 1163-1182
    • Carter, C.J.1
  • 44
    • 79551541660 scopus 로고    scopus 로고
    • Maternal infl uenza viral infection causes schizophrenia-like alterations of 5-HT 2 A and mGlu 2 receptors in the adult offspring
    • Moreno JL, Kurita M, Holloway T, Lpez J, Cadagan R, Martinez-Sobrido L, et al. Maternal infl uenza viral infection causes schizophrenia-like alterations of 5-HT 2 A and mGlu 2 receptors in the adult offspring. J Neurosci. 2011 ; 31 : 1863-1872
    • (2011) J Neurosci , vol.31 , pp. 1863-1872
    • Moreno, J.L.1    Kurita, M.2    Holloway, T.3    Lpez, J.4    Cadagan, R.5    Martinez-Sobrido, L.6
  • 46
    • 0031557184 scopus 로고    scopus 로고
    • Production of interferon-gamma in families with multiple occurrence of schizophrenia
    • Arolt V, Weitzsch C, Wilke I, Nolte A, Pinnow M, Rothermundt M, et al. Production of interferon-gamma in families with multiple occurrence of schizophrenia. Psychiatry Res. 1997 ; 66 : 145-152
    • (1997) Psychiatry Res , vol.66 , pp. 145-152
    • Arolt, V.1    Weitzsch, C.2    Wilke, I.3    Nolte, A.4    Pinnow, M.5    Rothermundt, M.6
  • 47
    • 0034057150 scopus 로고    scopus 로고
    • Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment
    • Arolt V, Rothermundt M, Wandinger KP, Kirchner H. Decreased in vitro production of interferon-gamma and interleukin-2 in whole blood of patients with schizophrenia during treatment. Mol Psychiatry. 2000 ; 5 : 150-158
    • (2000) Mol Psychiatry , vol.5 , pp. 150-158
    • Arolt, V.1    Rothermundt, M.2    Wandinger, K.P.3    Kirchner, H.4
  • 48
    • 18844454972 scopus 로고    scopus 로고
    • Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia
    • Avgustin B, Wraber B, Tavcar R. Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia. Croat Med J. 2005 ; 46 : 268-274
    • (2005) Croat Med J , vol.46 , pp. 268-274
    • Avgustin, B.1    Wraber, B.2    Tavcar, R.3
  • 52
    • 84877989534 scopus 로고    scopus 로고
    • Is T-helper type 2 shift schizophrenia-specifi c Primary results from a comparison of related psychiatric disorDers and healthy controls
    • Chiang SS, RieDel M, Schwarz M, Mueller N. Is T-helper type 2 shift schizophrenia-specifi c Primary results from a comparison of related psychiatric disorDers and healthy controls. Psychiatry Clin Neurosci. 2013 ; 67 : 228-236
    • (2013) Psychiatry Clin Neurosci , vol.67 , pp. 228-236
    • Chiang, S.S.1    Riedel, M.2    Schwarz, M.3    Mueller, N.4
  • 53
    • 0034742546 scopus 로고    scopus 로고
    • Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-Alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment
    • Erbagci AB, Herken H, Koyluoglu O, Yilmaz N, Tarak C ioglu M. Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-Alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment. Mediators Infl amm. 2001 ; 10 : 109-115
    • (2001) Mediators Infl Amm , vol.10 , pp. 109-115
    • Erbagci, A.B.1    Herken, H.2    Koyluoglu, O.3    Yilmaz, N.4    Tarak, C.5    Ioglu, M.6
  • 54
    • 0026534305 scopus 로고
    • SchrODer HC. Abnormalities in serum concentrations of interleukin-2, interferon-Alpha and interferon-gamma in schizophrenia not Detected
    • Gattaz WF, Dalgalarrondo P, SchrODer HC. Abnormalities in serum concentrations of interleukin-2, interferon-Alpha and interferon-gamma in schizophrenia not Detected. Schizophr Res. 1992 ; 6 : 237-241
    • (1992) Schizophr Res , vol.6 , pp. 237-241
    • Gattaz, W.F.1    Dalgalarrondo, P.2
  • 55
    • 0028970074 scopus 로고
    • Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia
    • Hornberg M, Arolt V, Wilke I, Kruse A, Kirchner H. Production of interferons and lymphokines in leukocyte cultures of patients with schizophrenia. Schizophr Res. 1995 ; 15 : 237-242
    • (1995) Schizophr Res , vol.15 , pp. 237-242
    • Hornberg, M.1    Arolt, V.2    Wilke, I.3    Kruse, A.4    Kirchner, H.5
  • 56
    • 79961128129 scopus 로고    scopus 로고
    • Soluble interleukin-2 receptor levels correlated with positive symptoms during quetiapine treatment in schizophrenia-spectrum disorDers
