Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: Link between phosphatidylserine exposure and cytoskeleton organization

Blood

Volumn 100, Issue 8, 2002, Pages 2882-2890

  Mateo, Véronique ^a,b,c,d   Brown, Eric J ^a,b,c,d   Biron, Guy ^a,b,c,d   Rubio, Manuel ^a,b,c,d   Fischer, Alain ^a,b,c,d   Le Deist, Françoise ^a,b,c,d   Sarfati, Marika ^a,b,c,d,e  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUT PASTEUR   (France)

^d HÔPITAL NECKER ENFANTS MALADES   (France)

^e NOTRE DAME HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CD47 ANTIGEN; CYTOCHALASIN D; PHOSPHATIDYLSERINE; THROMBOSPONDIN; WISKOTT ALDRICH SYNDROME PROTEIN;

ANTIGEN PRESENTING CELL; APOPTOSIS; ARTICLE; CELL DEATH; CHIMERA; CONTROLLED STUDY; CYTOSKELETON; DENDRITIC CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PHAGOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; WISKOTT ALDRICH SYNDROME;

EID: 0037108440     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2001-12-0217     Document Type: Article

References (79)

1. Rathmell JC, Thompson CB. The central effectors of cell death in the immune system. Annu Rev Immunol. 1999;17:781-828.
2. Vaux DL, Korsmeyer SJ. Cell death in development. Cell. 1999;96:245-254.
3. Scaffidi C, Kirchhoff S, Krammer PH, Peter ME. Apoptosis signaling in lymphocytes. Curr Opin Immunol. 1999;11:277-285.
4. Larsson M, Fonteneau JF, Bhardwaj N. Dendritic cells resurrect antigens from dead cells. Trends Immunol. 2001;22:141-148.
5. Strasser A, O'Connor L, Dixit VM. Apoptosis signaling. Annu Rev Biochem. 2000;69:217-245.
6. Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulation in apoptosis and necrosis. Annu Rev Physiol. 1998;60:619-642.
7. Savill J, Fadok V. Corpse clearance defines the meaning of cell death. Nature. 2000;407: 784-788.
8. Sarin A, Wu ML, Henkart PA. Different interleukin-1 beta converting enzyme (ICE) family protease requirements for the apoptotic death of T lymphocytes triggered by diverse stimuli. J Exp Med. 1996;184:2445-2450.
9. Xiang J, Chao DT, Korsmeyer SJ. BAX-induced cell death may not require interleukin 1 betaconverting enzyme-like proteases. Proc Natl Acad Sci U S A. 1996;93:14559-14563.
10. Kim K, Lee C, Sayers TJ, Muegge K, Durum SK. The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways. J Immunol. 1998;160: 5735-5741.
11. Deas O, Dumont C, MacFarlane M, et al. Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes. J Immunol. 1998;161:3375-3383.
12. Lesage S, Steff AM, Philippoussis F, et al. CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway. J Immunol. 1997;159:4762-4771.
13. Mateo V, Lagneaux L, Bron D, et al. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nat Med. 1999;5: 1277-1284.
14. Pettersen RD, Hestdal K, Olafsen MK, Lie SO, Lindberg FP. CD47 signals T cell death. J Immunol. 1999;162:7031-7040.
15. Pettersen RD, Bernard G, Olafsen MK, Pourtein M, Lie SO. Cd99 signals caspase-independent T cell death. J Immunol. 2001;166:4931-4942.
16. Skov S, Klausen P, Claesson MH. Ligation of major histocompatability complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: a novel apoptotic pathway distinct from Fas-induced apoptosis. J Cell Biol. 1997; 139:1523-1531.
17. Drenou B, Blancheteau V, Burgess DH, Fauchet R, Charron DJ, Mooney NA. A caspase-independent pathway of MHC class II antigen-mediated apoptosis of human B lymphocytes. J Immunol. 1999;163:4115-4124.
18. Reinhold MI, Lindberg FP, Plas D, Reynolds S, Peters MG, Brown EJ. In vivo expression of alternatively spliced forms of integrin-associated protein (CD47). J Cell Sci. 1995;108:3419-3425.
19. Gao AG, Lindberg FP, Finn MB, Blystone SD, Brown EJ, Frazier WA. Integrin-associated protein is a receptor for the C-terminal domain of thrombospondin. J Biol Chem. 1996;271:21-24.
20. Vernon-Wilson EF, Kee WJ, Willis AC, Barclay AN, Simmons DL, Brown MH. CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1. EurJ Immunol. 2000;30:2130-2137.
21. Brown EJ, Frazier WA. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol. 2001;11:130-135.
22. Armant M, Avice MN, Hermann P, et al. CD47 ligation selectively downregulates human interleukin 12 production. J Exp Med. 1999;190:1175-1182.
