Balkan endemic nephropathy and associated urinary tract tumours: A review on aetiological causes and the potential role of mycotoxins

Food Additives and Contaminants

Volumn 19, Issue 3, 2002, Pages 282-302

  Pfohl Leszkowicz, A ^a   Petkova Bocharova, T ^b   Chernozemsky, I N ^b   Castegnaro, M ^c  

^a UNIVERSITÉ DE TOULOUSE   (France)

^b National Oncology Center Bulgaria   (Bulgaria)

^c INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Aetiology; Balkan endemic nephropathy; Heavy metals; Mycotoxins; Ochratoxin A citrinin; Urinary tract tumours; Virus

Indexed keywords

ARISTOLOCHIC ACID; HEAVY METAL; LIGNITE; MINERAL; MYCOTOXIN; OCHRATOXIN;

ARTICLE; BACTERIAL INFECTION; BLADDER CANCER; BULGARIA; CANCER INCIDENCE; CONTROLLED STUDY; DATA ANALYSIS; DEGENERATION; DISEASE ASSOCIATION; DISEASE COURSE; ENDEMIC DISEASE; ENVIRONMENTAL FACTOR; ENZYMURIA; FOOD CONTAMINATION; GENETIC PREDISPOSITION; GENOTOXICITY; HUMAN; HUMAN TISSUE; HYALINE DEGENERATION; INTERSTITIAL NEPHRITIS; KIDNEY BIOPSY; KIDNEY DISEASE; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY PELVIS TUMOR; KIDNEY TUBULE DISORDER; LEPTOSPIROSIS; NEPHROTIC SYNDROME; NONHUMAN; PLIOCENE; PRIORITY JOURNAL; RAT; RISK FACTOR; ROMANIA; STAGING; URETER TUMOR; URINARY TRACT DISEASE; URINARY TRACT TUMOR; VIRUS INFECTION; WORLD HEALTH ORGANIZATION; YUGOSLAVIA;

BALKAN NEPHROPATHY; CITRININ; HUMANS; METALS, HEAVY; MYCOTOXINS; OCHRATOXINS; UROLOGIC NEOPLASMS;

BACTERIA (MICROORGANISMS); LEPTOSPIRA;

EID: 0036161508     PISSN: 0265203X     EISSN: None     Source Type: Journal    
DOI: 10.1080/02652030110079815     Document Type: Article

References (233)

