Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice

Diabetes, Obesity and Metabolism

Volumn 13, Issue 12, 2011, Pages 1097-1104

  Caton, P W ^a   Kieswich, J ^a   Yaqoob, M M ^a   Holness, M J ^a   Sugden, M C ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

AMP activated protein kinase; Circadian clock; Metformin; Obesity; SIRT1; White adipose tissue

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; DAPORINAD; GLUCOSE; INSULIN; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 4; METFORMIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BMAL1; SIRTUIN 1; TRANSCRIPTION FACTOR CLOCK;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT DURATION; WHITE ADIPOSE TISSUE;

EID: 80055051189     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2011.01466.x     Document Type: Article

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