23. Demeure CE, Tanaka H, Mateo V, Rubio M, Delespesse G, Sarfati M. CD47 engagement inhibits cytokine production and maturation of human dendritic cells. J Immunol. 2000;164:2193-2199.
24. Avice MN, Rubio M, Sergerie M, Delespesse G, Sarfati M. CD47 ligation selectively inhibits the development of human naive T cells into Th1 effectors. J Immunol. 2000;165:4624-4631.
25. Avice MN, Rubio M, Sergerie M, Delespesse G, Sarfati M. Role of cd47 in the induction of human naive T cell anergy. J Immunol. 2001;167:2459-2468.
26. Reinhold MI, Lindberg FP, Kersh GJ, Allen PM, Brown EJ. Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway. J Exp Med. 1997;185:1-11.
27. Rebres RA, Green JM, Reinhold MI, Ticchioni M, Brown EJ. Membrane raft association of CD47 is necessary for actin polymerization and PKCθ translocation in T cells. J Biol Chem. 2000;15:2.
28. Latour S, Tanaka H, Demeure C, et al. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation. J Immunol. 2001;167:2547-2554.
29. Ticchioni M, Deckert M, Mary F, Bernard G, Brown EJ, Bernard A. Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells. J Immunol. 1997;158: 677-684.
30. Waclavicek M, Majdic O, Stulnig T, et al. T cell stimulation via CD47: agonistic and antagonistic effects of CD47 monoclonal antibody 1/1A4. J Immunol. 1997;159;5345-5354.
31. Green JM, Zhelesnyak A, Chung J. Role of cholesterol in formation and function of a signaling complex involving alphaVbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins. J Cell Biol. 1999;146:673-682.
32. Zhou M, Brown EJ. Leukocyte response integrin and integrin-associated protein act as a signal transduction unit in generation of a phagocyte respiratory burst. J Exp Med. 1993;178:1165-1174.
33. Susin SA, Daugas E, Ravagnan L, et al. Two distinct pathways leading to nuclear apoptosis. J Exp Med. 2000;192:571-580.
34. Kawahara A, Ohsawa Y, Matsumura H, Uchiyama Y, Nagata S. Caspase-independent cell killing by Fas-associated protein with death domain. J Cell Biol. 1998;143:1353-1360.
35. Holler N, Zaru R, Micheau O, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 2000;1:489-495.
36. Dumont C, Durrbach A, Bidere N. Caspase-independent commitment phase to apoptosis in activated blood T lymphocytes: reversibility at low apoptotic insult. Blood. 2000;96:1030-1038.
37. Blystone SD, Lindberg FP, Williams MP, McHugh KP, Brown EJ. Inducible tyrosine phosphorylation of the beta3 integrin requires the alphaV integrin cytoplasmic tail. J Biol Chem. 1996;271:31458-31462.
38. Bortner CD, Hughes FM, Cidlowski JA. A primary role for K+ and Na+ efflux in the activation of apoptosis. J Biol Chem. 1997;272:32436-32442.
39. Samali A, Zhivotovsky B, Jones D, Nagata S, Orrenius S. Apoptosis: cell death defined by caspase activation. Cell Death Differ. 1999;6:495-496.
40. Krahling S, Callahan MK, Williamson P, Schlegel RA. Exposure of phosphatidylserine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages. Cell Death Differ. 1999;6: 183-189.
41. Albert ML, Pearce SF, Francisco LM, et al. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J Exp Med. 1998;188:1359-1368.
42. Chandra J, Gilbreath J, Freireich EJ, et al. Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes. Blood. 1997;90:3673-3681.
43. Holyoake TL, Alcorn MJ. CD34+ positive haemopoietic cells: biology and clinical applications. Blood Rev. 1994;8:113-124.
44. Messner HA. Assessment and characterization of hemopoietic stem cells. Stem Cells. 1995; 13(suppl 3):13-18.
45. Lindberg FP, Gresham HD, Schwarz E, Brown EJ. Molecular cloning of integdn-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J Cell Biol. 1993;123:485-496.
46. Reinhold MI, Green JM, Lindberg FP, Ticchioni M, Brown EJ. Cell spreading distinguishes the mechanism of augmentation of T cell activation by integrin-associated protein/CD47 and CD28. Int Immunol. 1999;11:707-718.
47. Lindberg FP, Gresham HD, Reinhold MI, Brown EJ. Integrin-associated protein immunoglobulin domain is necessary for efficient vitronectin bead binding. J Cell Biol. 1996;134:1313-1322.
48. Gomez-Angelats M, Bortner CD, Cidlowski JA. Cell volume regulation in immune cell apoptosis. Cell Tissue Res. 2000;301:33-42.
49. Dallaporta B, Hirsch T, Susin SA, et al. Potassium leakage during the apoptotic degradation phase. J Immunol. 1998;160:5605-5615.
