Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice

Metabolism: Clinical and Experimental

Volumn 64, Issue 7, 2015, Pages 845-856

  Fu, Lizhi ^a   Bruckbauer, Antje ^b   Li, Fenfen ^a   Cao, Qiang ^a   Cui, Xin ^a   Wu, Rui ^a   Shi, Hang ^a   Zemel, Michael B ^b   Xue, Bingzhong ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b NuSirt Sciences Inc   (United States)

Author keywords

AMPK; Diabetes; Leucine; Metformin; Sirt1

Indexed keywords

GLUCOSE; LEUCINE; METFORMIN; RESVERATROL; SIRTUIN 1; GLUCOSE BLOOD LEVEL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DEACETYLATION; DIET INDUCED OBESITY; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; GLYCEMIC CONTROL; HYPERGLYCEMIA; IN VITRO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; WEIGHT GAIN; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; DIET RESTRICTION; DRUG EFFECTS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PROCEDURES;

ADIPOCYTES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BLOOD GLUCOSE; DIET, HIGH-FAT; FASTING; GLUCOSE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE; LEUCINE; MALE; METFORMIN; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 84929653284     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.03.007     Document Type: Article

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