Glutathione-S-transferase activity toward aflatoxin epoxide in livers of mastomys and other rodents

Toxicon

Volumn 40, Issue 7, 2002, Pages 941-945

  Esaki, H ^a   Kumagai, S ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Aflatoxin; Glutathione S transferase; Liver; Mastomys

Indexed keywords

AFLATOXIN; AFLATOXIN EPOXIDE; EPOXIDE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; UNCLASSIFIED DRUG; AFLATOXIN B1; AFLATOXIN B1 2,3 OXIDE; AFLATOXIN B1-2,3-OXIDE; CARCINOGEN; DNA; DRUG DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONJUGATION; CONTROLLED STUDY; DNA ADDUCT; DNA BINDING; ENZYME ACTIVITY; HAMSTER; LIVER; LIVER METABOLISM; LIVER MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; RODENT; ANIMAL; COMPARATIVE STUDY; CYTOSOL; ENZYMOLOGY; FISCHER 344 RAT; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MURIDAE; SPECIES DIFFERENCE; SYRIAN HAMSTER;

AFLATOXIN B1; ANIMAL; CARCINOGENS; COMPARATIVE STUDY; CYTOSOL; DNA; GLUTATHIONE TRANSFERASE; HAMSTERS; LIVER; MESOCRICETUS; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; MURIDAE; RATS; RATS, INBRED F344; SPECIES SPECIFICITY; ANIMALS; CRICETINAE;

ANIMALIA; CRICETINAE; MASTOMYS; RODENTIA;

EID: 0035998323     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(02)00090-9     Document Type: Article

References (27)

1. Effects of dietary oltipraz and ethoxyquin on aflatoxin B1 biotransformation in non-human primates
2. Differences in aflatoxin b1-susceptibility of rat and mouse are correlated with the capability in vitro to inactivate aflatoxin b1-epoxide
3. Expression of stably transfected murine glutathione S-transferase A3-3 protects against nucleic acid alkylation and cytotoxicity by aflatoxin B1 in hamster V79 cells expressing rat cytochrome P450-2B1
4. Effects of phenobarbital on the biliary excretion of aflatoxin P1-glucuronide and aflatoxin b1-S-glutathione in the rat
5. DNA adduction by the potent carcinogen aflatoxin B1: Mechanistic studies
6. Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: Role of induction of glutathione S-transferases
7. Biochemical basis for the extreme sensitivity of turkeys to aflatoxin B1
8. In vitro aflatoxin b1-DNA binding by microsomes and its moduration by cytosol: Comparison of various mammalian and avian livers in relation to species difference in susceptibility
9. The fate and acute toxicity of aflatoxin b1 in the mastomys and rat
10. Modulation of microsome-mediated aflatoxin B1 binding to exogenous and endogenous DNA by cytosolic glutathione S-transferases in rat and hamster livers
11. Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin b1 hepatocarcinogenesis in the rat
12. Comparative effects of butylated hydroxyanisole on hepatic in vivo DNA binding and in vitro biotransformation of aflatoxin B1 in the rat and mouse
13. The formation of 2,3-dihydroxy-2,3-dihydro-aflatoxin B1 by the metabolism of aflatoxin B1 by liver microsomes isolated from certain avian and mammalian species and the possible role of this metabolite in the acute toxicity of aflatoxin B1
14. Conjugation of model substrates or microsomally activated aflatoxin B1 with reduced glutathione, catalysed by cytosolic glutathione-S-transferases in livers of rats, mice, and guinea pigs
15. Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: A review
16. Metabolic basis of the species difference to aflatoxin B1 induced hepatotoxicity
17. Metabolism as a factor in determining the toxic action of the aflatoxins in different animal species
18. Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases
19. Protective activity of different hepatic cytosolic glutathione S-transferases against DNA-binding metabolites of aflatoxin B1
20. Comparative kinetic studies on aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation with rat and hamster livers in vitro
21. Species susceptibility to aflatoxin B1 carcinogenesis: Comparative kinetics of microsomal biotransformation
22. Glutathione conjugation of aflatoxin b1 exo- and endo-epoxides by rat and human glutathione S-transferases
23. Human variability in hepatic glutathione S-transferase-mediated conjugation of aflatoxin B1-epoxide and other substrates
24. Growth hormone- and teststerone-dependent regulation of glutathione transferase subunit A5 in rat liver
25. Glutathione S-transferase-catalyzed conjugation of bioactivated aflatoxin B1 in rabbit lung and liver
26. The comparative metabolism and toxicokinetics of aflatoxin B1 in the monkey, rat, and mouse
27. Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat