Perforin and gamma interferon are critical CD8+ T-cell-mediated responses in vaccine-induced immunity against Leishmania amazonensis infection

Infection and Immunity

Volumn 71, Issue 6, 2003, Pages 3172-3182

  Colmenares, María ^a   Kima, Peter E ^a,b   Samoff, Erika ^a,c   Soong, Lynn ^a,c   McMahon Pratt, Diane ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PERFORIN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LEISHMANIA; LEISHMANIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VACCINATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; INTERFERON TYPE II; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; LYMPH NODES; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; PORE FORMING CYTOTOXIC PROTEINS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; VACCINATION;

EID: 0037767300     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.71.6.3172-3182.2003     Document Type: Article

References (68)

1. Afonso, L. C., and P. Scott. 1993. Immune responses associated with susceptibility of C57BL/10 mice to Leishmania amazonensis. Infect. Immun. 61:2952-2959.
2. Anstead, G. M., B. Chandrasekar, W. Zhao, J. Yang, L. E. Perez, and P. C. Melby. 2001. Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection. Infect. Immun. 69:4709-4718.
3. + T cell homeostasis by perforin and interferon-gamma. Science 290:1354-1358.
4. Barten, D. M., and N. H. Ruddle. 1994. Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis. J. Neuroimmunol. 51:123-133.
5. Belkaid, Y., H. Jouin, and G. Milon. 1996. A method to recover, enumerate and identify lymphomyeloid cells present in an inflammatory dermal site: a study in laboratory mice. J. Immunol. Methods 199:5-25.
6. Belkaid, Y., S. Kamhawi, G. Modi, J. Valenzuela, N. Noben-Trauth, E. Rowton, J. Ribeiro, and D. L. Sacks. 1998. Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J. Exp. Med. 188:1941-1953.
7. + T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major. J. Immunol. 168:3992-4000.
8. Berke, G. 1995, The CTL's kiss of death. Cell 81:9-12.
9. Champsi, J., and D. McMahon-Pratt. 1988. Membrane glycoprotein M-2 protects against Leishmania amazonensis infection. Infect. Immun. 56:3272-3279.
10. Christianson, G. J., W. Brooks, S. Vekasi, E. A. Manolfi, J. Niles, S. L. Roopenian, J. B. Roths, R. Rothlein, and D. C. Roopenian. 1997. Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism. J. Immunol. 159:4781-4792.
11. Colmenares, M., S. L. Constant, P. E. Kima, and D. McMahon-Pratt. 2002. Leishmania pifanoi pathogenesis: selective lack of a local cutaneous response in the absences of circulating antibody. Infect. Immun. 70:6597-6605.
12. Colmenares, M., S. Kar, K. Goldsmith-Pestana, and D. McMahon-Pratt. 2002. Mechanisms of pathogenesis: differences amongst Leishmania species. Trans. R. Soc. Trop. Med. Hyg, 96:S1-S3.
13. Colmenares, M., M. Tiemeyer, P. Kima, and D. McMahon-Pratt. 2001. Biochemical and biological characterization of the protective Leishmania pifanoi amastigote antigen P-8. Infect. Immun. 69:6776-6784.
14. Conceicao-Silva, F., M. Hahne, M. Schroter, J. Louis, and J. Tschopp. 1998. The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity. Eur. J. Immunol. 28:237-245.
15. Coutinho, S. G., M. P. Oliveira, A. M. Da-Cruz, P. M. De Luca, S. C. Mendonca, A. L. Bertho, L. Soong, and D. McMahon-Pratt. 1996. T-cell responsiveness of American cutaneous leishmaniasis patients to purified Leishmania pifanoi amastigote antigens and Leishmania braziliensis promastigote antigens: immunologic patterns associated with cure. Exp. Parasitol. 84:144-155.
16. + T cells associated with cure of human cutaneous leishmaniasis. Infect. Immun. 62:2614-2618.
17. + T cells in resistance to cutaneous leishmaniasis in immunized mice. J. Immunol. 142:2052-2056.
18. Gerber, J. S., and D. M. Mosser. 2001. Reversing lipopolysaccharide toxicity by ligating the macrophage Fc gamma receptors. J. Immunol. 166:6861-6868.
