-
2
-
-
35449005346
-
-
Tanaka F. UFT (Tegafur and Uracil) as postoperative adjuvant chemotherapy for solid tumors (Carcinoma of the lung, stomach, colon/rectum, and breast): clinical evidence, mechanism of action, and future direction. Surg Today 2007;37:923-43.
-
Tanaka F. UFT (Tegafur and Uracil) as postoperative adjuvant chemotherapy for solid tumors (Carcinoma of the lung, stomach, colon/rectum, and breast): clinical evidence, mechanism of action, and future direction. Surg Today 2007;37:923-43.
-
-
-
-
3
-
-
0031691506
-
Comparison of 5-fluorouracil pharma-cokinetics in patients receiving continuous 5-fluorouraci infusion and oral uracil plus 1-5(2-tertahydrofuryl)-5-fluorouracil
-
Ho DH, Pazdur R, Covington WP, et al. Comparison of 5-fluorouracil pharma-cokinetics in patients receiving continuous 5-fluorouraci infusion and oral uracil plus 1-5(2-tertahydrofuryl)-5-fluorouracil. Clin Cancer Res 1998;4:2085-8.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 2085-2088
-
-
Ho, D.H.1
Pazdur, R.2
Covington, W.P.3
-
4
-
-
33645744835
-
Advanced metastatic breast cancer using combination oral UFT-cyclophosphamide metronomic chemotherapy
-
Munoz R, Man S, Shaked Y, et al. Advanced metastatic breast cancer using combination oral UFT-cyclophosphamide metronomic chemotherapy. Cancer Res 2006;66:3386-91.
-
(2006)
Cancer Res
, vol.66
, pp. 3386-3391
-
-
Munoz, R.1
Man, S.2
Shaked, Y.3
-
5
-
-
45849103518
-
Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts
-
Ooyama A, Oka T, Zhao HY, et al. Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts. Cancer Lett 2008;267:26-36.
-
(2008)
Cancer Lett
, vol.267
, pp. 26-36
-
-
Ooyama, A.1
Oka, T.2
Zhao, H.Y.3
-
6
-
-
0036057596
-
Clinical studies of three oral prodrugs of 5-fluorouracil
-
Malet-Martino M, Martino R. Clinical studies of three oral prodrugs of 5-fluorouracil. Oncologist 2002;7:288-323.
-
(2002)
Oncologist
, vol.7
, pp. 288-323
-
-
Malet-Martino, M.1
Martino, R.2
-
8
-
-
19944432454
-
Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; implicatio ns for cellular surrogate marker analysis of antiangiogenesis
-
Shaked Y, Bertolini F, Man S, et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; implicatio ns for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell 2005;7:101-11.
-
(2005)
Cancer Cell
, vol.7
, pp. 101-111
-
-
Shaked, Y.1
Bertolini, F.2
Man, S.3
-
9
-
-
28044436491
-
Anti-angiogenic treatment of breast cancer using metronomic low-dose chemotherapy
-
Munoz R, Shaked Y, Bertolini F, et al. Anti-angiogenic treatment of breast cancer using metronomic low-dose chemotherapy. Breast 2005;14:466-79.
-
(2005)
Breast
, vol.14
, pp. 466-479
-
-
Munoz, R.1
Shaked, Y.2
Bertolini, F.3
-
10
-
-
0037138818
-
Up-regulation of thrombospondin-1gene by epidermal growth factor and transforming growth factor β in human cancer cells-transcriptional activation and messenger RNA stabilization
-
Okamoto M, Ono M, Uchiumi T, et al. Up-regulation of thrombospondin-1gene by epidermal growth factor and transforming growth factor β in human cancer cells-transcriptional activation and messenger RNA stabilization. Biochim Biophys Acta 2002;1574:24-34.
-
(2002)
Biochim Biophys Acta
, vol.1574
, pp. 24-34
-
-
Okamoto, M.1
Ono, M.2
Uchiumi, T.3
-
11
-
-
50649105970
-
Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells
-
In press
-
Zhao HY, Ooyama A, Yamamoto M, et al. Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells. Cancer Lett. In press. 2008.
-
(2008)
Cancer Lett
-
-
Zhao, H.Y.1
Ooyama, A.2
Yamamoto, M.3
-
12
-
-
54749093285
-
The egr-1 gene is induced by DNA-damaging agents and nongenotoxic drugs in both normal and neoplastic human cells
-
Quinones A, Dobberstein KU, Rainov NG. The egr-1 gene is induced by DNA-damaging agents and nongenotoxic drugs in both normal and neoplastic human cells. Life Sci 2003;2:297-5.
