Lithium attenuates cannabinoid-induced dependence in the animal model: Involvement of phosphorylated ERK1/2 and GSK-3β signaling pathways

Acta Medica Iranica

Volumn 52, Issue 9, 2014, Pages 656-663

  Rahimi, Hamid Reza ^a   Dehpour, Ahmad Reza ^a   Mehr, Shahram Ejtemaei ^a   Sharifzadeh, Mohammad ^a   Ghahremani, Mohammad Hossein ^a   Razmi, Ali ^b   Ostad, Seyed Nasser ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

Author keywords

212 2; Cannabinoid receptor; Neuroprotection; Protein kinase; WIN 55

Indexed keywords

ALPHA [AMINO(4 AMINOPHENYLTHIO)METHYLENE] 2 (TRIFLUOROMETHYL)PHENYLACETONITRILE; CANNABINOID; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; BENZOXAZINE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE;

ADULT; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; IMMUNOBLOTTING; MALE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; WITHDRAWAL SYNDROME; ANIMAL; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; WISTAR RAT;

ANIMALS; BENZOXAZINES; CANNABINOIDS; DISEASE MODELS, ANIMAL; GLYCOGEN SYNTHASE KINASE 3; LITHIUM; MALE; MORPHOLINES; NAPHTHALENES; PHOSPHORYLATION; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84929868933     PISSN: 00446025     EISSN: 17359694     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Perkonigg A, Lieb R, Höfler M, et al. Patterns of cannabis use, abuse and dependence over time: incidence, progression and stability in a sample of 1228 adolescents. Addiction 1999;94(11):1663-78.
2. Crowley TJ, Macdonald MJ, Whitmore EA, et al. Cannabis dependence, withdrawal, and reinforcing effects among adolescents with conduct symptoms and substance use disorders. Drug Alcohol Depend 1998;50(1):27-37.
3. Kouri EM, Pope HG Jr, Lukas SE. Changes in aggressive behavior during withdrawal from long-term marijuana use. Psychopharmacology (Berl) 1999;143(3):302-8.
4. Valverde O, Maldonado R, Valjent E, et al. Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice. J Neurosci 2000;20(24):9284-9.
5. Castañé A, Maldonado R, Valverde O. Role of different brain structures in the behavioural expression of WIN 55,212-2 withdrawal in mice. Br J Pharmacol 2004;142(8):1309-17.
6. Pan B, Zhong P, Sun D, et al. Extracellular signalregulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects. J Neurosci 2011;31(31):11244-55.
7. Hutcheson DM, Tzavara ET, Smadja C, ValjentEet al. Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9- tetrahydrocannabinol. Br J Pharmacol 1998;125(7):1567-77.
8. Howlett AC. The cannabinoid receptors. Prostaglandins Other Lipid Mediat 2002;68-69:619-31.
9. Valjent E, Pagès C, Rogard M, et al. Delta 9- tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depend on dopaminergic transmission. Eur J Neurosci 2001;14(2):342-52.
10. Valjent E, Pagès C, Hervé D, et al. Addictive and nonaddictive drugs induce distinct and specific patterns of ERK activation in mouse brain. Eur J Neurosci 2004;19(7):1826-36.
11. Barbara JG, Auclair N, Roisin MP, et al. Direct and indirect interactions between cannabinoid CB1 receptor and group II metabotropic glutamate receptor signaling in layer V pyramidal neurons from the rat prefrontal cortex. Eur J Neurosci 2003;17(5):981-90.
12. Derkinderen P, Valjent E, Toutant M, et al. Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. J Neurosci 2003;23(6):2371-82.
13. Rubino T, Forlani G, Viganò D, et al. Ras/ERKsignalling in cannabinoidtolerance: from behaviour to cellular aspects. J Neurochem 2005;93(4):984-91.
14. Wei YM, Li SX, Shi HS, et al. Protracted cocaine withdrawal produces circadian rhythmic alterations of phosphorylated GSK-3β in reward-related brain areas in rats. Behav Brain Res 2011;218(1):228-33.
15. Kim S, Lee KY, Koh SH, et al. Role of the phosphatidylinositol 3-kinase and extracellular signalregulated kinase pathways in the neuroprotective effects of cilnidipine against hypoxia in a primary culture of cortical neurons. NeurochemInt 2012;61(7):1172-82.
16. Linseman DA, Butts BD, Precht TA, Phelps RA, et al. Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 2004;24(44):9993-10002.
17. Hongisto V, Smeds N, Brecht S, et al. Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Mol Cell Biol 2003;23(17):6027-36.
18. Beaulieu JM, Gainetdinov RR, Caron MG. The Akt-GSK- 3 signaling cascade in the actions of dopamine. Trends Pharmacol Sci 2007;28(4):166-72.
19. Chuang DM, Wang Z, Chiu CT. GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke. Front Mol Neurosci 2011;4(1):15.
20. Pardo R, Andreolotti AG, Ramos B, et al. Opposed effects of lithium on the MEK-ERK pathway in neural cells: inhibition in astrocytes and stimulation in neurons by GSK3 independent mechanisms. J Neurochem 2003;87(2):417-26.
21. Rezania F, Mehr SE, Kheirkhah M, et al. The effect of lithium chloride on WIN 55,212-2-induced tolerance in isolated guinea pig ileum. Eur J Pharmacol 2010;627(1- 3):265-8.