19. Greenblatt, C. L. 1980. The present and future of vaccination for cutaneous leishmaniasis. Prog. Clin. Biol. Res. 47:259-285.
20. Gurunathan, S., D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder. 1997. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186:1137-1147.
21. + T cells. J. Immunol. 165:915-924.
22. + T lymphocytes to mediate protective immunity against Leishmania. J. Exp. Med. 169:1819-1827.
23. Hommel-Berrey, G. A., M. R. Bochan, A. H. Montel, W. S. Goebel, C. J. Froelich, and Z. Brahmi. 1997. Granzyme B independently of perforin mediates noncytolytic intracellular inactivation of vesicular stomatitis virus. Cell. Immunol. 180:1-9.
24. Howard, J. G., S. Nicklin, C. Hale, and F. Y. Liew. 1982. Prophylactic immunization against experimental leishmaniasis. I. Protection induced in mice genetically vulnerable to fatal Leishmania tropica infection. J. Immunol. 129:2206-2212.
25. Huang, F. P., D. Xu, E. O. Esfandiari, W. Sands, X. Q. Wei, and F. Y. Liew. 1998. Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production. J. Immunol. 160:4143-4147.
26. Ilg, T., M. Demar, and D. Harbecke. 2001. Phosphoglycan repeat-deficient Leishmania mexicana parasites remain infectious to macrophages and mice. J. Biol. Chem. 276:4988-4997.
27. Jones, D. E., L U. Buxbaum, and P. Scott. 2000. IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection. J. Immunol. 165:364-372.
28. Kane, M. M., and D. M. Mosser. 2001. The role of IL-10 in promoting disease progression in leishmaniasis. J. Immunol. 166:1141-1147.
29. Kaufmann, S. H. 1999. Cell-mediated immunity: dealing a direct blow to pathogens. Curr. Biol. 9:R97-R99.
30. Kima, P. E., S. L. Constant, L. Hannum, M. Colmenares, K. S. Lee, A. M. Haberman, M. J. Shlomchik, and D. McMahon-Pratt. 2000. Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis. J. Exp. Med. 191:1063-1068.
31. + T cells. J. Immunol. 159:1828-1834.
32. Laskay, T., A. Diefenbach, M. Rollinghoff, and W. Solbach. 1995. Early parasite containment is decisive for resistance to Leishmania major infection. Eur. J. Immunol. 25:2220-2227.
33. + T cells which are NK 1.1. Eur. J. Immunol. 25:3298-3307.
34. Liu, C. C., P. M. Persechini, and J. D. Young. 1995. Perforin and lymphocyte-mediated cytolysis. Immunol. Rev. 146:145-175.
35. Liu, Z., D. C. Roopenian, X. Zhou, G. J. Christianson, L. A. Diaz, D. D. Sedmak, and C. L. Anderson. 1997. β2-Microglobulin-deficient mice are resistant to bullous pemphigoid. J. Exp. Med. 186:777-783.
36. Masopust, D., V. Vezys, A. L. Marzo, and L. Lefrancois. 2001. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413-2417.
37. McMahon-Pratt, D., D. Rodriguez, J. R. Rodriguez, Y. Zhang, K. Manson, C. Bergman, L. Rivas, J. F. Rodriguez, K. L. Lohman, N. H. Ruddle, et al. 1993. Recombinant vaccinia viruses expressing GP46/M-2 protect against Leishmania infection. Infect. Immun. 61:3351-3359.
38. Mendez, S., S. Gurunathan, S. Kamhawi, Y. Belkaid, M. A. Moga, Y. A. Skeiky, A. Campos-Neto, S. Reed, R. A. Seder, and D. Sacks. 2001. The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge. J. Immunol. 166:5122-5128.
39. Mendonca, S. C., P. M. De Luca, W. Mayrink, T. G. Restom, F. Conceicao-Silva, A. M. Da-Cruz, A. L. Bertho, C. A. Da Costa, O. Genaro, V. P. Toledo, et al. 1995. Characterization of human T lymphocyte-mediated immune responses induced by a vaccine against American tegumentary leishmaniasis. Am. J. Trop. Med. Hyg. 53:195-201.
40. + cells are different from TH2 cells. Eur. J. Immunol. 20:2067-2074.
41. Mullbacher, A., P. Waring, R. Tha Hla, T. Tran, S. Chin, T. Stehle, C. Museteanu, and M. M. Simon. 1999. Granzymes are the essential down-stream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. USA 96:13950-13955.
42. Muller, I. 1992. Role of T cell subsets during the recall of immunologic memory to Leishmania major. Eur. J. Immunol. 22:3063-3069.
43. + T cells. Int. Immunol. 3:587-597.
