메뉴 건너뛰기




Volumn 22, Issue 3, 2013, Pages 305-310

Aflatoxins as a cause of hepatocellular carcinoma

Author keywords

Aflatoxins; Contaminant; Eastern Asia; Hepatocellular carcinoma; South America; Staple foods; Sub Saharan Africa

Indexed keywords

AFLATOXIN; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; MYCOTOXIN; CARCINOGEN;

EID: 84884597715     PISSN: 18418724     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (220)

References (63)
  • 1
    • 84884613016 scopus 로고    scopus 로고
    • IARC, International Agency for Research on Cancer (IARC). IARC Press, Lyon, France
    • IARC. Monographs on the evaluation of carcinogenic risks in humans. International Agency for Research on Cancer (IARC). IARC Press, Lyon, France 2002, Vol. 82.
    • (2002) Monographs on the evaluation of carcinogenic risks in humans , vol.82
  • 2
    • 16544376533 scopus 로고    scopus 로고
    • Human aflatoxicosis in developing countries: A review of toxicology, exposure, potential health consequences, and interventions
    • Williams JH, Phillips TD, Jolly PE, Stiles JK, Jolly CM, Aggarwal D. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am J Clin Nutr 2004; 80: 1106-1122.
    • (2004) Am J Clin Nutr , vol.80 , pp. 1106-1122
    • Williams, J.H.1    Phillips, T.D.2    Jolly, P.E.3    Stiles, J.K.4    Jolly, C.M.5    Aggarwal, D.6
  • 3
    • 33845302929 scopus 로고    scopus 로고
    • Work group report: Public health strategies for reducing aflatoxin exposure in developing countries
    • Strosnider H, Azziz-Baumgartner E, Banziger M, et al. Work group report: Public health strategies for reducing aflatoxin exposure in developing countries. Environ Health Perspect 2006; 114: 1898-1903.
    • (2006) Environ Health Perspect , vol.114 , pp. 1898-1903
    • Strosnider, H.1    Azziz-Baumgartner, E.2    Banziger, M.3
  • 4
    • 84865497602 scopus 로고    scopus 로고
    • Population attributable risk of aflatoxin-related liver cancer: Systematic review and meta-analysis
    • Liu Y, Chang CC, Marsh GM, Wu F. Population attributable risk of aflatoxin-related liver cancer: systematic review and meta-analysis. Eur J Cancer 2012; 48: 2125-2136.
    • (2012) Eur J Cancer , vol.48 , pp. 2125-2136
    • Liu, Y.1    Chang, C.C.2    Marsh, G.M.3    Wu, F.4
  • 5
    • 77953237514 scopus 로고    scopus 로고
    • Global burden of aflatoxin-induced hepatocellular carcinoma: A risk assessment
    • Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 2010; 118: 818-824.
    • (2010) Environ Health Perspect , vol.118 , pp. 818-824
    • Liu, Y.1    Wu, F.2
  • 6
    • 0034113808 scopus 로고    scopus 로고
    • Primary prevention of hepatocellular carcinoma in developing countries
    • Wild CP, Hall AJ. Primary prevention of hepatocellular carcinoma in developing countries. Mutat Res 2000; 46: 381-393.
    • (2000) Mutat Res , vol.46 , pp. 381-393
    • Wild, C.P.1    Hall, A.J.2
  • 9
    • 84859218298 scopus 로고    scopus 로고
    • Association of serum aflatoxin B1-lysine adductlevel with socio-demographic factors and aflatoxin intake from nuts and related nut products in Malaysia
    • Leong YH, Rosma MA, Latiff AA, Izzah AN. Association of serum aflatoxin B1-lysine adductlevel with socio-demographic factors and aflatoxin intake from nuts and related nut products in Malaysia. Int J Hyg Environ Health 2012; 215: 368-372.
    • (2012) Int J Hyg Environ Health , vol.215 , pp. 368-372
    • Leong, Y.H.1    Rosma, M.A.2    Latiff, A.A.3    Izzah, A.N.4
  • 11
    • 0033210301 scopus 로고    scopus 로고
    • Mycotoxins: Their implications for human and animal health
    • Fink-Gremmels J. Mycotoxins: their implications for human and animal health. Vet Q 1999; 21: 115-120.
