INF-γ sensitizes head and neck squamous cell carcinoma cells to chemotherapy-induced apoptosis and necroptosis through up-regulation of Egr-1

Histology and Histopathology

Volumn 29, Issue 11, 2014, Pages 1437-1443

  Xu, Bei ^a   Shu, Yongqian ^a   Liu, Peng ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Egr 1; HNSCC; INF ; Necroptosis

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, HUMAN; FLUOROURACIL; GAMMA INTERFERON; THROMBOSPONDIN 1;

APOPTOSIS; DRUG EFFECTS; DRUG POTENTIATION; GENE EXPRESSION REGULATION; HEAD AND NECK TUMOR; HUMAN; METABOLISM; NECROSIS; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CISPLATIN; DRUG SYNERGISM; EARLY GROWTH RESPONSE PROTEIN 1; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; INTERFERON-GAMMA; NECROSIS; THROMBOSPONDIN 1; UP-REGULATION;

EID: 84929871457     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Ahn E.Y., Pan G., Vickers S.M. and McDonald J.M. (2002). IFN-gamma upregulates apoptosis-related molecules and enhances Fasmediated apoptosis in human cholangiocarcinoma. Int. J. Cancer 100, 445-451.
2. Baek S.J., Kim J.S., Moore S.M., Lee S.H., Martinez J. and Eling T.E. (2005). Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein. Mol. Pharmacol. 67, 356-364.
3. Balachandran S. and Adams G.P. (2013). Interferon-γ-induced necrosis: an antitumor biotherapeutic perspective. J. Interferon. Cytokine Res. 33, 171-180.
4. Bek M.J., Reinhardt H.C., Fischer K.G., Hirsch J.R., Hupfer C., Dayal E. and Pavenstädt H. (2003). Up-regulation of early growth response gene-1 via the CXCR3 receptor induces reactive oxygen species and inhibits Na+/K+-ATPase activity in an immortalized human proximal tubule cell line. J. Immunol. 170, 931-940.
5. Carlson C.B., Lawler J. and Mosher D.F. (2008). Structures of thrombospondins. Cell. Mol. Life. Sci. 65, 672-886.
6. Chen H., Herndon M.E. and Lawler J. (2000). The cell biology of thrombospondin-1. Matrix. Biol. 19, 597-614.
7. Declercq W., Vanden Berghe T. and Vandenabeele P. (2009). RIP kinases at the crossroads of cell death and survival. Cell 138, 229-232.
8. Degterev A., Huang Z., Boyce M., Li Y., Jagtap P., Mizushima N., Cuny G.D., Mitchison T.J., Moskowitz M.A. and Yuan J. (2005). Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat. Chem. Biol. 1, 112-119.
9. Fulda S. and Debatin K.M. (2006). 5-Aza-2'-deoxycytidine and IFNgamma cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8. Oncogene 25, 5125-5133.
10. Good D.J., Polverini P.J., Rastinejad F., Le Beau M.M., Lemons R.S., Frazier W.A. and Bouck N.P. (1990). A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin. Proc. Natl. Acad. Sci. USA 87, 6624-6628.
11. Häcker S., Dittrich A., Mohr A., Schweitzer T., Rutkowski S., Krauss J., Debatin K.M. and Fulda S. (2009). Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8. Oncogene 28, 3097-3110.
12. Han W., Pan H., Jiang L., Wei K., Zou D. and Zhang Z. (2011). A novel approach to rescue immune escape in oral squamous cell carcinoma: Combined use of interferon-γ and LY294002. Oncol. Rep. 25, 181-187.
13. He S., Wang L., Miao L., Wang T., Du F., Zhao L. and Wang X. (2009). Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 137, 1100-1111.
14. Hitomi J., Christofferson D.E., Ng A., Yao J., Degterev A., Xavier R.J. and Yuan J. (2008). Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 135, 1311-1323.
15. Horita H., Frankel A.E. and Thorburn A. (2008). Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms. PLoS. One 3, e3909.
16. Howard J.D., Lu B. and Chung C.H. (2012). Therapeutic targets in head and neck squamous cell carcinoma: identification, evaluation, and clinical translation. Oral. Oncol. 48, 10-17.
17. Jeon H.M., Lee S.Y., Ju M.K., Kim C.H., Park H.G. and Kang H.S. (2013). Early growth response 1 regulates glucose deprivationinduced necrosis. Oncol. Rep. 29, 669-675.
18. Kang H.S., Ock J., Lee H.J., Lee Y.J., Kwon B.M. and Hong S.H. (2013). Early growth response protein 1 upregulation and nuclear translocation by 2'-benzoyloxycinnamaldehyde induces prostate cancer cell death. Cancer Lett. 329, 217-227.
19. Kurdi M. and Booz G.W. (2007). Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fasinduced apoptosis of A549 human non-small cell lung cancer cells. J. Interferon Cytokine Res. 27, 23-31.
20. Lallemant B., Evrard A., Chambon G., Sabra O., Kacha S., Lallemant J.G., Lumbroso S. and Brouillet J.P. (2010). Gene expression profiling in head and neck squamous cell carcinoma: Clinical perspectives. Head Neck 32, 1712-1719.
21. Li K., Yang M., Yuen P.M., Chik K.W., Li C.K., Shing M.M., Lam H.K. and Fok T.F. (2003). Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3. Int. J. Mol. Med. 12, 995-1001.
