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Volumn 37, Issue 3, 2015, Pages 251-259

CD8+ T cells in cutaneous leishmaniasis: the good, the bad, and the ugly

Author keywords

CD4+ T cells; CD8+ T cells; Cytotoxicity; Dendritic cells; Immunopathology; Immunotherapy; Leishmania; Macrophages; MHC class I; Phagolysosome; Th1 cells and vaccine

Indexed keywords

CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 4; HLA ANTIGEN CLASS 1;

EID: 84929835926     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-015-0475-7     Document Type: Review
Times cited : (64)

References (80)
  • 1
    • 84906313162 scopus 로고    scopus 로고
    • Perforin: a key pore-forming protein for immune control of viruses and cancer
    • PID: 24798013
    • Thiery J, Lieberman J (2014) Perforin: a key pore-forming protein for immune control of viruses and cancer. Subcell Biochem 80:197–220
    • (2014) Subcell Biochem , vol.80 , pp. 197-220
    • Thiery, J.1    Lieberman, J.2
  • 2
    • 0345269791 scopus 로고    scopus 로고
    • Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice
    • COI: 1:CAS:528:DC%2BD3sXitVaisbc%3D, PID: 12601154
    • Johnson BJ, Costelloe EO, Fitzpatrick DR, Haanen JB, Schumacher TN, Brown LE, Kelso A (2003) Single-cell perforin and granzyme expression reveals the anatomical localization of effector CD8+ T cells in influenza virus-infected mice. Proc Natl Acad Sci U S A 100:2657–62
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2657-2662
    • Johnson, B.J.1    Costelloe, E.O.2    Fitzpatrick, D.R.3    Haanen, J.B.4    Schumacher, T.N.5    Brown, L.E.6    Kelso, A.7
  • 3
    • 34250877389 scopus 로고    scopus 로고
    • Cutting edge: migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells
    • COI: 1:CAS:528:DC%2BD2sXmsF2gsr4%3D, PID: 17579018
    • Marzo AL, Yagita H, Lefrancois L (2007) Cutting edge: migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells. J Immunol 179:36–40
    • (2007) J Immunol , vol.179 , pp. 36-40
    • Marzo, A.L.1    Yagita, H.2    Lefrancois, L.3
  • 5
    • 79960392640 scopus 로고    scopus 로고
    • Leishmaniasis: complexity at the host-pathogen interface
    • COI: 1:CAS:528:DC%2BC3MXoslynsLo%3D, PID: 21747391
    • Kaye P, Scott P (2011) Leishmaniasis: complexity at the host-pathogen interface. Nat Rev Microbiol 9:604–15
    • (2011) Nat Rev Microbiol , vol.9 , pp. 604-615
    • Kaye, P.1    Scott, P.2
  • 7
    • 79958265461 scopus 로고    scopus 로고
    • Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection
    • COI: 1:CAS:528:DC%2BC3MXns1Skurg%3D, PID: 21606505
    • Goncalves R, Zhang X, Cohen H, Debrabant A, Mosser DM (2011) Platelet activation attracts a subpopulation of effector monocytes to sites of Leishmania major infection. J Exp Med 208:1253–65
    • (2011) J Exp Med , vol.208 , pp. 1253-1265
    • Goncalves, R.1    Zhang, X.2    Cohen, H.3    Debrabant, A.4    Mosser, D.M.5
  • 8
    • 0027395378 scopus 로고
    • Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host
    • COI: 1:CAS:528:DyaK3sXitFSntbY%3D, PID: 8093358
    • Aebischer T, Moody SF, Handman E (1993) Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host. Infect Immun 61:220–6
    • (1993) Infect Immun , vol.61 , pp. 220-226
    • Aebischer, T.1    Moody, S.F.2    Handman, E.3
  • 9
    • 0027528795 scopus 로고
    • Recombinant interleukin 12 cures mice infected with Leishmania major
    • COI: 1:CAS:528:DyaK3sXitFWisbs%3D, PID: 8097524
    • Heinzel FP, Schoenhaut DS, Rerko RM, Rosser LE, Gately MK (1993) Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 177:1505–9
    • (1993) J Exp Med , vol.177 , pp. 1505-1509
    • Heinzel, F.P.1    Schoenhaut, D.S.2    Rerko, R.M.3    Rosser, L.E.4    Gately, M.K.5
  • 10
    • 0027309318 scopus 로고
    • Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response
    • COI: 1:CAS:528:DyaK3sXitFWisb4%3D, PID: 8098733