    • (1999) Vet Q , vol.21 , pp. 115-120
    • Fink-Gremmels, J.1
  • 13
    • 0032904779 scopus 로고    scopus 로고
    • Advances in the development of host resistance in corn to aflatoxin contamination by Aspergillus flavus
    • Brown RL, Chen ZY, Cleveland TE, Russin JS. Advances in the development of host resistance in corn to aflatoxin contamination by Aspergillus flavus. Phytopathology 1999; 89: 113-117.
    • (1999) Phytopathology , vol.89 , pp. 113-117
    • Brown, R.L.1    Chen, Z.Y.2    Cleveland, T.E.3    Russin, J.S.4
  • 14
    • 33846269628 scopus 로고    scopus 로고
    • Aflatoxin-albumin adducts: A basis for comparative carcinogenesis between animals and humans
    • Wild CP, Hasegawa R, Barraud L, et al. Aflatoxin-albumin adducts: a basis for comparative carcinogenesis between animals and humans. Cancer Epidemiol Biomarkers Prev 1996; 5: 179-189.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 179-189
    • Wild, C.P.1    Hasegawa, R.2    Barraud, L.3
  • 15
    • 0000344404 scopus 로고    scopus 로고
    • Aflatoxin exposure as a risk factor in the etiology of hepatocellular carcinoma
    • In: Okuda K, Tabor E (eds), Churchill Livingstone, New York
    • Wogan GN. Aflatoxin exposure as a risk factor in the etiology of hepatocellular carcinoma. In: Okuda K, Tabor E (eds). Liver Cancer. Churchill Livingstone, New York 1997: S1-S8.
    • (1997) Liver Cancer
    • Wogan, G.N.1
  • 16
    • 0036856464 scopus 로고    scopus 로고
    • The toxicity of aflatoxins as a basis for public health decisions
    • Wild CP, Turner PC. The toxicity of aflatoxins as a basis for public health decisions. Mutagenesis 2002; 17: 471-481.
    • (2002) Mutagenesis , vol.17 , pp. 471-481
    • Wild, C.P.1    Turner, P.C.2
  • 17
    • 0037276683 scopus 로고    scopus 로고
    • Dietary aflatoxin exposure and chemoprevention of cancer: A clinical review
    • Sudakin DL. Dietary aflatoxin exposure and chemoprevention of cancer: a clinical review. J Toxicol Clin Toxicol 2003; 41: 195-204.
    • (2003) J Toxicol Clin Toxicol , vol.41 , pp. 195-204
    • Sudakin, D.L.1
  • 19
    • 0028965135 scopus 로고
    • Cellular interactions and metabolism of aflatoxin: An update
    • McLean, Dutton MF. Cellular interactions and metabolism of aflatoxin: an update. Pharmacol Ther 1995; 65: 163-192.
    • (1995) Pharmacol Ther , vol.65 , pp. 163-192
    • McLean, D.M.F.1
  • 22
    • 0025828517 scopus 로고
    • Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
    • Bressac B, Kew MC, Wands J, Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991; 350: 429-431.
    • (1991) Nature , vol.350 , pp. 429-431
    • Bressac, B.1    Kew, M.C.2    Wands, J.3    Ozturk, M.4
  • 23
  • 24
    • 34047210411 scopus 로고    scopus 로고
    • TP53 mutations and hepatocellular carcinoma: Insights into the etiology and pathogenesis of liver cancer
    • Hussain SP, Schwank J, Staib F, Wang XW, Harris CC. TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. Oncogene 2007; 26: 2166-2176
    • (2007) Oncogene , vol.26 , pp. 2166-2176
    • Hussain, S.P.1    Schwank, J.2    Staib, F.3    Wang, X.W.4    Harris, C.C.5
  • 27
    • 0028965135 scopus 로고
    • Cellular interactions and metabolism of aflatoxin: An update
    • McLean M, Dutton MF. Cellular interactions and metabolism of aflatoxin: an update. Pharmacol Ther 1995; 65: 163-192.
