The effects of season and gender on the serum aflatoxins and ochratoxin A levels of healthy adult subjects from the Central Anatolia Region, Turkey

European Journal of Nutrition

Volumn 54, Issue 4, 2015, Pages 629-638

  Sabuncuoglu, Suna ^a   Erkekoglu, Pinar ^a   Aydin, Sevtap ^a   Şahin, Gönül ^b   Kocer Gumusel, Belma ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b EASTERN MEDITERRANEAN UNIVERSITY   (Turkey)

Author keywords

Aflatoxin; Healthy adult population; HPLC; Mycotoxin; Ochratoxin A; Turkey

Indexed keywords

AFLATOXIN B1; AFLATOXIN B2; AFLATOXIN G1; AFLATOXIN G2; OCHRATOXIN; AFLATOXIN;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NORMAL HUMAN; SEASONAL VARIATION; SERUM AFLATOXIN; SERUM OCHRATOXIN A; SEX DIFFERENCE; SUMMER; TURKEY (REPUBLIC); WINTER; ADOLESCENT; ANALYSIS; BLOOD; DIET RESTRICTION; FOOD CONTAMINATION; FOOD CONTROL; MIDDLE AGED; SEASON; TURKEY; YOUNG ADULT;

ADOLESCENT; ADULT; AFLATOXINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; FASTING; FEMALE; FOOD CONTAMINATION; FOOD MICROBIOLOGY; HUMANS; MALE; MIDDLE AGED; OCHRATOXINS; SEASONS; SEX FACTORS; TURKEY; YOUNG ADULT;

EID: 84929702701     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-014-0744-6     Document Type: Article

References (67)