    • Sypek JP, Chung CL, Mayor SE, Subramanyam JM, Goldman SJ, Sieburth DS, Wolf SF, Schaub RG (1993) Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 177:1797–802
    • (1993) J Exp Med , vol.177 , pp. 1797-1802
    • Sypek, J.P.1    Chung, C.L.2    Mayor, S.E.3    Subramanyam, J.M.4    Goldman, S.J.5    Sieburth, D.S.6    Wolf, S.F.7    Schaub, R.G.8
  • 11
    • 0033968432 scopus 로고    scopus 로고
    • The role of nitric oxide in innate immunity
    • COI: 1:CAS:528:DC%2BD3cXhs1Gru7o%3D, PID: 10719664
    • Bogdan C, Rollinghoff M, Diefenbach A (2000) The role of nitric oxide in innate immunity. Immunol Rev 173:17–26
    • (2000) Immunol Rev , vol.173 , pp. 17-26
    • Bogdan, C.1    Rollinghoff, M.2    Diefenbach, A.3
  • 12
    • 84897420698 scopus 로고    scopus 로고
    • Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species
    • COI: 1:CAS:528:DC%2BC2cXkslCnsb0%3D, PID: 24403561
    • Novais FO, Nguyen BT, Beiting DP, Carvalho LP, Glennie ND, Passos S, Carvalho EM, Scott P (2014) Human classical monocytes control the intracellular stage of Leishmania braziliensis by reactive oxygen species. J Infect Dis 209:1288–96
    • (2014) J Infect Dis , vol.209 , pp. 1288-1296
    • Novais, F.O.1    Nguyen, B.T.2    Beiting, D.P.3    Carvalho, L.P.4    Glennie, N.D.5    Passos, S.6    Carvalho, E.M.7    Scott, P.8
  • 13
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
    • COI: 1:CAS:528:DyaL1MXntlKnsw%3D%3D, PID: 2521244
    • Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM (1989) Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J Exp Med 169:59–72
    • (1989) J Exp Med , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 14
    • 0024236111 scopus 로고
    • Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens
    • COI: 1:STN:280:DyaL1M%2FjsF2qsg%3D%3D, PID: 2903212
    • Scott P, Natovitz P, Coffman RL, Pearce E, Sher A (1988) Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 168:1675–84
    • (1988) J Exp Med , vol.168 , pp. 1675-1684
    • Scott, P.1    Natovitz, P.2    Coffman, R.L.3    Pearce, E.4    Sher, A.5
  • 15
    • 3242787209 scopus 로고    scopus 로고
    • Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity
    • COI: 1:CAS:528:DC%2BD2cXmtFSqs7w%3D, PID: 15263027
    • Mendez S, Reckling SK, Piccirillo CA, Sacks D, Belkaid Y (2004) Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med 200:201–10
    • (2004) J Exp Med , vol.200 , pp. 201-210
    • Mendez, S.1    Reckling, S.K.2    Piccirillo, C.A.3    Sacks, D.4    Belkaid, Y.5
  • 16
    • 33847163271 scopus 로고    scopus 로고
    • CD4(+)CD25(−)Foxp3(−) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis
    • COI: 1:CAS:528:DC%2BD2sXitVekt7c%3D, PID: 17283207
    • Anderson CF, Oukka M, Kuchroo VJ, Sacks D (2007) CD4(+)CD25(−)Foxp3(−) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 204:285–97
    • (2007) J Exp Med , vol.204 , pp. 285-297
    • Anderson, C.F.1    Oukka, M.2    Kuchroo, V.J.3    Sacks, D.4
  • 17
    • 0025133974 scopus 로고
    • Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism
    • COI: 1:CAS:528:DyaK3cXhtFKqsLw%3D, PID: 2104918
    • Sadick MD, Heinzel FP, Holaday BJ, Pu RT, Dawkins RS, Locksley RM (1990) Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J Exp Med 171:115–27
    • (1990) J Exp Med , vol.171 , pp. 115-127
    • Sadick, M.D.1    Heinzel, F.P.2    Holaday, B.J.3    Pu, R.T.4    Dawkins, R.S.5    Locksley, R.M.6
  • 18
    • 0035863867 scopus 로고    scopus 로고
    • The role of IL-10 in promoting disease progression in leishmaniasis
    • COI: 1:CAS:528:DC%2BD3MXlvVWnsg%3D%3D, PID: 11145695
    • Kane MM, Mosser DM (2001) The role of IL-10 in promoting disease progression in leishmaniasis. J Immunol 166:1141–7
    • (2001) J Immunol , vol.166 , pp. 1141-1147
    • Kane, M.M.1    Mosser, D.M.2
  • 19