    • (1995) Pharmacol Ther , vol.65 , pp. 163-192
    • McLean, M.1    Dutton, M.F.2
  • 28
    • 84861872186 scopus 로고    scopus 로고
    • Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: Association with tumors developing in the absence of liver cirrhosis
    • Villar S, Ortiz-Cuaran S, Abedi-Ardekani B, et al. Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. PLoS One 2012; 7: e737707.
    • (2012) PLoS One , vol.7
    • Villar, S.1    Ortiz-Cuaran, S.2    Abedi-Ardekani, B.3
  • 29
    • 0034684954 scopus 로고    scopus 로고
    • Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from the Gambia
    • Kirk GD, Camus-Randon AM, Mendy M, et al. Ser-249 p53 mutations in plasma DNA of patients with hepatocellular carcinoma from the Gambia. J Natl Cancer Inst 2000; 92: 148-153.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 148-153
    • Kirk, G.D.1    Camus-Randon, A.M.2    Mendy, M.3
  • 30
    • 70349937002 scopus 로고    scopus 로고
    • The aflatoxin-induced TP53 mutation at codon 249 (R249S): Biomarker of exposure, early detection and target for therapy
    • Gouas D, Shi H, Hainaut P. The aflatoxin-induced TP53 mutation at codon 249 (R249S): biomarker of exposure, early detection and target for therapy. Cancer Lett 2009; 286: 29-37.
    • (2009) Cancer Lett , vol.286 , pp. 29-37
    • Gouas, D.1    Shi, H.2    Hainaut, P.3
  • 31
    • 26944494627 scopus 로고    scopus 로고
    • 249(Ser) TP53 mutation in plasma DNA, hepatitis B virus infection, and risk of hepatocellular carcinoma
    • Kirk GD, Lesi OA, Mendy M, et al. 249(Ser) TP53 mutation in plasma DNA, hepatitis B virus infection, and risk of hepatocellular carcinoma. Oncogene 2005; 24: 5858-5867.
    • (2005) Oncogene , vol.24 , pp. 5858-5867
    • Kirk, G.D.1    Lesi, O.A.2    Mendy, M.3
  • 32
    • 0025857503 scopus 로고
    • Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice
    • Sell S, Hunt JM, Dunsford HJ, Chisari FV. Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. Cancer Res 1991; 51: 1278-1285.
    • (1991) Cancer Res , vol.51 , pp. 1278-1285
    • Sell, S.1    Hunt, J.M.2    Dunsford, H.J.3    Chisari, F.V.4
  • 33
    • 0029096455 scopus 로고
    • Synergistic hepatocarcinogenic effect of hepadnaviral infection and dietary aflatoxin B1 in woodchucks
    • Bannasch P, Khoshkhou NI, Havker HJ, et al. Synergistic hepatocarcinogenic effect of hepadnaviral infection and dietary aflatoxin B1 in woodchucks. Cancer Res 1995; 55: 3318-3330.
    • (1995) Cancer Res , vol.55 , pp. 3318-3330
    • Bannasch, P.1    Khoshkhou, N.I.2    Havker, H.J.3
  • 34
    • 0025194962 scopus 로고
    • Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks
    • Cova L, Wild CP, Mehrotra R, et al. Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumors in ducks. Cancer Res 1990; 50: 2156-2163.
    • (1990) Cancer Res , vol.50 , pp. 2156-2163
    • Cova, L.1    Wild, C.P.2    Mehrotra, R.3
  • 35
    • 0032604738 scopus 로고    scopus 로고
    • Synergistic effect of hepatitis B virus and aflatoxin B1 in hepatocarcinogenesis in tree shrews
    • Li Y, Su JJ, Qin LL, Yang C, Ban KC, Yan RQ. Synergistic effect of hepatitis B virus and aflatoxin B1 in hepatocarcinogenesis in tree shrews. Ann Acad Med Singapore 1999; 28: 67-71.