22. Dehpour AR, Farsam H, Azizabadi-Farahani M. Inhibition of the morphine withdrawal syndrome and the development of physical dependence by lithium in mice. Neuropharmacology 1995;34(1):115-21.
23. Dehpour AR, Sadr SS, Nouroddini M, et al. Comparison of simultaneous administration of lithium with L-NAME or L-arginine on morphine withdrawal syndrome in mice. Hum Psychopharmacol 2000;15(2):87-93.
24. Dehpour AR, Sadr SS, Azizi MR, et al. Lithium inhibits the development of physical dependence to clonidine in mice. Pharmacol Toxicol 2002;90(2):89-93.
25. Ghasemi M, Dehpour AR. Ethical considerations in animal studies. J Med Ethics Hist Med 2009;2(1):12.
26. Moranta D, Esteban S, García-Sevilla JA. Acute, chronic and withdrawal effects of the cannabinoid receptor agonist WIN55212-2 on the sequential activation of MAPK/Raf- MEK-ERK signaling in the rat cerebral frontal cortex: short-term regulation by intrinsic and extrinsic pathways. J Neurosci Res 2007;85(3):656-67.
27. Hosseini-Sharifabad A, Ghahremani MH, Sabzevari O, et al. Effects of protein kinase A and G inhibitors on hippocampal cholinergic markers expressions in rolipramand sildenafil-induced spatial memory improvement. Pharmacol Biochem Behav 2012;101(3):311-9.
28. Rahimi HR, Hasanli E, Jamalifar H.A mini review on new pharmacological and toxicological considerations of protease inhibitors' application in cancer prevention and biological research. Asian J Cell Biol 2012;7(1):1-12.
29. Sim-Selley LJ. Regulation of cannabinoid CB1 receptorsin the central nervous system by chronic cannabinoids. Crit Rev Neurobiol 2003;15(2):91-119.
30. Pourkhalili N, Ghahremani MH, Farsandaj N, et al. Evaluation of anti-invasion effect of cannabinoids on human hepatocarcinoma cells. Toxicol Mech Methods 2013;23(2):120-6.
31. Farsandaj N, Ghahremani MH, Ostad SN. Role of cannabinoid and vanilloid receptors in invasion of human breast carcinoma cells. J Environ Pathol Toxicol Oncol 2012;31(4):377-87.
32. Swift W, Hall W, Teesson M. Cannabis use and dependence among Australian adults: results from the National Survey of Mental Health and Wellbeing. Addiction 2001;96(5):737-48.
33. Copeland J, Swift W. Cannabis use disorder: epidemiology and management. Int Rev Psychiatry 2009;21(2):96-103.
34. Alimoradi H, Pourmohammadi N, Mehr SE, et al. Effects of lithium on peripheral neuropathy induced by vincristine in rats. Acta Med Iran 2012;50(6):373-9.
35. Pourmohammadi N, Alimoradi H, Mehr SE, et al. Lithium attenuates peripheral neuropathy induced by paclitaxel in rats. Basic Clin Pharmacol Toxicol 2012;110(3):231-7.
36. Sharifzadeh M, Rezaei H, Ghamsari MR. Interactive Effects of Acute and Chronic Lithium with Dopamine Receptor Antagonists on Naloxone-Induced Jumping in Morphine-Dependent Mice. Iran J Pharm Res 2003;2(4): 217-223.
37. Kiyani A, Javadi-Paydar M, Mohammadkhani H, et al. Lithium chloride disrupts consolidation of morphineinduced conditioned place preference in male mice: the nitric oxide/cyclic GMP signaling pathway. Behav Brain Res 2011;219(2):240-7.
38. De Vries TJ, Shaham Y, Homberg JR, et al. A cannabinoid mechanism in relapse to cocaine seeking. Nat Med 2001;7(10):1151-4.
39. Karimi S, Azizi P, Shamsizadeh A, et al. Role of intraaccumbal cannabinoid CB1 receptors in the potentiation, acquisition and expression of morphine-induced conditioned place preference. Behav Brain Res 2013;247:125-31.
40. Huang CC, Chen YL, Lo SW, et al. Activation of cAMPdependent protein kinase suppresses the presynaptic cannabinoid inhibition of glutamatergic transmission at corticostriatal synapses. Mol Pharmacol 2002;61(3):578-85.
41. Filip M, Zaniewska M, Frankowska M, et al. The importance of the adenosine A(2A) receptor-dopamine D(2) receptor interaction in drug addiction. Curr Med Chem 2012;19(3):317-55.
42. Ghasemi M, Dehpour AR. The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium. Trends Pharmacol Sci 2011;32(7):420-34.
43. Cale JM, Bird IM. Inhibition of MEK/ERK1/2 signalling alters endothelial nitric oxide synthase activity in an agonistdependent manner. Biochem J 2006;398(2):279-88.
44. Tzavara ET, Valjent E, Firmo C, et al. Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum. Eur J Neurosci 2000;12(3),1038-46.
45. Hammonds MD, Shim SS, Feng P, Calabrese JR. Effects of subchronic lithium treatment on levels of BDNF, Bcl-2 and phospho-CREB in the rat hippocampus. Basic Clin Pharmacol Toxicol 2007;100(5):356-9.
46. Zhuang LL, Jin R, Zhu LH, Xu HG, Li Y, Gao S, Liu JY, Zhou GP. Promoter Characterization and Role of cAMP/PKA/CREB in the Basal Transcription of the Mouse ORMDL3 Gene. PLoS One 2013;8(4):e60630.
47. Cao JL, Liu HL, Wang JK, Zeng YM. Cross talk between nitric oxide and ERK1/2 signaling pathway in the spinal cord mediates naloxone-precipitated withdrawal in morphine-dependent rats. Neuropharmacology 2006;51(2):315-26.
48. Pertwee RG. Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities. Philos Trans R SocLond B Biol Sci 2012;367(1607):3353-63.