    • 2242423605 scopus 로고    scopus 로고
    • CD4 + CD25+ regulatory T cells control Leishmania major persistence and immunity
    • COI: 1:CAS:528:DC%2BD38Xpt1Whs7w%3D, PID: 12466842
    • Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL (2002) CD4 + CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 420:502–7
    • (2002) Nature , vol.420 , pp. 502-507
    • Belkaid, Y.1    Piccirillo, C.A.2    Mendez, S.3    Shevach, E.M.4    Sacks, D.L.5
  • 21
    • 34548543615 scopus 로고    scopus 로고
    • Interleukin-10 and the pathogenesis of human visceral leishmaniasis
    • COI: 1:CAS:528:DC%2BD2sXhtVCgsr3E, PID: 17689290
    • Nylen S, Sacks D (2007) Interleukin-10 and the pathogenesis of human visceral leishmaniasis. Trends Immunol 28:378–84
    • (2007) Trends Immunol , vol.28 , pp. 378-384
    • Nylen, S.1    Sacks, D.2
  • 27
    • 84874253704 scopus 로고    scopus 로고
    • Successful therapy of visceral leishmaniasis with curdlan involves T-helper 17 cytokines
    • COI: 1:CAS:528:DC%2BC3sXivVGhtbc%3D, PID: 23255562
    • Ghosh K, Sharma G, Saha A, Kar S, Das PK, Ukil A (2013) Successful therapy of visceral leishmaniasis with curdlan involves T-helper 17 cytokines. J Infect Dis 207:1016–25
    • (2013) J Infect Dis , vol.207 , pp. 1016-1025
    • Ghosh, K.1    Sharma, G.2    Saha, A.3    Kar, S.4    Das, P.K.5    Ukil, A.6
  • 28
    • 0027255488 scopus 로고
    • Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice
    • COI: 1:CAS:528:DyaK3sXltlOhsb0%3D, PID: 8101861
    • Scharton TM, Scott P (1993) Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice. J Exp Med 178:567–77
    • (1993) J Exp Med , vol.178 , pp. 567-577
    • Scharton, T.M.1    Scott, P.2
  • 29
    • 0027216898 scopus 로고
    • Natural killer cells participate in the early defense against Leishmania major infection in mice
    • COI: 1:CAS:528:DyaK3sXms1yltrs%3D, PID: 8370404
    • Laskay T, Rollinghoff M, Solbach W (1993) Natural killer cells participate in the early defense against Leishmania major infection in mice. Eur J Immunol 23:2237–41
    • (1993) Eur J Immunol , vol.23 , pp. 2237-2241
    • Laskay, T.1    Rollinghoff, M.2    Solbach, W.3
  • 33
    • 16244378045 scopus 로고    scopus 로고
    • Interleukin 10- and fcgamma receptor-deficient mice resolve Leishmania Mexicana lesions
    • COI: 1:CAS:528:DC%2BD2MXjtFygtbw%3D, PID: 15784551
    • Buxbaum LU, Scott P (2005) Interleukin 10- and fcgamma receptor-deficient mice resolve Leishmania Mexicana lesions. Infect Immun 73:2101–8
    • (2005) Infect Immun , vol.73 , pp. 2101-2108
    • Buxbaum, L.U.1    Scott, P.2
  • 34
    • 0034689062 scopus 로고    scopus 로고
    • Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis
    • COI: 1:CAS:528:DC%2BD3cXitVehsLo%3D, PID: 10727468
    • Kima PE, Constant SL, Hannum L, Colmenares M, Lee KS, Haberman AM, Shlomchik MJ, McMahon-Pratt D (2000) Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis. J Exp Med 191:1063–8
    • (2000) J Exp Med , vol.191 , pp. 1063-1068
    • Kima, P.E.1    Constant, S.L.2    Hannum, L.3    Colmenares, M.4    Lee, K.S.5    Haberman, A.M.6    Shlomchik, M.J.7    McMahon-Pratt, D.8
  • 35
    • 84874215238 scopus 로고    scopus 로고
    • Protective and pathologic immune responses in human tegumentary leishmaniasis
    • COI: 1:CAS:528:DC%2BC3sXms1CksLw%3D, PID: 23060880
    • Carvalho LP, Passos S, Schriefer A, Carvalho EM (2012) Protective and pathologic immune responses in human tegumentary leishmaniasis. Front Immunol 3:301
    • (2012) Front Immunol , vol.3 , pp. 301
    • Carvalho, L.P.1    Passos, S.2    Schriefer, A.3    Carvalho, E.M.4
  • 37
    • 0029038546 scopus 로고
    • Polar and subpolar diffuse cutaneous leishmaniasis in Brazil: clinical and immunopathologic aspects
    • COI: 1:STN:280:DyaK28%2Fmslyqsw%3D%3D, PID: 7591410