    • (1999) Ann Acad Med Singapore , vol.28 , pp. 67-71
    • Li, Y.1    Su, J.J.2    Qin, L.L.3    Yang, C.4    Ban, K.C.5    Yan, R.Q.6
  • 36
    • 0022404097 scopus 로고
    • Risk factors for hepatocellular carcinoma in Guangxi, People's Republic of China
    • Yeh FS, Mo CC, Yen RC. Risk factors for hepatocellular carcinoma in Guangxi, People's Republic of China. Nat Cancer Inst Monogr 1985; 69: 47-48.
    • (1985) Nat Cancer Inst Monogr , vol.69 , pp. 47-48
    • Yeh, F.S.1    Mo, C.C.2    Yen, R.C.3
  • 37
    • 0029882109 scopus 로고    scopus 로고
    • Molecular biomarkers for aflatoxins: From adducts to gene mutations to human liver cancer
    • Groopman JD, Wang JS, Scholl P. Molecular biomarkers for aflatoxins: from adducts to gene mutations to human liver cancer. Can J Physiol Pharmacol 1996; 74: 203-209.
    • (1996) Can J Physiol Pharmacol , vol.74 , pp. 203-209
    • Groopman, J.D.1    Wang, J.S.2    Scholl, P.3
  • 38
    • 0348013131 scopus 로고    scopus 로고
    • Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis
    • Kew MC. Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis. Liver Internat 2003; 23: 405-409.
    • (2003) Liver Internat , vol.23 , pp. 405-409
    • Kew, M.C.1
  • 39
    • 13944251714 scopus 로고    scopus 로고
    • Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinoma from Thailand
    • Kuang SY, Lekawanavijit S, Maneekarn N, et al. Hepatitis B 1762T/1764A mutations, hepatitis C infection, and codon 249 p53 mutations in hepatocellular carcinoma from Thailand. Cancer Epidemiol Biomarkers Prev 2005; 14: 380-384.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 380-384
    • Kuang, S.Y.1    Lekawanavijit, S.2    Maneekarn, N.3
  • 40
    • 33749558598 scopus 로고    scopus 로고
    • Molecular epidemiology of human liver cancer: Insights into etiology, pathogenesis and prevention from the Gambia, West Africa
    • Kirk GD, Bah E, Montesano R. Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from the Gambia, West Africa. Carcinogenesis 2006; 27: 2070-2082.
    • (2006) Carcinogenesis , vol.27 , pp. 2070-2082
    • Kirk, G.D.1    Bah, E.2    Montesano, R.3
  • 41
    • 70449122418 scopus 로고    scopus 로고
    • A model of interaction: Aflatoxins and hepatitis viruses in liver cancer aetiology and prevention
    • Wild CP, Montesano R. A model of interaction: aflatoxins and hepatitis viruses in liver cancer aetiology and prevention. Cancer Lett 2009; 286: 22-28.
    • (2009) Cancer Lett , vol.286 , pp. 22-28
    • Wild, C.P.1    Montesano, R.2
  • 42
    • 0000344404 scopus 로고    scopus 로고
    • Aflatoxin exposure as a risk factor in the etiology of hepatocellular carcinoma
    • In: Okuda K, Tabor E (eds), Churchill, Livingstone, New York
    • Wogan GM. Aflatoxin exposure as a risk factor in the etiology of hepatocellular carcinoma. In: Okuda K, Tabor E (eds). Liver Cancer. Churchill, Livingstone, New York 1997: S1-S8.
    • (1997) Liver Cancer
    • Wogan, G.M.1
  • 43
    • 0026566829 scopus 로고
    • Urinary aflatoxin biomarkers and the risk of hepatocellular carcinoma
    • Ross RK, Yuan JM, Yu MC, et al. Urinary aflatoxin biomarkers and the risk of hepatocellular carcinoma. Lancet 1992; 339: 943-946.
    • (1992) Lancet , vol.339 , pp. 943-946
    • Ross, R.K.1    Yuan, J.M.2    Yu, M.C.3
  • 44
    • 0028356088 scopus 로고
    • A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China
    • Qian GS, Ross RK, Yu MC, et al. A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiol Biomarkers Prev 1994; 3: 3-10.