1. Acute histopathological changes produced by Penicillium aurantiogriseum nephrotoxin in the rat
2. Epidemiology of endemic nephropathy
3. Histopathologic and electron microscopic studies on the acute toxicity of ochratoxin A in rats
4. A study of the viral etiology of endemic nephropathy
5. Some element traces and the endemic nephropathy disease
6. Evidence of a viral aetiology in endemic (Balkan) nephropathy
7. Comparative ultrastructural studies on endemic (Balkan) nephropathy and chicken embryo nephritis caused by infectious bronchitis virus. II. Chick embryo nephritis
8. Comparative ultrastructural studies on endemic (Balkan) nephropathy and chicken embryo nephritis caused by infectious bronchitis virus. I. Endemic (Balkan) nephropathy
9. Tumorigenicity of citrinin in male F344 rats
10. Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy
11. Evaluation of the genotoxic activity of some mycotoxins using E. coli, in the SOS spot test
12. Ochratoxin A and dietary protein. 2: Effects on hematology and clinical chemistry measurements
13. Ochratoxin A carcinogenesis in the (C57B1/6J C3H)F1 mouse
14. First investigations of endemic nephropathy in the area of Brodska Posavina
15. Myelotoxicity and macrophage alteration in mice exposed to ochratoxin A
16. Etude épidémiologique de la néphropathie
17. Balkan Nephropathy: Still a mysterious disease
18. The individual and combined effects of citrinin and ochratoxin A on renal ultrastructure in layer chicks
19. Chromosomal changes in Balkan nephropathy
20. Ochratoxicosis A in young Khabi Campbell ducklings
21. Meeting Report: Endemic nephropathy and urinary tract tumours in the Balkans
22. Concentration of ochratoxin A in the urine of endemic nephropathy patients and controls in Bulgaria: Lack of detection of 4-hydroxyochratoxin A
23. Strain- and sex-specific induction of renal tumours by ochratoxin A in rats correlates with DNA adduction
24. Some epidemiologic data in the Slavonski Brod area
25. An etiological approach to Balkan Endemic Nephropathy based on the investigation of two genetically different populations
26. Epidemiological features of endemic nephropathy in the focal area of Brodska Posovina, Croatia
27. Endemic nephropathy in Brodska Posavina-in a twenty year period
28. Impaired phagocytosis by monocytes from fowls with ochratoxicosis
29. Impairment of phagocytosis by heterophils from chickens during ochrtatoxicosis
30. A leucocytopenia induced in chickens by dietary ochratoxin A
31. Geographic correlation between the occurrence of endemic nephropathy and urinary tract tumours in Vratza district, Bulgaria
32. Interaction of ochratoxin A with bovine serum albumin
33. Chronic aristolochic acid toxicity in rabbits A model of Chinese herbs nephropathy?
34. Urothelial lesions in Chinese-herb nephropathy
35. Genotoxicity of ochratoxin A in mice, DNA single-strand break evaluation in spleen, liver and kidney
36. Porodična oboljenja bubrega u selu Šopić izvazvana hroničnom intoksikácijon olovorm
37. Chronic nephritis caused by poisoning with lead via the digestive tract (flour)
38. Genotoxicity and cytotoxicity of ochratoxin A in ovine seminal vesicle cell cultures
39. Induction of micronuclei with ochratoxin A in ovine seminal vesicle cells
40. Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs
41. Acute renal failure from inhalation of mycotoxins
42. Studies on carcinogenesis of lactones and related substances
43. Results of current studies on the etiology of Balkan endemic nephropathy
44. Induction of genotoxic effects and modulation of the intracellular calcium level in Syrian hamster embryo (SHE) fibroblasts caused by ochratoxin A
45. Induction of unscheduled DNA synthesis in primary human urothelial cells by the mycotoxin ochratoxin A
46. Acute toxicity and carcinogenicity of ochratoxin A in rainbow trout (Salmo garidneri)
47. Screening tests for bacteriuria in patients with endemic nephropathy
48. Endemic Balkan nephropathy, a slow virus disease?
49. Pathology of ochratoxicosis in young broiler chicks
50. Effect of ochratoxin A on immunoglobulins in broiler chickens
51. Immunosuppressive effects of ochratoxin A in young turkeys
52. Spontaneous cases of toxic nephropathy in poultry associated with ochratoxin A
53. Ochratoxin A induced porcine nephropathy: Enzyme and ultrastructure changes after short-term exposure
54. Relationship between weathered coal deposits and the etiology of Balkan endemic nephropathy
55. Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated by OTA and alpha OTA
56. Nefrita cronica azotemica endo-epidemica
57. Citrinin
58. Isolation of citrinin and oxalic acid from Penicillium viridicatum and their neprotoxicity in rats and pigs
59. Human exposure to ochratoxin A
60. Oxidative damage and stress response from ochratoxin A exposure in rats
