Inhibition of MEK/ERK1/2 signalling alters endothelial nitric oxide synthase activity in an agonist-dependent manner

Biochemical Journal

Volumn 398, Issue 2, 2006, Pages 279-288

  Cale, Jacqueline M ^a   Bird, Ian M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Agonist; Ca2+; COS 7 cell; Endothelial nitric oxide synthase; Mitogen activated protein kinase extracellular signal regulated kinase (ERK) kinase (MEK); Phosphorylation

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOCHEMISTRY; CELL MEMBRANES; ENZYMES; MATHEMATICAL MODELS; MUTAGENESIS;

AGONIST; COS-7 CELL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN-ACTIVATED PROTEIN KINASE/EXTRACELLULAR-SIGNAL-REGULATED KINASE (ERK) KINASE (MEK); PHOSPHORYLATION;

ENZYME INHIBITION;

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ADENOSINE TRIPHOSPHATE; CALCIMYCIN; COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; GREEN FLUORESCENT PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MUCIN 1; NITRIC OXIDE; TRANSFER RNA; 1,3 BUTADIENE DERIVATIVE; CALCIUM; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRILE;

ACYLATION; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; DRUG ACTIVITY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; CERCOPITHECUS; DRUG EFFECT; GENETICS; METABOLISM; MUTATION; PHOSPHORYLATION; SHEEP;

OVIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; BUTADIENES; CALCIMYCIN; CALCIUM; CELL LINE; CERCOPITHECUS AETHIOPS; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MUTATION; NITRIC OXIDE SYNTHASE TYPE III; NITRILES; PHOSPHORYLATION; SHEEP;

EID: 33748371015     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060371     Document Type: Article

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