    • (1994) Cancer Epidemiol Biomarkers Prev , vol.3 , pp. 3-10
    • Qian, G.S.1    Ross, R.K.2    Yu, M.C.3
  • 45
    • 33646234399 scopus 로고    scopus 로고
    • Temporal patterns of aflatoxinalbumin adducts in hepatitis B surface antigen-positive and antigennegative residents of Darxin, Qidong County, People's Republic of China
    • Wang JS, Qian GS, Zarba A, et al. Temporal patterns of aflatoxinalbumin adducts in hepatitis B surface antigen-positive and antigennegative residents of Darxin, Qidong County, People's Republic of China. Cancer Epidemiol Biomarkers Prev 1996; 5: 253-261.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 253-261
    • Wang, J.S.1    Qian, G.S.2    Zarba, A.3
  • 46
    • 0030791718 scopus 로고    scopus 로고
    • P53 mutations, chronic hepatitis B infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan
    • Lunn RM, Zhang YJ, Wang LY, et al. p53 mutations, chronic hepatitis B infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan. Cancer Res 1997; 57: 3471-3477.
    • (1997) Cancer Res , vol.57 , pp. 3471-3477
    • Lunn, R.M.1    Zhang, Y.J.2    Wang, L.Y.3
  • 47
    • 3042648563 scopus 로고    scopus 로고
    • Population-attributable risk of dietary aflatoxins and hepatitis B virus infection with respect to hepatocellular carcinoma
    • Omer RE, Kuijsten A, Kaduru AM, et al. Population-attributable risk of dietary aflatoxins and hepatitis B virus infection with respect to hepatocellular carcinoma. Nutr Cancer 2004; 48: 15-21.
    • (2004) Nutr Cancer , vol.48 , pp. 15-21
    • Omer, R.E.1    Kuijsten, A.2    Kaduru, A.M.3
  • 48
    • 0032793909 scopus 로고    scopus 로고
    • Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1
    • Sun Z, Lu P. Gail MH, et al. Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology 1999; 30; 379-383.
    • (1999) Hepatology , vol.30 , pp. 379-383
    • Sun, Z.1    Lu, P.2    Gail, M.H.3
  • 49
    • 0026612968 scopus 로고
    • Aflatoxin B1 adducts in smeared tumor tissue from patients with hepatocellular carcinoma
    • Chen CJ, Zhang YJ, Lu SN, Santella RM. Aflatoxin B1 adducts in smeared tumor tissue from patients with hepatocellular carcinoma. Hepatology 1992; 16: 1150-1155.
    • (1992) Hepatology , vol.16 , pp. 1150-1155
    • Chen, C.J.1    Zhang, Y.J.2    Lu, S.N.3    Santella, R.M.4
  • 50
    • 0026767925 scopus 로고
    • Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children
    • Allen SJ, Wild CP, Wheeler JG, et al. Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children. Trans R Soc Trop Med Hyg 1992; 86: 426-430.
    • (1992) Trans R Soc Trop Med Hyg , vol.86 , pp. 426-430
    • Allen, S.J.1    Wild, C.P.2    Wheeler, J.G.3
  • 52
    • 9544236289 scopus 로고    scopus 로고
    • Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan
    • Wang LY, Hatch M, Chen CJ, et al. Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. Int J Cancer 1996; 67: 620-625.
    • (1996) Int J Cancer , vol.67 , pp. 620-625
    • Wang, L.Y.1    Hatch, M.2    Chen, C.J.3
  • 53
    • 0347706142 scopus 로고
    • A p53 mutational hotspot in primary liver cancer is geographically localised in high aflatoxin areas of the world
    • Ozturk M. Bressac B, Pusieux A, et al. A p53 mutational hotspot in primary liver cancer is geographically localised in high aflatoxin areas of the world. Lancet 1991; 338; 260-265.
    • (1991) Lancet , vol.338 , pp. 260-265
    • Ozturk, M.1    Bressac, B.2    Pusieux, A.3
  • 54
    • 0027325389 scopus 로고
    • High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinoma from Senegal
    • Coursaget P, Depril N, Chabaud M, et al. High prevalence of mutations at codon 249 of the p53 gene in hepatocellular carcinoma from Senegal. Br J Cancer 1993; 67: 1395-1397.