61. Metabolism of ochratoxin A: Absence of formation of genotoxic derivatives by human and rat enzymes
62. Virus-like particles in the kidneys of three patients with endemic Balkan nephropathy
63. Porcine coronavirus antibodies in endemic (Balkan) nephropathy
64. Letter: Viruses in endemic (Balkan) nephropathy
65. Ochratoxin A and dietary protein. 1. Effects on body weight, feed conversion, relative organ weight, and mortality in three-week-old broilers
66. Impact of L-phenylalanine supplementation on the performance of three-week-old broilers fed diets containing ochratoxin A. 1. Effects on body weight, feed conversion, relative organ weight and mortality
67. Balkan-nephropathy, a particular form of interstitial nephritis
68. Correlation of Balkan endemic nephropathy with fluorescent organic compounds in shallow ground water
69. Ochratoxin A metabolites and DNA-adducts formation in monkey kidney cell
70. Evaluation of ochratoxin A genotoxicity by DNA-adducts detection: Cytochromes P450 implicated
71. Retinol, ascorbic acid and alpha tocopherol prevent DNA adduct formation in mice treated with the mycotoxins ochratoxin A and zearalenone
72. Use of bronchial epithelial cells expressing human cytochrome p450 for study on metabolism and genotoxicity of ochratoxin A
73. Beneficial effects of dietary ascorbic acid supplement on hens subjective to ochratoxin A toxicosis under normal and high ambient temperature
74. Toxicokinetics of ochratoxin A in several species and its plasma-binding properties
75. Balkan Nephropathy
76. Moulds and mycotoxins in herb tea and medicinal plants
77. Natural occurrences of ochratoxicosis in poultry
78. Citrinin mycotoxicosis in the rabbit: Clinicopathological alterations
79. Citrinin mycotoxicosis in the rabbit
80. Citrinin mycotoxicosis in the rabbit: Ultrastructural alterations
81. Immunotoxicity of ochratoxin A to growing gilts
82. Evaluation of diets contaminated with aflatoxin and ochratoxin fed to growing pigs
83. Immunosuppression by ochratoxin A and its prevention by phenylalanine
84. Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation
85. Residual hematopoietic effect in mice exposed to ochratoxin A prior to irradiation
86. Nephrotoxicity of dietary ochratoxin A in broiler chickens
87. Ochratoxin A in blood from slaughter pigs in Sweden, use in evaluation of toxin content of consumed feed
88. Ochratoxin A in pig blood: Method of analysis and use as a tool for feed studies
89. Ochratoxin A in human blood and Balkan endemic nephropathy
90. Ochratoxin in blood of slaughter pigs
91. The problem of etiology of endemic nephropathy
92. Citrinin induced chromosomal abnormalities in the bone marrow cells of Mus musculus
93. Citrinin mycotoxicosis in the rat, toxicology and pathology
94. Citrinin mycotoxicosis in the Syrian hamster
95. Low molecular weight proteinuria in Chinese herbs nephropathy
96. 3H]-label from low doses of radioactive ochratoxin A ingested by rats, and evidence for DNA single-strand breaks caused in liver and kidneys
97. Synergistic effect of citrinin on hepatorenal carcinogenesis of ochratoxin A in mice
98. Induction of renal and hepatic tumors in mice by ochratoxin A, a mycotoxin
99. Ochratoxin A and citrinin induced nephrosis in beagle dogs. III Terminal renal ultrastructural alterations
100. Experimental citrinin nephrotoxicosis in dogs: Renal function evaluation
101. Mycotoxic porcine nephropathy - A possible model for Balkan (endemic) nephropathy. Endemic nephropathy
102. Mycotoxic nephropathy
103. Ochratoxins: Occurrence, biological effects and causal role in disease
104. Experimental porcine nephropathy changes of renal function and structure induced by ochratoxin A-contaminated feed
105. Porcine nephropathy induced by long-term ingestion of ochratoxin A
106. Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy
107. Balkan (endemic) nephropathy and food borne ochratoxin A: Preliminary results of a survey in foodstuff
108. Studies on fungal nephrotoxicity. 2. Isolation of two nephrotoxic compounds from Penicillium viridicatum Westling: Citrinin and oxalic acid
109. Evaluation of the mutagenic potential of mycotoxins using Salmonella typhimurium and Saccharomyces cerevisiae
110. Risk assessment of the mycotoxin ochratoxin A
111. On the content of some microelements in the surrounding milieu in the villages of the Vratza country affected by endemic nephritis
112. Mechanism of ochratoxin A induced immunosuppression
113. The aflatoxins and human liver cancer
114. Citrinin nephrotoxicity in rats: A light and electron microscopic study
115. Selective immunosuppressions in mice of natural killer cell activity by ochratoxin A
116. Assessment of human exposure to ochratoxin A in the UK - Relationship between dietary intake and plasma and urine
117. Nephrotoxicity of Penicillium aurantiogriseum and P. commune from an endemic nephropathy area in Yugoslavia