    • Igue R, Potvin S, Bah R, Stip E, Bouchard RH, Lipp O, et al. Soluble interleukin-2 receptor levels correlated with positive symptoms during quetiapine treatment in schizophrenia-spectrum disorDers. Prog Neuropsychopharmacol Biol Psychiatry. 2011 ; 35 : 1695-1698
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 1695-1698
    • Igue, R.1    Potvin, S.2    Bah, R.3    Stip, E.4    Bouchard, R.H.5    Lipp, O.6
  • 58
    • 0345627971 scopus 로고    scopus 로고
    • Decreased interleukin-2 production in Korean schizophrenic patients
    • Kim YK, Lee MS, Suh KY. Decreased interleukin-2 production in Korean schizophrenic patients. Biol Psychiatry. 1998 ; 43 : 701-704
    • (1998) Biol Psychiatry , vol.43 , pp. 701-704
    • Kim, Y.K.1    Lee, M.S.2    Suh, K.Y.3
  • 60
    • 84892414495 scopus 로고    scopus 로고
    • Impact of different antipsychotics on cytokines and tryptophan metabolites in stimulated cultures from patients with schizophrenia
    • Krause D, Weidinger E, Dippel C, RieDel M, Schwarz MJ, Mller N, et al. Impact of different antipsychotics on cytokines and tryptophan metabolites in stimulated cultures from patients with schizophrenia. Psychiatr Danub. 2013 ; 25 : 389-397
    • (2013) Psychiatr Danub , vol.25 , pp. 389-397
    • Krause, D.1    Weidinger, E.2    Dippel, C.3    Riedel, M.4    Schwarz, M.J.5    Mller, N.6
  • 61
    • 80052668528 scopus 로고    scopus 로고
    • Increased interleukin-6 level in Taiwanese schizophrenic patients
    • Lin CC, Chang CM, Chang PY, Huang TL. Increased interleukin-6 level in Taiwanese schizophrenic patients. Chang Gung Med J. 2011 ; 34 : 375-381
    • (2011) Chang Gung Med J , vol.34 , pp. 375-381
    • Lin, C.C.1    Chang, C.M.2    Chang, P.Y.3    Huang, T.L.4
  • 62
    • 40349111658 scopus 로고    scopus 로고
    • Monocytic Th1 and th2 cytokine alterations in the pathophysiology of schizophrenia
    • Na KS, Kim YK. Monocytic, Th1 and th2 cytokine alterations in the pathophysiology of schizophrenia. Neuropsychobiol. 2007 ; 56 : 55-63
    • (2007) Neuropsychobiol , vol.56 , pp. 55-63
    • Na, K.S.1    Kim, Y.K.2
  • 63
    • 50449086420 scopus 로고    scopus 로고
    • Increased tumor necrosis factor-Alpha concentrations with interleukin-4 concentrations in exacerbations of schizophrenia
    • O Brien SM, Scully P, Dinan TG. Increased tumor necrosis factor-Alpha concentrations with interleukin-4 concentrations in exacerbations of schizophrenia. Psychiatry Res. 2008 ; 160 : 256-262
    • (2008) Psychiatry Res , vol.160 , pp. 256-262
    • Obrien, S.M.1    Scully, P.2    Dinan, T.G.3
  • 65
    • 67449103836 scopus 로고    scopus 로고
    • Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients
    • Singh B, Bera NK, Nayak CR, Chaudhuri TK. Decreased serum levels of interleukin-2 and interleukin-6 in Indian Bengalee schizophrenic patients. Cytokine. 2009 ; 47 : 1-5
    • (2009) Cytokine , vol.47 , pp. 1-5
    • Singh, B.1    Bera, N.K.2    Nayak, C.R.3    Chaudhuri, T.K.4
  • 67
    • 80052853015 scopus 로고    scopus 로고
    • Meta-Analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects
    • Miller BJ, Buckley P, Seabolt W, Mellor A, Kirkpatrick B. Meta-Analysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects. Biol Psychiatry. 2011 ; 70 : 663-671
    • (2011) Biol Psychiatry , vol.70 , pp. 663-671
    • Miller, B.J.1    Buckley, P.2    Seabolt, W.3    Mellor, A.4    Kirkpatrick, B.5
  • 68
    • 40949107708 scopus 로고    scopus 로고
    • Infl ammatory cytokine alterations in schizophrenia: A systematic quantitative review
    • Potvin S, Stip E, Sepehry AA, Gendron A, Bah R, Kouassi E. Infl ammatory cytokine alterations in schizophrenia: A systematic quantitative review. Biol Psychiatry. 2008 ; 63 : 801-808
    • (2008) Biol Psychiatry , vol.63 , pp. 801-808
    • Potvin, S.1    Stip, E.2    Sepehry, A.A.3    Gendron, A.4    Bah, R.5    Kouassi, E.6
  • 70
    • 0034641533 scopus 로고    scopus 로고
    • Science commentary: Th1 and Th2 responses: What are they?