    • (1993) Br J Cancer , vol.67 , pp. 1395-1397
    • Coursaget, P.1    Depril, N.2    Chabaud, M.3
  • 55
    • 0034905993 scopus 로고    scopus 로고
    • Hepatitis B, aflatoxin B1, and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a metaanalysis of existing studies
    • Stern M, Umbach DM, Yu MC, London SJ, Zhang ZQ, Taylor JA. Hepatitis B, aflatoxin B1, and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China, and a metaanalysis of existing studies. Cancer Epidemiol Biomarkers Prev 2001; 10: 617-625.
    • (2001) Cancer Epidemiol Biomarkers Prev , vol.10 , pp. 617-625
    • Stern, M.1    Umbach, D.M.2    Yu, M.C.3    London, S.J.4    Zhang, Z.Q.5    Taylor, J.A.6
  • 56
    • 78650769017 scopus 로고    scopus 로고
    • Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma
    • Kew MC. Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma. J Gastroenterol Hepatol 2011; 26: 144-152.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 144-152
    • Kew, M.C.1
  • 57
    • 0036843524 scopus 로고    scopus 로고
    • Dual effects of hepatitis B virus x protein the regulation of cell cycle control depending on the status of cellular p53
    • Ahn JY, Jung EY, Kwun HJ, Lee CW, Sung YC, Jang KL. Dual effects of hepatitis B virus x protein the regulation of cell cycle control depending on the status of cellular p53. J Gen Virol 2002; 83: 2765-2772.
    • (2002) J Gen Virol , vol.83 , pp. 2765-2772
    • Ahn, J.Y.1    Jung, E.Y.2    Kwun, H.J.3    Lee, C.W.4    Sung, Y.C.5    Jang, K.L.6
  • 58
    • 0036828029 scopus 로고    scopus 로고
    • Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein
    • Madden CR, Finegold MJ, Slagle BL. Altered DNA mutation spectrum in aflatoxin b1-treated transgenic mice that express the hepatitis B virus x protein. J Virol 2002; 76: 11770-11774.
    • (2002) J Virol , vol.76 , pp. 11770-11774
    • Madden, C.R.1    Finegold, M.J.2    Slagle, B.L.3
  • 59
    • 0033559939 scopus 로고    scopus 로고
    • Hepatitis B virus x protein inhibits nucleotide excision repair
    • Jia L, Wang XW, Harris CC. Hepatitis B virus x protein inhibits nucleotide excision repair. Int J Cancer 1999; 80: 875-879.
    • (1999) Int J Cancer , vol.80 , pp. 875-879
    • Jia, L.1    Wang, X.W.2    Harris, C.C.3
  • 60
    • 0024818649 scopus 로고
    • Molecular pathogenesis of hepatocellular carcinoma in hepatitis B transgenic mice
    • Chisari FV, Klopchin K, Moriyama T, et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B transgenic mice. Cell 1989; 59: 1145-1156.
    • (1989) Cell , vol.59 , pp. 1145-1156
    • Chisari, F.V.1    Klopchin, K.2    Moriyama, T.3
  • 61
    • 0028218474 scopus 로고
    • Chronic infection and inflammatory processes as cancer risk factors: Possible role of nitric oxide in carcinogenesis
    • Ohshima H, Bartsch H. Chronic infection and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 1994; 305: 253-264.
    • (1994) Mutat Res , vol.305 , pp. 253-264
    • Ohshima, H.1    Bartsch, H.2
  • 62
    • 0028365709 scopus 로고
    • Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene
    • Hussain SP, Aquilar F, Amstad P, Cerutti P. Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene. Oncogene 1994; 9; 2277-2281.
    • (1994) Oncogene , vol.9 , pp. 2277-2281
    • Hussain, S.P.1    Aquilar, F.2    Amstad, P.3    Cerutti, P.4
  • 63
    • 0036789450 scopus 로고    scopus 로고
    • High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adducts in human hepatocellular carcinoma
    • Zhang YJ, Ahsan H, Chen Y, et al. High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adducts in human hepatocellular carcinoma. Mol Carcinog 2002; 35: 85-92.
    • (2002) Mol Carcinog , vol.35 , pp. 85-92
    • Zhang, Y.J.1    Ahsan, H.2    Chen, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.