118. Genotoxicity of ochratoxin A and structurally related compounds in E. coli strains, studies on their mode of actions
119. Structure-activity studies in E. coli strains on ochratoxin A (OTA) and its analogues implicate a genotoxic free radical and a cytotoxic thiol derivative as reactive metabolites
120. The etiology and epidemiology of the leptospirosis in Bulgaria
121. Chromosomal alterations in lymphocytes of patients with Balkan endemic nephropathy and of healthy individuals after incubation in vitro with ochratoxin A
122. Induction of characteristic chromosomal aberrations, particularly x-trisomy, in cultured human lymphocytes treated by ochratoxin A, a mycotoxin implicated in Balkan endemic nephropathy
123. Nephrotoxic fungi in foods from nephropathy households in Bulgaria
124. Persistent kariomegaly caused by Penicillium nephrotoxins in the rat
125. Penicillium aurantiogriseum-induced, persistent renal histopathological changes in rat; an experimental model for Balkan endemic nephropathy competitive with ochratoxin A
126. Selenium deficiency in Serbia and possible effect on health
127. Selenium deficiency in Yugoslavia
128. Néphropathie des Balkans et carcinomes à cellules transitionnelles
129. Pathogenicité et cancérogénèse environnementale des néphropathies interstitielles chroniques accompagnées de cancer urothelial
130. Néphropathie des Balkans: Problèmes courants de pathogénie et de cancérogénèse
131. Endemic urinary tract cancer in Bulgaria, Yugoslavia and Romania: Etiology and pathogenesis
132. A review of recent advances in understanding ochratoxicosis
133. Ultrastructural study of ochratoxicosis in turkey poults
134. Studies on the sequential development and pathogenesis of citrinin mycotoxicosis in turkeys and ducklings
135. Effects of ochratoxin A on gene expression in rat kidneys
136. Genotoxicity of a variety of mycotoxins in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes
137. Studies on the influence of ochratoxin A in immune and defense reactions in the mouse model
138. Studies of the influence of ochratoxin A on immune and defence reactions in weaners
139. Toxicologic changes in rats fed graded dietary levels of ochratoxin A
140. Prevalence of hemagglutination-inhibiting antibodies to BK virus in patients with endemic Balkan nephropathy
141. Further data on the prevalence of serum antibodies to papova viruses (BK and SV40) in subjects from the Romanian area with Balkan endemic nephropathy
142. Studies on the familial character of endemic Balkan nephropathy. Possible role of the toxic hydric factor in the determination of 'familial agglomerations' in endemic Balkan nephropathy
143. On the proof and determination of some heavy metals in the water and biological products as related to the investigation of endemic nephritis
144. Urothelial carcinoma associated with the use of Chinese herbs (Aristolochia species)
145. Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes
146. Protection by indomethacin and aspirin against genotoxicity of ochratoxin A, particularly in the urinary bladder and kidney
147. Geotricum candidum. Rolul sǎu în fiziologia digestivǎ si în clinicǎ
148. Le rôle de la pollution du milieu dans l'étiologie de la néphropathie endémique
149. 1
150. Ochratoxin A contamination of foodstuffs in an area with Balkan (endemic) nephropathy
151. Contamination with moulds and occurrence of ochratoxin A in smoked meat products from endemic nephropathy regions in Yugoslavia
152. The occurrence of ochratoxin A in blood in general population of Croatia
153. Ochratoxin A contamination of cereals in an area of high incidence of Balkan endemic nephropathy in Bulgaria
154. Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary system tumours in Bulgaria
155. Ochratoxin A and other mycotoxins in cereals from an area of Balkan endemic nephropathy and urinary tract tumours in Bulgaria
156. Ochratoxin A in human blood in relation to Balkan endemic nephropathy and urinary system tumours in Bulgaria
157. DNA adduct formation in mice treated with ochratoxin A
158. Ochratoxin A related DNA adducts in urinary tract tumours of Bulgarian subjects
159. Differential DNA adduct formation and disappearance in three mice tissues after treatment by the mycotoxin ochratoxin A
160. Is the oxidative pathway implicated in the genotoxicity of ochratoxin A?
161. Preponderance of DNA-adducts in kidney after ochratoxin A exposure
162. Involvement of antioxidants and inhibitors of glutathione conjugation in ochratoxin A genotoxicity in mice liver and kidney
163. Sex- and strain-specific expression of CYPs involved in ochratoxin A genotoxicity and carcinogenicity in rats
164. Effects of citrinin on renal function and structure
165. Respective implication of cyclooxygenase in ochratoxin A genotoxicity on human epithelial lung cells
