Lessons learned at the intersection of immunology and neuroscience

Journal of Clinical Investigation

Volumn 122, Issue 4, 2012, Pages 1146-1148

  Steinman, Lawrence ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTRANSMITTER;

HUMAN; IMMUNE SYSTEM; IMMUNOLOGY; LYMPHOCYTE; MEMORY; NEUROSCIENCE; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SCIENTIST; SYNAPSE;

ADAPTIVE IMMUNITY; ALLERGY AND IMMUNOLOGY; ANIMALS; BRAIN; HUMANS; IMMUNITY; IMMUNITY, INNATE; IMMUNOLOGIC MEMORY; IMMUNOLOGICAL SYNAPSES; NERVOUS SYSTEM PHYSIOLOGICAL PHENOMENA; NEURODEGENERATIVE DISEASES; NEUROIMMUNOMODULATION; NEUROSCIENCES; SYNAPSES; TERMINOLOGY AS TOPIC;

EID: 84859701278     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI63493     Document Type: Review

References (20)

1. Irvine DJ, Purbhoo MA, Krogsgaard M, Davis MM. Direct observation of ligand recognition by T cells. Nature. 2002;419(6909):845-849. (Pubitemid 35238571)
2. Shatz CJ. MHC class I: an unexpected role in neuronal plasticity. Neuron. 2009;64(1):40-45.
3. Stevens B, et al. The classical complement cascade mediates CNS synapse elimination. Cell. 2007;131(6):1164-1178. (Pubitemid 350235022)
4. Dustin ML. Signaling at neuro/immune synapses. J Clin Invest. 2012;122(4):1149-1155.
5. Clark B, Hausser M. Neural coding: hybrid analog and digital signaling in axons. Curr Biol. 2009;16(15):R585-R588. (Pubitemid 44142990)
6. Das V, et al. Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. Immunity. 2004;20(5):577-588. (Pubitemid 38638127)
7. Bhat R, et al. Inhibitory role for GABA in auto-immune inflammation. Proc Natl Acad Sci U S A. 2010;107(6):2580-2585.
8. Glynn MW, et al. MHCI negatively regulates synapse density during the establishment of cortical connections. Nat Neurosci. 2011;14(4):442-451.
9. Andersson U, Tracey KJ. Reflex principles of immunological homeostasis [published online ahead of print March 24, 2011]. Annu Rev Immunol. doi:10.1146/annurev-immunol-020711-075015.
10. Wrammert J, et al. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature. 2008;453(7195):667-671. (Pubitemid 351769295)
11. Czirr E, Wyss-Coray T. The immunology of neurodegeneration. J Clin Invest. 2012;122(4):1156-1163.
12. Ransohoff RM, Brown MA. Innate immunity in the central nervous system. J Clin Invest. 2012; 122(4):1164-1171.
13. Wentzell JS, Bolkan BJ, Carmine-Simmen K, Swanson TL, Musashe DT, Kretzschmar D. Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration [published online ahead of print January 10, 2012]. Neurobiol Dis. doi:http://dx.doi.org/10.1016/ j.bbr.2011.03.031.
14. Schenk D. Amyloid-beta immunotherapy for Alzheimer's disease: the end of the beginning. Nat Rev Neurosci. 2002;3(10):824-828. (Pubitemid 135706694)
15. Wraith DC, Nicholson LB. The adaptive immune system in diseases of the central nervous system. J Clin Invest. 2012;122(4):1172-1179.
16. Kaul M, Lipton SA. Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS. J Neuroimmune Pharmacol. 2006;1(2):138-151. (Pubitemid 44257489)
17. Steinman L. Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab. Nat Rev Drug Discov. 2005;4(6):510-519.
18. Steinman L, Merrill JT, McInnes IB, Peakman M. Optimization of current and future therapy for autoimmune diseases. Nat Med. 2012; 18(1):59-65.
19. Steinman L, Oldstone MBA. More mayhem from molecular mimics. Nat Med. 1997;3(12):1321-1322. (Pubitemid 28011027)
20. Nylander A, Hafler DA. Multiple sclerosis. J Clin Invest. 2012;122(4):1180-1188.