IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection

Parasite Immunology

Volumn 33, Issue 2, 2011, Pages 132-136

  Novoa, R ^a   Bacellar, O ^a,b   Nascimento, M ^a   Cardoso, T M ^a,b   Ramasawmy, R ^a,b   Oliveira, W N ^a,b   Schriefer, A ^a,b   Carvalho, E M ^a,b  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^b Instituto de Ciências da Saúde   (Brazil)

Author keywords

Cutaneous leishmaniasis; IL 17; Leishmania braziliensis; Regulatory cytokines; Subclinical infection

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 27; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ASYMPTOMATIC INFECTION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DOWN REGULATION; HUMAN; HUMAN CELL; INFECTION CONTROL; INNATE IMMUNITY; LEISHMANIA BRAZILIENSIS; PRIORITY JOURNAL; SKIN LEISHMANIASIS;

ASYMPTOMATIC INFECTIONS; CHILD; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INFANT; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKINS; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS, CUTANEOUS; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

LEISHMANIA BRAZILIENSIS;

EID: 78651433723     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2010.01256.x     Document Type: Article

References (21)

1. Jones TC, Johnson WD Jr, Barretto AC, et al. Epidemiology of American cutaneous leishmaniasis due to Leishmania braziliensis braziliensis. J Infect Dis 1987; 156: 73-83.
2. Follador I, Araujo C, Orge G, et al. Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony-stimulating factor. Vaccine 2002; 20: 1365-1368.
3. Follador I, Araujo C, Bacellar O, et al. Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection. Clin Infect Dis 2002; 34: E54-E58.
4. Bittar RC, Nogueira RS, Vieira-Goncalves R, et al. T-cell responses associated with resistance to Leishmania infection in individuals from endemic areas for Leishmania (Viannia) braziliensis. Mem Inst Oswaldo Cruz 2007; 102: 625-630.
5. Trinchieri G, Pflanz S & Kastelein RA. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2003; 19: 641-644.
6. Yoshimura T, Takeda A, Hamano S, et al. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J Immunol 2006; 177: 5377-5385.
7. Ben Salah A, Louzir H, Chlif S, et al. The predictive validity of naturally acquired delayed-type hypersensitivity to leishmanin in resistance to Leishmania major-associated cutaneous leishmaniasis. J Infect Dis 2005; 192: 1981-1987.
8. Pitta MG, Romano A, Cabantous S, et al. IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani. J Clin Invest 2009; 119: 2379-2387.
9. Reed SG, Badaro R, Masur H, et al. Selection of a skin test antigen for American visceral leishmaniasis. Am J Trop Med Hyg 1986; 35: 79-85.
10. Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE & Weiner HL. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol 2009; 183: 2435-2443.
11. Bacellar O, Lessa H, Schriefer A, et al. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect Immun 2002; 70: 6734-6740.
12. Holscher C, Holscher A, Ruckerl D, et al. The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. J Immunol 2005; 174: 3534-3544.
13. Pearl JE, Khader SA, Solache A, et al. IL-27 signaling compromises control of bacterial growth in mycobacteria-infected mice. J Immunol 2004; 173: 7490-7496.
14. Villarino A, Hibbert L, Lieberman L, et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 2003; 19: 645-655.
15. Anderson CF, Stumhofer JS, Hunter CA & Sacks D. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. J Immunol 2009; 183: 4619-4627.
16. Antonelli LR, Dutra WO, Almeida RP, Bacellar O & Gollob KJ. Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation. Clin Exp Immunol 2004; 136: 341-348.
17. Brodskyn CI, Barral A, Boaventura V, Carvalho E & Barral-Netto M. Parasite-driven in vitro human lymphocyte cytotoxicity against autologous infected macrophages from mucosal leishmaniasis. J Immunol 1997; 159: 4467-4473.
18. Maasho K, Sanchez F, Schurr E, Hailu A & Akuffo H. Indications of the protective role of natural killer cells in human cutaneous leishmaniasis in an area of endemicity. Infect Immun 1998; 66: 2698-2704.
19. Novais FO, Santiago RC, Bafica A, et al. Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection. J Immunol 2009; 183: 8088-8098.
20. Bacellar O, Faria D, Nascimento M, et al. Interleukin 17 production among patients with American cutaneous leishmaniasis. J Infect Dis 2009; 200: 75-78.
21. Lopez Kostka S, Dinges S, Griewank K, Iwakura Y, Udey MC & von Stebut E. IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice. J Immunol 2009; 182: 3039-3046.