1. Wogan GN, Kensler TW, Groopman JD (2012) Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29:249–257
2. EFSA (European Food Safety Autority) (2006) Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food. EFSA J 365:1–56
3. IARC (International Agency for Research on Cancer). (1993) Aflatoxins. In: Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines, and mycotoxins. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. IARC Pres: Lyon. 56: 245–395
4. Giray B, Girgin G, Engin AB, Aydin S, Sahin G (2007) Aflatoxin levels in wheat samples consumed in some regions of Turkey. Food Control 18:23–29
5. Giray B, Atasayar S, Sahin G (2009) Determination of ochratoxin A and total aflatoxin levels in corn samples from Turkey by enzyme-linked immunosorbent assay. Mycotoxin Res 25:113–116
6. Kensler TW, Roebuck BD, Wogan GN, Groopman JD (2011) Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicol Sci 120:28–48
7. Probst C, Njapau H, Cotty PJ (2007) Outbreak of an acute aflatoxicosis in Kenya in 2004: identification of the causal agent. Appl Environ Microbiol 73:2762–2764
8. IARC (International Agency for Research on Cancer) (2002) Aflatoxins. In: Traditional herbal medicines, some mycotoxins, naphthalene and styrene. IARC monographs on the evaluation of carcinogenic risks to humans. IARC Press, Lyon vol 82, pp 171–366
9. NTP (National Toxicology Program) (2011) Aflatoxins. In: 12th Report on Carcinogens. Research Department of Health and Human Services, Triangle Park, NC: Public Health Service. http://ntp.niehs.nih.gov/ntp/roc/twelfth/roc12.pdf. Accessed on 20 August 2013
10. Kew MC (2013) Aflatoxins as a cause of hepatocellular carcinoma. J Gastrointestin Liver Dis 22:305–310
11. Kotsonis FN, Burdock GA (2008) Food toxicology. In: Klaassen CD (ed) Casarett and Doull’s toxicology. The basic science of Poisons. McGraw-Hill, New York, pp 1191–1236
12. Peraica M, Domijan AM, Fuchs R, Lucić A, Radić B (1999) The occurrence of ochratoxin A in blood in general population of Croatia. Toxicol Lett 110:105–112
13. Diaz GJ, Murcia HW, Cepeda SM (2010) Cytochrome P450 enzymes involved in the metabolism of aflatoxin B1 in chickens and quail. Poult Sci 89:2461–2469
14. Ueng YF, Shimada T, Yamazaki H, Guengerich FP (1995) Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes. Chem Res Toxicol 8:218–225
15. Blesa J, Soriano JM, Moltó JC, Mañes J (2006) Factors affecting the presence of ochratoxin A in wines. Crit Rev Food Sci Nutr 46:473–478
16. Pfohl-Leszkowicz A, Manderville RA (2007) Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans. Mol Nutr Food Res 51:61–99
17. Lian H, Cui J, Wang Y et al (2014) Downregulation of Rad51 participates in OTA-induced DNA double-strand breaks in GES-1 cells in vitro. Toxicol Lett 226:214–221
18. Marin-Kuan M, Ehrlich V, Delatour T et al (2011) Evidence for a role of oxidative stress in the carcinogenicity of ochratoxin A. J Toxicol 2011:645361
19. Pfohl-Leszkowicz A, Petkova-Bocharova T, Chernozemsky IN et al (2002) Balkan endemic nephropathy and associated urinary tract tumours: a review on aetiological causes and the potential role of mycotoxins. Food Addit Contam 19:282–302
20. Marin S, Ramos AJ, Cano-Sancho G et al (2013) Mycotoxins: occurrence, toxicology, and exposure assessment. Food Chem Toxicol 60:218–237
21. Akdeniz AS, Ozden S, Alpertunga B (2013) Ochratoxin A in dried grapes and grape-derived products in Turkey. Food Addit Contam Part B Surveill 6:265–269
22. Aldini G, Vistoli G, Regazzoni L et al (2008) Albumin is the main nucleophilic target of human plasma: a protective role against pro-atherogenic electrophilic reactive carbonyl species? Chem Res Toxicol 21:824–835
23. Wild CP, Yin F, Turner PC et al (2000) Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia. Int J Cancer 86:1–7
24. Nelson DB, Kimbrough R, Landrigan PS, Hayes AW, Yang GC, Benanides J (1980) Aflatoxin and Reye’s syndrome: a case control study. Pediatrics 66:865–869
25. AOAC International (1995) Natural toxins. In: Cunniff P (ed) Official methods of analysis of AOAC international, section 990.33. AOAC International, Gaithersburg
26. Breitholtz A, Olsen M, Dahlbäck A et al (1991) Plasma ochratoxin A levels in three Swedish populations surveyed using an ion-pair HPLC technique. Food Addit Contam 8:183–192
27. Johnson WW, Yamazaki H, Shimada T et al (1997) Aflatoxin B1 8,9-epoxide hydrolysis in the presence of rat and human epoxide hydrolase. Chem Res Toxicol 10:672–676
28. Esaki H, Kumagai S (2002) Glutathione-S-transferase activity toward aflatoxin epoxide in livers of mastomys and other rodents. Toxicon 40:941–945
29. Paterson RR, Lima N (2010) Toxicology of mycotoxins. EXS 100:31–63
30. Groopman JD, Kensler TW (1999) The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight? Carcinogenesis 20:1–11
31. Lye MS, Ghazali AA, Mohan J et al (1995) An outbreak of acute hepatic encephalopathy due to severe aflatoxicosis in Malaysia. Am J Trop Med Hyg 53:68–72
32. Wogan GN (1992) Aflatoxins as risk factors for hepatocellular carcinoma in humans. Cancer Res 52:2114–2118
33. Chen CH, Wang MH, Wang JH et al (2007) Aflatoxin exposure and hepatitis C virus in advanced liver disease in a hepatitis C virus endemic area in Taiwan. Am J Trop Med Hyg 77:747–752
34. Johnson NM, Qian G, Xu L et al (2010) Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma. Sci Total Environ 408:6027–6031
35. Hassan AM, Sheashaa HA, Abdel Fatah MF (2006) Does aflatoxin as an environmental mycotoxin adversely affect the renal and hepatic functions of Egyptian lactating mothers and their infants? A preliminary report. Int Urol Nephrol 38:339–342