-
(2003)
Life Sci
, vol.2
, pp. 297-305
-
-
Quinones, A.1
Dobberstein, K.U.2
Rainov, N.G.3
-
14
-
-
0030660391
-
Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli
-
Hazzalin CA, Cuenda A, Cano E, et al. Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli. Oncogene 1997;15:2321-31.
-
(1997)
Oncogene
, vol.15
, pp. 2321-2331
-
-
Hazzalin, C.A.1
Cuenda, A.2
Cano, E.3
-
15
-
-
33750584030
-
HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: Implications for HER2-targeted antibody therapy
-
Wen XF, Yang G, Mao W, et al. HER2 signaling modulates the equilibrium between pro- and antiangiogenic factors via distinct pathways: implications for HER2-targeted antibody therapy. Oncogene 2006;25:6986-96.
-
(2006)
Oncogene
, vol.25
, pp. 6986-6996
-
-
Wen, X.F.1
Yang, G.2
Mao, W.3
-
16
-
-
0242331613
-
Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy
-
Bocci G, Francia G, Man S, Lawler J, Kerbel RS. Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A 2003;100:12917-22.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 12917-12922
-
-
Bocci, G.1
Francia, G.2
Man, S.3
Lawler, J.4
Kerbel, R.S.5
-
17
-
-
0037360164
-
Thrombospondins 1 and 2 function as inhibitors of angiogenesis
-
Armstrong LC, Bornstein P. Thrombospondins 1 and 2 function as inhibitors of angiogenesis. Matrix Biol 2003;22:63-71.
-
(2003)
Matrix Biol
, vol.22
, pp. 63-71
-
-
Armstrong, L.C.1
Bornstein, P.2
-
18
-
-
0024266436
-
Structural analysis and expression of the human thrombospondin gene promoter
-
Donoviel DB, Framson P, Eldridge CF, et al. Structural analysis and expression of the human thrombospondin gene promoter. J Biol Chem 1988;263:18590-93.
-
(1988)
J Biol Chem
, vol.263
, pp. 18590-18593
-
-
Donoviel, D.B.1
Framson, P.2
Eldridge, C.F.3
-
19
-
-
0024320180
-
Characterization of the promoter region of the human thrombospondin gene. DNA sequences within the first intron increase transcription
-
Laherty CD, Gierman TM, Dixit VM. Characterization of the promoter region of the human thrombospondin gene. DNA sequences within the first intron increase transcription. J Biol Chem 1989;264:11222-7.
-
(1989)
J Biol Chem
, vol.264
, pp. 11222-11227
-
-
Laherty, C.D.1
Gierman, T.M.2
Dixit, V.M.3
-
20
-
-
0028559569
-
Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene
-
Shingu T, Bornstein P. Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene. J Biol Chem 1994;269:32551-7.
-
(1994)
J Biol Chem
, vol.269
, pp. 32551-32557
-
-
Shingu, T.1
Bornstein, P.2
-
21
-
-
0041464740
-
Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth
-
Fahmy RG, Dass CR, Sun LQ, Chesterman CN, Khachigian LM. Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth. Nat Med 2003;9:1026-32.
-
(2003)
Nat Med
, vol.9
, pp. 1026-1032
-
-
Fahmy, R.G.1
Dass, C.R.2
Sun, L.Q.3
Chesterman, C.N.4
Khachigian, L.M.5
-
22
-
-
0034533374
-
Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
-
Yan SF, Fujita T, Lu J, et al. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med 2000;6:1355-61.
-
(2000)
Nat Med
, vol.6
, pp. 1355-1361
-
-
Yan, S.F.1
Fujita, T.2
Lu, J.3
-
23
-
-
0033000998
-
Pathways of Egr-1-mediated gene transcription in vascular biology
-
Silverman ES, Collins T. Pathways of Egr-1-mediated gene transcription in vascular biology. Am J Pathol 1999;154:665-70.
-
(1999)
Am J Pathol
, vol.154
, pp. 665-670
-
-
Silverman, E.S.1
Collins, T.2
-
24
-
-
0042068270
-
The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells
-
Pignatelli M, Luna-Medina R, Perez-Rendon A, Santos A, Perez-Castillo A. The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells. Biochem J 2003;373:739-46.