44. Murray, H. W., and S. Delph-Etienne. 2000. Roles of endogenous gamma interferon and macrophage microbicidal mechanisms in host response to chemotherapy in experimental visceral leishmaniasis. Infect. Immun. 68:288-293.
45. Overath, P., and D. Harbecke. 1993. Course of Leishmania infection in beta 2-microglobulin-deficient mice. Immunol. Lett. 37:13-17.
46. + cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice. J. Virol. 74:1029-1032.
47. Raulet, D. H. 1994. MHC class I-deficient mice. Adv. Immunol. 55:381-421.
48. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
49. Russell, D. G., and J. Alexander. 1988. Effective immunization against cutaneous leishmaniasis with defined membrane antigens reconstituted into liposomes. J. Immunol. 140:1274-1279.
50. Sambhara, S., I. Switzer, A. Kurichh, R. Miranda, L. Urbanczyk, O. James, B. Underdown, M. Klein, and D. Burt. 1998. Enhanced antibody and cytokine responses to influenza viral antigens in perforin-deficient mice. Cell. Immunol. 187:13-18.
51. Scott, P., and A. Sher. 1986. A spectrum in the susceptibility of leishmanial strains to intracellular killing by murine macrophages. J. Immunol. 136:1461-1466.
52. + T cells. Nature 401:76-79.
53. + cytotoxic T cells and Leishmania-infected macrophages. J. Exp. Med. 174:499-505.
54. + T cells in pathogenesis associated with Leishmania amazonensis infection. J. Immunol. 158:5374-5383.
55. Soong, L., S. M. Duboise, P. Kima, and D. McMahon-Pratt. 1995. Leishmania pifanoi amastigote antigens protect mice against cutaneous leishmaniasis. Infect. Immun. 63:3559-3566.
56. Soong, L., J. C. Xu, I. S. Grewal, P. Kima, J. Sun, B. J. Longley, N. H. Ruddle, D. McMahon-Pratt, and R. A. Flavell. 1996. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4:263-273.
57. Stenger, S., D. A. Hanson, R. Teitelbaum, P. Dewan, K. R. Niazi, C. J. Froelich, T. Ganz, S. Thoma-Uszynski, A. Melian, C. Bogdan, S. A. Porcelli, B. R. Bloom, A. M. Krensky, and R. L. Modlin. 1998. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282:121-125.
58. Stenger, S., R. J. Mazzaccaro, K. Uyemura, S. Cho, P. F. Barnes, J. P. Rosat, A. Sette, M. B. Brenner, S. A. Porcelli, B. R. Bloom, and R. L. Modlin. 1997. Differential effects of cytolytic T cell subsets on intracellular infection. Science 276:1684-1687.
59. Sunderkotter, C., M. Kunz, K. Steinbrink, G. Meinardus-Hager, M. Goebeler, H. Bildau, and C. Sorg. 1993. Resistance of mice to experimental leishmaniasis is associated with more rapid appearance of mature macrophages in vitro and in vivo. J. Immunol. 151:4891-4901.
60. + T cell response. J. Exp. Med. 181:961-971.
61. Sypek, J. P., C. L. Chung, S. E. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J. Exp. Med. 177:1797-1802.
62. Titus, R. G., M. Marchand, T. Boon, and J. A. Louis. 1985. A limiting dilution assay for quantifying Leishmania major in tissues of infected mice. Parasite Immunol. 7:545-555.
63. + T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis. Eur. J. Immunol. 17:1429-1433.
64. Torrentera, F. A., N. Glaichenhaus, J. D. Laman, and Y. Carlier. 2001. T-cell responses to immunodominant LACK antigen do not play a critical role in determining susceptibility of BALB/c mice to Leishmania mexicana. Infect. Immun. 69:617-621.
65. Turco, S. J., G. F. Spath, and S. M. Beverley. 2001. Is lipophosphoglycan a virulence factor? A surprising diversity between Leishmania species. Trends Parasitol. 17:223-226.
66. Vester, B., K. Muller, W. Solbach, and T. Laskay. 1999. Early gene expression of NK cell-activating chemokines in mice resistant to Leishmania major. Infect. Immun. 67:3155-3159.
67. Wang, Z. E., S. L. Reiner, F. Hatam, F. P. Heinzel, J. Bouvier, C. W. Turck, and R. M. Locksley. 1993. Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis. J. Immunol. 151:2077-2086.
68. + effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J. Exp. Med. 179:1367-1371.