36. Tchana AN, Moundipa PF, Tchouanguep FM (2010) Aflatoxin contamination in food and body fluids in relation to malnutrition and cancer status in Cameroon. Int J Environ Res Public Health 7:178–188
37. Jonsyn-Ellis FE (2001) Seasonal variation in exposure frequency and concentration levels of aflatoxins and ochratoxins in urine samples of boys and girls. Mycopathologia 152:35–40
38. Jonsyn-Ellis FE (2007) Aflatoxins and ochratoxins in serum samples of school children. J Nutr Environ Med 16:52–58
39. CAST (Council for Agricultural Science and Technology) (2003) Mycotoxins: risks in plant, animal, and human systems. Council for Agricultural Science and Technology: Ames (Iowa)
40. Williams JH, Phillips TD, Jolly PE et al (2004) Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr 80:1106–1122
41. Strosnider H, Azziz-Baumgartner E, Banziger M et al (2006) Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries. Environ Health Perspect 114:1898–1903
42. Shephard GS (2008) Impact of mycotoxins on human health in developing countries. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 25:146–151
43. Wu F (2004) Mycotoxin risk assessment for the purpose of setting international regulatory standards. Environ Sci Technol 38:4049–4055
44. Erkekoglu P, Sabuncuoğlu S, Aydin S et al (2010) Determination of seasonal variations in serum ochratoxin A levels in healthy population living in some regions of Turkey by enzyme-linked immunosorbent assay. Toxicon 55:507–513
45. Golinski P (1987) Ochratoxin A in human organism as a result of food and feed contamination. Rocz AR Poznaniu 168:1–61
46. Scott PM, Kanhere SR, Lau BPY et al (1998) Survey of Canadian human blood plasma for ochratoxin A. Food Addit Contam 15:555–562
47. Ueno Y, Maki S, Lin J et al (1998) A 4-year study of plasma ochratoxin A in a selected population in Tokyo by immunoassay and immunoaffinity column-linked HPLC. Food Chem Toxicol 36:445–449
48. Akdemir C, Ulker OC, Basaran A (2010) Estimation of ochratoxin A in some Turkish populations: an analysis in urine as a simple, sensitive and reliable biomarker. Food Chem Toxicol 48:877–882
49. Ozçelik N, Koşar A, Soysal D (2001) Ochratoxin A in human serum samples collected in Isparta-Turkey from healthy individuals and individuals suffering from different urinary disorders. Toxicol Lett 121:9–13
50. Rosner H, Rohrmann B, Peiker G (2000) Ochratoxin A in human serum. Archiv Lebensmittelhyg 51:104–107
51. Cholmakov-Bodechtel C, Wolff J, Gareis M et al (2000) Ochratoxin A: representative food consumption survey and epidemiological analysis. Archiv Lebensmittelhyg 51:111–117
52. Coronel MB, Sanchis V, Ramos AJ et al (2011) Ochratoxin A in adult population of Lleida, Spain: presence in blood plasma and consumption in different regions and seasons. Food Chem Toxicol 49:2697–2705
53. Palli D, Miraglia M, Saieva C et al (1999) Serum levels of ochratoxin A in healthy adults in Tuscany: correlation with individual characteristics and between repeat measurements. Cancer Epidemiol Biomarkers Prev 8:265–269
54. Peraica M, Domijan AM, Matasin M et al (2001) Variations of ochratoxin A concentration in the blood of healthy populations in some Croatian cities. Arch Toxicol 75:410–414
55. Assaf H, Betbeder AM, Creppy EE et al (2004) Ochratoxin A levels in human plasma and foods in Lebanon. Hum Exp Toxicol 23(10):495–501
56. Wafa EW, Yahya RS, Sobh MA et al (1998) Human ochratoxicosis and nephropathy in Egypt: a preliminary study. Hum Exp Toxicol 17:124–129
57. Khalef A, Zidane C, Charef A, Gharbi A, Tadjerouna M, Betbeder AM, Creppy EE (1993) In: Creppy E, Castegnaro M, Dirheimer G (eds) Human ochratoxicosis and its pathologies. John Libbey Eurotext, France, pp 123–127
58. Maaroufi K, Achour A, Hammami M et al (1995) Ochratoxin A in human blood in relation to nephropathy in Tunisia. Hum Exp Toxicol 14:609–614
59. Grosso F, Saíd S, Mabrouk I et al (2003) New data on the occurrence of ochratoxin A in human sera from patients affected or not by renal diseases in Tunisia. Food Chem Toxicol 41:1133–1140
60. Abid S, Hassen W, Achour A et al (2003) Ochratoxin A and human chronic nephropathy in Tunisia: is the situation endemic? Hum Exp Toxicol 22:77–84
61. Filali A, Betbeder AM, Baudrimont I et al (2002) Ochratoxin A in human in Morocco: a preliminary survey. Hum Exp Toxicol 21:241–245
62. Thuvander A, Paulsen JE, Axberg K et al (2001) Levels of ochratoxin A in blood from Norwegian and Swedish blood donors and their possible correlation with food consumption. Food Chem Toxicol 39:1145–1151
63. Nordic Working group on Food Toxicology and Risk Evaluation (1991) Health evaluation of ochratoxin A in food products/The Nordic Working Group on Food Toxicology and Risk Evaluation. The Nordic Council of Ministers: Copenhagen
64. WHO (World Health Organization) (1996) Ochratoxin A, toxicological evaluation of certain food additives and contaminants. WHO Food Additives Series 35. WHO Press, Geneva, pp 363–376
65. Wild CP, Turner PC (2001) Exposure biomarkers in chemoprevention studies of liver cancer. IARC Sci Publ 154:215–222
66. Valencia-Quintana R, Sánchez-Alarcón J, Tenorio-Arvide MG et al (2014) The microRNAs as potential biomarkers for predicting the onset of aflatoxin exposure in human beings: a review. Front Microbiol 5:102
67. Lutz W, Nowakowska-Swirta E (2002) Gene p53 mutations, protein p53, and anti-p53 antibodies as biomarkers of cancer process. Int J Occup Med Environ Health 15:209–218