-
(2003)
Biochem J
, vol.373
, pp. 739-746
-
-
Pignatelli, M.1
Luna-Medina, R.2
Perez-Rendon, A.3
Santos, A.4
Perez-Castillo, A.5
-
25
-
-
0035199914
-
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
-
Virolle T, Adamson ED, Baron V, et al. The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling. Nat Cell Biol 2001;3:1124-8.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 1124-1128
-
-
Virolle, T.1
Adamson, E.D.2
Baron, V.3
-
26
-
-
0028212589
-
Suppression of v-sis-dependent transformation by the transcription factor, Egr-1
-
Huang RP, Darland T, Okamura D, Mercola D, Adamson ED. Suppression of v-sis-dependent transformation by the transcription factor, Egr-1. Oncogene 1994;9:1367-77.
-
(1994)
Oncogene
, vol.9
, pp. 1367-1377
-
-
Huang, R.P.1
Darland, T.2
Okamura, D.3
Mercola, D.4
Adamson, E.D.5
-
27
-
-
33746119582
-
Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth
-
Lucerna M, Pomyje J, Mechtcheriakova D, et al. Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth. Cancer Res 2006;66:6708-13.
-
(2006)
Cancer Res
, vol.66
, pp. 6708-6713
-
-
Lucerna, M.1
Pomyje, J.2
Mechtcheriakova, D.3
-
28
-
-
0035034537
-
Modulating sensitivity to drug-induced apoptosis: The future for chemotherapy
-
Makin G, Dive C. Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy. Breast Cancer Res 2001;3:150-3.
-
(2001)
Breast Cancer Res
, vol.3
, pp. 150-153
-
-
Makin, G.1
Dive, C.2
-
29
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, p38 protein kinases
-
Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, p38 protein kinases. Science 2002;298:1911-2.
-
(2002)
Science
, vol.298
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
30
-
-
0028022750
-
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
-
Rouse J, Cohen P, Trigon S, et al. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 1994;78:1027-37.
-
(1994)
Cell
, vol.78
, pp. 1027-1037
-
-
Rouse, J.1
Cohen, P.2
Trigon, S.3
-
31
-
-
0033538513
-
Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner
-
Rolli M, Kotlyarov A, Sakamoto KM, et al. Stress-induced stimulation of early growth response gene-1 by p38/stress-activated protein kinase 2 is mediated by a cAMP-responsive promoter element in a MAPKAP kinase 2-independent manner. J Biol Chem 1999;274:9559-64.
-
(1999)
J Biol Chem
, vol.274
, pp. 9559-9564
-
-
Rolli, M.1
Kotlyarov, A.2
Sakamoto, K.M.3
-
32
-
-
34447631538
-
Hsp27 (HspB1) and αB-crystallin (HspB5) as therapeutic targets
-
Arrigo AP, Simon S, Gibert B, et al. Hsp27 (HspB1) and αB-crystallin (HspB5) as therapeutic targets. FEBS Lett 2007;581:3665-74.
-
(2007)
FEBS Lett
, vol.581
, pp. 3665-3674
-
-
Arrigo, A.P.1
Simon, S.2
Gibert, B.3
-
33
-
-
0025934067
-
Cisplatin induces the small heat shock protein hsp25 and thermotolerance in Ehrlich ascites tumor cells
-
Oesterreich S, Schunck H, Benndorf R, Bielka H. Cisplatin induces the small heat shock protein hsp25 and thermotolerance in Ehrlich ascites tumor cells. Biochem Biophys Res Commun 1991;180:243-8.
-
(1991)
Biochem Biophys Res Commun
, vol.180
, pp. 243-248
-
-
Oesterreich, S.1
Schunck, H.2
Benndorf, R.3
Bielka, H.4
-
34
-
-
0029662027
-
Synthesis and accumulation of αB crystallin in C6 glioma cells is induced by agents that promote the disassembly of microtubules
-
Kato K, Ito H, Inaguma Y, et al. Synthesis and accumulation of αB crystallin in C6 glioma cells is induced by agents that promote the disassembly of microtubules. J Biol Chem 1996;271:26989-94.
-
(1996)
J Biol Chem
, vol.271
, pp. 26989-26994
-
-
Kato, K.1
Ito, H.2
Inaguma, Y.3
|