50. Bortner CD, Cidlowski JA. Caspase independent/dependent regulation of K(+), cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis. J Biol Chem, 1999;274:21953-21962.
51. Frasch SC, Henson PM, Kailey JM, et al. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J Biol Chem. 2000;275:23063-23073.
52. Yoshida H, Tomiyama Y, Ishikawa J, et al. Integrin-associated protein/CD47 regulates motile activity in human B-cell lines through CDC42. Blood. 2000;96:234-241.
53. Brown SB, Clarke MCH, Magowan L, Sanderson H, Savill J. Constitutive death of platelets leading to scavenger receptor-mediated phagocytosis: a caspase-independent cell clearance program. J Biol Chem. 2000;275:5987-5996.
54. Fadok VA, de Cathelineau A, Daleke DL, Henson PM, Bratton DL. Loss of phospholipid asymmetry and surface exposure of phosphatidylserine is required for phagocytosis of apoptotic cells by macrophages and fibroblasts. J Biol Chem. 2001; 276:1071-1077.
55. Fadok VA, Bratton DL, Rose DM, Pearson A, Ezekewitz RA, Henson PM. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature. 2000;405:85-90.
56. Zhuang J, Ren Y, Snowden RT, et al. Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program. J Biol Chem. 1998;273:15628-15632.
57. Hirt UA, Gantner F, Leist M. Phagocytosis of nonapoptotic cells dying by caspase-independent mechanisms. J Immunol. 2000;164:6520-6529.
58. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312-1316.
59. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med. 2000;6:513-519.
60. Daugas E, Susin SA, Zamzami N, et al. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J. 2000;14:729-739.
61. Reed JC. Cytochrome c: can't live with it-can't live without it. Cell. 1997;91:559-562.
62. Bruey J-M, Ducasset C, Bonniaud P, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000;2:645-652.
63. Katz E, Deehan MR, Seatter S, Lord C, Sturrock RD, Hamett MM. B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells. J lmmunol. 2001;166:137-147.
64. Shimizu S, Tsujimoto Y. Proapoptotic BH3-only Bcl-2 family members induce cytochrome c release, but not mitochondrial membrane potential loss, and do not directly modulate voltage-dependent anion channel activity. Proc Natl Acad Sci U S A. 2000;97:577-582.
65. Yu SP, Choi DW. Ions, cell volume, and apoptosis. Proc Natl Acad Sci U S A. 2000;97:9360-9362.
66. Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y. Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci U S A. 2000; 97:9487-9492.
67. Tzung SP, Kim KM, Basanez G, et al. Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. Nat Cell Biol. 2001;3:183-191.
68. Erickson JW, Cerione RA. Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol. 2001;13:153-157.
69. Thrasher AJ, Burns S, Lorenzi R, Jones GE. The Wiskott-Aldrich syndrome: disordered actin dynamics in haematopoietic cells. Immunol Rev. 2000;178:118-128.
70. Machesky LM, Insall RH. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Curr Biol. 1998;8:1347-1356.
71. Bertho N, Drenou B, Laupeze B, et al. HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC. J Immunol. 2000;164:2379-2385.
72. Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br Med Bull. 1997;53:491-508.
73. Chen W, Frank ME, Jin W, Wahl SM. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity. 2001;14: 715-725.
74. Henson PM, Bratton DL, Fadok V. The phosphatidylserine receptor: a crucial molecular switch? Nat Rev Mol Cell Biol. 2001;2:627-633.
75. Crawford SE, Stellmach V, Murphy-Ullrich JE, Hynes RO, Boivin GP, Bouck N. Thrombospondin-1 is a major activator of TGF-β1 in vivo. Cell. 1998;93:1159-1170.
76. Masli S, Turpie B, Hecker KH, Streilein JW. Expression of thrombospondin in TGFβ-treated APCs and its relevance to their immune deviation-promoting properties. J Immunol. 2002;168: 2264-2273.
77. Oldenborg PA, Zheleznyak A, Fang YF, Lagenaur CF, Gresham HD, Lindberg FP. Role of CD47 as a marker of self on red blood cells. Science. 2000;288:2051-2054.
78. Guo K, Wolf V, Dharmarajan AM, et al. Apoptosis-associated gene expression in the corpus luteum of the rat. Biol Reprod. 1998;58:739-746.
79. Savill J, Dransfield I, Hogg N, Haslett C. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature. 1990;343:170-173.