    • Berger A. Science commentary: Th1 and Th2 responses: What are they? BMJ. 2000 ; 321 : 424
    • (2000) BMJ , vol.321 , pp. 424
    • Berger, A.1
  • 71
    • 0037500008 scopus 로고    scopus 로고
    • Prevalence of hepatitis B virus among chronic schizophrenia patients
    • Said WM, Saleh R, Jumaian N. Prevalence of hepatitis B virus among chronic schizophrenia patients. East Mediterr Health J. 2001 ; 7 : 526-530
    • (2001) East Mediterr Health J , vol.7 , pp. 526-530
    • Said, W.M.1    Saleh, R.2    Jumaian, N.3
  • 72
    • 84862546714 scopus 로고    scopus 로고
    • Prevalence of hepatitis B and hepatitis C in patients with chronic schizophrenia living in institutions
    • Hung CC, Loh el-W, Hu TM, Chiu HJ, Hsieh HC, Chan CH, et al. Prevalence of hepatitis B and hepatitis C in patients with chronic schizophrenia living in institutions. J Chin Med Assoc. 2012 ; 75 : 275-280
    • (2012) J Chin Med Assoc , vol.75 , pp. 275-280
    • Hung, C.C.1    Loh, E.-W.2    Hu, T.M.3    Chiu, H.J.4    Hsieh, H.C.5    Chan, C.H.6
  • 73
    • 84873165474 scopus 로고    scopus 로고
    • Increased risk of hepatitis e virus infection in schizophrenia
    • Xue Y, Sun X, Li Y, Liu X, Dong C. Increased risk of hepatitis E virus infection in schizophrenia. Arch Virol. 2013 ; 158 : 359-365
    • (2013) Arch Virol , vol.158 , pp. 359-365
    • Xue, Y.1    Sun, X.2    Li, Y.3    Liu, X.4    Dong, C.5
  • 74
    • 84860120334 scopus 로고    scopus 로고
    • Absence of eviDence for bornavirus infection in schizophrenia, bipolar disorDer and major Depressive disorDer
    • Hornig M, Briese T, Licinio J, Khabbaz RF, Altshuler LL, Potkin SG, et al. Absence of eviDence for bornavirus infection in schizophrenia, bipolar disorDer and major Depressive disorDer. Mol Psychiatry. 2012 ; 17 : 486-493
    • (2012) Mol Psychiatry , vol.17 , pp. 486-493
    • Hornig, M.1    Briese, T.2    Licinio, J.3    Khabbaz, R.F.4    Altshuler, L.L.5    Potkin, S.G.6
  • 75
    • 84860132401 scopus 로고    scopus 로고
    • The game s afoot: Seeking viruses that cause chronic and Degenerative neurologic and psychiatric disorDer
    • Oldstone MB. The game s afoot: Seeking viruses that cause chronic and Degenerative neurologic and psychiatric disorDer. Mol Psychiatry. 2012 ; 17 : 472-473
    • (2012) Mol Psychiatry , vol.17 , pp. 472-473
    • Oldstone, M.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.