22. Lissat A., Vraetz T., Tsokos M., Klein R., Braun M., Koutelia N., Fisch P., Romero M.E., Long L., Noellke P., Mackall C.L., Niemeyer C.M. and Kontny U. (2007). Interferon-gamma sensitizes resistant Ewing's sarcoma cells to tumor necrosis factor apoptosis-inducing ligand-induced apoptosis by up-regulation of caspase-8 without altering chemosensitivity. Am. J. Pathol. 170, 1917-1930.
23. Liu P., Wang Y., Li Y.H., Yang C., Zhou Y.L., Li B., Lu S.H., Yang R.C., Cai Y.L., Tobelem G., Caen J. and Han Z.C. (2003). Adenovirusmediated gene therapy with an antiangiogenic fragment of thrombospondin-1 inhibits human leukemia xenograft growth in nude mice. Leuk. Res. 27, 701-708.
24. Liu P., Li J., Lu H. and Xu B. (2009). Thalidomide inhibits leukemia cell invasion and migration by upregulation of early growth response gene 1. Leuk. Lymphoma 50, 109-113.
25. Liu F., Hu X., Zimmerman M., Waller J.L., Wu P., Hayes-Jordan A., Lev D. and Liu K. (2011). TNFα cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAILmediated apoptosis. PLoS. One 6, e16241.
26. Liu P., Xu B., Shen W., Zhu H., Wu W., Fu Y., Chen H., Dong H., Zhu Y., Miao K., Xu W. and Li J. (2012). Dysregulation of TNFα-induced necroptotic signaling in chronic lymphocytic leukemia: suppression of CYLD gene by LEF1. Leukemia 26, 1293-1300.
27. Mateo V., Brown E.J., Biron G., Rubio M., Fischer A., Deist F.L. and Sarfati M. (2002). Mechanisms of CD47-induced caspaseindependent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood 100, 2882-2890.
28. Nair P., Muthukkumar S., Sells S.F., Han S.S., Sukhatme V.P. and Rangnekar VM. (1997). Early growth response-1-dependent apoptosis is mediated by p53. J. Biol. Chem. 272, 20131-20138.
29. Rothenberg S.M. and Ellisen L.W. (2012). The molecular pathogenesis of head and neck squamous cell carcinoma. J. Clin. Invest. 122, 1951-1957.
30. Roué G., Bitton N., Yuste V.J., Montange T., Rubio M., Dessauge F., Delettre C., Merle-Béral H., Sarfati M. and Susin S.A. (2003). Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release. Biochimie 85, 741-746.
31. Saumet A., Slimane M.B., Lanotte M., Lawler J. and Dubernard V. (2005). Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells. Blood 106, 658-667.
32. Shin S.Y., Bahk Y.Y., Ko J., Chung I.Y., Lee Y.S., Downward J., Eibel H., Sharma P.M., Olefsky J.M., Kim Y.H., Lee B. and Lee Y.H. (2006). Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras. EMBO J. 25, 1093-1103.
33. Sun L., Wang H., Wang Z., He S., Chen S., Liao D., Wang L., Yan J., Liu W., Lei X. and Wang X. (2012). Mixed lineage kinase domainlike protein mediates necrosis signaling downstream of RIP3 kinase. Cell 148, 213-227.
34. Tekautz T.M., Zhu K., Grenet J., Kaushal D., Kidd V.J. and Lahti JM. (2006). Evaluation of IFN-gamma effects on apoptosis and gene expression in neuroblastoma--preclinical studies. Biochim. Biophys. Acta 1763, 1000-1010.
35. Weber A., Hengge U.R., Stricker I., Tischoff I., Markwart A., Anhalt K., Dietz A., Wittekind C. and Tannapfel A. (2007). Protein microarrays for the detection of biomarkers in head and neck squamous cell carcinomas. Hum. Pathol. 38, 228-238.
36. Wei H., Hongya P., Linlin J., Mujiang A., Kuijie W., Duohong Z., Qingang H. and Zhiyuan Z. (2011). IFN-γ enhances the anti-tumour immune response of dendritic cells against oral squamous cell carcinoma. Arch. Oral. Biol. 56, 891-898.
37. Wu W., Liu P. and Li J. (2012). Necroptosis: an emerging form of programmed cell death. Crit. Rev. Oncol. Hematol. 82, 249-258.
38. Xu B. and Liu P. (2009). 5-FU pretreatment potentiates cisplatin-induced apoptosis through up-regulation of thrombospondin-1 in head and neck squamous cell carcinomas. Cancer. Chemother. Pharmacol. 63, 1181-1183.
39. Xu B., Liu P., Li J. and Lu H. (2010). c-MYC depletion potentiates cisplatin-induced apoptosis in head and neck squamous cell carcinoma: involvement of TSP-1 up-regulation. Ann. Oncol. 21, 670-672.
40. Zhang D.W., Shao J., Lin J., Zhang N., Lu B.J., Lin S.C., Dong M.Q. and Han J. (2009). RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 325, 332-336.
41. Zhao H.Y., Ooyama A., Yamamoto M., Ikeda R., Haraguchi M., Tabata S., Furukawa T., Che X.F., Zhang S., Oka T., Fukushima M., Nakagawa M., Ono M., Kuwano M. and Akiyama S. (2008). Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil. Cancer Res. 68, 7035-7041.
42. Zhou Y., Weyman C.M., Liu H., Almasan A. and Zhou A. (2008). IFNgamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression. J. Interferon Cytokine Res. 28, 65-72.