Decreased interleukin-2 production in Korean schizophrenic patients

Biological Psychiatry

Volumn 43, Issue 9, 1998, Pages 701-704

  Kim, Yong Ku ^a   Lee, Min Soo ^a   Suh, Kwang Yoon ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Autoimmune hypothesis; Ethnicity; Interleukin; Schizophrenia

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; PHYTOHEMAGGLUTININ;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; KOREA; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-2; INTERLEUKIN-6; KOREA; MALE; PHYTOHEMAGGLUTININS; SCHIZOPHRENIA;

EID: 0345627971     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(97)00357-0     Document Type: Article

References (20)

1. Diagnostic and Statistical Manual of Mental Disorders. 4th ed :1994;American Psychiatric Press, Washington, DC.
2. Durum SK, Oppenheim JJ. Macrophage-derived mediators Interleukin 1, tumor necrosis factor, interleukin 6, interferon, and related cytokine . Paul WE. Fundamental Immunology. 1989;639-676 Raven Press, New York.
3. Eaton WW, Hayward C, Ram R. Schizophrenia and rheumatoid arthritis A review . Schizophr Res. 6:1992;181-192.
4. Ganguli R, Rabin BS, Belle SH. Decreased interleukin-2 production in schizophrenic patients. Biol Psychiatry. 26:1989;427-430.
5. Ganguli R, Rabin BS. Increased serum interleukin 2 receptor concentration in schizophrenic and brain-damaged subjects. Arch Gen Psychiatry. 46:1989;292.
6. Ganguli R, Yang Z, Shurin G, Chengappa KNR, Brar JS, Gubbi AV, Rabin BS. Serum Interleukin-6 concentration in schizophrenia Elevation associated with duration of illness . Psychiatry Res. 51:1994;1-10.
7. Ganguli R, Brar JS, Chengappa KNR, Deleo M, Yang ZW, Shurin G, et al. Mitogen-stimulated interleukin-2 production in never-medicated, first-episode schizophrenic patients. Arch Gen Psychiatry. 52:1995;668-672.
8. Gattaz WF, Dalgalarrondo P, Schroder HC. Abnormalities in serum concentrations of interleukin-2, interferon-γ in schizophrenia not detected. Schizophr Res. 6:1992;237-241.
9. Kim YK, Lee MS (1996): Changes of interleukin levels in the serum of schizophrenic patients before and after haloperidol treatment. Presented at the 149th Annual Meeting of the American Psychiatric Association, New York, New York, May 4-9.
10. Kirch DG. Infection and autoimmunity as etiologic factors in schizophrenia A Review and reappraisal . Schizophr Bull. 19:1993;355-370.
11. Knight JG. Dopamine receptor stimulating autoantibody A possible cause of schizophrenia . Lancet. II:1982;1073-1075.
12. Kroemer G, Andreu JL, Gonzalo JA, Gutierrez RJ, Martinez C. Interleukin-2, autotolerance, and autoimmunity. Adv Immunol. 50:1991;147-235.
13. Licinio J, Seibyl JP, Altemus M, Charney DS, Krystal JH. Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. Am J Psychiatry. 150:1993;1408-1410.
14. McAllister CG, van Kammen DP, Rehn TJ, Miller AL, Gurklis J, Kelley ME, et al. Increases in CSF levels of IL-2 in schizophrenia Effects of recurrence of psychosis and medical status . Am J Psychiatry. 152:1995;1291-1297.
15. Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep. 10:1962;799-812.
16. Rapaport MH, McAllister CG, Nelson DL, Pickar D, Paul SM. Elevated levels of soluble interleukin 2 receptors in schizophrenia. Arch Gen Psychiatry. 46:1989;291-292.
17. Rapaport MH, McAllister CG, Kim YS, Han JH, Pickar D, Nelson DL, et al. Increased serum soluble interleukin-2 receptors in Caucasian and Korean schizophrenic patients. Biol Psychiatry. 35:1994;767-771.
18. Shintani F, Kanba S, Mauro N, Nakaki N, Nibuya M, Suzuki E, et al. Serum interleukin-6 in schizophrenic patients. Life Sci. 49:1991;661-664.
19. Smith RS. A comprehensive macrophage - T-lymphocyte theory of schizophrenia. Med Hypotheses. 39:1992;248-257.
20. Villemain F, Chatenoud L, Galinowski A, Homo-Delarche F, Ginestet D, Loo H, et al. Aberrant T cell-immunity in untreated schizophrenic patients Deficient interleukin-2 production . Am J Psychiatry. 146:1989;609-616.