Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis

Parasite Immunology

Volumn 31, Issue 8, 2009, Pages 432-439

  Faria, D R ^a   Souza, P E A ^b   Duraes F V ^a   Carvalho, E M ^c   Gollob, K J ^a   MacHado, P R ^c   Dutra, W O ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF MINAS GERAIS   (Brazil)

^c FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

CD8+ T cells; Granzyme; Leishmaniasis; Lesion; Progression

Indexed keywords

CD68 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANZYME A; INTERLEUKIN 10;

ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPOSITION; DISEASE COURSE; EOSINOPHIL COUNT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INFLAMMATORY INFILTRATE; MONOCYTE; MONONUCLEAR CELL; NEUTROPHIL COUNT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN LEISHMANIASIS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COUNT; DISEASE PROGRESSION; EOSINOPHILS; GRANZYMES; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-10; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS, CUTANEOUS; LEUKOCYTES, MONONUCLEAR; NEUTROPHILS; SKIN;

LEISHMANIA BRAZILIENSIS;

EID: 68249135239     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2009.01125.x     Document Type: Article

References (28)

1. Schriefer A, Schriefer AL, Góes-Neto A, et al. Multiclonal Leishmania braziliensis population structure and its clinical implication in a region of endemicity for American tegumentary leishmaniasis. Infect Immun 2004 72 : 508 514.
2. Bittencourt AL Barral A. Evaluation of the histopathological classifications of American cutaneous and mucocutaneous leishmaniasis. Mem Inst Oswaldo Cruz 1991 86 : 51 56.
3. Lee SA. Hasburn R. Therapy of cutaneous leishmaniasis. Int J Infect Dis 2003 7 : 86 93.
4. Machado P, Araújo C, Da Silva AT, et al. Failure of early treatment of cutaneous leishmaniasis in preventing the development of an ulcer. Clin Infect Dis 2002 34 : 69 73.
5. Bottrel RL, Dutra WO, Martins FA, et al. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect Immun 2001 69 : 3232 3239.
6. Pirmez C, Yamamura M, Uyemura K, Paes-Oliveira M, Conceição- Silva F Modlin RL. Cytokine patterns in the pathogenesis of human leishmaniasis. J Clin Invest 1993 91 : 1390 1395.
7. Cáceres-Dittmar G, Tapia FJ, Sánchez MA, et al. Determination of the cytokine profile in American cutaneous leishmaniasis using the polymerase chain reaction. Clin Exp Immunol 1993 91 : 500 505.
8. Coutinho SG, Oliveira MP, Da-Cruz AM, et al. T-cell responsiveness of American cutaneous leishmaniasis patients to purified Leishmania pifanoi amastigote antigens and Leishmania braziliensis promastigote antigens: immunologic patterns associated with cure. Exp Parasitol 1996 84 : 144 155.
9. Coutinho SG, Da-Cruz AM, Bertho AL, Santiago MA De-Luca P. Immunologic patterns associated with cure in human American cutaneous leishmaniasis. Braz J Med Biol Res 1998 31 : 139 142.
10. Bacellar O, Lessa H, Schriefer A, et al. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun 2002 70 : 6734 6740.
11. Faria DR, Gollob KJ, Barbosa J Jr., et al. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infect Immun 2005 73 : 7853 7859.
12. Rocha PN, Almeida RP, Bacellar O, et al. Down-regulation of Th1 type of response in early human American cutaneous leishmaniasis. J Infect Dis 1999 180 : 1731 1734.
13. Ribeiro-de-Jesus A, Almeida RP, Lessa H, Bacellar O Carvalho EM. Cytokine profile and pathology in human leishmaniasis. Braz J Med Biol Res 1998 31 : 143 148.
14. Van Zandbergen G, Klinger M, Mueller A, et al. Cutting edge: neutrophil granulocyte serves as a vector for Leishmania entry into macrophages. J Immunol 2004 173 : 6521 6525.
15. Liew FY, Li Y Millott S. Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol 1990 145 : 4306 4310.
16. -) alphabeta and gammadelta T cells from human patients with cutaneous leishmaniasis. Infect Immun 2006 74 : 6317 6323.
17. Antonelli LR, Dutra WO, Almeida RP, Bacellar O, Carvalho EM Gollob KJ. Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis. Immunol Lett 2005 101 : 226 230.
18. + T lymphocytes. J Immunol 1990 144 : 574 582.
19. Trapani JA Smyth MJ. Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2002 2 : 735 747.
20. Moll H, Müller C, Gillitzer R, et al. Expression of T-cell-associated serine proteinase 1 during murine Leishmania major infection correlates with susceptibility to disease. Infect Immun 1991 59 : 4701 4705.
21. Machado P, Kanitakis J, Almeida R, Chalon A, Araújo C Carvalho EM. Evidence of in situ cytotoxicity in American cutaneous leishmaniasis. Eur J Dermatol 2002 12 : 449 451.
22. Mosmann TR Moore K. The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol Today 1991 12 : 49 53.
23. Carvalho EM, Barral A, Pedral-Sampaio D, et al. Immunologic markers of clinical evolution in children recently infected with Leishmania donovani chagasi. J Infect Dis 1992 165 : 535 540.
24. Bomfim G, Nascimento C, Costa J, Carvalho EM, Barral-Netto M Barral A. Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis. Exp Parasitol 1996 84 : 188 194.
25. Bacellar O, D'Oliveira A Jr., Jeronimo S Carvalho EM. IL-10 and IL-12 are the main regulatory cytokines in visceral leishmaniasis. Cytokine 2000 12 : 1228 1231.
26. + regulatory T cells control Leishmania major persistence and immunity. Nature 2002 420 : 502 507.
27. Antonelli LR, Dutra WO, Almeida RP, Bacellar O Gollob KJ. Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation. Clin Exp Immunol 2004 136 : 341 348.
28. Gaze ST, Dutra WO, Lessaz M., et al. Mucosal leishmaniasis patients display an activated inflammatory T-cell phenotype associated with a nonbalanced monocyte population. Scand J Immunol 2006 63 : 70 78.