    • Barral A, Costa JM, Bittencourt AL, Barral-Netto M, Carvalho EM (1995) Polar and subpolar diffuse cutaneous leishmaniasis in Brazil: clinical and immunopathologic aspects. Int J Dermatol 34:474–9
    • (1995) Int J Dermatol , vol.34 , pp. 474-479
    • Barral, A.1    Costa, J.M.2    Bittencourt, A.L.3    Barral-Netto, M.4    Carvalho, E.M.5
  • 40
    • 0031571199 scopus 로고    scopus 로고
    • Presentation via the class I pathway by Leishmania amazonensis-infected macrophages of an endogenous leishmanial antigen to CD8+ T cells
    • COI: 1:CAS:528:DyaK2sXltlCktrc%3D, PID: 9257846
    • Kima PE, Ruddle NH, McMahon-Pratt D (1997) Presentation via the class I pathway by Leishmania amazonensis-infected macrophages of an endogenous leishmanial antigen to CD8+ T cells. J Immunol 159:1828–34
    • (1997) J Immunol , vol.159 , pp. 1828-1834
    • Kima, P.E.1    Ruddle, N.H.2    McMahon-Pratt, D.3
  • 41
    • 33748513274 scopus 로고    scopus 로고
    • Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD28XptlOhurs%3D, PID: 16951311
    • Bertholet S, Goldszmid R, Morrot A, Debrabant A, Afrin F, Collazo-Custodio C, Houde M, Desjardins M, Sher A, Sacks D (2006) Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo. J Immunol 177:3525–33
    • (2006) J Immunol , vol.177 , pp. 3525-3533
    • Bertholet, S.1    Goldszmid, R.2    Morrot, A.3    Debrabant, A.4    Afrin, F.5    Collazo-Custodio, C.6    Houde, M.7    Desjardins, M.8    Sher, A.9    Sacks, D.10
  • 42
    • 0027200941 scopus 로고
    • Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis
    • COI: 1:CAS:528:DyaK3sXms1ykurw%3D, PID: 8102158
    • Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM (1993) Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J Immunol 151:2077–86
    • (1993) J Immunol , vol.151 , pp. 2077-2086
    • Wang, Z.E.1    Reiner, S.L.2    Hatam, F.3    Heinzel, F.P.4    Bouvier, J.5    Turck, C.W.6    Locksley, R.M.7
  • 43
    • 0027254943 scopus 로고
    • Course of Leishmania infection in beta 2-microglobulin-deficient mice
    • COI: 1:CAS:528:DyaK2cXhtlWktrg%3D, PID: 7901152
    • Overath P, Harbecke D (1993) Course of Leishmania infection in beta 2-microglobulin-deficient mice. Immunol Lett 37:13–7
    • (1993) Immunol Lett , vol.37 , pp. 13-17
    • Overath, P.1    Harbecke, D.2
  • 44
    • 0031825618 scopus 로고    scopus 로고
    • Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice
    • COI: 1:CAS:528:DyaK1cXltFCqsbg%3D, PID: 9673288
    • Huber M, Timms E, Mak TW, Rollinghoff M, Lohoff M (1998) Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect Immun 66:3968–70
    • (1998) Infect Immun , vol.66 , pp. 3968-3970
    • Huber, M.1    Timms, E.2    Mak, T.W.3    Rollinghoff, M.4    Lohoff, M.5
  • 45
    • 0026536194 scopus 로고
    • Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection
    • COI: 1:CAS:528:DyaK38Xitlelsbw%3D, PID: 1549177
    • Tarleton RL, Koller BH, Latour A, Postan M (1992) Susceptibility of beta 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 356:338–40
    • (1992) Nature , vol.356 , pp. 338-340
    • Tarleton, R.L.1    Koller, B.H.2    Latour, A.3    Postan, M.4
  • 46
    • 0037090268 scopus 로고    scopus 로고
    • CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major
    • COI: 1:CAS:528:DC%2BD38XivV2is7o%3D, PID: 11937556
    • Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, Udey MC, Sacks D (2002) CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J Immunol 168:3992–4000
    • (2002) J Immunol , vol.168 , pp. 3992-4000
    • Belkaid, Y.1    Von Stebut, E.2    Mendez, S.3    Lira, R.4    Caler, E.5    Bertholet, S.6    Udey, M.C.7    Sacks, D.8
  • 47
    • 2942679337 scopus 로고    scopus 로고
    • Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon gamma-producing CD8+ T cells
    • COI: 1:CAS:528:DC%2BD2cXkvV2jsbs%3D, PID: 15184505
