Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Horita, Henrick ^a   Frankel, Arthur E ^b   Thorburn, Andrew ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; DIPHTHERIA TOXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYBRID PROTEIN; APOPTOSIS REGULATORY PROTEIN; IMIDAZOLE DERIVATIVE; IMMUNOTOXIN; INDOLE DERIVATIVE; NECROSTATIN 1; NECROSTATIN-1; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL KILLING; CELL STRAIN U937; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NECROSIS; PROTEIN SYNTHESIS INHIBITION; DRUG EFFECT; ENZYMOLOGY; METABOLISM; PATHOLOGY; PROTEIN SYNTHESIS; TUMOR CELL LINE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; DIPHTHERIA TOXIN; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMIDAZOLES; IMMUNOTOXINS; INDOLES; LEUKEMIA, MYELOID, ACUTE; NECROSIS; PROTEIN BIOSYNTHESIS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS;

EID: 57749184733     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003909     Document Type: Article

References (24)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, et al. (2007) Cancer statistics, 2007. CA Cancer J Clin 57: 43-66.
2. Cros E, Jordheim L, Dumontet C, Galmarini CM (2004) Problems related to resistance to cytarabine in acute myeloid leukemia. Leuk Lymphoma 45: 1123-1132.
3. Kern W, Estey EH (2006) High-dose cytosine arabinoside in the treatment of acute myeloid leukemia: Review of three randomized trials. Cancer 107: 116-124.
4. Hogge DE, Willman CL, Kreitman RJ, Berger M, Hall PD, et al. (1998) Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein. Blood 92: 589-595.
5. Budel LM, Touw IP, Delwel R, Clark SC, Lowenberg B (1989) Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response. Blood 74: 565-571.
6. Terpstra W, Rozemuller H, Breems DA, Rombouts EJ, Prins A, et al. (1997) Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor eliminates acute myeloid leukemia cells with the potential to initiate leukemia in immunodeficient mice, but spares normal hemopoietic stem cells. Blood 90: 3735-3742.
7. Pastan I, Hassan R, Fitzgerald DJ, Kreitman RJ (2006) Immunotoxin therapy of cancer. Nat Rev Cancer 6: 559-565.
8. Thorburn A, Thorburn J, Frankel AE (2004) Induction of apoptosis by tumor cell-targeted toxins. Apoptosis 9: 19-25.
9. Holmes RK (2000) Biology and molecular epidemiology of diphtheria toxin and the tox gene. J Infect Dis 181 Suppl 1: S156-167.
10. Thorburn J, Frankel AE, Thorburn A (2003) Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin Cancer Res 9: 861-865.
11. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, et al. (2005) Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol 1: 112-119.
12. Han W, Li L, Qiu S, Lu Q, Pan Q, et al. (2007) Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther 6: 1641-1649.
13. Lin Y, Choksi S, Shen HM, Yang QF, Hur GM, et al. (2004) Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation. J Biol Chem 279: 10822-10828.
14. Vanden Berghe T, van Loo G, Saelens X, Van Gurp M, Brouckaert G, et al. (2004) Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. J Biol Chem 279: 7925-7933.
15. Lewis J, Devin A, Miller A, Lin Y, Rodriguez Y, et al. (2000) Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation. J Biol Chem 275: 10519-10526.
16. Horita H, Frankel AE, Thorburn A (2007) Acute myeloid leukemia-targeted toxins kill tumor cells by cell type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death. Leukemia 22: 652-655.
17. Hara T, Miyajima A (1996) Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis. Stem Cells 14: 605-618.
18. Thorburn A, Thorburn J, Frankel AE (2004) Induction of apoptosis by tumor cell-targeted toxins. Apoptosis 9: 19-25.
19. Thorburn J, Horita H, Redzic J, Hansen K, Frankel AE, et al. (2008) Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ, in Press; doi:10.1038/cdd.2008.143.
20. Thorburn A, Behbakht K, Ford H (2008) TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid them. Drug Resist Updates 11: 17-24.
21. Frankel AE, Powell BL, Hall PD, Case LD, Kreitman RJ (2002) Phase I trial of a novel diphtheria toxin/granulocyte macrophage colony-stimulating factor fusion protein (DT388GMCSF) for refractory or relapsed acute myeloid leukemia. Clin Cancer Res 8: 1004-1013.
22. Abi-Habib RJ, Liu S, Bugge TH, Leppla SH, Frankel AE (2004) A urokinase-activated recombinant diphtheria toxin targeting the granulocyte-macrophage colony-stimulating factor receptor is selectively cytotoxic to human acute myeloid leukemia blasts. Blood 104: 2143-2148.
23. Westcott MM, Abi-Habib RJ, Cohen KA, Willingham MC, Liu S, et al. (2004) Diphtheria toxin-murine granulocyte-macrophage colony-stimulating factor-induced hepatotoxicity is mediated by Kupffer cells. Mol Cancer Ther 3: 1681-1689.
24. Frankel A, Liu JS, Rizzieri D, Hogge D (2008) Phase I clinical study of diphtheria toxin-interleukin 3 fusion protein in patients with acute myeloid leukemia and myelodysplasia. Leuk Lymphoma 49: 543-553.