166. Effect of ochratoxin A on arachidonic pathway use of epithelial bronchial cells
167. Ochratoxin A, a review
168. Effects of ochratoxin A on growth response and residues in broilers
169. Ochratoxicosis in White Leghorn hens
170. The long term toxicity of ochratoxin A to rats
171. Ochratoxin A in human sera in the area with endemic nephropathy in Croatia
172. Clinical feature of Balkan endemic nephropathy
173. Epidemiological evidence on Balkan nephropathy as a viral disease
174. Aetiology of Balkan nephropathy: A reappraisal after 30 years
175. Well water characteristics and the Balkan Nephropathy
176. The toxicity of ochratoxin A to ruminants
177. The occurrence of ochratoxin A in dust collected from a problem household
178. Attempts to isolate in tissue cultures a cytopathogenic virus from the blood serum of cattles in Beli Izvor
179. Mutagenicity of commercial Monascus fermentation products and the role of citrinin contamination
180. Synergistic toxic effects of citrinin, ochratoxin A and penicillic acid in mice
181. Virological studies of the etiology of endemic nephropathy
182. Combination effect of citrinin and other chemicals on rat kidney tumorigenesis
183. Immunosuppression due to chronic ochratoxicosis in broiler chicks
184. Effects of the mycotoxins citrinin and ochratoxin A on hepatic mixed-function oxidase and adenosine triphosphatase in neonatal rats
185. Ochratoxin in dust and fungal spores
186. Characteristic of urinary tract tumours in the area of Balkan Endemic Nephropathy in Croatia
187. Monitoring genotoxic exposure in uranium miners
188. Monitoring genotoxic exposure in uranium mines
189. Balkan Nephropathy: A need for novel aetological approaches
190. Balkan Nephropathy
191. Experimental mycotoxic nephropathy in pigs. Pathomorphological studies
192. The role of ochratoxin A as a possible cause of Balkan endemic nephropathy and its risk evaluation
193. Susceptibility to bacterial infections in growing pigs as an early response in ochratoxicosis
194. Ultrastructural and toxicological investigations in spontaneous cases of porcine nephropathy in Bulgaria
195. Porcine nephropathy in Bulgaria: A progressive syndrome of complex and uncertain (mycotoxin) aetiology
196. Haematological, biochemical and toxicological investigations in spontaneous cases of mycotoxic nephropathy (ochratoxicosis) in pigs
197. Haematological, biochemical and toxicological investigations in spontaneous cases with different frequency of porcine nephropathy in Bulgaria
198. Serum antibodies to papova viruses (BK and SV 40) in subjects from the area with Balkan endemic nephropathy
199. Does ochratoxin A prevent the iron uptake in bacteria?
200. Citrinin, ochratoxin A and iron. Possible implications for their biological function and induction of nephropathy
201. Iron deprivation: Physiology and gene regulation
202. Ochratoxicosis in beagle dogs. II Pathology
203. Ochratoxin A toxicosis in swine
204. Studies on nephritis in the region of Vratza
205. The etiology of Balkan endemic nephropathy: Still more questions than answers
206. Citrinin mycotoxicosis in the guinea pig
207. A toxicity of citrinin and ochratoxin A in guinea pigs
208. Activity of citrinin metabolised by rat and human microsome fractions in clastogenicity and SCE assay on Chinese hamster V79E cells
209. Etiology of Balkan endemic nephropathy: A multifactorial disease?
210. Prenatal exposure of Balbc/C mice to ochratoxin A: Effects on the immune system in the offspring
211. DNA-attacking ability of carcinogenic mycotoxins in recombination-deficient mutant cells of Bacillus subtilis
212. Mutagenicity of carcinogenic mycotoxins in Salmonella typhimurium
213. Mutagenicity and inducibility of DNA single strand breaks and chromosome aberrations by various mycotoxins
214. Isolation of a coronavirus from kidney biopsies of endemic Balkan nephropathy patients
215. Rapidly progressive interstitial renal fibrosis in young women: Association with slimming regimen including Chinese herbs
216. Performance of 181 chemicals in a Drosophila assay predominantly monitoring inter-chromosomal mitotic recombination
217. Virological and immunological study of 20 patients with Balkan endemic nephropathy
218. Zum Nachweis von Mykotoxinen nach Aktivierung mit Rattenleber-homogenaten Mittels Histidin-mangel-mutanten von Salmonella typhimurium
219. Co-occurrence of ochratoxin A and citrinin in cereals from Bulgarian villages with a history of Balkan endemic nephropathy
220. Pathomorphology of Balkan endemic nephropathy
221. Environmental renal disease: Lead, cadmium and Balkan endemic nephropathy
222. Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins
223. Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102
224. Nephrotoxicity of Penicillium aurantiogriseum, a possible factor in the aetiology of Balkan endemic nephropathy