    • Uzonna JE, Joyce KL, Scott P (2004) Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon gamma-producing CD8+ T cells. J Exp Med 199:1559–66
    • (2004) J Exp Med , vol.199 , pp. 1559-1566
    • Uzonna, J.E.1    Joyce, K.L.2    Scott, P.3
  • 48
    • 0028874351 scopus 로고
    • The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model
    • COI: 1:CAS:528:DyaK2MXovFWqsLo%3D, PID: 7595228
    • Hosken NA, Shibuya K, Heath AW, Murphy KM, O’Garra A (1995) The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med 182:1579–84
    • (1995) J Exp Med , vol.182 , pp. 1579-1584
    • Hosken, N.A.1    Shibuya, K.2    Heath, A.W.3    Murphy, K.M.4    O’Garra, A.5
  • 49
    • 0027304299 scopus 로고
    • Gamma interferon response in secondary Leishmania major infection: role of CD8+ T cells
    • COI: 1:STN:280:DyaK3szms1Cgsw%3D%3D, PID: 8359894
    • Muller I, Kropf P, Etges RJ, Louis JA (1993) Gamma interferon response in secondary Leishmania major infection: role of CD8+ T cells. Infect Immun 61:3730–8
    • (1993) Infect Immun , vol.61 , pp. 3730-3738
    • Muller, I.1    Kropf, P.2    Etges, R.J.3    Louis, J.A.4
  • 50
    • 0028235914 scopus 로고
    • Expansion of gamma interferon-producing CD8+ T cells following secondary infection of mice immune to Leishmania major
    • COI: 1:CAS:528:DyaK2cXksFGlsrs%3D, PID: 8188380
    • Muller I, Kropf P, Louis JA, Milon G (1994) Expansion of gamma interferon-producing CD8+ T cells following secondary infection of mice immune to Leishmania major. Infect Immun 62:2575–81
    • (1994) Infect Immun , vol.62 , pp. 2575-2581
    • Muller, I.1    Kropf, P.2    Louis, J.A.3    Milon, G.4
  • 51
    • 0028148460 scopus 로고
    • Leishmania major infection in mice primes for specific major histocompatibility complex class I-restricted CD8+ cytotoxic T cell responses
    • PID: 7957573
    • da Conceicao-Silva F, Perlaza BL, Louis JA, Romero P (1994) Leishmania major infection in mice primes for specific major histocompatibility complex class I-restricted CD8+ cytotoxic T cell responses. Eur J Immunol 24:2813–7
    • (1994) Eur J Immunol , vol.24 , pp. 2813-2817
    • da Conceicao-Silva, F.1    Perlaza, B.L.2    Louis, J.A.3    Romero, P.4
  • 52
    • 2642613665 scopus 로고    scopus 로고
    • The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity
    • COI: 1:CAS:528:DyaK1cXpvVyhsA%3D%3D, PID: 9485203
    • Conceicao-Silva F, Hahne M, Schroter M, Louis J, Tschopp J (1998) The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity. Eur J Immunol 28:237–45
    • (1998) Eur J Immunol , vol.28 , pp. 237-245
    • Conceicao-Silva, F.1    Hahne, M.2    Schroter, M.3    Louis, J.4    Tschopp, J.5
  • 53
    • 25444500973 scopus 로고    scopus 로고
    • Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells
    • COI: 1:CAS:528:DC%2BD2MXhtVyhurnL, PID: 16177338
    • Bertholet S, Debrabant A, Afrin F, Caler E, Mendez S, Tabbara KS, Belkaid Y, Sacks DL (2005) Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells. Infect Immun 73:6620–8
    • (2005) Infect Immun , vol.73 , pp. 6620-6628
    • Bertholet, S.1    Debrabant, A.2    Afrin, F.3    Caler, E.4    Mendez, S.5    Tabbara, K.S.6    Belkaid, Y.7    Sacks, D.L.8
  • 54
    • 0030822043 scopus 로고    scopus 로고
    • Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major
    • COI: 1:CAS:528:DyaK2sXmsFaqs74%3D, PID: 9314562
    • Gurunathan S, Sacks DL, Brown DR, Reiner SL, Charest H, Glaichenhaus N, Seder RA (1997) Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med 186:1137–47
    • (1997) J Exp Med , vol.186 , pp. 1137-1147
    • Gurunathan, S.1    Sacks, D.L.2    Brown, D.R.3    Reiner, S.L.4    Charest, H.5    Glaichenhaus, N.6    Seder, R.A.7
  • 55
    • 79959853005 scopus 로고    scopus 로고
    • TLR1/2 activation during heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T cell responses providing protection against Leishmania (viannia)
