Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus

EMBO Molecular Medicine

Volumn 7, Issue 3, 2015, Pages 240-258

  Herbst, Susanne ^a   Shah, Anand ^a   Mazon Moya, Maria ^a   Marzola, Vanessa ^a   Jensen, Barbara ^a   Reed, Anna ^b   Birrell, Mark A ^c   Saijo, Shinobu ^d   Mostowy, Serge ^a   Shaunak, Sunil ^a   Armstrong James, Darius ^a,c  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^d CHIBA UNIVERSITY   (Japan)

Author keywords

Aspergillus; Calcineurin; Phagocytosis; TLR9; Transplant

Indexed keywords

BRUTON TYROSINE KINASE; CALCINEURIN; DECTIN 1; HYDROCORTISONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE SYK; TACROLIMUS; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; ZYMOSAN; AGAMMAGLOBULINAEMIA TYROSINE KINASE; CALCINEURIN INHIBITOR; PROTEIN TYROSINE KINASE; TUMOR NECROSIS FACTOR;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MEGADOSE; FUNGUS IMMUNITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; LUNG ALVEOLUS MACROPHAGE; LUNG ASPERGILLOSIS; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ZEBRA FISH; ANIMAL; ASPERGILLOSIS; C57BL MOUSE; CELL CULTURE; DISEASE MODEL; IMMUNOLOGY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MICROBIOLOGY; SECRETION (PROCESS);

ANIMALS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CALCINEURIN; CALCINEURIN INHIBITORS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; MACROPHAGES; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PHAGOCYTOSIS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TACROLIMUS; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA; ZEBRAFISH;

EID: 84929843950     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404556     Document Type: Article

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