Promoter Characterization and Role of cAMP/PKA/CREB in the Basal Transcription of the Mouse ORMDL3 Gene

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Zhuang, Li Li ^a   Jin, Rui ^a   Zhu, Liang Hua ^a   Xu, Hua Guo ^a   Li, Yue ^a   Gao, Shan ^a   Liu, Jia Yin ^a   Zhou, Guo Ping ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; FORSKOLIN; LUCIFERASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA FLANKING REGION; FIBROBLAST; GEL MOBILITY SHIFT ASSAY; GENE; GENE DELETION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; ORMDL3 GENE; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION;

ANIMALS; BASAL METABOLISM; BASE SEQUENCE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MICE; NIH 3T3 CELLS; PROMOTER REGIONS, GENETIC; RATS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

ANIMALIA; MUS;

EID: 84875940234     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0060630     Document Type: Article

References (26)

1. Hjelmqvist L, Tuson M, Marfany G, Herrero E, Balcells S, et al. (2002) ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Genome Biol 3: RESEARCH0027.
2. Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, et al. (2007) Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448: 470-473.
3. Brauner EV, Loft S, Raaschou-Nielsen O, Vogel U, Andersen PS, et al. (2012) Effects of a 17q21 chromosome gene variant, tobacco smoke and furred pets on infant wheeze. Genes Immun 13: 94-97.
4. McGovern DP, Gardet A, Torkvist L, Goyette P, Essers J, et al. (2010) Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 42: 332-337.
5. Laukens D, Georges M, Libioulle C, Sandor C, Mni M, et al. (2010) Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis. PLoS One 5: e13795.
6. Saleh NM, Raj SM, Smyth DJ, Wallace C, Howson JM, et al. (2011) Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes. Diabetes Metab Res Rev 27: 838-843.
7. Kurreeman FA, Stahl EA, Okada Y, Liao K, Diogo D, et al. (2012) Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12. Am J Hum Genet 90: 524-532.
8. Lluis A, Schedel M, Liu J, Illi S, Depner M, et al. (2011) Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion. J Allergy Clin Immunol 127: 1587-1594 e1586.
9. Miller M, Tam AB, Cho JY, Doherty TA, Pham A, et al. (2012) ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6. Proc Natl Acad Sci U S A 109: 16648-16653.
10. Hirota T, Harada M, Sakashita M, Doi S, Miyatake A, et al. (2008) Genetic polymorphism regulating ORM1-like 3 (Saccharomyces cerevisiae) expression is associated with childhood atopic asthma in a Japanese population. J Allergy Clin Immunol 121: 769-770.
11. Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, et al. (2010) A large-scale, consortium-based genomewide association study of asthma. N Engl J Med 363: 1211-1221.
12. Contoli M, Caramori G, Mallia P, Johnston S, Papi A, (2005) Mechanisms of respiratory virus-induced asthma exacerbations. Clin Exp Allergy 35: 137-145.
13. Jin R, Xu HG, Yuan WX, Zhuang LL, Liu LF, et al. (2012) Mechanisms elevating ORMDL3 expression in recurrent wheeze patients: Role of Ets-1, p300 and CREB. Int J Biochem Cell Biol.
14. Siow DL, Wattenberg BW (2012) Mammalian ORMDL Proteins Mediate the Feedback Response in Ceramide Biosynthesis. J Biol Chem.
15. Breslow DK, Collins SR, Bodenmiller B, Aebersold R, Simons K, et al. (2010) Orm family proteins mediate sphingolipid homeostasis. Nature 463: 1048-1053.
16. Cantero-Recasens G, Fandos C, Rubio-Moscardo F, Valverde MA, Vicente R, (2010) The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress. Hum Mol Genet 19: 111-121.
17. Du K, Asahara H, Jhala US, Wagner BL, Montminy M, (2000) Characterization of a CREB gain-of-function mutant with constitutive transcriptional activity in vivo. Mol Cell Biol 20: 4320-4327.
18. Xue H, Qiao Y, Ni P, Wang J, Chen C, et al. (2011) A CRE that binds CREB and contributes to PKA-dependent regulation of the proximal promoter of human RAB25 gene. Int J Biochem Cell Biol 43: 348-357.
19. Martianov I, Choukrallah MA, Krebs A, Ye T, Legras S, et al. (2010) Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells. BMC Genomics 11: 530.
20. Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, et al. (2005) Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci U S A 102: 4459-4464.
21. Kadonaga JT, Courey AJ, Ladika J, Tjian R, (1988) Distinct regions of Sp1 modulate DNA binding and transcriptional activation. Science 242: 1566-1570.
22. Kuscu C, Evensen N, Kim D, Hu YJ, Zucker S, et al. (2012) Transcriptional and Epigenetic Regulation of KIAA1199 Gene Expression in Human Breast Cancer. PLoS One 7: e44661.
23. Billington CK, Ojo OO, Penn RB, Ito S (2012) cAMP regulation of airway smooth muscle function. Pulm Pharmacol Ther.
24. Sathish V, Thompson MA, Bailey JP, Pabelick CM, Prakash YS, et al. (2009) Effect of proinflammatory cytokines on regulation of sarcoplasmic reticulum Ca2+ reuptake in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 297: L26-34.
25. Makkonen KM, Pasonen-Seppanen S, Torronen K, Tammi MI, Carlberg C, (2009) Regulation of the hyaluronan synthase 2 gene by convergence in cyclic AMP response element-binding protein and retinoid acid receptor signaling. J Biol Chem 284: 18270-18281.
26. Mahn K, Hirst SJ, Ying S, Holt MR, Lavender P, et al. (2009) Diminished sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) expression contributes to airway remodelling in bronchial asthma. Proc Natl Acad Sci U S A 106: 10775-10780.