    • COI: 1:CAS:528:DC%2BC3MXnvFegtb8%3D, PID: 21695103
    • Jayakumar A, Castilho TM, Park E, Goldsmith-Pestana K, Blackwell JM, McMahon-Pratt D (2011) TLR1/2 activation during heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T cell responses providing protection against Leishmania (viannia). PLoS Negl Trop Dis 5:e1204
    • (2011) PLoS Negl Trop Dis , vol.5 , pp. 1204
    • Jayakumar, A.1    Castilho, T.M.2    Park, E.3    Goldsmith-Pestana, K.4    Blackwell, J.M.5    McMahon-Pratt, D.6
  • 56
    • 0037124332 scopus 로고    scopus 로고
    • Vaccination with heat-killed Leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against Leishmania major infection
    • COI: 1:CAS:528:DC%2BD38XkslWht74%3D, PID: 12070284
    • Rhee EG, Mendez S, Shah JA, Wu CY, Kirman JR, Turon TN, Davey DF, Davis H, Klinman DM, Coler RN, Sacks DL, Seder RA (2002) Vaccination with heat-killed Leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against Leishmania major infection. J Exp Med 195:1565–73
    • (2002) J Exp Med , vol.195 , pp. 1565-1573
    • Rhee, E.G.1    Mendez, S.2    Shah, J.A.3    Wu, C.Y.4    Kirman, J.R.5    Turon, T.N.6    Davey, D.F.7    Davis, H.8    Klinman, D.M.9    Coler, R.N.10    Sacks, D.L.11    Seder, R.A.12
  • 57
    • 0037767300 scopus 로고    scopus 로고
    • Perforin and gamma interferon are critical CD8+ T-cell-mediated responses in vaccine-induced immunity against Leishmania amazonensis infection
    • COI: 1:CAS:528:DC%2BD3sXkt1KqtLk%3D, PID: 12761096
    • Colmenares M, Kima PE, Samoff E, Soong L, McMahon-Pratt D (2003) Perforin and gamma interferon are critical CD8+ T-cell-mediated responses in vaccine-induced immunity against Leishmania amazonensis infection. Infect Immun 71:3172–82
    • (2003) Infect Immun , vol.71 , pp. 3172-3182
    • Colmenares, M.1    Kima, P.E.2    Samoff, E.3    Soong, L.4    McMahon-Pratt, D.5
  • 58
    • 84874143982 scopus 로고    scopus 로고
    • CD8(+) T cells in Leishmania infections: friends or foes?
    • COI: 1:CAS:528:DC%2BC3sXms1Cktrk%3D, PID: 22566891
    • Stager S, Rafati S (2012) CD8(+) T cells in Leishmania infections: friends or foes? Front Immunol 3:5
    • (2012) Front Immunol , vol.3 , pp. 5
    • Stager, S.1    Rafati, S.2
  • 59
    • 0023903734 scopus 로고
    • Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis
    • COI: 1:STN:280:DyaL1c3ivFSqtg%3D%3D, PID: 3131421
    • Stern JJ, Oca MJ, Rubin BY, Anderson SL, Murray HW (1988) Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis. J Immunol 140:3971–7
    • (1988) J Immunol , vol.140 , pp. 3971-3977
    • Stern, J.J.1    Oca, M.J.2    Rubin, B.Y.3    Anderson, S.L.4    Murray, H.W.5
  • 60
    • 1842586922 scopus 로고    scopus 로고
    • CD8(+) T cells with parasite-specific cytotoxic activity and a Tc1 profile of cytokine and chemokine secretion develop in experimental visceral leishmaniasis
    • COI: 1:CAS:528:DC%2BD2cXjslGms7s%3D, PID: 15053778
    • Tsagozis P, Karagouni E, Dotsika E (2003) CD8(+) T cells with parasite-specific cytotoxic activity and a Tc1 profile of cytokine and chemokine secretion develop in experimental visceral leishmaniasis. Parasite Immunol 25:569–79
    • (2003) Parasite Immunol , vol.25 , pp. 569-579
    • Tsagozis, P.1    Karagouni, E.2    Dotsika, E.3
  • 61
    • 18144388288 scopus 로고    scopus 로고
    • Function of CD8+ T lymphocytes in a self-curing mouse model of visceral leishmaniasis
    • COI: 1:CAS:528:DC%2BD2MXjs1Ohsb4%3D, PID: 15866476
    • Tsagozis P, Karagouni E, Dotsika E (2005) Function of CD8+ T lymphocytes in a self-curing mouse model of visceral leishmaniasis. Parasitol Int 54:139–46
    • (2005) Parasitol Int , vol.54 , pp. 139-146
    • Tsagozis, P.1    Karagouni, E.2    Dotsika, E.3
  • 62
    • 84921341764 scopus 로고    scopus 로고
    • Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection
    • COI: 1:CAS:528:DC%2BC2MXhvVKmurw%3D, PID: 25452549
    • Murray HW, Mitchell-Flack M, Zheng H, Ma X (2015) Granzyme-mediated regulation of host defense in the liver in experimental Leishmania donovani infection. Infect Immun 83:702–12
    • (2015) Infect Immun , vol.83 , pp. 702-712
    • Murray, H.W.1    Mitchell-Flack, M.2    Zheng, H.3    Ma, X.4
  • 65
    • 0031156475 scopus 로고    scopus 로고
    • Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection
    • COI: 1:CAS:528:DyaK2sXjtl2mtLo%3D, PID: 9164958
    • Soong L, Chang CH, Sun J, Longley BJ Jr, Ruddle NH, Flavell RA, McMahon-Pratt D (1997) Role of CD4+ T cells in pathogenesis associated with Leishmania amazonensis infection. J Immunol 158:5374–83
    • (1997) J Immunol , vol.158 , pp. 5374-5383
    • Soong, L.1    Chang, C.H.2    Sun, J.3    Longley, B.J.4    Ruddle, N.H.5    Flavell, R.A.6    McMahon-Pratt, D.7
  • 66
    • 68249135239 scopus 로고    scopus 로고
    • Recruitment of CD8(+) T cells expressing granzyme a is associated with lesion progression in human cutaneous leishmaniasis
    • COI: 1:CAS:528:DC%2BD1MXhtVGis73O, PID: 19646207
    • Faria DR, Souza PE, Duraes FV, Carvalho EM, Gollob KJ, Machado PR, Dutra WO (2009) Recruitment of CD8(+) T cells expressing granzyme a is associated with lesion progression in human cutaneous leishmaniasis. Parasite Immunol 31:432–9
    • (2009) Parasite Immunol , vol.31 , pp. 432-439
    • Faria, D.R.1    Souza, P.E.2    Duraes, F.V.3    Carvalho, E.M.4    Gollob, K.J.5    Machado, P.R.6    Dutra, W.O.7
  • 69
    • 0027139766 scopus 로고
    • CD4+ type 1 and CD8+ type 2 T cell subsets in human leishmaniasis have distinct T cell receptor repertoires
    • COI: 1:CAS:528:DyaK2cXnsFSitA%3D%3D, PID: 7903101
    • Uyemura K, Pirmez C, Sieling PA, Kiene K, Paes-Oliveira M, Modlin RL (1993) CD4+ type 1 and CD8+ type 2 T cell subsets in human leishmaniasis have distinct T cell receptor repertoires. J Immunol 151:7095–104
    • (1993) J Immunol , vol.151 , pp. 7095-7104
    • Uyemura, K.1    Pirmez, C.2    Sieling, P.A.3    Kiene, K.4    Paes-Oliveira, M.5    Modlin, R.L.6
  • 70
    • 84897681023 scopus 로고    scopus 로고
    • Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection
    • PID: 24586170
    • Crosby EJ, Goldschmidt MH, Wherry EJ, Scott P (2014) Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection. PLoS Pathog 10:e1003970
    • (2014) PLoS Pathog , vol.10 , pp. 1003970
    • Crosby, E.J.1    Goldschmidt, M.H.2    Wherry, E.J.3    Scott, P.4
  • 71
    • 84866946835 scopus 로고    scopus 로고
    • Transcriptome patterns from primary cutaneous Leishmania braziliensis infections associate with eventual development of mucosal disease in humans
    • COI: 1:CAS:528:DC%2BC38Xhtl2msb7E, PID: 23029578
    • Maretti-Mira AC, Bittner J, Oliveira-Neto MP, Liu M, Kang D, Li H, Pirmez C, Craft N (2012) Transcriptome patterns from primary cutaneous Leishmania braziliensis infections associate with eventual development of mucosal disease in humans. PLoS Negl Trop Dis 6:e1816
    • (2012) PLoS Negl Trop Dis , vol.6 , pp. 1816
    • Maretti-Mira, A.C.1    Bittner, J.2    Oliveira-Neto, M.P.3    Liu, M.4    Kang, D.5    Li, H.6    Pirmez, C.7    Craft, N.8
  • 72
    • 0025719027 scopus 로고
    • Expression of T-cell-associated serine proteinase 1 during murine Leishmania major infection correlates with susceptibility to disease
    • COI: 1:CAS:528:DyaK38XlslWrug%3D%3D, PID: 1937831
    • Moll H, Muller C, Gillitzer R, Fuchs H, Rollinghoff M, Simon MM, Kramer MD (1991) Expression of T-cell-associated serine proteinase 1 during murine Leishmania major infection correlates with susceptibility to disease. Infect Immun 59:4701–5
    • (1991) Infect Immun , vol.59 , pp. 4701-4705
    • Moll, H.1    Muller, C.2    Gillitzer, R.3    Fuchs, H.4    Rollinghoff, M.5    Simon, M.M.6    Kramer, M.D.7
  • 73
    • 0031278398 scopus 로고    scopus 로고
    • Parasite-driven in vitro human lymphocyte cytotoxicity against autologous infected macrophages from mucosal leishmaniasis
    • COI: 1:CAS:528:DyaK2sXmvVyltrs%3D, PID: 9379046
    • Brodskyn CI, Barral A, Boaventura V, Carvalho E, Barral-Netto M (1997) Parasite-driven in vitro human lymphocyte cytotoxicity against autologous infected macrophages from mucosal leishmaniasis. J Immunol 159:4467–73
    • (1997) J Immunol , vol.159 , pp. 4467-4473
    • Brodskyn, C.I.1    Barral, A.2    Boaventura, V.3    Carvalho, E.4    Barral-Netto, M.5
  • 74
    • 84925964964 scopus 로고    scopus 로고
    • Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology
    • Novais FO, Carvalho LP, Passos S, Roos DS, Carvalho EM, Scott P, Beiting DP (2014) Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology. J Invest Dermatol
    • (2014) J Invest Dermatol
    • Novais, F.O.1    Carvalho, L.P.2    Passos, S.3    Roos, D.S.4    Carvalho, E.M.5    Scott, P.6    Beiting, D.P.7
  • 75
    • 84855989829 scopus 로고    scopus 로고
    • Inflammasomes in health and disease
    • COI: 1:CAS:528:DC%2BC38Xps1GmsA%3D%3D, PID: 22258606
    • Strowig T, Henao-Mejia J, Elinav E, Flavell R (2012) Inflammasomes in health and disease. Nature 481:278–86
    • (2012) Nature , vol.481 , pp. 278-286
    • Strowig, T.1    Henao-Mejia, J.2    Elinav, E.3    Flavell, R.4
  • 77
    • 1842450836 scopus 로고    scopus 로고
    • Analysis of granzyme B activity as a surrogate marker of Leishmania-specific cell-mediated cytotoxicity in zoonotic cutaneous leishmaniasis
    • COI: 1:CAS:528:DC%2BD2cXjsleqsbw%3D, PID: 15031796
    • Bousoffara T, Louzir H, Ben Salah A, Dellagi K (2004) Analysis of granzyme B activity as a surrogate marker of Leishmania-specific cell-mediated cytotoxicity in zoonotic cutaneous leishmaniasis. J Infect Dis 189:1265–73
    • (2004) J Infect Dis , vol.189 , pp. 1265-1273
    • Bousoffara, T.1    Louzir, H.2    Ben Salah, A.3    Dellagi, K.4
  • 78
    • 24344508241 scopus 로고    scopus 로고
    • Flow cytometric analysis of cellular infiltrate from American tegumentary leishmaniasis lesions
    • COI: 1:STN:280:DC%2BD2Mvltlarsg%3D%3D, PID: 16120139
    • Da-Cruz AM, Bertho AL, Oliveira-Neto MP, Coutinho SG (2005) Flow cytometric analysis of cellular infiltrate from American tegumentary leishmaniasis lesions. Br J Dermatol 153:537–43
    • (2005) Br J Dermatol , vol.153 , pp. 537-543
    • Da-Cruz, A.M.1    Bertho, A.L.2    Oliveira-Neto, M.P.3    Coutinho, S.G.4
  • 79
    • 0033047215 scopus 로고    scopus 로고
    • Characterization of the local and systemic immune responses in patients with cutaneous leishmaniasis due to Leishmania major
    • COI: 1:STN:280:DyaK1M3pvVGitw%3D%3D, PID: 10370377
    • Gaafar A, Veress B, Permin H, Kharazmi A, Theander TG, el Hassan AM (1999) Characterization of the local and systemic immune responses in patients with cutaneous leishmaniasis due to Leishmania major. Clin Immunol 91:314–20
    • (1999) Clin Immunol , vol.91 , pp. 314-320
    • Gaafar, A.1    Veress, B.2    Permin, H.3    Kharazmi, A.4    Theander, T.G.5    el Hassan, A.M.6
  • 80
    • 77951091467 scopus 로고    scopus 로고
    • T cells specific to Leishmania and other nonrelated microbial antigens can migrate to human leishmaniasis skin lesions
    • COI: 1:CAS:528:DC%2BC3cXkvVSrtbo%3D, PID: 20107484
    • Da-Cruz AM, Oliveira-Neto MP, Bertho AL, Mendes-Aguiar CO, Coutinho SG (2010) T cells specific to Leishmania and other nonrelated microbial antigens can migrate to human leishmaniasis skin lesions. J Investig Dermatol 130:1329–36
    • (2010) J Investig Dermatol , vol.130 , pp. 1329-1336
    • Da-Cruz, A.M.1    Oliveira-Neto, M.P.2    Bertho, A.L.3    Mendes-Aguiar, C.O.4    Coutinho, S.G.5


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